| ADAMTS4 exacerbates lung cancer progression via regulating c-Myc protein stability and activating MAPK signaling pathway. | ADAMTS4 exacerbates lung cancer progression via regulating c-Myc protein stability and activating MAPK signaling pathway.
Zhai W, Yang W, Ge J, Xiao X, Wu K, She K, Zhou Y, Kong Y, Wu L, Luo S, Pu X., Free PMC Article | 10/23/2024 |
| miR-126a-5p inhibits H1N1-induced inflammation and matrix protease secretion in lung fibroblasts by targeting ADAMTS-4. | miR-126a-5p inhibits H1N1-induced inflammation and matrix protease secretion in lung fibroblasts by targeting ADAMTS-4.
Fang F, Wang B, Lu X, Wang L, Chen X, Wang G, Yang Y. | 07/15/2024 |
| Amino-terminally elongated Abeta peptides are generated by the secreted metalloprotease ADAMTS4 and deposit in a subset of Alzheimer's disease brains. | Amino-terminally elongated Aβ peptides are generated by the secreted metalloprotease ADAMTS4 and deposit in a subset of Alzheimer's disease brains.
Wirths O, Lehnen C, Fricke M, Talucci I, Klafki HW, Morgado B, Lehmann S, Münch C, Liepold T, Wiltfang J, Rostagno A, Ghiso J, Maric HM, Jahn O, Weggen S. | 06/26/2024 |
| ADAMTS4 is a crucial proteolytic enzyme for versican cleavage in the amnion at parturition. | ADAMTS4 is a crucial proteolytic enzyme for versican cleavage in the amnion at parturition.
Li MD, Lu JW, Zhang F, Lei WJ, Pan F, Lin YK, Ling LJ, Myatt L, Wang WS, Sun K., Free PMC Article | 03/28/2024 |
| Oxidized LDL-mediated upregulation of ADAMTS-4 in monocytes/macrophages involves ROS-NF-kappaB-SIRT-1 pathway. | Oxidized LDL-mediated upregulation of ADAMTS-4 in monocytes/macrophages involves ROS-NF-κB-SIRT-1 pathway.
Aswani SS, Mohan MS, Aparna NS, Boban PT, Saja K. | 06/22/2023 |
| ADAMTS4 is involved in the production of the Alzheimer disease amyloid biomarker APP669-711. | ADAMTS4 is involved in the production of the Alzheimer disease amyloid biomarker APP669-711.
Matsuzaki M, Yokoyama M, Yoshizawa Y, Kaneko N, Naito H, Kobayashi H, Korenaga A, Sekiya S, Ikemura K, Opoku G, Hirohata S, Iwamoto S, Tanaka K, Tomita T., Free PMC Article | 05/30/2023 |
| Identification of Adamts4 as a novel adult cardiac injury biomarker with therapeutic implications in patients with cardiac injuries. | Identification of Adamts4 as a novel adult cardiac injury biomarker with therapeutic implications in patients with cardiac injuries.
Khanam R, Sengupta A, Mukhopadhyay D, Chakraborty S., Free PMC Article | 07/2/2022 |
| The Role of ADAMTS-4 in Atherosclerosis and Vessel Wall Abnormalities. | The Role of ADAMTS-4 in Atherosclerosis and Vessel Wall Abnormalities.
Novak R, Hrkac S, Salai G, Bilandzic J, Mitar L, Grgurevic L. | 04/30/2022 |
| Synergistic upregulation of ADAMTS4 (aggrecanase-1) by cytokines and its suppression in knee osteoarthritic synovial fibroblasts. | Synergistic upregulation of ADAMTS4 (aggrecanase-1) by cytokines and its suppression in knee osteoarthritic synovial fibroblasts.
