| Endothelial DR6 in blood-brain barrier malfunction in Alzheimer's disease. | Endothelial DR6 in blood-brain barrier malfunction in Alzheimer's disease.
Huang X, Qi J, Su Y, Zhou Y, Wang Q, Huang T, Xue D, Zeng Y, Verkhratsky A, Zhou B, Chen H, Yi C., Free PMC Article | 04/17/2024 |
| The metabolite alpha-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8. | The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8.
Zhang JY, Zhou B, Sun RY, Ai YL, Cheng K, Li FN, Wang BR, Liu FJ, Jiang ZH, Wang WJ, Zhou D, Chen HZ, Wu Q., Free PMC Article | 01/22/2022 |
| DR6 drives catastrophic degeneration in axons demarcated by spheroid rupture. | p75NTR and DR6 Regulate Distinct Phases of Axon Degeneration Demarcated by Spheroid Rupture.
Yong Y, Gamage K, Cheng I, Barford K, Spano A, Winckler B, Deppmann C., Free PMC Article | 07/4/2020 |
| DR6 contributes to autoimmunity in lupus-prone mice. | Death receptor 6 contributes to autoimmunity in lupus-prone mice.
Fujikura D, Ikesue M, Endo T, Chiba S, Higashi H, Uede T., Free PMC Article | 11/17/2018 |
| An orphan receptor, death receptor 6 (DR6), is required to drive Wallerian axon degeneration after axotomy in sympathetic and sensory neurons cultured in microfluidic devices. | Death Receptor 6 Promotes Wallerian Degeneration in Peripheral Axons.
Gamage KK, Cheng I, Park RE, Karim MS, Edamura K, Hughes C, Spano AJ, Erisir A, Deppmann CD., Free PMC Article | 08/4/2018 |
| miR-17-5p induction was verified during renal ischemia-reperfusion injury. The induction was mediated by p53 and, following induction, this microRNA may repress death receptor 6 (DR6) to protect kidney cells and tissues from injury. | Induction of microRNA-17-5p by p53 protects against renal ischemia-reperfusion injury by targeting death receptor 6.
Hao J, Wei Q, Mei S, Li L, Su Y, Mei C, Dong Z., Free PMC Article | 11/4/2017 |
| data identify a new mechanism underlying tumour cell extravasation and metastasis, and suggest endothelial DR6-mediated necroptotic signalling pathways as targets for anti-metastatic therapies | Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis.
Strilic B, Yang L, Albarrán-Juárez J, Wachsmuth L, Han K, Müller UC, Pasparakis M, Offermanns S. | 09/10/2016 |
| This study demonistrated that DR6 to contribute to axonal pruning occurring during experience-dependent cortical plasticity throughout life. | Death receptor 6 regulates adult experience-dependent cortical plasticity.
Marik SA, Olsen O, Tessier-Lavigne M, Gilbert CD., Free PMC Article | 11/30/2013 |
| A DR6/p75(NTR) complex is responsible for beta-amyloid-induced cortical neuron death. | A DR6/p75(NTR) complex is responsible for β-amyloid-induced cortical neuron death.
Hu Y, Lee X, Shao Z, Apicco D, Huang G, Gong BJ, Pepinsky RB, Mi S., Free PMC Article | 08/31/2013 |
| Pla2g7 and Tnfrsf21 have been identified as genetic susceptibility to influenza genes in mice. | Mapping of clinical and expression quantitative trait loci in a sex-dependent effect of host susceptibility to mouse-adapted influenza H3N2/HK/1/68.
Boivin GA, Pothlichet J, Skamene E, Brown EG, Loredo-Osti JC, Sladek R, Vidal SM. | 06/23/2012 |
| role in oligodendrocyte survival, differentiation and myelination | Death receptor 6 negatively regulates oligodendrocyte survival, maturation and myelination.
Mi S, Lee X, Hu Y, Ji B, Shao Z, Yang W, Huang G, Walus L, Rhodes K, Gong BJ, Miller RH, Pepinsky RB. | 09/24/2011 |
| findings show that DR6 expression is significantly but transiently upregulated only in activated both CD4+ and CD8+ T cells in NF-kappaB and NF-AT dependent manner with a contribution of PI3K-dependent signaling | T-cell activation triggers death receptor-6 expression in a NF-κB and NF-AT dependent manner.
Klíma M, Broučková A, Koc M, Anděra L. | 08/13/2011 |
| Death receptor 6 plays an important role in regulating leukocyte infiltration and function in the induction and progression of experimental autoimmune encephalomyelitis. | Resistance to myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis by death receptor 6-deficient mice.
Schmidt CS, Zhao J, Chain J, Hepburn D, Gitter B, Sandusky G, Chintalacharuvu S, Glasebrook A, Na S. | 01/21/2010 |
| T cells lacking the DR6 receptor generate a severe form of acute graft-versus-host disease with accelerated onset, increased severity, rapid weight loss, and earlier organ damage and mortality. | Accelerated onset and increased severity of acute graft-versus-host disease following adoptive transfer of DR6-deficient T cells.
Liu J, Heuer JG, Na S, Galbreath E, Zhang T, Yang DD, Glasebrook A, Song HY. | 01/21/2010 |
| Enhanced B cell expansion, survival, and humoral responses by targeting death receptor 6. | Enhanced B cell expansion, survival, and humoral responses by targeting death receptor 6.
Schmidt CS, Liu J, Zhang T, Song HY, Sandusky G, Mintze K, Benschop RJ, Glasebrook A, Yang DD, Na S., Free PMC Article | 01/21/2010 |
| point to a critical role of DR6 in regulating airway inflammation in the ovalbumin-induced mouse model of asthma | Death receptor-6 regulates the development of pulmonary eosinophilia and airway inflammation in a mouse model of asthma.
Venkataraman C, Justen K, Zhao J, Galbreath E, Na S. | 01/21/2010 |