| Identification and functional characteristics of CHD1L gene variants implicated in human Mullerian duct anomalies. | Identification and functional characteristics of CHD1L gene variants implicated in human Müllerian duct anomalies.
Chen S, Fan Y, Sun Y, Li S, Zheng Z, Chu C, Li L, Yin C., Free PMC Article | 10/1/2024 |
| Host genetic variation at a locus near CHD1L impacts HIV sequence diversity in a South African population. | Host genetic variation at a locus near CHD1L impacts HIV sequence diversity in a South African population.
Schulz VE, Tuff JF, Tough RH, Lewis L, Chimukangara B, Garrett N, Abdool Karim Q, Abdool Karim SS, McKinnon LR, Kharsany ABM, McLaren PJ., Free PMC Article | 01/3/2024 |
| The chromatin remodeler ALC1 underlies resistance to PARP inhibitor treatment. | The chromatin remodeler ALC1 underlies resistance to PARP inhibitor treatment.
Juhász S, Smith R, Schauer T, Spekhardt D, Mamar H, Zentout S, Chapuis C, Huet S, Timinszky G., Free PMC Article | 04/30/2022 |
| Chromodomain Helicase DNA Binding Protein 1-like, a negative regulator of Forkhead box O3a, promotes the proliferation and migration of Angiotensin II-induced vascular smooth muscle cells. | Chromodomain Helicase DNA Binding Protein 1-like, a negative regulator of Forkhead box O3a, promotes the proliferation and migration of Angiotensin II-induced vascular smooth muscle cells.
Zhang X, Sun Y., Free PMC Article | 02/26/2022 |
| Genome-wide scanning for CHD1L gene in papillary thyroid carcinoma complicated with type 2 diabetes mellitus. | Genome-wide scanning for CHD1L gene in papillary thyroid carcinoma complicated with type 2 diabetes mellitus.
Kang YY, Li JJ, Sun JX, Wei JX, Ding C, Shi CL, Wu G, Li K, Ma YF, Sun Y, Qiao H. | 02/12/2022 |
| CHD1L prevents lipopolysaccharide-induced hepatocellular carcinomar cell death by activating hnRNP A2/B1-nmMYLK axis. | CHD1L prevents lipopolysaccharide-induced hepatocellular carcinomar cell death by activating hnRNP A2/B1-nmMYLK axis.
Wang G, Zhang X, Cheng W, Mo Y, Chen J, Cao Z, Chen X, Cui H, Liu S, Huang L, Liu M, Ma L, Ma NF., Free PMC Article | 02/5/2022 |
| CHD1L augments autophagy-mediated migration of hepatocellular carcinoma through targeting ZKSCAN3. | CHD1L augments autophagy-mediated migration of hepatocellular carcinoma through targeting ZKSCAN3.
Zhang X, Bai Y, Huang L, Liu S, Mo Y, Cheng W, Wang G, Cao Z, Chen X, Cui H, Qi L, Ma L, Liu M, Guan XY, Ma NF., Free PMC Article | 02/5/2022 |
| Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling. | Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling.
Mohapatra J, Tashiro K, Beckner RL, Sierra J, Kilgore JA, Williams NS, Liszczak G., Free PMC Article | 01/29/2022 |
| Multiple roles for PARP1 in ALC1-dependent nucleosome remodeling. | Multiple roles for PARP1 in ALC1-dependent nucleosome remodeling.
Ooi SK, Sato S, Tomomori-Sato C, Zhang Y, Wen Z, Banks CAS, Washburn MP, Unruh JR, Florens L, Conaway RC, Conaway JW., Free PMC Article | 01/8/2022 |
| Mechanistic Insights into Regulation of the ALC1 Remodeler by the Nucleosome Acidic Patch. | Mechanistic Insights into Regulation of the ALC1 Remodeler by the Nucleosome Acidic Patch.
Lehmann LC, Bacic L, Hewitt G, Brackmann K, Sabantsev A, Gaullier G, Pytharopoulou S, Degliesposti G, Okkenhaug H, Tan S, Costa A, Skehel JM, Boulton SJ, Deindl S., Free PMC Article | 12/25/2021 |
| Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome. | Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome.
Bacic L, Gaullier G, Sabantsev A, Lehmann LC, Brackmann K, Dimakou D, Halic M, Hewitt G, Boulton SJ, Deindl S., Free PMC Article | 10/23/2021 |
| Structural basis of ALC1/CHD1L autoinhibition and the mechanism of activation by the nucleosome. | Structural basis of ALC1/CHD1L autoinhibition and the mechanism of activation by the nucleosome.
Wang L, Chen K, Chen Z., Free PMC Article | 08/7/2021 |
| Suppressing CHD1L reduces the proliferation and chemoresistance in osteosarcoma. | Suppressing CHD1L reduces the proliferation and chemoresistance in osteosarcoma.
