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    CD53 CD53 molecule [ Homo sapiens (human) ]

    Gene ID: 963, updated on 17-Jun-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Open conformation of tetraspanins shapes interaction partner networks on cell membranes.

    Open conformation of tetraspanins shapes interaction partner networks on cell membranes.
    Yang Y, Liu XR, Greenberg ZJ, Zhou F, He P, Fan L, Liu S, Shen G, Egawa T, Gross ML, Schuettpelz LG, Li W., Free PMC Article

    04/13/2021
    Tetraspanin CD53: an overlooked regulator of immune cell function.

    Tetraspanin CD53: an overlooked regulator of immune cell function.
    Dunlock VE., Free PMC Article

    02/2/2021
    Eight SNPs of CD53 were found to be associated with tuberculosis case.

    Association between CD53 genetic polymorphisms and tuberculosis cases.
    Jin HS, Cho JE, Park S.

    05/25/2019
    In this study, significant and lineage-dependent association of CD53 locus with Tuberculosis (TB) onset was identified from the pathogen lineage-based genome-wide association study (GWAS).

    Pathogen lineage-based genome-wide association study identified CD53 as susceptible locus in tuberculosis.
    Omae Y, Toyo-Oka L, Yanai H, Nedsuwan S, Wattanapokayakit S, Satproedprai N, Smittipat N, Palittapongarnpim P, Sawanpanyalert P, Inunchot W, Pasomsub E, Wichukchinda N, Mushiroda T, Kubo M, Tokunaga K, Mahasirimongkol S., Free PMC Article

    07/21/2018
    CD53 is associated with population asthma risk via the functional promoter polymorphism -1560 C>T.

    CD53, a suppressor of inflammatory cytokine production, is associated with population asthma risk via the functional promoter polymorphism -1560 C>T.
    Lee H, Bae S, Jang J, Choi BW, Park CS, Park JS, Lee SH, Yoon Y.

    06/22/2013
    SNP rs6679497 in gene CD53 showed significant association with TNFalpha levels (P=0.001); no association of this SNP was observed with osteoarthritis

    A genome-wide linkage scan reveals CD53 as an important regulator of innate TNF-alpha levels.
    Bos SD, Lakenberg N, van der Breggen R, Houwing-Duistermaat JJ, Kloppenburg M, de Craen AJ, Beekman M, Meulenbelt I, Slagboom PE., Free PMC Article

    11/6/2010
    Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

    Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article

    09/15/2010
    Observational study of gene-disease association. (HuGE Navigator)See all PubMed (2) articles

    New genetic associations detected in a host response study to hepatitis B vaccine.
    Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M.

    Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium.

    04/7/2010
    Ligation of CD53 triggers a survival response and reduces the number of cells that enter apoptosis. The CD53 antigen interactions might contribute to cell survival in poorly vascularized regions of the tumor mass.

    Apoptosis protection and survival signal by the CD53 tetraspanin antigen.
    Yunta M, Lazo PA.

    01/21/2010
    Analysis of lymphocyte subsets showed that the total number of CD3+, CD4+, CD8+ and CD56+ lymphocytes increased after the intensive protocol before falling below pre-exercise values at 1 h post-exercise.

    The effects of intensive, moderate and downhill treadmill running on human blood lymphocytes expressing the adhesion/activation molecules CD54 (ICAM-1), CD18 (beta2 integrin) and CD53.
    Simpson RJ, Florida-James GD, Whyte GP, Guy K.

    01/21/2010
    The paradox is that lymphocytes from RA patients are believed to resist apoptosis, and we suggest that the elevated expression of CD53, which results from the increased oxidative stress, may protect against apoptosis.

    Analysis of the thiol status of peripheral blood leukocytes in rheumatoid arthritis patients.
    Pedersen-Lane JH, Zurier RB, Lawrence DA.

    01/21/2010
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