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    FOXP2 forkhead box P2 [ Homo sapiens (human) ]

    Gene ID: 93986, updated on 19-Sep-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Novel FOXP2 variant associated with speech and language dysfunction in a Chinese family and literature review.

    Novel FOXP2 variant associated with speech and language dysfunction in a Chinese family and literature review.
    Che F, Li C, Zhang L, Qian C, Mo L, Li B, Wu H, Wang L, Yang Y.

    04/16/2024
    FOXP2 suppresses the proliferation, invasion, and aerobic glycolysis of hepatocellular carcinoma cells by regulating the KDM5A/FBP1 axis.

    FOXP2 suppresses the proliferation, invasion, and aerobic glycolysis of hepatocellular carcinoma cells by regulating the KDM5A/FBP1 axis.
    Yan L, Sun H, Chen Y, Yu X, Zhang J, Li P.

    01/3/2024
    LncRNA CERS6-AS1, sponging miR-6838-5p, promotes proliferation and invasion in cervical carcinoma cells by upregulating FOXP2.

    LncRNA CERS6-AS1, sponging miR-6838-5p, promotes proliferation and invasion in cervical carcinoma cells by upregulating FOXP2.
    Yan K, Hu C, Liu C, Chu G, Wang X, Ma S, Li L.

    07/3/2023
    In-depth characterisation of a cohort of individuals with missense and loss-of-function variants disrupting FOXP2.

    In-depth characterisation of a cohort of individuals with missense and loss-of-function variants disrupting FOXP2.
    Morison LD, Meffert E, Stampfer M, Steiner-Wilke I, Vollmer B, Schulze K, Briggs T, Braden R, Vogel A, Thompson-Lake D, Patel C, Blair E, Goel H, Turner S, Moog U, Riess A, Liegeois F, Koolen DA, Amor DJ, Kleefstra T, Fisher SE, Zweier C, Morgan AT., Free PMC Article

    05/24/2023
    Human-specific changes in two functional enhancers of FOXP2.

    Human-specific changes in two functional enhancers of FOXP2.
    Benítez-Burraco A, Torres-Ruiz R, Gelabert P, Lalueza-Fox C, Rodríguez-Perales S, García-Bellido P.

    05/3/2023
    Functional dissection of two amino acid substitutions unique to the human FOXP2 protein.

    Functional dissection of two amino acid substitutions unique to the human FOXP2 protein.
    Bornschein U, Zeberg H, Enard W, Hevers W, Pääbo S., Free PMC Article

    03/13/2023
    Dissecting the cross-trait effects of the FOXP2 GWAS hit on clinical and brain phenotypes in adults with ADHD.

    Dissecting the cross-trait effects of the FOXP2 GWAS hit on clinical and brain phenotypes in adults with ADHD.
    Meyer GP, da Silva BS, Bandeira CE, Tavares MEA, Cupertino RB, Oliveira EP, Müller D, Kappel DB, Teche SP, Vitola ES, Rohde LA, Rovaris DL, Grevet EH, Bau CHD.

    03/2/2023
    Investigation of the forkhead box protein P2 gene by the next-generation sequence analysis method in children diagnosed with specific learning disorder.

    Investigation of the forkhead box protein P2 gene by the next-generation sequence analysis method in children diagnosed with specific learning disorder.
    Yazıcı M, Yektaş Ç, Eröz R, Kaplan Karakaya ES, Sarıgedik E.

    01/14/2023
    Silencing FOXP2 reverses vemurafenib resistance in BRAF[V600E] mutant papillary thyroid cancer and melanoma cells.

    Silencing FOXP2 reverses vemurafenib resistance in BRAF(V600E) mutant papillary thyroid cancer and melanoma cells.
    Jiang S, Huang Y, Li Y, Gu Q, Jiang C, Tao X, Sun J., Free PMC Article

    01/14/2023
    Do variants in the coding regions of FOXP2, a gene implicated in speech disorder, confer a risk for congenital amusia?

    Do variants in the coding regions of FOXP2, a gene implicated in speech disorder, confer a risk for congenital amusia?
    Peretz I, Ross J, Bourassa CV, Perreault LL, Dion PA, Weiss MW, Felezeu M, Rouleau GA, Dubé MP.

    11/26/2022
    A comprehensive in silico analysis of the deleterious nonsynonymous SNPs of human FOXP2 protein.

    A comprehensive in silico analysis of the deleterious nonsynonymous SNPs of human FOXP2 protein.
    Akter M, Khan SF, Sajib AA, Rima FS., Free PMC Article

    08/20/2022
    MiR-221-3p Facilitates Thyroid Cancer Cell Proliferation and Inhibit Apoptosis by Targeting FOXP2 Through Hedgehog Pathway.

    MiR-221-3p Facilitates Thyroid Cancer Cell Proliferation and Inhibit Apoptosis by Targeting FOXP2 Through Hedgehog Pathway.
    Chang W, Chang Q, Lu H, Li Y, Chen C.

