| IGSF8 is an innate immune checkpoint and cancer immunotherapy target. | IGSF8 is an innate immune checkpoint and cancer immunotherapy target.
Li Y, Wu X, Sheng C, Liu H, Liu H, Tang Y, Liu C, Ding Q, Xie B, Xiao X, Zheng R, Yu Q, Guo Z, Ma J, Wang J, Gao J, Tian M, Wang W, Zhou J, Jiang L, Gu M, Shi S, Paull M, Yang G, Yang W, Landau S, Bao X, Hu X, Liu XS, Xiao T. | 05/31/2024 |
| EWI2 and its relatives in Tetraspanin-enriched membrane domains regulate malignancy. | EWI2 and its relatives in Tetraspanin-enriched membrane domains regulate malignancy.
Ding Y, Chen J, Li S, Wren JD, Bajpai AK, Wang J, Tanaka T, Rice HC, Hays FA, Lu L, Zhang XA. | 03/30/2023 |
| EWI2 prevents EGFR from clustering and endocytosis to reduce tumor cell movement and proliferation. | EWI2 prevents EGFR from clustering and endocytosis to reduce tumor cell movement and proliferation.
Fu C, Wang J, Pallikkuth S, Ding Y, Chen J, Wren JD, Yang Y, Wong KK, Kameyama H, Jayaraman M, Munshi A, Tanaka T, Lidke KA, Zhang XA., Free PMC Article | 07/16/2022 |
| EWI2 promotes endolysosome-mediated turnover of growth factor receptors and integrins to suppress lung cancer. | EWI2 promotes endolysosome-mediated turnover of growth factor receptors and integrins to suppress lung cancer.
Wang J, Wren JD, Ding Y, Chen J, Mittal N, Xu C, Li X, Zeng C, Wang M, Shi J, Zhang YH, Han SJ, Zhang XA., Free PMC Article | 05/14/2022 |
| EWI-2 controls nucleocytoplasmic shuttling of EGFR signaling molecules and miRNA sorting in exosomes to inhibit prostate cancer cell metastasis. | EWI-2 controls nucleocytoplasmic shuttling of EGFR signaling molecules and miRNA sorting in exosomes to inhibit prostate cancer cell metastasis.
Fu C, Zhang Q, Wang A, Yang S, Jiang Y, Bai L, Wei Q., Free PMC Article | 04/2/2022 |
| EWI-2 Inhibits Cell-Cell Fusion at the HIV-1 Virological Presynapse. | EWI-2 Inhibits Cell-Cell Fusion at the HIV-1 Virological Presynapse.
Whitaker EE, Matheson NJ, Perlee S, Munson PB, Symeonides M, Thali M., Free PMC Article | 10/10/2020 |
| EWI-2 negatively regulates TGF-beta signaling and its downstream events including cytostasis (in vitro and in vivo), EMT-like changes, cell migration, CD271-dependent invasion, and lung metastasis (in vivo). | EWI-2 negatively regulates TGF-β signaling leading to altered melanoma growth and metastasis.
Wang HX, Sharma C, Knoblich K, Granter SR, Hemler ME., Free PMC Article | 12/19/2015 |
| Authors demonstrated that EWI-2wint promotes CD81 clustering and confinement in CD81-enriched areas. | EWI-2wint promotes CD81 clustering that abrogates Hepatitis C Virus entry.
Potel J, Rassam P, Montpellier C, Kaestner L, Werkmeister E, Tews BA, Couturier C, Popescu CI, Baumert TF, Rubinstein E, Dubuisson J, Milhiet PE, Cocquerel L., Free PMC Article | 12/28/2013 |
| The EWI-2/alpha-actinin complex is involved in regulation of the actin cytoskeleton at T cell immune and virological synapses, providing a link between membrane microdomains and the formation of polarized membrane structures involved in T cell recognition. | EWI-2 association with α-actinin regulates T cell immune synapses and HIV viral infection.
Gordón-Alonso M, Sala-Valdés M, Rocha-Perugini V, Pérez-Hernández D, López-Martín S, Ursa A, Alvarez S, Kolesnikova TV, Vázquez J, Sánchez-Madrid F, Yáñez-Mó M. | 11/24/2012 |
| A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration. | Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
Martins-de-Souza D, Guest PC, Mann DM, Roeber S, Rahmoune H, Bauder C, Kretzschmar H, Volk B, Baborie A, Bahn S. | 04/26/2012 |
| analysis of interacting regions of CD81 and two of its partners, EWI-2 and EWI-2wint, and their effect on hepatitis C virus infection | Interacting regions of CD81 and two of its partners, EWI-2 and EWI-2wint, and their effect on hepatitis C virus infection.
Montpellier C, Tews BA, Poitrimole J, Rocha-Perugini V, D'Arienzo V, Potel J, Zhang XA, Rubinstein E, Dubuisson J, Cocquerel L., Free PMC Article | 07/2/2011 |
| EWI-2 causes a substantial molecular reorganization of multiple molecules known to affect proliferation and/or invasion of astrocytes and/or glioblastomas. | Glioblastoma inhibition by cell surface immunoglobulin protein EWI-2, in vitro and in vivo.
Kolesnikova TV, Kazarov AR, Lemieux ME, Lafleur MA, Kesari S, Kung AL, Hemler ME., Free PMC Article | 01/21/2010 |
| CD81 partner EWI-2wint inhibits hepatitis C virus entry [EWI-2wint] | The CD81 partner EWI-2wint inhibits hepatitis C virus entry.
Rocha-Perugini V, Montpellier C, Delgrange D, Wychowski C, Helle F, Pillez A, Drobecq H, Le Naour F, Charrin S, Levy S, Rubinstein E, Dubuisson J, Cocquerel L., Free PMC Article | 01/21/2010 |
| Important functions of recently activated dendritic cells are thus critically modulated by the newly discovered HSPA8-EWI-2 interaction. | EWI-2/CD316 is an inducible receptor of HSPA8 on human dendritic cells.
Kettner S, Kalthoff F, Graf P, Priller E, Kricek F, Lindley I, Schweighoffer T., Free PMC Article | 01/21/2010 |
| EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins | EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins.
Sala-Valdés M, Ursa A, Charrin S, Rubinstein E, Hemler ME, Sánchez-Madrid F, Yáñez-Mó M. | 01/21/2010 |
| EWI-2-dependent reorganization of alpha4beta1-CD81 complexes on the cell surface is responsible for EWI-2 effects on integrin-dependent morphology and motility functions | EWI-2 modulates lymphocyte integrin alpha4beta1 functions.
Kolesnikova TV, Stipp CS, Rao RM, Lane WS, Luscinskas FW, Hemler ME. | 01/21/2010 |
| EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells. | EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells.
Zhang XA, Lane WS, Charrin S, Rubinstein E, Liu L. | 01/21/2010 |
| EWI proteins EWI-2 and EWI-F, alpha3beta1 and alpha6beta4 integrins, and protein palmitoylation have contrasting effects on cell surface CD9 organization | Contrasting effects of EWI proteins, integrins, and protein palmitoylation on cell surface CD9 organization.
Yang XH, Kovalenko OV, Kolesnikova TV, Andzelm MM, Rubinstein E, Strominger JL, Hemler ME. | 01/21/2010 |