| Exploring Structural Insights of Abeta42 and alpha-Synuclein Monomers and Heterodimer: A Comparative Study Using Implicit and Explicit Solvent Simulations. | Exploring Structural Insights of Aβ42 and α-Synuclein Monomers and Heterodimer: A Comparative Study Using Implicit and Explicit Solvent Simulations.
Varenyk Y, Theodorakis PE, Pham DQH, Li MS, Krupa P., Free PMC Article | 07/15/2024 |
| results indicated that synphilin-1 may play neuroprotective roles in Parkinson Disease pathogenesis by inhibiting ROS production and apoptosis. | Synphilin-1 has neuroprotective effects on MPP(+)-induced Parkinson's disease model cells by inhibiting ROS production and apoptosis.
Shishido T, Nagano Y, Araki M, Kurashige T, Obayashi H, Nakamura T, Takahashi T, Matsumoto M, Maruyama H. | 03/16/2019 |
| Differential expression of synphilin-1 isoforms (and alpha-synuclein and parkin) was found in multiple system atrophy brains compared to control brain. | Altered α-synuclein, parkin, and synphilin isoform levels in multiple system atrophy brains.
Brudek T, Winge K, Rasmussen NB, Bahl JM, Tanassi J, Agander TK, Hyde TM, Pakkenberg B. | 04/30/2016 |
| Synphilin-1 binds ATP, but not CTP. | Synphilin-1 binds ATP and regulates intracellular energy status.
Li T, Liu J, Smith WW., Free PMC Article | 09/5/2015 |
| Overexpression of human synphilin-1 in mice resulted in hyperphagia and obesity. | Behavioral characterization of the hyperphagia synphilin-1 overexpressing mice.
Li X, Treesukosol Y, Moghadam A, Smith M, Ofeldt E, Yang D, Li T, Tamashiro K, Choi P, Moran TH, Smith WW., Free PMC Article | 01/3/2015 |
| Overexpression of SP1 in neurons, but not peripheral cells, increased the body weight of flies compared with that of non-transgenic controls. SP1 increased food intake but did not affect locomotor activity | Synphilin-1 alters metabolic homeostasis in a novel Drosophila obesity model.
Liu J, Li T, Yang D, Ma R, Moran TH, Smith WW., Free PMC Article | 05/18/2013 |
| Although serine-129 phosphorylation of alpha-synuclein facilitates tubulin polymerization promoting protein (TPPP)-mediated alpha-SYN oligomerization, this modification does not seem to play an inevitable role in the early step of alpha-SYN oligomer formation. | Role of TPPP/p25 on α-synuclein-mediated oligodendroglial degeneration and the protective effect of SIRT2 inhibition in a cellular model of multiple system atrophy.
Hasegawa T, Baba T, Kobayashi M, Konno M, Sugeno N, Kikuchi A, Itoyama Y, Takeda A. | 11/24/2012 |
| Mutation screening of SNCAIP identifies novel sequence variants using a bioinformatic approach; further studies are necessary to determine their possible functional consequences in South African patients with Parkinson's disease. | Identification of Parkinson's disease candidate genes using CAESAR and screening of MAPT and SNCAIP in South African Parkinson's disease patients.
Keyser RJ, Oppon E, Carr JA, Bardien S. | 05/5/2012 |
| Neuronal survival factor MEF2D is decreased in human and experimental Parkinson's disease, a decrease that is specifically associated with alpha-synuclein accumulation and aggregation. | α-synuclein aggregation reduces nigral myocyte enhancer factor-2D in idiopathic and experimental Parkinson's disease.
Chu Y, Mickiewicz AL, Kordower JH. | 10/1/2011 |
| Synphilin-1 inhibits alpha-synuclein degradation by the proteasome. | Synphilin-1 inhibits alpha-synuclein degradation by the proteasome.
Alvarez-Castelao B, Castaño JG., Free PMC Article | 09/10/2011 |
| Knockdown of Herp gene unexpectedly facilitated the degradation of synphilin-1, and improved cell viability during proteasomal inhibition. | Deletion of Herp facilitates degradation of cytosolic proteins.
Miura H, Hashida K, Sudo H, Awa Y, Takarada-Iemata M, Kokame K, Takahashi T, Matsumoto M, Kitao Y, Hori O. | 02/26/2011 |
| Data show that periphilin displays an overlapping expression pattern with synphilin-1 in cellular and animal models and in Lewy bodies of Parkinson's disease (PD) patients, and support involvement of periphilin in PD. | Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease.
Soehn AS, Franck T, Biskup S, Giaime E, Melle C, Rott R, Cebo D, Kalbacher H, Ott E, Pahnke J, Meitinger T, Krüger R, Gasser T, Berg D, von Eggeling F, Engelender S, da Costa CA, Riess O. | 07/19/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| expression of synphilin-1 shortens N1E-115 cell division doubling time, promotes neurite outgrowth, and protects against Rotenone-induced toxicity; synphilin-1 displays a neurotrophic effect in vitro, may play a neuroprotective role in Parkinson's disease | Synphilin-1 exhibits trophic and protective effects against Rotenone toxicity.
