| The potential biomarker TIFA regulates pyroptosis in sepsis-induced acute kidney injury. | The potential biomarker TIFA regulates pyroptosis in sepsis-induced acute kidney injury.
Li Y, Zhang J, Zhai P, Hu C, Suo J, Wang J, Liu C, Peng Z. | 02/28/2023 |
| TIFA promotes colorectal cancer cell proliferation in an RSK- and PRAS40-dependent manner. | TIFA promotes colorectal cancer cell proliferation in an RSK- and PRAS40-dependent manner.
Shen W, Du W, Li Y, Huang Y, Jiang X, Yang C, Tang J, Liu H, Luo N, Zhang X, Zhang Z., Free PMC Article | 09/24/2022 |
| TIFA protein expression is associated with pulmonary arterial hypertension. | TIFA protein expression is associated with pulmonary arterial hypertension.
Chang HC, Wei TW, Wu PY, Tsai MD, Yu WC, Chen CH, Sung SH., Free PMC Article | 11/13/2021 |
| TIFA has dual functions in Helicobacter pylori-induced classical and alternative NF-kappaB pathways. | TIFA has dual functions in Helicobacter pylori-induced classical and alternative NF-κB pathways.
Maubach G, Lim MCC, Sokolova O, Backert S, Meyer TF, Naumann M., Free PMC Article | 10/30/2021 |
| TIFA and TIFAB: FHA-domain proteins involved in inflammation, hematopoiesis, and disease. | TIFA and TIFAB: FHA-domain proteins involved in inflammation, hematopoiesis, and disease.
Niederkorn M, Agarwal P, Starczynowski DT. | 01/16/2021 |
| The ALPK1/TIFA/NF-kappaB axis links a bacterial carcinogen to R-loop-induced replication stress. | The ALPK1/TIFA/NF-κB axis links a bacterial carcinogen to R-loop-induced replication stress.
Bauer M, Nascakova Z, Mihai AI, Cheng PF, Levesque MP, Lampart S, Hurwitz R, Pfannkuch L, Dobrovolna J, Jacobs M, Bartfeld S, Dohlman A, Shen X, Gall AA, Salama NR, Töpfer A, Weber A, Meyer TF, Janscak P, Müller A., Free PMC Article | 11/21/2020 |
| The results provide direct evidence and a structural basis for the TIFA-TRAF6 interaction, and show how this important biological function can be modulated. | Binding and Enhanced Binding between Key Immunity Proteins TRAF6 and TIFA.
Huang WC, Liao JH, Hsiao TC, Wei TW, Maestre-Reyna M, Bessho Y, Tsai MD. | 11/9/2019 |
| REVIEW: various mechanisms and pathways involved in H. pylori induction of NF-kappaB-dependent responses in gastric epithelial cells, including a 'state-of-the-art' review on the respective roles of NOD1 and ALPK1/TIFA pathways in these responses | Role of NOD1 and ALPK1/TIFA Signalling in Innate Immunity Against Helicobacter pylori Infection.
Ying L, Ferrero RL. | 07/20/2019 |
| TIFA expression limited proliferation of multiple myeloma cancer cells. In conclusion these results indicate that TIFA functions as a key transducer in DNA damage-induced NF-kappaB activation | TRAF-interacting protein with forkhead-associated domain (TIFA) transduces DNA damage-induced activation of NF-κB.
Fu J, Huang D, Yuan F, Xie N, Li Q, Sun X, Zhou X, Li G, Tong T, Zhang Y., Free PMC Article | 01/26/2019 |
| TIFA may serve as a biomarker in the prediction of lung adenocarcinoma. Furthermore, TIFA may modulate lung cancer cell survival and proliferation through regulating the synthesis of apoptosis-associated proteins. | TIFA Promotes Cell Survival and Migration in Lung Adenocarcinoma.
Men W, Li W, Zhao J, Li Y. | 08/18/2018 |
| TIFA is a crucial mediator in the endothelial innate immune response by potentiating and amplifying NLRP3 inflammasome via augmenting signals 1 and 2 | TIFA as a crucial mediator for NLRP3 inflammasome.
