| MiR-205-5p-Mediated MAGI1 Inhibition Attenuates the Injury Induced by Diabetic Nephropathy. | MiR-205-5p-Mediated MAGI1 Inhibition Attenuates the Injury Induced by Diabetic Nephropathy.
Xiang Y, Sun M, Wu Y, Hu Y. | 04/12/2024 |
| MAGI1 Prevents Senescence and Promotes the DNA Damage Response in ER[+] Breast Cancer. | MAGI1 Prevents Senescence and Promotes the DNA Damage Response in ER(+) Breast Cancer.
Wörthmüller J, Disler S, Pradervand S, Richard F, Haerri L, Ruiz Buendía GA, Fournier N, Desmedt C, Rüegg C., Free PMC Article | 08/14/2023 |
| Stimulated expression of ELR+ chemokines, VEGFA and TNF-AIP3 promote mycobacterial dissemination in extrapulmonary tuberculosis patients and Cavia porcellus model of tuberculosis. | Stimulated expression of ELR+ chemokines, VEGFA and TNF-AIP3 promote mycobacterial dissemination in extrapulmonary tuberculosis patients and Cavia porcellus model of tuberculosis.
Davuluri KS, Singh AK, Kumar V, Singh SV, Singh AV, Kumar S, Yadav R, Kushwaha S, Chauhan DS. | 08/20/2022 |
| Molecular insights into the interaction of HPV-16 E6 variants against MAGI-1 PDZ1 domain. | Molecular insights into the interaction of HPV-16 E6 variants against MAGI-1 PDZ1 domain.
Araujo-Arcos LE, Montaño S, Bello-Rios C, Garibay-Cerdenares OL, Leyva-Vázquez MA, Illades-Aguiar B., Free PMC Article | 03/12/2022 |
| MAGI1 inhibits the AMOTL2/p38 stress pathway and prevents luminal breast tumorigenesis. | MAGI1 inhibits the AMOTL2/p38 stress pathway and prevents luminal breast tumorigenesis.
Kantar D, Mur EB, Mancini M, Slaninova V, Salah YB, Costa L, Forest E, Lassus P, Géminard C, Boissière-Michot F, Orsetti B, Theillet C, Colinge J, Benistant C, Maraver A, Heron-Milhavet L, Djiane A., Free PMC Article | 12/11/2021 |
| Genome-Wide Association Study of Ocular Sarcoidosis Confirms HLA Associations and Implicates Barrier Function and Autoimmunity in African Americans. | Genome-Wide Association Study of Ocular Sarcoidosis Confirms HLA Associations and Implicates Barrier Function and Autoimmunity in African Americans.
Garman L, Pezant N, Pastori A, Savoy KA, Li C, Levin AM, Iannuzzi MC, Rybicki BA, Adrianto I, Montgomery CG., Free PMC Article | 12/4/2021 |
| MAGI1, a Scaffold Protein with Tumor Suppressive and Vascular Functions. | MAGI1, a Scaffold Protein with Tumor Suppressive and Vascular Functions.
Wörthmüller J, Rüegg C., Free PMC Article | 10/30/2021 |
| MAGI1 was markedly decreased in the Renal cell carcinoma (RCC) and indicated poor survival. Furthermore, we found that MAGI1 suppressed the invasion and migration of human RCC cells. Mechanistic investigations revealed that MAGI1 stabilized the PTEN/MAGI1/beta-catenin complex to inhibit beta-catenin signaling pathway. Moreover, MAGI1 was targeted by miR-520h which was transcriptionally activated by c-Myb. | MAGI1 mediates tumor metastasis through c-Myb/miR-520h/MAGI1 signaling pathway in renal cell carcinoma.
Wang W, Yang Y, Chen X, Shao S, Hu S, Zhang T. | 08/12/2020 |
| The authors report MAGI1 as a novel fluid shear stress-induced transcript/protein in endothelial cells that regulates eNOS (endothelial nitric oxide synthase) phosphorylation and nitric oxide production through PKA/AMPK-dependent phosphorylation. | MAGI1 Mediates eNOS Activation and NO Production in Endothelial Cells in Response to Fluid Shear Stress.
Ghimire K, Zaric J, Alday-Parejo B, Seebach J, Bousquenaud M, Stalin J, Bieler G, Schnittler HJ, Rüegg C., Free PMC Article | 01/4/2020 |
| Decreased MAGI1 expression in the colonic mucosa might contribute to the pathogenesis of microscopic colitis. | Genetic Variation and Gene Expression Levels of Tight Junction Genes Indicates Relationships Between PTEN as well as MAGI1 and Microscopic Colitis.