Fan GT, Ling ZH, He ZW, Wu SJ, Zhou GX. | 07/17/2021 |
| CHD1L promotes EOC cell invasiveness and metastasis via the regulation of METAP2. | CHD1L promotes EOC cell invasiveness and metastasis via the regulation of METAP2.
He WP, Guo YY, Yang GP, Lai HL, Sun TT, Zhang ZW, Ouyang LL, Zheng Y, Tian LM, Li XH, You ZS, Xie D, Yang GF., Free PMC Article | 07/10/2021 |
| First-in-Class Inhibitors of Oncogenic CHD1L with Preclinical Activity against Colorectal Cancer. | First-in-Class Inhibitors of Oncogenic CHD1L with Preclinical Activity against Colorectal Cancer.
Abbott JM, Zhou Q, Esquer H, Pike L, Broneske TP, Rinaldetti S, Abraham AD, Ramirez DA, Lunghofer PJ, Pitts TM, Regan DP, Tan AC, Gustafson DL, Messersmith WA, LaBarbera DV., Free PMC Article | 05/29/2021 |
| ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination-deficient cells. | ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination-deficient cells.
Verma P, Zhou Y, Cao Z, Deraska PV, Deb M, Arai E, Li W, Shao Y, Puentes L, Li Y, Patankar S, Mach RH, Faryabi RB, Shi J, Greenberg RA., Free PMC Article | 04/3/2021 |
| The high expression of CHD1L and its clinical significance in human solid tumors: A meta-analysis. | The high expression of CHD1L and its clinical significance in human solid tumors: A meta-analysis.
Zhang L, Jiang Y, Jiao P, Deng X, Xie Y., Free PMC Article | 03/27/2021 |
| Effect of chromodomain helicase/ATPase DNA binding protein 1-like gene on the invasion and metastasis of tongue squamous cell carcinoma CAL27 cells. | Effect of chromodomain helicase/ATPase DNA binding protein 1-like gene on the invasion and metastasis of tongue squamous cell carcinoma CAL27 cells.
Hu KL, Fan X, Hu WT, Li HL, Tang QH, Sun XH., Free PMC Article | 03/20/2021 |
| The Oncogenic Helicase ALC1 Regulates PARP Inhibitor Potency by Trapping PARP2 at DNA Breaks. | The Oncogenic Helicase ALC1 Regulates PARP Inhibitor Potency by Trapping PARP2 at DNA Breaks.
Blessing C, Mandemaker IK, Gonzalez-Leal C, Preisser J, Schomburg A, Ladurner AG. | 12/19/2020 |
| Results show that ALC1 facilitates DNA end resection and homologous recombination and, as a consequence, impairs NHEJ. This role is exerted by controlling CtIP expression and relies on the presence of a G4 structure in the 5'-UTR of the CtIP major mRNA isoform. | ALC1/eIF4A1-mediated regulation of CtIP mRNA stability controls DNA end resection.
Mejías-Navarro F, Rodríguez-Real G, Ramón J, Camarillo R, Huertas P., Free PMC Article | 08/1/2020 |
| The data demonstrate that CHD1L could induce cisplatin resistance in non-small-cell lung cancer via c-Jun-ABCB1-NF-kappaB axis. | CHD1L contributes to cisplatin resistance by upregulating the ABCB1-NF-κB axis in human non-small-cell lung cancer.
Li Y, He LR, Gao Y, Zhou NN, Liu Y, Zhou XK, Liu JF, Guan XY, Ma NF, Xie D., Free PMC Article | 04/11/2020 |
| High CHD1L expression is associated with proliferation and metastasis of intrahepatic cholangiocarcinoma. | CHD1L is associated with poor survival and promotes the proliferation and metastasis of intrahepatic cholangiocarcinoma.
Li S, Chai Y, Ding Y, Yuan T, Wu C, Huang C., Free PMC Article | 01/25/2020 |
| CHD1L overexpression was associated with poor prognosis and advanced clinicopathological features, CHD1L may be a valuable biomarker for prognostication of cancer patients. | Prognostic role of chromodomain helicase DNA binding protein 1-like protein in human solid cancers: A meta-analysis.
Liu W, Xu J, Zhang C., Free PMC Article | 08/4/2018 |
| overexpression of CHD1L in embryonic cells upregulated the expression of ectoderm genes, especially PAX6 | CHD1L Promotes Neuronal Differentiation in Human Embryonic Stem Cells by Upregulating PAX6.
Dou D, Zhao H, Li Z, Xu L, Xiong X, Wu X, Sun Y, Zeng S, Ouyang Q, Zhou D, Ma N, Lin G, Hu L. | 07/28/2018 |
| implies a previously unappreciated role for ALC1 in DNA replication, in which ALC1 may regulate replication-fork slowing at CPT-induced DNA-damage sites | Chromatin remodeler ALC1 prevents replication-fork collapse by slowing fork progression.
Ooka M, Abe T, Cho K, Koike K, Takeda S, Hirota K., Free PMC Article | 04/7/2018 |