| GABBR2 as a Downstream Effector of the Androgen Receptor Induces Cisplatin Resistance in Bladder Cancer. | GABBR2 as a Downstream Effector of the Androgen Receptor Induces Cisplatin Resistance in Bladder Cancer.
Elahi Najafi MA, Yasui M, Teramoto Y, Tatenuma T, Jiang G, Miyamoto H., Free PMC Article | 10/24/2023 |
| A preliminary genetic association study of GAD1 and GABAB receptor genes in patients with treatment-resistant schizophrenia. | A preliminary genetic association study of GAD1 and GABAB receptor genes in patients with treatment-resistant schizophrenia.
Miyazawa A, Kanahara N, Kogure M, Otsuka I, Okazaki S, Watanabe Y, Yamasaki F, Nakata Y, Oda Y, Hishimoto A, Iyo M. | 04/9/2022 |
| Structural Basis for Activation of the Heterodimeric GABAB Receptor. | Structural Basis for Activation of the Heterodimeric GABA(B) Receptor.
Kim Y, Jeong E, Jeong JH, Kim Y, Cho Y. | 03/13/2021 |
| Structure of human GABAB receptor in an inactive state. | Structure of human GABA(B) receptor in an inactive state.
Park J, Fu Z, Frangaj A, Liu J, Mosyak L, Shen T, Slavkovich VN, Ray KM, Taura J, Cao B, Geng Y, Zuo H, Kou Y, Grassucci R, Chen S, Liu Z, Lin X, Williams JP, Rice WJ, Eng ET, Huang RK, Soni RK, Kloss B, Yu Z, Javitch JA, Hendrickson WA, Slesinger PA, Quick M, Graziano J, Yu H, Fiehn O, Clarke OB, Frank J, Fan QR., Free PMC Article | 09/19/2020 |
| Structures of metabotropic GABAB receptor. | Structures of metabotropic GABA(B) receptor.
Papasergi-Scott MM, Robertson MJ, Seven AB, Panova O, Mathiesen JM, Skiniotis G., Free PMC Article | 09/19/2020 |
| Structural basis of the activation of a metabotropic GABA receptor. | Structural basis of the activation of a metabotropic GABA receptor.
Shaye H, Ishchenko A, Lam JH, Han GW, Xue L, Rondard P, Pin JP, Katritch V, Gati C, Cherezov V., Free PMC Article | 09/19/2020 |
| GABA B receptor expression in myometrium | Profiling of GABA(A) and GABA(B) receptor expression in the myometrium of the human uterus.
Söderhielm PC, Klein AB, Bomholtz SH, Jensen AA. | 12/22/2018 |
| We demonstrated that GABBR2 gene might be a novel potential epigenetic treatment target with induction erlotinib treatment for stage IIIa (N2) EGFR 19 deletion lung adenocarcinoma | Genome-wide DNA Methylation Analysis Reveals GABBR2 as a Novel Epigenetic Target for EGFR 19 Deletion Lung Adenocarcinoma with Induction Erlotinib Treatment.
Niu X, Liu F, Zhou Y, Zhou Z, Zhou D, Wang T, Li Z, Ye X, Yu Y, Weng X, Zhang H, Ye J, Liao M, Liu Y, Chen Z, Lu S. | 06/23/2018 |
| There was no statistically significant association for the two SNPs of the GABBR1 gene (rs29230 and rs29267). However, a significant difference between AUD individuals and controls was observed at genotype level for rs2900512 of GABBR2 gene. | Alcohol use disorder and GABA(B) receptor gene polymorphisms in an Italian sample: haplotype frequencies, linkage disequilibrium and association studies.
Caputo F, Ciminelli BM, Jodice C, Blasi P, Vignoli T, Cibin M, Zoli G, Malaspina P. | 02/3/2018 |
| Missense Mutation in GABBR2 gene is associated with Neurodevelopmental Disorders. | Spatial Clustering of de Novo Missense Mutations Identifies Candidate Neurodevelopmental Disorder-Associated Genes.
Lelieveld SH, Wiel L, Venselaar H, Pfundt R, Vriend G, Veltman JA, Brunner HG, Vissers LELM, Gilissen C., Free PMC Article | 10/28/2017 |
| GABBR2 is a genetic factor that determines Rett syndrome- or epileptic encephalopathy-like phenotype expression depending on the variant positions. GABBR2-mediated gamma-aminobutyric acid signaling is a crucial factor in determining the severity and nature of neurodevelopmental phenotypes. | GABBR2 mutations determine phenotype in rett syndrome and epileptic encephalopathy.
Yoo Y, Jung J, Lee YN, Lee Y, Cho H, Na E, Hong J, Kim E, Lee JS, Lee JS, Hong C, Park SY, Wie J, Miller K, Shur N, Clow C, Ebel RS, DeBrosse SD, Henderson LB, Willaert R, Castaldi C, Tikhonova I, Bilgüvar K, Mane S, Kim KJ, Hwang YS, Lee SG, So I, Lim BC, Choi HJ, Seong JY, Shin YB, Jung H, Chae JH, Choi M. | 10/7/2017 |
| Using a ligand-guided approach, eight GABAB2 homology models have been chosen as possible structural representatives of the transmembrane domain of the GABAB2 subunit. | Ligand-guided homology modelling of the GABAB2 subunit of the GABAB receptor.