Norén E, Mellander MR, Almer S, Söderman J., Free PMC Article | 06/30/2018 |
| it negatively controls the cell growth of various types of cells and positively controls cell-cell interaction and the decreased expression of MAGI-1 in human T cells contributes to the development of several types of T-cell leukemia, partly through the stimulation of the Akt and MEK pathways. | MAGI-1 expression is decreased in several types of human T-cell leukemia cell lines, including adult T-cell leukemia.
Kozakai T, Takahashi M, Higuchi M, Hara T, Saito K, Tanaka Y, Masuko M, Takizawa J, Sone H, Fujii M. | 06/23/2018 |
| Study presented a combined molecular dynamics/infrared spectroscopy approach to the study of ligand binding (11-residue peptide derived from the C terminus of HPV16 E6) by the PDZ1 domain of MAGI1, focusing in particular on the far-infrared region of the spectrum. | Peptide-Protein Binding Investigated by Far-IR Spectroscopy and Molecular Dynamics Simulations.
Cote Y, Nominé Y, Ramirez J, Hellwig P, Stote RH., Free PMC Article | 08/26/2017 |
| Here we present the result of a 4-stage genome-wide association study composed of 5,953 adolescent idiopathic scoliosis patients and 8,137 controls. Overall, we identified three novel susceptible loci including rs7593846 at 2p14 near MEIS1 , rs7633294 at 3p14.1 near MAGI1 and rs9810566 at 3q26.2 near TNIK | Genome-wide association study identifies novel susceptible loci and highlights Wnt/beta-catenin pathway in the development of adolescent idiopathic scoliosis.
Zhu Z, Xu L, Leung-Sang Tang N, Qin X, Feng Z, Sun W, Zhu W, Shi B, Liu P, Mao S, Qiao J, Liu Z, Sun X, Li F, Chun-Yiu Cheng J, Qiu Y. | 05/20/2017 |
| A deletion at ADAMTS9-MAGI1 locus is associated with psoriatic arthritis risk. | A deletion at ADAMTS9-MAGI1 locus is associated with psoriatic arthritis risk.
Julià A, Pinto JA, Gratacós J, Queiró R, Ferrándiz C, Fonseca E, Montilla C, Torre-Alonso JC, Puig L, Pérez Venegas JJ, Fernández Nebro A, Fernández E, Muñoz-Fernández S, Daudén E, González C, Roig D, Sánchez Carazo JL, Zarco P, Erra A, López Estebaranz JL, Rodríguez J, Ramírez DM, de la Cueva P, Vanaclocha F, Herrera E, Castañeda S, Rubio E, Salvador G, Díaz-Torné C, Blanco R, Willisch Domínguez A, Mosquera JA, Vela P, Tornero J, Sánchez-Fernández S, Corominas H, Ramírez J, López-Lasanta M, Tortosa R, Palau N, Alonso A, García-Montero AC, Gelpí JL, Codó L, Day K, Absher D, Myers RM, Cañete JD, Marsal S. | 12/5/2015 |
| MAGI1 rs35855737 is a novel locus for neuroticism. [Meta-Analysis] | Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder.
Genetics of Personality Consortium, de Moor MH, van den Berg SM, Verweij KJ, Krueger RF, Luciano M, Arias Vasquez A, Matteson LK, Derringer J, Esko T, Amin N, Gordon SD, Hansell NK, Hart AB, Seppälä I, Huffman JE, Konte B, Lahti J, Lee M, Miller M, Nutile T, Tanaka T, Teumer A, Viktorin A, Wedenoja J, Abecasis GR, Adkins DE, Agrawal A, Allik J, Appel K, Bigdeli TB, Busonero F, Campbell H, Costa PT, Davey Smith G, Davies G, de Wit H, Ding J, Engelhardt BE, Eriksson JG, Fedko IO, Ferrucci L, Franke B, Giegling I, Grucza R, Hartmann AM, Heath AC, Heinonen K, Henders AK, Homuth G, Hottenga JJ, Iacono WG, Janzing J, Jokela M, Karlsson R, Kemp JP, Kirkpatrick MG, Latvala A, Lehtimäki T, Liewald DC, Madden PA, Magri C, Magnusson PK, Marten J, Maschio A, Medland SE, Mihailov E, Milaneschi Y, Montgomery GW, Nauck M, Ouwens KG, Palotie A, Pettersson E, Polasek O, Qian Y, Pulkki-Råback L, Raitakari OT, Realo A, Rose RJ, Ruggiero D, Schmidt CO, Slutske WS, Sorice R, Starr JM, St Pourcain B, Sutin AR, Timpson NJ, Trochet H, Vermeulen S, Vuoksimaa E, Widen E, Wouda J, Wright MJ, Zgaga L, Porteous D, Minelli A, Palmer AA, Rujescu D, Ciullo M, Hayward C, Rudan I, Metspalu A, Kaprio J, Deary IJ, Räikkönen K, Wilson JF, Keltikangas-Järvinen L, Bierut LJ, Hettema JM, Grabe HJ, van Duijn CM, Evans DM, Schlessinger D, Pedersen NL, Terracciano A, McGue M, Penninx BW, Martin NG, Boomsma DI., Free PMC Article | 09/26/2015 |
| Variants in MAGI1 were associated with a Crohn's disease phenotype involving a complicated stricturing disease course. | Identification of risk loci for Crohn's disease phenotypes using a genome-wide association study.
