| LIM Homeobox 2 Increases Adhesion-Regulating Molecule 1 Transcription to Facilitate the Pathological Progression of Oxidized Low-Density Lipoprotein-Stimulated Atherosclerotic Cell Models. | LIM Homeobox 2 Increases Adhesion-Regulating Molecule 1 Transcription to Facilitate the Pathological Progression of Oxidized Low-Density Lipoprotein-Stimulated Atherosclerotic Cell Models.
Xiao J, Xie Y, Duan Q, Liu T, Ye R, Duan X, Le Z, Deng N, Liu F. | 08/4/2023 |
| LHX2 haploinsufficiency causes a variable neurodevelopmental disorder. | LHX2 haploinsufficiency causes a variable neurodevelopmental disorder.
Schmid CM, Gregor A, Costain G, Morel CF, Massingham L, Schwab J, Quélin C, Faoucher M, Kaplan J, Procopio R, Saunders CJ, Cohen ASA, Lemire G, Sacharow S, O'Donnell-Luria A, Segal RJ, Kianmahd Shamshoni J, Schweitzer D, Ebrahimi-Fakhari D, Monaghan K, Palculict TB, Napier MP, Tao A, Isidor B, Moradkhani K, Reis A, Sticht H, Care4Rare Canada, Chung WK, Zweier C. | 07/24/2023 |
| The LHX2-OTX2 transcriptional regulatory module controls retinal pigmented epithelium differentiation and underlies genetic risk for age-related macular degeneration. | The LHX2-OTX2 transcriptional regulatory module controls retinal pigmented epithelium differentiation and underlies genetic risk for age-related macular degeneration.
Cohen-Gulkar M, David A, Messika-Gold N, Eshel M, Ovadia S, Zuk-Bar N, Idelson M, Cohen-Tayar Y, Reubinoff B, Ziv T, Shamay M, Elkon R, Ashery-Padan R., Free PMC Article | 01/21/2023 |
| LHX2 facilitates the progression of nasopharyngeal carcinoma via activation of the FGF1/FGFR axis. | LHX2 facilitates the progression of nasopharyngeal carcinoma via activation of the FGF1/FGFR axis.
Xie T, Du K, Liu W, Liu C, Wang B, Tian Y, Li R, Huang X, Lin J, Jian H, Zhang J, Yuan Y., Free PMC Article | 10/8/2022 |
| REGgamma regulates hair cycle by activating Lgr5 positive hair follicle stem cells. | REGγ regulates hair cycle by activating Lgr5 positive hair follicle stem cells.
Gao X, Wang Q, Yuan L, Jiao C, Yu Y, Wang X, Xu P, Ma Y, Wu Y, Wu Z, Li L, Xiao J, Dang Y. | 07/31/2021 |
| LHX2 promotes malignancy and inhibits autophagy via mTOR in osteosarcoma and is negatively regulated by miR-129-5p. | LHX2 promotes malignancy and inhibits autophagy via mTOR in osteosarcoma and is negatively regulated by miR-129-5p.
Song H, Liu J, Wu X, Zhou Y, Chen X, Chen J, Deng K, Mao C, Huang S, Liu Z., Free PMC Article | 10/3/2020 |
| LIM homeobox 2 promotes interaction between human iPS-derived hepatic progenitors and iPS-derived hepatic stellate-like cells. | LIM homeobox 2 promotes interaction between human iPS-derived hepatic progenitors and iPS-derived hepatic stellate-like cells.
Miyoshi M, Kakinuma S, Kamiya A, Tsunoda T, Tsuchiya J, Sato A, Kaneko S, Nitta S, Kawai-Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Nakauchi H, Asahina Y, Watanabe M., Free PMC Article | 09/12/2020 |
| These data indicate that Lhx2 is capable of blocking proliferation of T-ALL-derived cells by both LMO2-dependent and -independent means. We propose Lhx2 as a new molecular tool for anti-T-ALL drug development. | Overexpression of Lhx2 suppresses proliferation of human T cell acute lymphoblastic leukemia-derived cells, partly by reducing LMO2 protein levels.
