| Casein kinase 1alpha mediates estradiol secretion via CYP19A1 expression in mouse ovarian granulosa cells. | Casein kinase 1α mediates estradiol secretion via CYP19A1 expression in mouse ovarian granulosa cells.
Luo X, Zhang D, Zheng J, Liu H, Sun L, Guo H, Wang L, Cui S., Free PMC Article | 08/30/2024 |
| Exploring the role of casein kinase 1alpha splice variants across cancer cell lines. | Exploring the role of casein kinase 1α splice variants across cancer cell lines.
Meléndez RA, Wynn DT, Merugu SB, Singh P, Kaplan KP, Robbins DJ., | 07/11/2024 |
| CK1alpha deficiency impairs mouse uterine adenogenesis by inducing epithelial cell apoptosis through GSK3beta pathway and inhibiting Foxa2 expression through p53 pathwaydagger. | CK1α deficiency impairs mouse uterine adenogenesis by inducing epithelial cell apoptosis through GSK3β pathway and inhibiting Foxa2 expression through p53 pathway†.
Zhang D, Lu C, Zhou Y, Luo X, Guo H, Zhang J, Gao Q, Liu H, Shang C, Cui S. | 02/20/2024 |
| Collaborative effect of Csnk1a1 haploinsufficiency and mutant p53 in Myc induction can promote leukemic transformation. | Collaborative effect of Csnk1a1 haploinsufficiency and mutant p53 in Myc induction can promote leukemic transformation.
Fuchs SNR, Stalmann USA, Snoeren IAM, Bindels E, Schmitz S, Banjanin B, Hoogenboezem RM, van Herk S, Saad M, Walter W, Haferlach T, Seillier L, Saez-Rodriguez J, Dugourd AJF, Lehmann KV, Ben-Neriah Y, Gleitz HFE, Schneider RK., Free PMC Article | 02/9/2024 |
| CSNK1A1/CK1alpha suppresses autoimmunity by restraining the CGAS-STING1 signaling. | CSNK1A1/CK1α suppresses autoimmunity by restraining the CGAS-STING1 signaling.
Pan M, Hu T, Lyu J, Yin Y, Sun J, Wang Q, Xu L, Hu H, Wang C., | 02/6/2024 |
| Casein Kinase 1alpha Regulates Testosterone Synthesis and Testis Development in Adult Mice. | Casein Kinase 1α Regulates Testosterone Synthesis and Testis Development in Adult Mice.
Guo H, Zhang D, Zhou Y, Sun L, Li C, Luo X, Liu J, Cui S. | 08/11/2023 |
| Glutaredoxin 1 protects lens epithelial cells from epithelial-mesenchymal transition by preventing casein kinase 1alpha S-glutathionylation during posterior capsular opacification. | Glutaredoxin 1 protects lens epithelial cells from epithelial-mesenchymal transition by preventing casein kinase 1α S-glutathionylation during posterior capsular opacification.
Li C, Chen X, Zhang S, Liang C, Ma X, Zhang R, Yan H., Free PMC Article | 05/28/2023 |
| Casein Kinase 1alpha as a Novel Factor Affects Thyrotropin Synthesis via PKC/ERK/CREB Signaling. | Casein Kinase 1α as a Novel Factor Affects Thyrotropin Synthesis via PKC/ERK/CREB Signaling.
Wang B, Zhang J, Zhang D, Lu C, Liu H, Gao Q, Niu T, Yin M, Cui S., Free PMC Article | 05/5/2023 |
| Knockdown of Csnk1a1 results in preimplantation developmental arrest in mice. | Knockdown of Csnk1a1 results in preimplantation developmental arrest in mice.
Ma Z, Zheng H, Li X, Yu B, Peng H. | 02/4/2023 |
| Class III beta-Tubulin Expression Is of Value in Selecting nab -Paclitaxel and Gemcitabine as First-Line Therapy in Unresectable Pancreatic Cancer. | Class III β-Tubulin Expression Is of Value in Selecting nab -Paclitaxel and Gemcitabine as First-Line Therapy in Unresectable Pancreatic Cancer.
Kato A, Naitoh I, Naiki-Ito A, Hayashi K, Okumura F, Fujita Y, Sano H, Nishi Y, Miyabe K, Inoue T, Hirano A, Takada H, Yoshida M, Hori Y, Natsume M, Kato H, Takahashi S, Kataoka H. | 07/9/2022 |
| Csnk1a1 inhibition modulates the inflammatory secretome and enhances response to radiotherapy in glioma. | Csnk1a1 inhibition modulates the inflammatory secretome and enhances response to radiotherapy in glioma.
Liu G, Li H, Zhang W, Yu J, Zhang X, Wu R, Niu M, Liu X, Yu R., Free PMC Article | 02/5/2022 |
| Cx43 phosphorylation sites regulate pancreatic cancer metastasis. | Cx43 phosphorylation sites regulate pancreatic cancer metastasis.
Solan JL, Hingorani SR, Lampe PD., Free PMC Article | 10/16/2021 |
| MDMX inhibits casein kinase 1alpha activity and stimulates Wnt signaling. | MDMX inhibits casein kinase 1α activity and stimulates Wnt signaling.
Huang Q, Chen L, Schonbrunn E, Chen J., Free PMC Article | 04/13/2021 |
| Using a newly described small-molecule, SSTC3, we show that CK1a activators could address a significant unmet clinical need for patients with SMO inhibitor-resistant medulloblastoma, including those harboring mutations in TRP53 | A CK1α Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma.