    07/16/2022
    HN1L promotes stem cell-like properties by regulating TGF-beta signaling pathway through targeting FOXP2 in prostate cancer.

    HN1L promotes stem cell-like properties by regulating TGF-β signaling pathway through targeting FOXP2 in prostate cancer.
    Nong S, Wang Z, Wei Z, Ma L, Guan Y, Ni J.

    03/19/2022
    miR-134-5p promotes inflammation and apoptosis of trophoblast cells via regulating FOXP2 transcription in gestational diabetes mellitus.

    miR-134-5p promotes inflammation and apoptosis of trophoblast cells via regulating FOXP2 transcription in gestational diabetes mellitus.
    Ke W, Chen Y, Zheng L, Zhang Y, Wu Y, Li L., Free PMC Article

    02/26/2022
    AGAP2-AS1/miR-628-5p/FOXP2 feedback loop facilitates the growth of prostate cancer via activating WNT pathway.

    AGAP2-AS1/miR-628-5p/FOXP2 feedback loop facilitates the growth of prostate cancer via activating WNT pathway.
    Zhao X, Liu Y, Luo C, Zuo Y.

    12/25/2021
    Molecular networks of the FOXP2 transcription factor in the brain.

    Molecular networks of the FOXP2 transcription factor in the brain.
    den Hoed J, Devaraju K, Fisher SE., Free PMC Article

    10/30/2021
    lncRNA PART1, manipulated by transcriptional factor FOXP2, suppresses proliferation and invasion in ESCC by regulating the miR18a5p/SOX6 signaling axis.

    lncRNA PART1, manipulated by transcriptional factor FOXP2, suppresses proliferation and invasion in ESCC by regulating the miR‑18a‑5p/SOX6 signaling axis.
    Zhao Y, Zhang Q, Liu H, Wang N, Zhang X, Yang S., Free PMC Article

    10/16/2021
    High Expression of FOXP2 Is Associated with Worse Prognosis in Glioblastoma.

    High Expression of FOXP2 Is Associated with Worse Prognosis in Glioblastoma.
    Plata-Bello J, Fariña-Jerónimo H, Betancor I, Salido E.

    08/21/2021
    A genome-wide association study finds genetic variants associated with neck or shoulder pain in UK Biobank.

    A genome-wide association study finds genetic variants associated with neck or shoulder pain in UK Biobank.
    Meng W, Chan BW, Harris C, Freidin MB, Hebert HL, Adams MJ, Campbell A, Hayward C, Zheng H, Zhang X, Colvin LA, Hales TG, Palmer CNA, Williams FMK, McIntosh A, Smith BH., Free PMC Article

    08/7/2021
    FOXP2 expression and gray matter density in the male brains of patients with schizophrenia.

    FOXP2 expression and gray matter density in the male brains of patients with schizophrenia.
    Sanjuán J, Castro-Martínez XH, García-Martí G, González-Fernández J, Sanz-Requena R, Haro JM, Meana JJ, Martí-Bonmatí L, Nacher J, Sebastiá-Ortega N, Gilabert-Juan J, Moltó MD., Free PMC Article

    07/31/2021
    beta-catenin regulates FOXP2 transcriptional activity via multiple binding sites.

    β-catenin regulates FOXP2 transcriptional activity via multiple binding sites.
    Richter G, Gui T, Bourgeois B, Koyani CN, Ulz P, Heitzer E, von Lewinski D, Burgering BMT, Malle E, Madl T., Free PMC Article

    07/24/2021
    7q31.2q31.31 deletion downstream of FOXP2 segregating in a family with speech and language disorder.

    7q31.2q31.31 deletion downstream of FOXP2 segregating in a family with speech and language disorder.
    Rieger M, Krumbiegel M, Reuter MS, Schützenberger A, Reis A, Zweier C.

    06/26/2021
    LncRNA TSLNC8 inhibits proliferation of breast cancer cell through the miR-214-3p/FOXP2 axis.

    LncRNA TSLNC8 inhibits proliferation of breast cancer cell through the miR-214-3p/FOXP2 axis.
    Qin CX, Yang XQ, Jin GC, Zhan ZY.

    12/19/2020
    MiR-9-5p suppresses cell metastasis and epithelial-mesenchymal transition through targeting FOXP2 and predicts prognosis of colorectal carcinoma.

    MiR-9-5p suppresses cell metastasis and epithelial-mesenchymal transition through targeting FOXP2 and predicts prognosis of colorectal carcinoma.
    Wang WX, Yu HL, Liu X.

    10/3/2020
    Mice carrying a humanized Foxp2 knock-in allele show region-specific shifts of striatal Foxp2 expression levels.

    Mice carrying a humanized Foxp2 knock-in allele show region-specific shifts of striatal Foxp2 expression levels.
    Schreiweis C, Irinopoulou T, Vieth B, Laddada L, Oury F, Burguière E, Enard W, Groszer M.

    10/3/2020
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