| lncRNA LINC00941 modulates MTA2/NuRD occupancy to suppress premature human epidermal differentiation. | lncRNA LINC00941 modulates MTA2/NuRD occupancy to suppress premature human epidermal differentiation.
Morgenstern E, Molthof C, Schwartz U, Graf J, Bruckmann A, Hombach S, Kretz M., Free PMC Article | 05/7/2024 |
| CircMTA2 Drives Gastric Cancer Progression through Suppressing MTA2 Degradation via Interacting with UCHL3. | CircMTA2 Drives Gastric Cancer Progression through Suppressing MTA2 Degradation via Interacting with UCHL3.
Xie G, Lei B, Yin Z, Xu F, Liu X., Free PMC Article | 03/14/2024 |
| Prognostic, Immunological, and Mutational Analysis of MTA2 in Pan-Cancer and Drug Screening for Hepatocellular Carcinoma. | Prognostic, Immunological, and Mutational Analysis of MTA2 in Pan-Cancer and Drug Screening for Hepatocellular Carcinoma.
Huang X, Tan J, Chen M, Zheng W, Zou S, Ye X, Li Y, Wu M., Free PMC Article | 07/5/2023 |
| MTA2 triggered R-loop trans-regulates BDH1-mediated beta-hydroxybutyrylation and potentiates propagation of hepatocellular carcinoma stem cells. | MTA2 triggered R-loop trans-regulates BDH1-mediated β-hydroxybutyrylation and potentiates propagation of hepatocellular carcinoma stem cells.
Zhang H, Chang Z, Qin LN, Liang B, Han JX, Qiao KL, Yang C, Liu YR, Zhou HG, Sun T., Free PMC Article | 03/26/2022 |
| MTA2 silencing attenuates the metastatic potential of cervical cancer cells by inhibiting AP1-mediated MMP12 expression via the ASK1/MEK3/p38/YB1 axis. | MTA2 silencing attenuates the metastatic potential of cervical cancer cells by inhibiting AP1-mediated MMP12 expression via the ASK1/MEK3/p38/YB1 axis.
Lin CL, Ying TH, Yang SF, Chiou HL, Chen YS, Kao SH, Hsieh YH., Free PMC Article | 10/16/2021 |
| Comparative analysis of the AIB1 interactome in breast cancer reveals MTA2 as a repressive partner which silences E-Cadherin to promote EMT and associates with a pro-metastatic phenotype. | Comparative analysis of the AIB1 interactome in breast cancer reveals MTA2 as a repressive partner which silences E-Cadherin to promote EMT and associates with a pro-metastatic phenotype.
Varešlija D, Ward E, Purcell SP, Cosgrove NS, Cocchiglia S, O'Halloran PJ, Charmsaz S, Bane FT, Brett FM, Farrell M, Cryan J, Beausang A, Hudson L, Turnbul AK, Dixon JM, Hill ADK, Priedigkeit N, Oesterreich S, Lee AV, Sims AH, Redmond AM, Carroll JS, Young LS., Free PMC Article | 07/31/2021 |
| Inhibition of MTA2 and MTA3 induces mesendoderm specification of human embryonic stem cells. | Inhibition of MTA2 and MTA3 induces mesendoderm specification of human embryonic stem cells.
You Y, Cui Y, Li Y, Zhang M, Wang X, Ji J, Zhang X, Zhou M, Zhang Z, Ye SD, Wang X. | 07/3/2021 |
| SNHG5 inhibits the progression of EMT through the ubiquitin-degradation of MTA2 in oesophageal cancer. | SNHG5 inhibits the progression of EMT through the ubiquitin-degradation of MTA2 in oesophageal cancer.
Wei S, Sun S, Zhou X, Zhang C, Li X, Dai S, Wang Y, Zhao L, Shan B. | 06/26/2021 |
| MTA2 promotes the metastasis of esophageal squamous cell carcinoma via EIF4E-Twist feedback loop. | MTA2 promotes the metastasis of esophageal squamous cell carcinoma via EIF4E-Twist feedback loop.
Dai SL, Wei SS, Zhang C, Li XY, Liu YP, Ma M, Lv HL, Zhang Z, Zhao LM, Shan BE., Free PMC Article | 03/20/2021 |
| Metastasis-Associated Protein 2 Represses NF-kappaB to Reduce Lung Tumor Growth and Inflammation. | Metastasis-Associated Protein 2 Represses NF-κB to Reduce Lung Tumor Growth and Inflammation.
El-Nikhely N, Karger A, Sarode P, Singh I, Weigert A, Wietelmann A, Stiewe T, Dammann R, Fink L, Grimminger F, Barreto G, Seeger W, Pullamsetti SS, Rapp UR, Savai R. | 02/13/2021 |
| Results indicate that metastasis associated 1 family member 2 (MTA2) represses a cohort of genes including FERM domain containing 6 protein (FRMD6) that are critically involved in the growth and mobility of hepatocellular carcinoma (HCC). | MTA2 promotes HCC progression through repressing FRMD6, a key upstream component of hippo signaling pathway.
Guan C, Chang Z, Gu X, Liu R. | 07/4/2020 |
| Authors revealed that MTA2 promoted PDAC cell proliferation, migration, and invasion in vitro and PDAC tumor growth in vivo by downregulation of PTEN. | MTA2-mediated inhibition of PTEN leads to pancreatic ductal adenocarcinoma carcinogenicity.
