| CD163[+] Macrophages Induce Endothelial-to-Mesenchymal Transition in Atheroma. | CD163(+) Macrophages Induce Endothelial-to-Mesenchymal Transition in Atheroma.
Mori M, Sakamoto A, Kawakami R, Guo L, Slenders L, Mosquera JV, Ghosh SKB, Wesseling M, Shiraki T, Bellissard A, Shah P, Weinkauf CC, Konishi T, Sato Y, Cornelissen A, Kawai K, Jinnouchi H, Xu W, Vozenilek AE, Williams D, Tanaka T, Sekimoto T, Kelly MC, Fernandez R, Grogan A, Coslet AJ, Fedotova A, Kurse A, Mokry M, Romero ME, Kolodgie FD, Pasterkamp G, Miller CL, Virmani R, Finn AV. | 07/29/2024 |
| TREM2 and CD163 Ameliorate Microglia-Mediated Inflammatory Environment in the Aging Brain. | TREM2 and CD163 Ameliorate Microglia-Mediated Inflammatory Environment in the Aging Brain.
Han X, Liu YJ, Liu BW, Ma ZL, Xia TJ, Gu XP. | 05/7/2022 |
| ANGPTL4 regulates CD163 expression and Kuppfer cell polarization induced cirrhosis via TLR4/NF-kappaB pathway. | ANGPTL4 regulates CD163 expression and Kuppfer cell polarization induced cirrhosis via TLR4/NF-κB pathway.
Zhang X, Yuan S, Zhang X, Zhang T, Meng C, Zhuang K, Dang S. | 10/16/2021 |
| CD163 deficiency increases foam cell formation and plaque progression in atherosclerotic mice. | CD163 deficiency increases foam cell formation and plaque progression in atherosclerotic mice.
Gutiérrez-Muñoz C, Méndez-Barbero N, Svendsen P, Sastre C, Fernández-Laso V, Quesada P, Egido J, Escolá-Gil JC, Martín-Ventura JL, Moestrup SK, Blanco-Colio LM. | 05/1/2021 |
| Mouse CD163 deficiency strongly enhances experimental collagen-induced arthritis. | Mouse CD163 deficiency strongly enhances experimental collagen-induced arthritis.
Svendsen P, Etzerodt A, Deleuran BW, Moestrup SK., Free PMC Article | 12/26/2020 |
| Study observed macrophage-induced tumor cell proliferation in cocultures of human monocyte-derived macrophages and leiomyosarcoma and myxofibrosarcoma human and mouse cell lines, which was abrogated by silencing of CD163. Tumor development of sarcoma cells in CD163-deficient mice was significantly abrogated in comparison with wild-type mice. | CD163 Is Required for Protumoral Activation of Macrophages in Human and Murine Sarcoma.
Shiraishi D, Fujiwara Y, Horlad H, Saito Y, Iriki T, Tsuboki J, Cheng P, Nakagata N, Mizuta H, Bekki H, Nakashima Y, Oda Y, Takeya M, Komohara Y. | 08/3/2019 |
| CD163 has a role in angiogenesis and vascular permeability with inflammation in atherosclerosis | CD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis.
Guo L, Akahori H, Harari E, Smith SL, Polavarapu R, Karmali V, Otsuka F, Gannon RL, Braumann RE, Dickinson MH, Gupta A, Jenkins AL, Lipinski MJ, Kim J, Chhour P, de Vries PS, Jinnouchi H, Kutys R, Mori H, Kutyna MD, Torii S, Sakamoto A, Choi CU, Cheng Q, Grove ML, Sawan MA, Zhang Y, Cao Y, Kolodgie FD, Cormode DP, Arking DE, Boerwinkle E, Morrison AC, Erdmann J, Sotoodehnia N, Virmani R, Finn AV., Free PMC Article | 07/20/2019 |
| While it is unclear why CD163 deficiency is initially beneficial, the late injurious effects are consistent with the key anti-inflammatory role of CD163 in the recovery phase of tissue damage | The absence of the CD163 receptor has distinct temporal influences on intracerebral hemorrhage outcomes.
