| Cocaine and amphetamine regulated transcript (CART): a newly characterized neuropeptide in human prostate. | Cocaine and amphetamine regulated transcript (CART): a newly characterized neuropeptide in human prostate.
Weaver C, Antony M, Fite J, Murugan P, Nelson AC, Manivel JC. | 11/13/2023 |
| Dietary glycemic index and glycemic load mediate the effect of CARTPT rs2239670 gene polymorphism on metabolic syndrome and metabolic risk factors among adults with obesity. | Dietary glycemic index and glycemic load mediate the effect of CARTPT rs2239670 gene polymorphism on metabolic syndrome and metabolic risk factors among adults with obesity.
Khodarahmi M, Siri G, Erahimzadeh F, Farhangi MA, Shanehbandi D., Free PMC Article | 11/26/2022 |
| Demystifying functional role of cocaine- and amphetamine-related transcript (CART) peptide in control of energy homeostasis: A twenty-five year expedition. | Demystifying functional role of cocaine- and amphetamine-related transcript (CART) peptide in control of energy homeostasis: A twenty-five year expedition.
Singh A, de Araujo AM, Krieger JP, Vergara M, Ip CK, de Lartigue G., Free PMC Article | 01/29/2022 |
| Hypothalamic-pituitary hormones will be affected by the interaction between 5q13-14-rs2239670 (CARTPT) gene variants and diet in different obesity phenotypes. | Hypothalamic-pituitary hormones will be affected by the interaction between 5q13-14-rs2239670 (CARTPT) gene variants and diet in different obesity phenotypes.
Mahmoudinezhad M, Abbasalizad-Farhangi M, Kahroba H., Free PMC Article | 12/18/2021 |
| Nucleobindin 2/nesfatin-1 expression and colocalisation with neuropeptide Y and cocaine- and amphetamine-regulated transcript in the human brainstem. | Nucleobindin 2/nesfatin-1 expression and colocalisation with neuropeptide Y and cocaine- and amphetamine-regulated transcript in the human brainstem.
Psilopanagioti A, Makrygianni M, Nikou S, Logotheti S, Papadaki H. | 10/30/2021 |
| Overcoming Stress, Hunger, and Pain: Cocaine- and Amphetamine-Regulated Transcript Peptide's Promise. | Overcoming Stress, Hunger, and Pain: Cocaine- and Amphetamine-Regulated Transcript Peptide's Promise.
Samson WK, Salvemini D, Yosten GLC., Free PMC Article | 10/23/2021 |
| Cocaine and amphetamine-regulated transcript prepropeptide gene (CARTPT) polymorphism interacts with Diet Quality Index-International (DQI-I) and Healthy Eating Index (HEI) to affect hypothalamic hormones and cardio-metabolic risk factors among obese individuals. | Cocaine and amphetamine-regulated transcript prepropeptide gene (CARTPT) polymorphism interacts with Diet Quality Index-International (DQI-I) and Healthy Eating Index (HEI) to affect hypothalamic hormones and cardio-metabolic risk factors among obese individuals.
Mahmoudi-Nezhad M, Farhangi MA, Kahroba H., Free PMC Article | 06/19/2021 |
| CART expression was found in glucose-dependent insulinotropic polypeptide (GIP)-producing K-cells and glucagon-like peptide-1 (GLP-1)-producing L-cells in human duodenum and jejunum. | Intestinal CART is a regulator of GIP and GLP-1 secretion and expression.
Shcherbina L, Lindqvist A, Thorén Fischer AH, Ahlqvist E, Zhang E, Falkmer SE, Renström E, Koffert J, Honka H, Wierup N. | 05/4/2019 |
| Studied use of cocaine- and amphetamine-regulated transcript protein (CART) and brain derived neurotrophic factor (BDNF) as biomarkers for obesity in a follow up cohort after gastric bypass for morbid obesity. | Cocaine and amphetamine regulated transcript and brain-derived neurotrophic factor in morbid obesity. One-year follow-up after gastric bypass.