Alonso A, Domènech E, Julià A, Panés J, García-Sánchez V, Mateu PN, Gutiérrez A, Gomollón F, Mendoza JL, Garcia-Planella E, Barreiro-de Acosta M, Muñoz F, Vera M, Saro C, Esteve M, Andreu M, Chaparro M, Manyé J, Cabré E, López-Lasanta M, Tortosa R, Gelpí JL, García-Montero AC, Bertranpetit J, Absher D, Myers RM, Marsal S, Gisbert JP. | 05/30/2015 |
| The data suggests that inactivation of MAGI-1 by the NS1 protein from avian influenza A virus elicits an interferon-beta induction signal. | Regulation of interferon-β by MAGI-1 and its interaction with influenza A virus NS1 protein with ESEV PBM.
Kumar M, Liu H, Rice AP., Free PMC Article | 04/20/2013 |
| The PDZ1 and PDZ3 domains of MAGI-1 regulate the eight-exon isoform of the CXADR-like membrane protein. | The PDZ1 and PDZ3 domains of MAGI-1 regulate the eight-exon isoform of the coxsackievirus and adenovirus receptor.
Kolawole AO, Sharma P, Yan R, Lewis KJ, Xu Z, Hostetler HA, Ashbourne Excoffon KJ., Free PMC Article | 11/17/2012 |
| MAGI1 may inhibit the cancer cell migration and invasion of hepatocellular carcinoma via regulating PTEN. | MAGI1 inhibits cancer cell migration and invasion of hepatocellular carcinoma via regulating PTEN.
Zhang G, Wang Z. | 09/8/2012 |
| Results presented herein provide further evidence for a role of MAGI1 in bipolar affective disorder and schizophrenia etiology. | MAGI1 copy number variation in bipolar affective disorder and schizophrenia.
Karlsson R, Graae L, Lekman M, Wang D, Favis R, Axelsson T, Galter D, Belin AC, Paddock S. | 09/1/2012 |
| MAGI1 expression is decreased in hepatocellular carcinoma, which correlates with poor prognosis, suggesting MAGI1 as a novel prognostic marker | Downregulation of MAGI1 associates with poor prognosis of hepatocellular carcinoma.
Zhang G, Liu T, Wang Z. | 07/28/2012 |
| HPV16 E6 association with PDZ domain-containing proteins, MAGI1, Dlg1 or Scrib, stabilized the levels of E6. | Stabilization of HPV16 E6 protein by PDZ proteins, and potential implications for genome maintenance.
Nicolaides L, Davy C, Raj K, Kranjec C, Banks L, Doorbar J. | 07/16/2011 |
| Mutations designed in the C-terminal flanking region of the human MAGI-1 PDZ domain resulted in a significant decrease in binding affinity for human papillomavirus E6 peptides. | The structural and dynamic response of MAGI-1 PDZ1 with noncanonical domain boundaries to the binding of human papillomavirus E6.
Charbonnier S, Nominé Y, Ramírez J, Luck K, Chapelle A, Stote RH, Travé G, Kieffer B, Atkinson RA. | 04/16/2011 |
| These results demonstrate that oncogenic HPV E6 proteins disrupt cellular tight junctions through the degradation of MAGI-1. | A systematic analysis of human papillomavirus (HPV) E6 PDZ substrates identifies MAGI-1 as a major target of HPV type 16 (HPV-16) and HPV-18 whose loss accompanies disruption of tight junctions.
Kranjec C, Banks L., Free PMC Article | 03/12/2011 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Schizophrenia and vitamin D related genes could have been subject to latitude-driven adaptation.
Amato R, Pinelli M, Monticelli A, Miele G, Cocozza S., Free PMC Article | 12/5/2010 |