Leclerc JL, Lampert AS, Loyola Amador C, Schlakman B, Vasilopoulos T, Svendsen P, Moestrup SK, Doré S., Free PMC Article | 03/9/2019 |
| house dust mite -challenged Cd163-/- mice displayed increases in airway eosinophils and mucous cell metaplasia | A CCL24-dependent pathway augments eosinophilic airway inflammation in house dust mite-challenged Cd163(-/-) mice.
Dai C, Yao X, Gordon EM, Barochia A, Cuento RA, Kaler M, Meyer KS, Keeran KJ, Nugent GZ, Jeffries KR, Qu X, Yu ZX, Aponte A, Gucek M, Dagur PK, McCoy JP, Levine SJ., Free PMC Article | 11/11/2017 |
| In diabetic mice, increased sCD163 at wk 5 and decreased percentage of CD163(+) monocytes at wk 10 preceded alteration in kidney collagen IV mRNA at wk 20. In vitro incubation of monocytes in anti-inflammatory glucocorticoid increased the percentage of CD163(+) monocytes. | Monocyte CD163 is altered in association with diabetic complications: possible protective role.
Min D, Brooks B, Wong J, Aamidor S, Seehoo R, Sutanto S, Harrisberg B, Yue DK, Twigg SM, McLennan SV. | 09/9/2017 |
| During ischaemia, soluble CD163 functions as a decoy receptor for TWEAK, to regulate TWEAK-induced activation of canonical nuclear factor-kappaB and Notch signalling necessary for myogenic progenitor cell proliferation. | CD163 interacts with TWEAK to regulate tissue regeneration after ischaemic injury.
Akahori H, Karmali V, Polavarapu R, Lyle AN, Weiss D, Shin E, Husain A, Naqvi N, Van Dam R, Habib A, Choi CU, King AL, Pachura K, Taylor WR, Lefer DJ, Finn AV., Free PMC Article | 05/14/2016 |
| Data indicate an essential substrate motif for ADAM17-mediated CD163 and proTNF-alpha cleavage in macrophages. | Structural basis for inflammation-driven shedding of CD163 ectodomain and tumor necrosis factor-α in macrophages.
Etzerodt A, Rasmussen MR, Svendsen P, Chalaris A, Schwarz J, Galea I, Møller HJ, Moestrup SK., Free PMC Article | 04/12/2014 |
| alpha(1)-Acid glycoprotein up-regulates CD163 via TLR4/CD14 protein pathway: possible protection against hemolysis-induced oxidative stress. | α(1)-Acid glycoprotein up-regulates CD163 via TLR4/CD14 protein pathway: possible protection against hemolysis-induced oxidative stress.
Komori H, Watanabe H, Shuto T, Kodama A, Maeda H, Watanabe K, Kai H, Otagiri M, Maruyama T., Free PMC Article | 11/24/2012 |
| Data show that telmisartan reduced the mRNA expression of CD11c and TNF-alpha, M1 macrophage markers, and significantly increased the expressions of M2 markers, such as CD163, CD209. | Telmisartan improves insulin resistance and modulates adipose tissue macrophage polarization in high-fat-fed mice.
Fujisaka S, Usui I, Kanatani Y, Ikutani M, Takasaki I, Tsuneyama K, Tabuchi Y, Bukhari A, Yamazaki Y, Suzuki H, Senda S, Aminuddin A, Nagai Y, Takatsu K, Kobayashi M, Tobe K. | 07/23/2011 |
| Assignment of the CD163 antigen to mouse chromosome 6 band F2. | Assignment of the CD163 antigen (CD163) to mouse chromosome 6 band F2 by radiation hybrid mapping.
Schaer DJ, Schoedon G, Schaffner A. | 01/21/2010 |