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    CHMP4C charged multivesicular body protein 4C [ Homo sapiens (human) ]

    Gene ID: 92421, updated on 1-Oct-2024

    GeneRIFs: Gene References Into Functions

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    GeneRIFPubMed TitleDate
    Exploring the clinical and biological significance of the cell cycle-related gene CHMP4C in prostate cancer.

    Exploring the clinical and biological significance of the cell cycle-related gene CHMP4C in prostate cancer.
    Xiao X, Li Z, Li Q, Qing L, Wang Y, Ye F, Dong Y, Di X, Mi J., Free PMC Article

    		09/24/2024
    VPS32, a member of the ESCRT complex, modulates adherence to host cells in the parasite Trichomonas vaginalis by affecting biogenesis and cargo sorting of released extracellular vesicles.

    VPS32, a member of the ESCRT complex, modulates adherence to host cells in the parasite Trichomonas vaginalis by affecting biogenesis and cargo sorting of released extracellular vesicles.
    Salas N, Coceres VM, Melo TDS, Pereira-Neves A, Maguire VG, Rodriguez TM, Sabatke B, Ramirez MI, Sha J, Wohlschlegel JA, de Miguel N., Free PMC Article

    		01/8/2022
    Novel Role for ESCRT-III Component CHMP4C in the Integrity of the Endocytic Network Utilized for Herpes Simplex Virus Envelopment.

    Novel Role for ESCRT-III Component CHMP4C in the Integrity of the Endocytic Network Utilized for Herpes Simplex Virus Envelopment.
    Russell T, Samolej J, Hollinshead M, Smith GL, Kite J, Elliott G., Free PMC Article

    		11/13/2021
    Chromatin modified protein 4C (CHMP4C) facilitates the malignant development of cervical cancer cells.

    Chromatin modified protein 4C (CHMP4C) facilitates the malignant development of cervical cancer cells.
    Lin SL, Wang M, Cao QQ, Li Q., Free PMC Article

    		10/30/2021
    The role of CHMP4C in the formation of stable kinetochore-microtubule attachments during the cell cycle is reported.

    Novel ESCRT functions at kinetochores.
    Petsalaki E, Zachos G., Free PMC Article

    		08/10/2019
    Chmp4c regulates kinetochore-microtubule interactions to promote accurate chromosome segregation.Chmp4c promotes Hec1 and Nuf2 kinetochore localization.Chmp4c binds and bundles microtubules.

    Chmp4c is required for stable kinetochore-microtubule attachments.
    Petsalaki E, Dandoulaki M, Zachos G.

    		07/6/2019
    These results show that Chmp4c regulates the mitotic spindle checkpoint by promoting localization of the RZZ complex to unattached kinetochores.

    The ESCRT protein Chmp4c regulates mitotic spindle checkpoint signaling.
    Petsalaki E, Dandoulaki M, Zachos G., Free PMC Article

    		02/23/2019
    Data demonstrate the biological importance of the abscission checkpoint and suggest that dysregulation of abscission by CHMP4CT232 may synergize with oncogene-induced mitotic stress to promote genomic instability and tumorigenesis.

    A cancer-associated polymorphism in ESCRT-III disrupts the abscission checkpoint and promotes genome instability.
    Sadler JBA, Wenzel DM, Strohacker LK, Guindo-Martínez M, Alam SL, Mercader JM, Torrents D, Ullman KS, Sundquist WI, Martin-Serrano J., Free PMC Article

    		10/13/2018
    Results show that CHMP4C, under the regulation of the chromosomal passenger complex, binds to highly curved membranes and promotes the closure of membrane gaps. Two distinctly localized pools of phosphorylated CHMP4C exist during cytokinesisI but the phosphorylation is not required for its assembly into spiral filaments. Also, the centralspindlin complex associates preferentially with the with unphosphorylated form.

    Coordinated regulation of the ESCRT-III component CHMP4C by the chromosomal passenger complex and centralspindlin during cytokinesis.
    Capalbo L, Mela I, Abad MA, Jeyaprakash AA, Edwardson JM, D'Avino PP., Free PMC Article

    		12/16/2017
    CHMP4C mediates radiation resistance in lung cancer cells.

    CHMP4C Disruption Sensitizes the Human Lung Cancer Cells to Irradiation.
    Li K, Liu J, Tian M, Gao G, Qi X, Pan Y, Ruan J, Liu C, Su X., Free PMC Article

    		10/22/2016
    The ESCRT-III subunit CHMP4B is a key effector in abscission, whereas its paralogue, CHMP4C, is a component in the abscission checkpoint that delays abscission until chromatin is cleared from the intercellular bridge.