Muñoz-Rodríguez JR, Agarrado A, Martín-Fernández J, Salas E, González-Martín C, Alguacil LF. | 04/6/2019 |
| Tumor into the stomach wall caused a decrease in the number of CART-positive (+) nerve fibers in the longitudinal (LML) and circular muscle layers (CML). | Distribution Patterns of Cocaine- and Amphetamine-Regulated Transcript- and/or Galanin-Containing Neurons and Nerve Fibers Located in the Human Stomach Wall Affected by Tumor.
Kozłowska A, Godlewski J, Majewski M., Free PMC Article | 02/9/2019 |
| Data suggest that the stress of intermittent hypoxia up-regulates expression of mRNA and protein for POMC and CART in neuronal cell lines; GATA2 and GATA3 appear to be involved in these stress mechanisms. (POMC = proopiomelanocortin; CART = cocaine- and amphetamine-regulated transcript protein; GATA2 = endothelial transcription factor GATA-2; GATA3 = T-cell-specific transcription factor GATA-3) | Up-regulation of POMC and CART mRNAs by intermittent hypoxia via GATA transcription factors in human neuronal cells.
Shobatake R, Takasawa K, Ota H, Itaya-Hironaka A, Yamauchi A, Sakuramoto-Tsuchida S, Uchiyama T, Makino M, Sugie K, Takasawa S, Ueno S. | 11/3/2018 |
| Adenocarcinoma growth into the colon wall caused an increase in the relative frequency of CART-like immunoreactive (CART-LI) neurons in enteric plexuses located in the vicinity of the infiltrating neoplasm. | Changes in the Distribution of Cocaine- and Amphetamine-Regulated Transcript-Containing Neural Structures in the Human Colon Affected by the Neoplastic Process.
Oponowicz A, Kozłowska A, Gonkowski S, Godlewski J, Majewski M., Free PMC Article | 09/8/2018 |
| In vitro neurochemical studies provide new insights into the interactions among CART peptide, dopamine and cocaine in the nucleus accumbens by showing a direct inhibitory effect of CART on dopamine both in normal conditions and after cocaine induction, as well as an effect of CART on the dopamine metabolites DOPAC, HVA and DOPET. | Neurochemical evidence that cocaine- and amphetamine-regulated transcript (CART) 55-102 peptide modulates the dopaminergic reward system by decreasing the dopamine release in the mouse nucleus accumbens.
Rakovska A, Baranyi M, Windisch K, Petkova-Kirova P, Gagov H, Kalfin R. | 05/12/2018 |
| Study conclude that CART is a regulator of glucose homeostasis and could play an important role in the pathophysiology of type 2 diabetes. Based on the ability of CART to increase insulin secretion and reduce glucagon secretion, CART-based agents could be a therapeutic modality in type 2 diabetes. | CART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion.
Abels M, Riva M, Bennet H, Ahlqvist E, Dyachok O, Nagaraj V, Shcherbina L, Fred RG, Poon W, Sörhede-Winzell M, Fadista J, Lindqvist A, Kask L, Sathanoori R, Dekker-Nitert M, Kuhar MJ, Ahrén B, Wollheim CB, Hansson O, Tengholm A, Fex M, Renström E, Groop L, Lyssenko V, Wierup N. | 09/2/2017 |
| polymorphisms in the gene may be useful in identifying women at risk for osteoporosis. | Polymorphisms in neuropeptide genes and bone mineral density in Korean postmenopausal women.
Chun EH, Kim H, Suh CS, Kim JH, Kim DY, Kim JG. | 08/20/2016 |
| In samples from patients undergoing IVF, there is a significant positive correlation between patient BMI, CART mRNA expression in granulosa cells, and CART peptide levels in follicular fluid. | Leptin-Induced CART (Cocaine- and Amphetamine-Regulated Transcript) Is a Novel Intraovarian Mediator of Obesity-Related Infertility in Females.
