| LncRNA MAGI2-AS3 inhibits tumor progression and angiogenesis by regulating ACY1 via interacting with transcription factor HEY1 in clear cell renal cell carcinoma. | LncRNA MAGI2-AS3 inhibits tumor progression and angiogenesis by regulating ACY1 via interacting with transcription factor HEY1 in clear cell renal cell carcinoma.
Wang G, Li H, Hou Y. | 05/28/2022 |
| Aminoacylase 1 (ACY-1) Mediates the Proliferation and Migration of Neuroblastoma Cells in Humans Through the ERK/Transforming Growth Factor beta (TGF-beta) Signaling Pathways. | Aminoacylase 1 (ACY-1) Mediates the Proliferation and Migration of Neuroblastoma Cells in Humans Through the ERK/Transforming Growth Factor β (TGF-β) Signaling Pathways.
Chen Z, Gao J, Sun J, Wu Z, Wang B., Free PMC Article | 05/29/2021 |
| with the elevated level in the disease progression of Chronic hepatitis B (CHB), ACY1 autoantibody may be a valuable serum biomarker for discriminating HBVrelated liver cirrhosis from CHB. | Identification and clinical significance of an elevated level of serum aminoacylase-1 autoantibody in patients with hepatitis B virus-related liver cirrhosis.
He X, Hong Y, Wang X, Zhang X, Long J, Li H, Zhang B, Chen S, Liu Q, Li H, Wang X, Ou X, Huang J. | 04/15/2017 |
| Biochemical analysis showed absence of ACY1 enzyme activity in the patient's fibroblasts. | Aminoacylase I deficiency due to ACY1 mRNA exon skipping.
Ferri L, Funghini S, Fioravanti A, Biondi EG, la Marca G, Guerrini R, Donati MA, Morrone A. | 05/30/2015 |
| ACY1 acts as a tumor suppressor in hepatocellular carcinoma. | Proteomics-based identification of the tumor suppressor role of aminoacylase 1 in hepatocellular carcinoma.
Wei X, Li J, Xie H, Ling Q, Wang J, Lu D, Zhou L, Xu X, Zheng S. | 09/6/2014 |
| Report serum aminoacylase-1 as a novel biomarker with potential prognostic utility for long-term outcome in renal transplant recipients with delayed graft function. | Serum aminoacylase-1 is a novel biomarker with potential prognostic utility for long-term outcome in patients with delayed graft function following renal transplantation.
Welberry Smith MP, Zougman A, Cairns DA, Wilson M, Wind T, Wood SL, Thompson D, Messenger MP, Mooney A, Selby PJ, Lewington AJ, Banks RE., Free PMC Article | 07/26/2014 |
| We concluded that ACY1 expression in colorectal cancer varies with stage and appears to play a role in cell proliferation and apoptosis | Overexpression of aminoacylase 1 is associated with colorectal cancer progression.
Shi H, Hayes MT, Kirana C, Miller RJ, Keating JP, Stubbs RS. | 07/20/2013 |
| These data suggest that aminoacylase expression is dysregulated in neuroblastoma. | Differential aminoacylase expression in neuroblastoma.
Long PM, Stradecki HM, Minturn JE, Wesley UV, Jaworski DM., Free PMC Article | 09/24/2011 |
| aminoacylase 1 proteins with the mutations p.Arg378Trp, p.Arg378Gln and p.Arg393His were also detected in Western blot analysis | The molecular basis of aminoacylase 1 deficiency.
Sommer A, Christensen E, Schwenger S, Seul R, Haas D, Olbrich H, Omran H, Sass JO. | 06/18/2011 |
| T347S variant of human Acy1 exhibited markedly increased catalytic efficiency against N-benzoylamino acids | Probing the acyl-binding pocket of aminoacylase-1.
Lindner HA, Alary A, Wilke M, Sulea T. | 01/21/2010 |
| by complementing different active site mutants of human aminoacylase-1, study shows that catalysis occurs at the dimer interface | Essential roles of zinc ligation and enzyme dimerization for catalysis in the aminoacylase-1/M20 family.
Lindner HA, Lunin VV, Alary A, Hecker R, Cygler M, Ménard R. | 01/21/2010 |
| Genetic deficiency of ACY1 leads to functional ACY1 deficiency and excretion of N-acetylated amino acids. | Mutations in ACY1, the gene encoding aminoacylase 1, cause a novel inborn error of metabolism.
Sass JO, Mohr V, Olbrich H, Engelke U, Horvath J, Fliegauf M, Loges NT, Schweitzer-Krantz S, Moebus R, Weiler P, Kispert A, Superti-Furga A, Wevers RA, Omran H., Free PMC Article | 01/21/2010 |
| Because hK1 amidase activity is significantly lower in urine of systolic HF patients, it can be supposed that activity of renal kallikrein-kinin system may be suppressed in this systolic heart failure. | The amidase activity of human tissue kallikrein is significantly lower in the urine of patients with systolic heart failure.
Figueiredo EL, Garcia Leão FV, De Oliveira LV, Moreira Mda C, De Souza Figueiredo AF. | 01/21/2010 |
| first report of a patient with aminoacylase I deficiency | Aminoacylase I deficiency: a novel inborn error of metabolism.
Van Coster RN, Gerlo EA, Giardina TG, Engelke UF, Smet JE, De Praeter CM, Meersschaut VA, De Meirleir LJ, Seneca SH, Devreese B, Leroy JG, Herga S, Perrier JP, Wevers RA, Lissens W. | 01/21/2010 |