| Our results provide the first evidence for an anxiolytic and anti-depressant-like actions of HK-1 through a presently unknown target-mediated mechanism | Hemokinin-1 mediates anxiolytic and anti-depressant-like actions in mice.
Borbély É, Hajna Z, Nabi L, Scheich B, Tékus V, László K, Ollmann T, Kormos V, Gaszner B, Karádi Z, Lénárd L, Paige CJ, Quinn JP, Szolcsányi J, Pintér E, Keeble J, Berger A, Helyes Z. | 08/25/2018 |
| hemokinin-1 plays a crucial pro-inflammatory role in the lung by increasing inflammatory cell activities, and might also be a specific regulator of lymphocyte functions. | Hemokinin-1 is an important mediator of endotoxin-induced acute airway inflammation in the mouse.
Hajna Z, Borbély É, Kemény Á, Botz B, Kereskai L, Szolcsányi J, Pintér E, Paige CJ, Berger A, Helyes Z. | 02/13/2016 |
| Hemokinin-1, but not substance P increases inflammation and hyperalgesia in the late phase of adjuvant-induced arthritis. | Role of tachykinin 1 and 4 gene-derived neuropeptides and the neurokinin 1 receptor in adjuvant-induced chronic arthritis of the mouse.
Borbély E, Hajna Z, Sándor K, Kereskai L, Tóth I, Pintér E, Nagy P, Szolcsányi J, Quinn J, Zimmer A, Stewart J, Paige C, Berger A, Helyes Z., Free PMC Article | 11/30/2013 |
| These findings suggest that tachykinins and NK1 receptors play a key role in joint inflammation, rather than in nociceptive sensitization, in collagen antibody-induced arthritis A. | Involvement of tachykinins and NK1 receptor in the joint inflammation with collagen type II-specific monoclonal antibody-induced arthritis in mice.
Makino A, Sakai A, Ito H, Suzuki H. | 10/26/2013 |
| HKs emerge as pivotal endogenous regulators of angiogenesis through neurokinin-1 receptor | Hemokinins modulate endothelium function and promote angiogenesis through neurokinin-1 receptor.
Song H, Yin W, Zeng Q, Jia H, Lin L, Liu X, Mu L, Wang R. | 12/8/2012 |
| Our findings suggest a role for TAC4 in cell differentiation, and represent a regulatory bridge between the nervous system and the immune system. | Early B-cell factor regulates the expression of Hemokinin-1 in the olfactory epithelium and differentiating B lymphocytes.
Tran AH, Berger A, Wu GE, Kee BL, Paige CJ. | 05/21/2011 |
| cultures from TAC4(-/-) bone marrow, sorted "fraction B" pro-B cells or purified long-term reconstituting stem cells, contain higher numbers of pro-B cells compared with controls, suggesting an inhibitory role for HK-1 on developing B cells | Targeted deletion of the tachykinin 4 gene (TAC4-/-) influences the early stages of B lymphocyte development.
Berger A, Benveniste P, Corfe SA, Tran AH, Barbara M, Wakeham A, Mak TW, Iscove NN, Paige CJ. | 01/1/2011 |
| Results suggest that Hemokinin-1 is regulated by a unique transcription regulation system that likely governs its differential expression pattern and suggests a role for Hemokinin-1 distinct from Substance P. | Regulatory mechanisms in the differential expression of Hemokinin-1.
Tran AH, Berger A, Wu GE, Paige CJ. | 01/21/2010 |
| mouse hemokinin 1 and mouse hemokinin 1(2-11) are tachykinin NK(1) receptor-preferring uterotonic agonists in non-pregnant mice but lack action at the myometrial tachykinin NK(2) receptors present in late pregnant mice | Functional characterisation of hemokinin-1 in mouse uterus.
Patak E, Pennefather JN, Gozali M, Candenas L, Kerr K, Exintaris B, Ziccone S, Potteck H, Chetty N, Page NM, Pinto F. | 01/21/2010 |
| Preprotachykinin (PPT)-C genes are expressed in uterine cells, oocytes, ovaries and embryos from mice, and may play a role in female reproductive function. | A role for tachykinins in female mouse and rat reproductive function.
Pintado CO, Pinto FM, Pennefather JN, Hidalgo A, Baamonde A, Sanchez T, Candenas ML. | 01/21/2010 |
| B cell lysates routinely demonstrated a low or undetectable immunoreactive peptide. | Quantification of hemokinin-1 peptide production and secretion from mouse B cells.
Nelson DA, Bost KL. | 01/21/2010 |
| HK-1 influences T-cell development, enhancing the proliferation of T-cell precursors and increased the number of thymocytes in fetal thymus organ cultures | T-cell developmental blockage by tachykinin antagonists and the role of hemokinin 1 in T lymphopoiesis.
Zhang Y, Paige CJ. | 01/21/2010 |
| Here we demonstrate the expression of mouse PPT-C (hemokinin 1 precursor) mRNA by CD11b+ macrophages, CD11c+ dendritic cells and in the microglial cell line EOC 13.31. | Expression of hemokinin 1 mRNA by murine dendritic cells.
Nelson DA, Marriott I, Bost KL. | 01/21/2010 |
| HK and SP are expressed at sites of chronic inflammation and share cell origin, receptor, and immunoregulatory function. | Cutting edge: hemokinin has substance P-like function and expression in inflammation.
Metwali A, Blum AM, Elliott DE, Setiawan T, Weinstock JV. | 01/21/2010 |