Ma X, Hayes E, Prizant H, Srivastava RK, Hammes SR, Sen A., Free PMC Article | 07/16/2016 |
| Colocalization experiments provided evidence for the presence of cocaine- and amphetamine-regulated transcript (CART) in KP-immunoreactive (IR) and perikarya and in KP-IR and NKB-IR axon varicosities. | Colocalization of cocaine- and amphetamine-regulated transcript with kisspeptin and neurokinin B in the human infundibular region.
Skrapits K, Borsay BÁ, Herczeg L, Ciofi P, Bloom SR, Ghatei MA, Dhillo WS, Liposits Z, Hrabovszky E., Free PMC Article | 11/21/2015 |
| In schizophrenia patients on clozapine monotherapy, CART levels did not correlate with age, weight, BMI, abdominal, waist and hip circumferences, WHR, blood pressure, clozapine dose or treatment duration, body composition, or markers of insulin resistance | Blood serum levels of CART peptide in patients with schizophrenia on clozapine monotherapy.
Wysokiński A, Kłoszewska I. | 10/10/2015 |
| Lower CART levels pose a risk for developing polycystic ovary syndrome. | Lower cocaine- and amphetamine-regulated transcript levels pose a risk for developing PCOS.
Yilmaz Ö, Calan M, Kume T, Yesil P, Isik D. | 06/20/2015 |
| CART SNPs (rs10515115, rs3763153, rs3857384, rs11575893, rs16871471) were not associated with antipsychotic-induced weight gain in schizophrenia patients. | Investigation of melanocortin system gene variants in antipsychotic-induced weight gain.
Chowdhury NI, Souza RP, Tiwari AK, Brandl EJ, Sicard M, Meltzer HY, Lieberman JA, Kennedy JL, Müller DJ. | 11/8/2014 |
| CART is expressed in nerve fibers and co-localizes with other neuronal factors in the circular muscle layer of human descending colon | Immunohistochemical distribution of cocaine- and amphetamine-regulated transcript peptide - like immunoreactive (CART-LI) nerve fibers and various degree of co-localization with other neuronal factors in the circular muscle layer of human descending colon.
Gonkowski S, Kamińska B, Landowski P, Całka J. | 02/8/2014 |
| Family-based association study failed to observe a statistically significant association for any of the genotyped SNPs in the CARTPT gene and attention-deficit hyperactivity disorder. | Family-based association study of cocaine- and amphetamine-regulated transcript (CARTPT) and protein interaction with C-kinase-1 (PICK1) genes in attention-deficit hyperactivity disorder.
Hsu CD, Tzang RF, Loh el-W, Liou YJ, Hong CJ, Tsai SJ. | 06/8/2013 |
| Ischemia insult triggered by oxygen-glucose deprivation (OGD) enhances NRSF mRNA levels and then NRSF antagonizes the CREB signaling on CART activation, leading to augmented cell death. | Neuron-restrictive silencer factor (NRSF) represses cocaine- and amphetamine-regulated transcript (CART) transcription and antagonizes cAMP-response element-binding protein signaling through a dual NRSE mechanism.
Zhang J, Wang S, Yuan L, Yang Y, Zhang B, Liu Q, Chen L, Yue W, Li Y, Pei X., Free PMC Article | 02/16/2013 |
| Serum CART can be detected in both diabetic and non-diabetic human pregnancy and may play an important role in body mass regulation in pregnancy. | Maternal and fetal cocaine- and amphetamine-regulated transcript in diabetic and non-diabetic pregnancy.
Hehir MP, Laursen H, Higgins MF, Brennan DJ, O'Connor DP, McAuliffe FM. | 01/26/2013 |
| a detailed description of the CART distribution pattern within the human alimentary tract. | Cocaine- and amphetamine-regulated transcript : identification and distribution in human gastrointestinal tract.
Kasacka I, Piotrowska Z, Car H, Janiuk I, Lebkowski W. | 12/8/2012 |