Freyd T, Warszycki D, Mordalski S, Bojarski AJ, Sylte I, Gabrielsen M., Free PMC Article | 08/26/2017 |
| a GABBR2 variant, predicted to be disease-causative, was significantly associated with corticospinal excitability at corrected levels. A subsequent uncorrected exploratory analysis revealed associations between GABBR2, GABRA2 and DRD2 variants with transcranial magnetic stimulation measures of corticospinal excitability and cortical inhibition in Huntington's disease, as well as with age at onset. | A GABBR2 gene variant modifies pathophysiology in Huntington's disease.
Philpott AL, Fitzgerald PB, Bailey NW, Churchyard A, Georgiou-Karistianis N, Cummins TD. | 07/29/2017 |
| The rare variants in GABBR2 were significantly associated with smoking status. | The contribution of rare and common variants in 30 genes to risk nicotine dependence.
Yang J, Wang S, Yang Z, Hodgkinson CA, Iarikova P, Ma JZ, Payne TJ, Goldman D, Li MD., Free PMC Article | 08/6/2016 |
| GABBR2 receptors are expressed in aortic smooth muscle cells and regulate the [Ca(2+)]i via a Gi/o-coupled receptor pathway and a phospholipase C activation pathway. | GABAB receptors are expressed in human aortic smooth muscle cells and regulate the intracellular Ca(2+) concentration.
Wang XP, Cheng ZY, Schmid KL. | 12/19/2015 |
| Putative GABAA and ASIC1a channels functionally interact with each other, possibly via an inter-molecular association by forming a novel protein complex. | Identification of a novel protein complex containing ASIC1a and GABAA receptors and their interregulation.
Zhao D, Ning N, Lei Z, Sun H, Wei C, Chen D, Li J., Free PMC Article | 12/19/2015 |
| The endoplasmic reticulum retention signal of GBR1 is not part of the core coiled-coil structure, suggesting that it is sterically shielded by GBR2 upon heterodimer formation. | Heterodimeric coiled-coil interactions of human GABAB receptor.
Burmakina S, Geng Y, Chen Y, Fan QR., Free PMC Article | 07/12/2014 |
| gamma-aminobutyric acidB receptor proteasomal degradation is mediated by the interaction of the GABAB2 C terminus with the proteasomal ATPase Rtp6 and regulated by neuronal activity | Proteasomal degradation of γ-aminobutyric acidB receptors is mediated by the interaction of the GABAB2 C terminus with the proteasomal ATPase Rtp6 and regulated by neuronal activity.
Zemoura K, Benke D., Free PMC Article | 05/17/2014 |
| and GABABR2 proteins are reduced in the prefrontal cortex of aged rats but these reductions are not associated with spatial learning abilities. | GABA(B) receptor GTP-binding is decreased in the prefrontal cortex but not the hippocampus of aged rats.
McQuail JA, Bañuelos C, LaSarge CL, Nicolle MM, Bizon JL., Free PMC Article | 01/26/2013 |
| Results show that GABA(B) receptors R1 and R2 must be activated for the modulation of N-type (Ca(v)2.2) calcium channels by analgesic alpha-conotoxins Vc1.1 and RgIA. | γ-Aminobutyric acid type B (GABAB) receptor expression is needed for inhibition of N-type (Cav2.2) calcium channels by analgesic α-conotoxins.
Cuny H, de Faoite A, Huynh TG, Yasuda T, Berecki G, Adams DJ., Free PMC Article | 10/13/2012 |
| The GABBR2 ectodomain adopts a constitutively open conformation, suggesting a structural asymmetry in the active state of GABA(B) receptor that is unique to the GABAergic system. | Structure and functional interaction of the extracellular domain of human GABA(B) receptor GBR2.
Geng Y, Xiong D, Mosyak L, Malito DL, Kniazeff J, Chen Y, Burmakina S, Quick M, Bush M, Javitch JA, Pin JP, Fan QR., Free PMC Article | 09/8/2012 |
| The results indicate that there may be specific GABA receptor gene expression variation in migraine, particularly involving the GABRA3 and GABBR2 genes. | Significant differences in gene expression of GABA receptors in peripheral blood leukocytes of migraineurs.
Plummer PN, Colson NJ, Lewohl JM, MacKay RK, Fernandez F, Haupt LM, Griffiths LR. | 01/7/2012 |
| Gamma-aminobutyric acid type B (GABA(B)) receptor internalization is regulated by the R2 subunit. | Gamma-aminobutyric acid type B (GABA(B)) receptor internalization is regulated by the R2 subunit.
Hannan S, Wilkins ME, Dehghani-Tafti E, Thomas P, Baddeley SM, Smart TG., Free PMC Article | 09/10/2011 |
| The results of this study provided evidence of Gabbr2 Deficit in schizophrenia and mood disorders. | Deficits in GABA(B) receptor system in schizophrenia and mood disorders: a postmortem study.
Fatemi SH, Folsom TD, Thuras PD., Free PMC Article | 08/27/2011 |
| GABA(B) receptor subunit 2 levels are significantly decreased in the cingulate cortex and fusiform gyrus of autism patients compared to controls. | Decreased GABA(B) receptors in the cingulate cortex and fusiform gyrus in autism.
Oblak AL, Gibbs TT, Blatt GJ., Free PMC Article | 09/20/2010 |