| The Prostate-Associated Gene 4 (PAGE4) Could Play a Role in the Development of Benign Prostatic Hyperplasia under Oxidative Stress. | The Prostate-Associated Gene 4 (PAGE4) Could Play a Role in the Development of Benign Prostatic Hyperplasia under Oxidative Stress.
Li Y, Liu J, Liu D, Wang Z, Zhou Y, Yang S, Guo F, Yang L, Zhang X., Free PMC Article | 06/11/2022 |
| Stromal-epithelial interactions in prostate cancer: Overexpression of PAGE4 in stromal cells inhibits the invasive ability of epithelial cells. | Stromal-epithelial interactions in prostate cancer: Overexpression of PAGE4 in stromal cells inhibits the invasive ability of epithelial cells.
Fu S, Liu T, Lv C, Fu C, Zeng R, Kakehi Y, Kulkarni P, Getzenberg RH, Zeng Y. | 08/7/2021 |
| Tissue-Specific Regulation of the Wnt/beta-Catenin Pathway by PAGE4 Inhibition of Tankyrase. | Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase.
Koirala S, Klein J, Zheng Y, Glenn NO, Eisemann T, Fon Tacer K, Miller DJ, Kulak O, Lu M, Finkelstein DB, Neale G, Tillman H, Vogel P, Strand DW, Lum L, Brautigam CA, Pascal JM, Clements WK, Potts PR. | 05/1/2021 |
| PAGE4 protects PCa cells from DNA damage and apoptosis under oxidative stress by modulating MAPK signalling pathway. PAGE4 expression may serve as a prognostic biomarker for clinical applications. | PAGE4 promotes prostate cancer cells survive under oxidative stress through modulating MAPK/JNK/ERK pathway.
Lv C, Fu S, Dong Q, Yu Z, Zhang G, Kong C, Fu C, Zeng Y., Free PMC Article | 04/13/2019 |
| phosphorylation of PAGE4 leads to conformational shifts | Phosphorylation-induced Conformational Ensemble Switching in an Intrinsically Disordered Cancer/Testis Antigen.
He Y, Chen Y, Mooney SM, Rajagopalan K, Bhargava A, Sacho E, Weninger K, Bryan PN, Kulkarni P, Orban J., Free PMC Article | 01/16/2016 |
| PAGE4, a regulator of c-Jun transactivation, is phosphorylated by homeodomain-interacting protein kinase 1. | Cancer/testis antigen PAGE4, a regulator of c-Jun transactivation, is phosphorylated by homeodomain-interacting protein kinase 1, a component of the stress-response pathway.
Mooney SM, Qiu R, Kim JJ, Sacho EJ, Rajagopalan K, Johng D, Shiraishi T, Kulkarni P, Weninger KR., Free PMC Article | 06/21/2014 |
| Data suggest that disrupting prostate-associated gene 4 (PAGE4)/c-Jun interaction using small molecules could be a novel strategy to treat prostate cancer. | The Stress-response protein prostate-associated gene 4, interacts with c-Jun and potentiates its transactivation.
Rajagopalan K, Qiu R, Mooney SM, Rao S, Shiraishi T, Sacho E, Huang H, Shapiro E, Weninger KR, Kulkarni P., Free PMC Article | 04/19/2014 |
| Dysregulation of epithelial PAGE4 modulates AR signaling. | PAGE4 positivity is associated with attenuated AR signaling and predicts patient survival in hormone-naive prostate cancer.
Sampson N, Ruiz C, Zenzmaier C, Bubendorf L, Berger P. | 02/9/2013 |
| PAGE4 is a highly intrinsically disordered protein with an anti-apoptotic function | The cancer/testis antigen prostate-associated gene 4 (PAGE4) is a highly intrinsically disordered protein.
Zeng Y, He Y, Yang F, Mooney SM, Getzenberg RH, Orban J, Kulkarni P., Free PMC Article | 07/2/2011 |
| PAGE4 mRNA is expressed only in the cytoplasm of epithelial cells of normal and prostate-cancer specimens | PAGE4 is a cytoplasmic protein that is expressed in normal prostate and in prostate cancers.
Iavarone C, Wolfgang C, Kumar V, Duray P, Willingham M, Pastan I, Bera TK. | 01/21/2010 |
| These results suggest that GAGE gene might have an important role in the development and progression of intestinal type of stomach cancer and the detection of GAGE mRNA may be eligible to the panel of molecular markers for aggressive behavior. | The expression of GAGE gene can predict aggressive biologic behavior of intestinal type of stomach cancer.
Kong U, Koo J, Choi K, Park J, Chang H. | 01/21/2010 |