Miyashita K, Kitajima K, Goyama S, Kitamura T, Hara T. | 02/17/2018 |
| Findings demonstrate that miR-1238 inhibit the proliferation of NSCLC cells at least partly via repression of LHX2, shedding light on the mechanistic interaction of miR-1238 and LHX2 in NSCLC carcinogenesis. | miR-1238 inhibits cell proliferation by targeting LHX2 in non-small cell lung cancer.
Shi X, Zhan L, Xiao C, Lei Z, Yang H, Wang L, Zhao J, Zhang HT., Free PMC Article | 07/2/2016 |
| Results show that LHX2 is overexpressed in pancreatic ductal adenocarcinoma cells and is involved in promoting cancer cell proliferation and enhanced tumor development. | Oncogenicity of LHX2 in pancreatic ductal adenocarcinoma.
Zhou F, Gou S, Xiong J, Wu H, Wang C, Liu T. | 05/21/2016 |
| Lhx2 directly regulates tanycyte specification and differentiation in the hypothalamus. | The LIM homeodomain factor Lhx2 is required for hypothalamic tanycyte specification and differentiation.
Salvatierra J, Lee DA, Zibetti C, Duran-Moreno M, Yoo S, Newman EA, Wang H, Bedont JL, de Melo J, Miranda-Angulo AL, Gil-Perotin S, Garcia-Verdugo JM, Blackshaw S., Free PMC Article | 03/21/2015 |
| This study demonistrated that LHx2 regulates the development of the forebrain hem system. | Lhx2 regulates the development of the forebrain hem system.
Roy A, Gonzalez-Gomez M, Pierani A, Meyer G, Tole S., Free PMC Article | 11/29/2014 |
| The data indicate a dual role of Lhx2 during EMT and tumor progression: by inducing the expression of PDGF-B, Lhx2 provokes an autocrine PDGF-B/PDGFRbeta loop required for cell migration, invasion and metastatic dissemination | LIM-homeobox gene 2 promotes tumor growth and metastasis by inducing autocrine and paracrine PDGF-B signaling.
Kuzmanov A, Hopfer U, Marti P, Meyer-Schaller N, Yilmaz M, Christofori G., Free PMC Article | 10/18/2014 |
| The findings indicate that LHX2 regulates the transcription of downstream intrinsic and extrinsic molecules that are essential for early neural differentiation. | LHX2 regulates the neural differentiation of human embryonic stem cells via transcriptional modulation of PAX6 and CER1.
Hou PS, Chuang CY, Kao CF, Chou SJ, Stone L, Ho HN, Chien CL, Kuo HC., Free PMC Article | 11/16/2013 |
| These results suggest that if LHX2 is involved in pituitary hormone deficiency associated with posterior pituitary and ocular defects, it would be a rare cause of this disease condition. | Screening of LHX2 in patients presenting growth retardation with posterior pituitary and ocular abnormalities.
Pérez C, Dastot-Le Moal F, Collot N, Legendre M, Abadie I, Bertrand AM, Amselem S, Sobrier ML. | 09/15/2012 |
| Mutations in LHX2 do not represent a frequent cause of micro/anophthalmia. | Mutations in the LHX2 gene are not a frequent cause of micro/anophthalmia.
Desmaison A, Vigouroux A, Rieubland C, Peres C, Calvas P, Chassaing N., Free PMC Article | 02/26/2011 |
| A large cohort of patients with schizencephaly, some with features of septo-optic dysplasia, were sequenced for mutations in LHX2, HESX1 and SOX2. | Candidate gene sequencing of LHX2, HESX1, and SOX2 in a large schizencephaly cohort.
Mellado C, Poduri A, Gleason D, Elhosary PC, Barry BJ, Partlow JN, Chang BS, Shaw GM, Barkovich AJ, Walsh CA., Free PMC Article | 02/5/2011 |