Cilek MZ, de Vega S, Shiozawa J, Yoshinaga C, Miyamae Y, Chijiiwa M, Mochizuki S, Ito M, Kaneko H, Kaneko K, Ishijima M, Okada Y. | 02/19/2022 |
| ADAMTS proteoglycanases downregulation with impaired oocyte quality in PCOS. | ADAMTS proteoglycanases downregulation with impaired oocyte quality in PCOS.
Gohari Taban S, Amiri I, Saidijam M, Soleimani Asl S, Yavangi M, Khanlarzadeh E, Mohammadpour N, Artimani T., Free PMC Article | 11/22/2021 |
| Interrelationship of Osteopontin, MMP-9 and ADAMTS4 in Patients With Osteoarthritis Undergoing Total Joint Arthroplasty. | Interrelationship of Osteopontin, MMP-9 and ADAMTS4 in Patients With Osteoarthritis Undergoing Total Joint Arthroplasty.
Slovacek H, Khanna R, Poredos P, Jezovnik M, Hoppensteadt D, Fareed J, Hopkinson W., Free PMC Article | 07/31/2021 |
| The utility of synovial fluid levels of ADAMTS9 and ADAMTS4 in predicting treatment responses to intraarticular steroid injections in patients with knee osteoarthritis | The utility of synovial fluid levels of ADAMTS9 and ADAMTS4 in predicting treatment responses to intraarticular steroid injections in patients with knee osteoarthritis.
Özler K., Free PMC Article | 07/17/2021 |
| Requirement for C-mannosylation to be secreted and activated a disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4). | Requirement for C-mannosylation to be secreted and activated a disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4).
Miura K, Suzuki T, Sun H, Takada H, Ishizawa Y, Mizuta H, Dohmae N, Simizu S. | 04/17/2021 |
| Expression Levels of A Disintegrin-like Metalloproteinase with Thrombospondin Motifs-4 and -5 (ADAMTS-4 and ADAMTS-5) in Inflamed and Healthy Gingival Tissues. | Expression Levels of A Disintegrin-like Metalloproteinase with Thrombospondin Motifs-4 and -5 (ADAMTS-4 and ADAMTS-5) in Inflamed and Healthy Gingival Tissues.
Tayman MA, Koyuncu İ, Köklü NÖ. | 04/3/2021 |
| Exuberant fibroblast activity compromises lung function via ADAMTS4. | Exuberant fibroblast activity compromises lung function via ADAMTS4.
Boyd DF, Allen EK, Randolph AG, Guo XJ, Weng Y, Sanders CJ, Bajracharya R, Lee NK, Guy CS, Vogel P, Guan W, Li Y, Liu X, Novak T, Newhams MM, Fabrizio TP, Wohlgemuth N, Mourani PM, PALISI Pediatric Intensive Care Influenza (PICFLU) Investigators, Wight TN, Schultz-Cherry S, Cormier SA, Shaw-Saliba K, Pekosz A, Rothman RE, Chen KF, Yang Z, Webby RJ, Zhong N, Crawford JC, Thomas PG., Free PMC Article | 02/20/2021 |
| ADAMTS4 and ADAMTS5 may be considered as new molecular therapeutic targets for cartilage damages with Kashin-Beck Disease. | ADAMTS4 and ADAMTS5 may be considered as new molecular therapeutic targets for cartilage damages with Kashin-Beck Disease.
Meng P, Zhang F, Zhang Y, Wei H, Tan S, Guo X, Wang S, Yu Y. | 02/2/2021 |
| Single-nucleotide polymorphisms in the coding region of a disintegrin and metalloproteinase with thrombospondin motifs 4 and hepatocellular carcinoma: A retrospective case-control study. | Single-nucleotide polymorphisms in the coding region of a disintegrin and metalloproteinase with thrombospondin motifs 4 and hepatocellular carcinoma: A retrospective case-control study.
Wang XZ, Tang WZ, Su QY, Yao JG, Huang XY, Long QQ, Wu XM, Xia Q, Long XD., Free PMC Article | 10/24/2020 |
| ADAMTS4 was exclusively expressed in oligodendrocytes | The metalloprotease ADAMTS4 generates N-truncated Aβ4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease.