Li X, Liu Z, Tamashiro K, Shi B, Rudnicki DD, Ross CA, Moran TH, Smith WW., Free PMC Article | 03/1/2010 |
| alpha-synuclein-synphilin-1 interaction significantly promotes the formation of cytoplasmic alpha-synuclein inclusions, which may have implications for Lewy body formation in neural cells | Interaction with synphilin-1 promotes inclusion formation of alpha-synuclein: mechanistic insights and pathological implication.
Xie YY, Zhou CJ, Zhou ZR, Hong J, Che MX, Fu QS, Song AX, Lin DH, Hu HY. | 02/8/2010 |
| All four alpha-synuclein isoforms were affected in dementia with LB (Lewy bodies), most parkin transcript variants in common LB disease, and all synphilin-1 isoforms in Parkinson disease. | Differential expression of alpha-synuclein, parkin, and synphilin-1 isoforms in Lewy body disease.
Beyer K, Domingo-Sàbat M, Humbert J, Carrato C, Ferrer I, Ariza A. | 01/21/2010 |
| synphilin-1A has a novel role as a regulator of SIAH activity, modulating alpha-synuclein, and formation of Lewy body-like inclusions | Synphilin-1A inhibits seven in absentia homolog (SIAH) and modulates alpha-synuclein monoubiquitylation and inclusion formation.
Szargel R, Rott R, Eyal A, Haskin J, Shani V, Balan L, Wolosker H, Engelender S., Free PMC Article | 01/21/2010 |
| Synphilin-1 might be involved in motor function, and its accumulation in the central nervous system can cause motor impairments. | Synphilin-1 transgenic mice exhibit mild motor impairments.
Jin HG, Yamashita H, Nakamura T, Fukuba H, Takahashi T, Hiji M, Kohriyama T, Matsumoto M. | 01/21/2010 |
| specific effects of C621 mutant synphilin-1 on gene expression that correlate with its role as a susceptibility factor in Parkinson's disease | Microarray expression analysis reveals genetic pathways implicated in C621 synphilin-1-mediated toxicity.
Bonin M, Marx FP, Kautzmann S, Riess O, Krüger R. | 01/21/2010 |
| translocation to aggresomes required a special aggresome-targeting signal within the sequence of synphilin 1, an ankyrin-like repeat domain. | Triggering aggresome formation. Dissecting aggresome-targeting and aggregation signals in synphilin 1.
Zaarur N, Meriin AB, Gabai VL, Sherman MY. | 01/21/2010 |
| review:Isoform Synphilin-1A inclusions recruit both alpha-synuclein and synphilin-1. Aggregation of synphilin-1 and synphilin-1A seems to be protective to cells | Synphilin-1 isoforms in Parkinson's disease: regulation by phosphorylation and ubiquitylation.
Szargel R, Rott R, Engelender S., Free PMC Article | 01/21/2010 |
| We found no evidence for association between genetic variability in synphilin-1 and Parkinson's disease | Genetic association study of synphilin-1 in idiopathic Parkinson's disease.
Myhre R, Klungland H, Farrer MJ, Aasly JO, Myhre R, Klungland H, Farrer MJ, Aasly JO., Free PMC Articles: PMC2329608, PMC2329608 | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (4) articlesGenetic association study of synphilin-1 in idiopathic Parkinson's disease.
Myhre R, Klungland H, Farrer MJ, Aasly JO, Myhre R, Klungland H, Farrer MJ, Aasly JO. Case-control study of the alpha-synuclein interacting protein gene and Parkinson's disease.
Maraganore DM, Farrer MJ, Lesnick TG, de Andrade M, Bower JH, Hernandez D, Hardy JA, Rocca WA. A putative polymorphic Val44Ala variation in the synphilin-1 gene is undetectable in Japanese sporadic Parkinson's disease patients.
Satoh JI, Kuroda Y. No pathogenic mutations in the synphilin-1 gene in Parkinson's disease.
Bandopadhyay R, de Silva R, Khan N, Graham E, Vaughan J, Engelender S, Ross C, Morris H, Morris C, Wood NW, Daniel S, Lees A. | 03/13/2008 |
| Siah-1 was found to abrogate the inhibitory effects of synphilin-1 on dopamine release | Siah-1 facilitates ubiquitination and degradation of synphilin-1.
Nagano Y, Yamashita H, Takahashi T, Kishida S, Nakamura T, Iseki E, Hattori N, Mizuno Y, Kikuchi A, Matsumoto M. | 01/21/2010 |
| The amino acid sequence of synphilin-1 shows extensive homology with its human counterpart, especially in regions containing ankyrin-like motifs and the coiled-coil domain. Expression of mouse synphilin-1 in tissues is similar to its human counterpart. | Sequence conservation between mouse and human synphilin-1.
O'Farrell C, Pickford F, Vink L, McGowan E, Cookson MR. | 01/21/2010 |