Lin TY, Wei TW, Li S, Wang SC, He M, Martin M, Zhang J, Shentu TP, Xiao H, Kang J, Wang KC, Chen Z, Chien S, Tsai MD, Shyy JY., Free PMC Article | 04/14/2018 |
| study revealed that host TIFA and H. pylori-derived heptose-1,7-bisphosphate are critical effectors of innate immune signaling that account for much of the inflammatory response to H. pylori in gastric epithelial cells | TIFA Signaling in Gastric Epithelial Cells Initiates the cag Type 4 Secretion System-Dependent Innate Immune Response to Helicobacter pylori Infection.
Gall A, Gaudet RG, Gray-Owen SD, Salama NR., Free PMC Article | 04/7/2018 |
| These results define TIFA as a rheostat for intracellular bacterial replication, escalating the immune response to invasive Gram-negative bacteria that exploit the host cytosol for growth. | Innate Recognition of Intracellular Bacterial Growth Is Driven by the TIFA-Dependent Cytosolic Surveillance Pathway.
Gaudet RG, Guo CX, Molinaro R, Kottwitz H, Rohde JR, Dangeard AS, Arrieumerlou C, Girardin SE, Gray-Owen SD. | 02/24/2018 |
| we report that Aurora A is essential for phosphorylation of the TRAF-interacting protein TIFA | Aurora A and NF-κB Survival Pathway Drive Chemoresistance in Acute Myeloid Leukemia via the TRAF-Interacting Protein TIFA.
Wei TW, Wu PY, Wu TJ, Hou HA, Chou WC, Teng CJ, Lin CR, Chen JM, Lin TY, Su HC, Huang CF, Yu CR, Hsu SL, Tien HF, Tsai MD. | 07/29/2017 |
| This study reports the crystal structures of TIFA (residues 1-150, with the unstructured C-terminal tail truncated) and its complex with the N-terminal phosphothreonine9 peptide (residues 1-15). | Uncovering the Mechanism of Forkhead-Associated Domain-Mediated TIFA Oligomerization That Plays a Central Role in Immune Responses.
Weng JH, Hsieh YC, Huang CC, Wei TY, Lim LH, Chen YH, Ho MR, Wang I, Huang KF, Chen CJ, Tsai MD. | 01/23/2016 |
| an innate immune signaling axis, mediated by phosphorylation-dependent oligomerization of the TRAF-interacting protein with forkhead-associated domain (TIFA) that is triggered by heptose-1,7-bisphosphate. | INNATE IMMUNITY. Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity.
Gaudet RG, Sintsova A, Buckwalter CM, Leung N, Cochrane A, Li J, Cox AD, Moffat J, Gray-Owen SD. | 07/25/2015 |
| identify a novel threonine phosphorylation site on TIFA and show that this phosphorylated threonine binds with the FHA domain of TIFA, leading to TIFA oligomerization and TIFA-mediated NF-kappaB activation | Intermolecular binding between TIFA-FHA and TIFA-pT mediates tumor necrosis factor alpha stimulation and NF-κB activation.
Huang CC, Weng JH, Wei TY, Wu PY, Hsu PH, Chen YH, Wang SC, Qin D, Hung CC, Chen ST, Wang AH, Shyy JY, Tsai MD., Free PMC Article | 09/22/2012 |
| Observational study of gene-disease association. (HuGE Navigator) | A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.
Kalsi G, Kuo PH, Aliev F, Alexander J, McMichael O, Patterson DG, Walsh D, Zhao Z, Schuckit M, Nurnberger J Jr, Edenberg H, Kramer J, Hesselbrock V, Tischfield JA, Vladimirov V, Prescott CA, Dick DM, Kendler KS, Riley BP., Free PMC Article | 06/30/2010 |
| TIFA induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism | TIFA activates IkappaB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6.
Ea CK, Sun L, Inoue J, Chen ZJ., Free PMC Article | 01/21/2010 |