Walter S, Jumpertz T, Hüttenrauch M, Ogorek I, Gerber H, Storck SE, Zampar S, Dimitrov M, Lehmann S, Lepka K, Berndt C, Wiltfang J, Becker-Pauly C, Beher D, Pietrzik CU, Fraering PC, Wirths O, Weggen S. | 03/28/2020 |
| significantly higher second-trimester amniotic fluid levels in pregnant women with spontaneous preterm birth | Associations between second-trimester amniotic fluid levels of ADAMTS4, ADAMTS5, IL-6, and TNF-α and spontaneous preterm delivery in singleton pregnancies.
Melekoglu R, Yilmaz E, Ciftci O, Kafadar YT, Celik E. | 09/7/2019 |
| Since only two of the collected studies referred to ADAMTS4, we did not perform meta-analysis for these comparisons. Taken together, rs226794 and rs2830585 in ADAMTS5 gene were not associated with musculoskeletal degenerative diseases in overall population, but there seemed to be an ethnicity-dependent effect of rs2830585 in the risk of musculoskeletal degenerative diseases | Association of ADAMTS4 and ADAMTS5 polymorphisms with musculoskeletal degenerative diseases: a systematic review and meta-analysis.
Huo JZ, Ji XH, Su ZY, Shang P, Gao F., Free PMC Article | 07/20/2019 |
| High ADAMTS4 expression is associated with osteoarthritic cartilage deterioration. | Sox4 is involved in osteoarthritic cartilage deterioration through induction of ADAMTS4 and ADAMTS5.
Takahata Y, Nakamura E, Hata K, Wakabayashi M, Murakami T, Wakamori K, Yoshikawa H, Matsuda A, Fukui N, Nishimura R. | 07/13/2019 |
| Study showed significant ADAMTS-4 expression in aortic tissues from patients with sporadic ascending thoracic aortic aneurysm and dissection, particularly in smooth muscle cells. | Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice.
Ren P, Hughes M, Krishnamoorthy S, Zou S, Zhang L, Wu D, Zhang C, Curci JA, Coselli JS, Milewicz DM, LeMaire SA, Shen YH., Free PMC Article | 07/6/2019 |
| The lower levels of ADAMTS4 in the primary ovarian insufficiency group, when compared with the idiopathic hypogonadotropic hypogonadism patients pointed out that even limited hormone secretion and ovulation in the POI group, may have protective effect on cardiovascular system. The higher levels of ADAMTS4 and lipid accumulation in the IHH group demonstrated the increased risk of these patients for cardiovascular disease. | The role of ADAMTS4 and ADAMTS9 in cardiovascular disease in premature ovarian insufficiency and idiopathic hypogonadotropic hypogonadism.
Ozler S, Isci Bostanci E, Oztas E, Kuru Pekcan M, Gumus Guler B, Yilmaz N. | 02/2/2019 |
| ADAMTS 1, 4, 12, and 13 levels in the maternal and cord blood were lower in the preeclampsia group than in the control group. ADAMTS 1, 4, and 12 levels in placental tissues were higher in the preeclampsia group. | ADAMTS 1, 4, 12, and 13 levels in maternal blood, cord blood, and placenta in preeclampsia.
Namlı Kalem M, Kalem Z, Yüce T, Soylemez F. | 09/1/2018 |
| ADAMTS4 was associated macrophages infiltration and polarization in the tumor microenvironment of CRC and ADAMTS4 knockdown had no inhibitory implications on cell proliferation and invasion in vitro, but significantly attenuated tumor growth in vivo. | Promotion of Tumor Growth by ADAMTS4 in Colorectal Cancer: Focused on Macrophages.
Chen J, Luo Y, Zhou Y, Qin S, Qiu Y, Cui R, Yu M, Qin J, Zhong M. | 07/7/2018 |