    ALIX and ESCRT-I/II function as parallel ESCRT-III recruiters in cytokinetic abscission.
    Christ L, Wenzel EM, Liestøl K, Raiborg C, Campsteijn C, Stenmark H., Free PMC Article

    		07/16/2016
    AURKB phosphorylates CHMP4C at 3 serines its C-terminal tail.Phosphorylation at these sites appears essential for CHMP4C function because their mutation leads to cytokinesis defects.

    The chromosomal passenger complex controls the function of endosomal sorting complex required for transport-III Snf7 proteins during cytokinesis.
    Capalbo L, Montembault E, Takeda T, Bassi ZI, Glover DM, D'Avino PP., Free PMC Article

    		07/6/2013
    Single nucleotide polymorphisms in CHMP4C gene is associated with ovarian cancer.

    GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
    Pharoah PD, Tsai YY, Ramus SJ, Phelan CM, Goode EL, Lawrenson K, Buckley M, Fridley BL, Tyrer JP, Shen H, Weber R, Karevan R, Larson MC, Song H, Tessier DC, Bacot F, Vincent D, Cunningham JM, Dennis J, Dicks E, Australian Cancer Study, Australian Ovarian Cancer Study Group, Aben KK, Anton-Culver H, Antonenkova N, Armasu SM, Baglietto L, Bandera EV, Beckmann MW, Birrer MJ, Bloom G, Bogdanova N, Brenton JD, Brinton LA, Brooks-Wilson A, Brown R, Butzow R, Campbell I, Carney ME, Carvalho RS, Chang-Claude J, Chen YA, Chen Z, Chow WH, Cicek MS, Coetzee G, Cook LS, Cramer DW, Cybulski C, Dansonka-Mieszkowska A, Despierre E, Doherty JA, Dörk T, du Bois A, Dürst M, Eccles D, Edwards R, Ekici AB, Fasching PA, Fenstermacher D, Flanagan J, Gao YT, Garcia-Closas M, Gentry-Maharaj A, Giles G, Gjyshi A, Gore M, Gronwald J, Guo Q, Halle MK, Harter P, Hein A, Heitz F, Hillemanns P, Hoatlin M, Høgdall E, Høgdall CK, Hosono S, Jakubowska A, Jensen A, Kalli KR, Karlan BY, Kelemen LE, Kiemeney LA, Kjaer SK, Konecny GE, Krakstad C, Kupryjanczyk J, Lambrechts D, Lambrechts S, Le ND, Lee N, Lee J, Leminen A, Lim BK, Lissowska J, Lubiński J, Lundvall L, Lurie G, Massuger LF, Matsuo K, McGuire V, McLaughlin JR, Menon U, Modugno F, Moysich KB, Nakanishi T, Narod SA, Ness RB, Nevanlinna H, Nickels S, Noushmehr H, Odunsi K, Olson S, Orlow I, Paul J, Pejovic T, Pelttari LM, Permuth-Wey J, Pike MC, Poole EM, Qu X, Risch HA, Rodriguez-Rodriguez L, Rossing MA, Rudolph A, Runnebaum I, Rzepecka IK, Salvesen HB, Schwaab I, Severi G, Shen H, Shridhar V, Shu XO, Sieh W, Southey MC, Spellman P, Tajima K, Teo SH, Terry KL, Thompson PJ, Timorek A, Tworoger SS, van Altena AM, van den Berg D, Vergote I, Vierkant RA, Vitonis AF, Wang-Gohrke S, Wentzensen N, Whittemore AS, Wik E, Winterhoff B, Woo YL, Wu AH, Yang HP, Zheng W, Ziogas A, Zulkifli F, Goodman MT, Hall P, Easton DF, Pearce CL, Berchuck A, Chenevix-Trench G, Iversen E, Monteiro AN, Gayther SA, Schildkraut JM, Sellers TA., Free PMC Article

    		05/25/2013
    findings show CHMP4C is involved in abscission timing; this function correlated with its differential spatiotemporal distribution during late stages of cytokinesis; CHMP4C functioned in the Aurora B-dependent abscission checkpoint

    ESCRT-III governs the Aurora B-mediated abscission checkpoint through CHMP4C.
    Carlton JG, Caballe A, Agromayor M, Kloc M, Martin-Serrano J., Free PMC Article

    		09/15/2012
    The Bro1 domain of ALIX binds specifically to C-terminal residues of the human CHMP4C.

    ALIX-CHMP4 interactions in the human ESCRT pathway.
    McCullough J, Fisher RD, Whitby FG, Sundquist WI, Hill CP., Free PMC Article

    		01/21/2010
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