Rodriguez-Blanco J, Li B, Long J, Shen C, Yang F, Orton D, Collins S, Kasahara N, Ayad NG, McCrea HJ, Roussel MF, Weiss WA, Capobianco AJ, Robbins DJ., Free PMC Article | 04/25/2020 |
| Pro-opiomelanocortin (POMC), a precursor of alpha-melanocyte-stimulating hormone (alpha-MSH), was not activated in the CK1alpha ablation-induced hyperpigmentation, which is in contrast to the mechanism of p53-dependent UV tanning. | CK1α ablation in keratinocytes induces p53-dependent, sunburn-protective skin hyperpigmentation.
Chang CH, Kuo CJ, Ito T, Su YY, Jiang ST, Chiu MH, Lin YH, Nist A, Mernberger M, Stiewe T, Ito S, Wakamatsu K, Hsueh YA, Shieh SY, Snir-Alkalay I, Ben-Neriah Y., Free PMC Article | 06/9/2018 |
| Interactome analyses revealed that the Jade-1S mutant unable to be phosphorylated by CK1alpha has an increased binding affinity to proteins involved in chromatin remodelling, histone deacetylation, transcriptional repression, and ribosome biogenesis. | Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression.
Borgal L, Rinschen MM, Dafinger C, Liebrecht VI, Abken H, Benzing T, Schermer B., Free PMC Article | 01/14/2017 |
| loss of one or two copies in the adipose lineage results in hyperglycaemia | Drosophila glucome screening identifies Ck1alpha as a regulator of mammalian glucose metabolism.
Ugrankar R, Berglund E, Akdemir F, Tran C, Kim MS, Noh J, Schneider R, Ebert B, Graff JM., Free PMC Article | 04/16/2016 |
| Phosphorylation of LRRK2 by casein kinase 1alpha regulates trans-Golgi clustering via differential interaction with ARHGEF7. | Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7.
Chia R, Haddock S, Beilina A, Rudenko IN, Mamais A, Kaganovich A, Li Y, Kumaran R, Nalls MA, Cookson MR., Free PMC Article | 11/7/2015 |
| Phosphorylation of FADD by the kinase CK1alpha promotes KRASG12D-induced lung cancer. | Phosphorylation of FADD by the kinase CK1α promotes KRASG12D-induced lung cancer.
Bowman BM, Sebolt KA, Hoff BA, Boes JL, Daniels DL, Heist KA, Galbán CJ, Patel RM, Zhang J, Beer DG, Ross BD, Rehemtulla A, Galbán S., Free PMC Article | 09/26/2015 |
| Csnk1a1 knockdown results in decreased Rps6 phosphorylation, increased p53 activity, and myeloid differentiation. | Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia.
Järås M, Miller PG, Chu LP, Puram RV, Fink EC, Schneider RK, Al-Shahrour F, Peña P, Breyfogle LJ, Hartwell KA, McConkey ME, Cowley GS, Root DE, Kharas MG, Mullally A, Ebert BL., Free PMC Article | 05/31/2014 |
| study for the first time demonstrates that CK1alpha is required for chromosome alignment and segregation during oocyte meiotic maturation and early embryo development | Casein kinase 1 alpha regulates chromosome congression and separation during mouse oocyte meiotic maturation and early embryo development.
Wang L, Lu A, Zhou HX, Sun R, Zhao J, Zhou CJ, Shen JP, Wu SN, Liang CG., Free PMC Article | 01/11/2014 |
| Silencing or deleting the p53 gene demonstrated that genotoxic stress elicited Wnt signaling in a p53-independent manner. Instead, this response occurred through reduced abundance of Csnk1a1 (CK1alpha), a kinase that inhibits beta-catenin. | Systems biology approach identifies the kinase Csnk1a1 as a regulator of the DNA damage response in embryonic stem cells.
Carreras Puigvert J, von Stechow L, Siddappa R, Pines A, Bahjat M, Haazen LC, Olsen JV, Vrieling H, Meerman JH, Mullenders LH, van de Water B, Danen EH. | 07/6/2013 |
| maintenance of intestinal homeostasis in CKIalpha-deficient gut requires p53-mediated growth control, because the combined ablation of Csnk1a1 and either p53 or its target gene p21 triggered high-grade dysplasia with extensive proliferation | CKIα ablation highlights a critical role for p53 in invasiveness control.
Elyada E, Pribluda A, Goldstein RE, Morgenstern Y, Brachya G, Cojocaru G, Snir-Alkalay I, Burstain I, Haffner-Krausz R, Jung S, Wiener Z, Alitalo K, Oren M, Pikarsky E, Ben-Neriah Y. | 03/5/2011 |
| CK1alpha-mediated phosphorylation modulates the mRNA binding ability of hnRNP-C | Protein kinase CK1alpha regulates mRNA binding by heterogeneous nuclear ribonucleoprotein C in response to physiologic levels of hydrogen peroxide.
Kattapuram T, Yang S, Maki JL, Stone JR. | 01/21/2010 |
| Casein kinase 1 alpha, a relevant double minute 2 (MDMX)-binding protein, plays an important role in regulating p53 activity in the absence or presence of stress. | Regulation of p53-MDMX interaction by casein kinase 1 alpha.
Chen L, Li C, Pan Y, Chen J., Free PMC Article | 01/21/2010 |