Si W, Liu X, Wei R, Zhang Y, Zhao Y, Cui L, Hong T., Free PMC Article | 06/6/2020 |
| The HOX antisense intergenic RNA (HOTAIR)-miR-326-metastasis-associated gene 2 (MTA2) axis may contribute to a better understanding of oral squamous cell carcinoma (OSCC) pathogenesis and be a potential therapeutic target for OSCC. | LncRNA HOTAIR promotes the invasion and metastasis of oral squamous cell carcinoma through metastasis-associated gene 2.
Tao D, Zhang Z, Liu X, Zhang Z, Fu Y, Zhang P, Yuan H, Liu L, Cheng J, Jiang H. | 04/25/2020 |
| MTA2 expression in oral cancer cells was markedly higher than that in normal oral cells. MTA2 knockdown can inhibit cell migration and invasion of human oral cancer cells. | Repression of metastasis-associated protein 2 for inhibiting metastasis of human oral cancer cells by promoting the p-cofilin-1/ LC3-II expression.
Tseng TY, Chiou HL, Lin CW, Chen YS, Hsu LS, Lee CH, Hsieh YH. | 01/18/2020 |
| Reciprocal loop of hypoxia-inducible factor-1alpha and metastasis-associated protein 2 contributes to the progression of pancreatic adenocarcinoma by suppressing E-cadherin transcription and promoting epithelial mesenchymal transformation. | Reciprocal loop of hypoxia-inducible factor-1α (HIF-1α) and metastasis-associated protein 2 (MTA2) contributes to the progression of pancreatic carcinoma by suppressing E-cadherin transcription.
Zhu S, Deng S, He C, Liu M, Chen H, Zeng Z, Zhong J, Ye Z, Deng S, Wu H, Wang C, Zhao G. | 10/26/2019 |
| MTA1 and MTA2 play opposing roles in the metastasis of ZR-75-30 luminal B breast cancer cells in vitro. | Overexpression of MTA1 inhibits the metastatic ability of ZR-75-30 cells in vitro by promoting MTA2 degradation.
Zhang L, Wang Q, Zhou Y, Ouyang Q, Dai W, Chen J, Ding P, Li L, Zhang X, Zhang W, Lv X, Li L, Zhang P, Cai G, Hu W., Free PMC Article | 06/15/2019 |
| This study is the first to demonstrate that SNHG5 is a critical and powerful regulator that is involved in GC progression through trapping MTA2 in the cytosol. | Long non-coding RNA SNHG5 suppresses gastric cancer progression by trapping MTA2 in the cytosol.
Zhao L, Guo H, Zhou B, Feng J, Li Y, Han T, Liu L, Li L, Zhang S, Liu Y, Shi J, Zheng D. | 09/9/2017 |
| Taken together with previous findings this suggests, that MTA-RBBP is a stable complex, with a central role in the initial assembly of the human NuRD complex. | Expression, purification and characterization of the human MTA2-RBBP7 complex.
Brasen C, Dorosz J, Wiuf A, Boesen T, Mirza O, Gajhede M. | 07/22/2017 |
| Authors identify non-canonical nuclear factor-kappaB (NF-kappaB) signaling up regulated and it was directly linked with the tumor necrosis with MT2A and pFADD genes. pFADD with MT2A can inhibit the apoptosis and promote proliferation, of colorectal cancer cells. | Metallothionein 2A an interactive protein linking phosphorylated FADD to NF-κB pathway leads to colorectal cancer formation.
Marikar FM, Jin G, Sheng W, Ma D, Hua Z. | 04/1/2017 |
| These results indicated there might be a tight correlation among MTA2, Ki-67 and hepatocellular carcinoma prognosis | Expression of MTA2 and Ki-67 in hepatocellular carcinoma and their correlation with prognosis.
Shi W, Hu J, Zhu S, Shen X, Zhang X, Yang C, Gao H, Zhang H., Free PMC Article | 10/8/2016 |
| MTA2 is a crucial biomarker that is closely related with prognosis of colorectal carcinoma and also a potential molecular target for evaluating the prognosis and treatment of CRC. | Prognostic correlation between MTA2 expression level and colorectal cancer.
Ding W, Hu W, Yang H, Ying T, Tian Y., Free PMC Article | 05/21/2016 |
| MTA2 overexpression enhances colony formation and tumor growth of gastric cancer cells, but not plays important role in cancer cell migration and metastasis. IL-11 is one of the downstream effectors of MTA2 in regulating gastric cancer cells growth | MTA2 enhances colony formation and tumor growth of gastric cancer cells through IL-11.
Zhou C, Ji J, Cai Q, Shi M, Chen X, Yu Y, Zhu Z, Zhang J., Free PMC Article | 01/30/2016 |
| MTA-2 protein may facilitate the invasive potential of non-small-cell lung cancer cells through the inhibition of the cell adhesion molecule Ep-CAM and E-cadherin, suggesting that it might be a potential therapeutic target in NSCLC. | Metastasis-associated protein 2 (MTA2) promotes the metastasis of non-small-cell lung cancer through the inhibition of the cell adhesion molecule Ep-CAM and E-cadherin.
Zhang B, Zhang H, Shen G. | 10/24/2015 |
| High MTA2 protein and mRNA expression is associated with glioma. | Metastasis tumor-associated protein-2 knockdown suppresses the proliferation and invasion of human glioma cells in vitro and in vivo.
Cheng CY, Chou YE, Ko CP, Yang SF, Hsieh SC, Lin CL, Hsieh YH, Chen KC. | 10/17/2015 |
| MTA2 acts as a central hub for cytoskeletal organization and transcription and provides a link between nuclear and cytoskeletal organization. | Role of MTA2 in human cancer.
Covington KR, Fuqua SA., Free PMC Article | 07/25/2015 |