| LRRFIP1, an epigenetically regulated gene, is a prognostic biomarker and predicts malignant phenotypes of glioma. | LRRFIP1, an epigenetically regulated gene, is a prognostic biomarker and predicts malignant phenotypes of glioma.
Ma W, Bao Z, Qian Z, Zhang K, Fan W, Xu J, Ren C, Zhang Y, Jiang T., Free PMC Article | 05/7/2022 |
| LRRFIP1/GCF2 is a bioregulator in multidisciplinary systems of the human body and its dysregulation can cause diverse human diseases. | Multidisciplinary Roles of LRRFIP1/GCF2 in Human Biological Systems and Diseases.
Takimoto M., Free PMC Article | 12/7/2019 |
| Results show that LRRFIP-1 is mainly produced by keratinocytes in the unwounded skin but is upregulated in both keratinocytes and fibroblasts in response to wounding, suggesting a role in the wound repair process. | Recombinant Leucine-Rich Repeat Flightless-Interacting Protein-1 Improves Healing of Acute Wounds through Its Effects on Proliferation Inflammation and Collagen Deposition.
Kopecki Z, Stevens NE, Yang GN, Melville E, Cowin AJ., Free PMC Article | 11/3/2018 |
| Silencing of LRRFIP1 reverses the epithelial-mesenchymal transition via inhibition of the Wnt/beta-catenin signaling pathway. | Silencing of LRRFIP1 reverses the epithelial-mesenchymal transition via inhibition of the Wnt/β-catenin signaling pathway.
Douchi D, Ohtsuka H, Ariake K, Masuda K, Kawasaki S, Kawaguchi K, Fukase K, Oikawa M, Motoi F, Naitoh T, Katayose Y, Egawa S, Unno M. | 08/29/2015 |
| High GCF2 expression is associated with hepatoma. | Knockdown of GCF2/LRRFIP1 by RNAi causes cell growth inhibition and increased apoptosis in human hepatoma HepG2 cells.
Li JP, Cao NX, Jiang RT, He SJ, Huang TM, Wu B, Chen DF, Ma P, Chen L, Zhou SF, Xie XX, Luo GR. | 01/10/2015 |
| Higher baseline LRRFIP1 expression in human glioblastoma multiforme tissue (n=60) is associated with better prognosis upon later treatment with teniposide. | Higher LRRFIP1 expression in glioblastoma multiforme is associated with better response to teniposide, a type II topoisomerase inhibitor.
Li WQ, Yu HY, Li YM, Wang X, He J, Yan HZ, Yang DH, Wu XJ, Hou LJ, Liu HM, Xia CY, Lu YC. | 06/28/2014 |
| Data indicate that LRRFIP1 knockdown increased resting TNF mRNA level altered the ncRNA abundance at the LRRFIP1 binding region. | Noncoding RNAs and LRRFIP1 regulate TNF expression.
Shi L, Song L, Fitzgerald M, Maurer K, Bagashev A, Sullivan KE., Free PMC Article | 06/14/2014 |
| Eight SNPs (rs7575941, rs3769053, rs11689421, rs3820808, rs11680012, rs3806505, rs6739130, and rs11686141) showed evidence of association with at least two adiposity phenotypes and plasma levels of one marker of inflammation. | A variant in the LRRFIP1 gene is associated with adiposity and inflammation.
Plourde M, Vohl MC, Bellis C, Carless M, Dyer T, Dolley G, Marette A, Després JP, Bouchard C, Blangero J, Pérusse L. | 08/31/2013 |
| The FLI-interacting domain of LRRFIP1 forms a classic parallel, homodimeric coiled coil with 10 heptad repeats and 22 helical turns. | Crystal structure of the dimeric coiled-coil domain of the cytosolic nucleic acid sensor LRRFIP1.
Nguyen JB, Modis Y., Free PMC Article | 05/25/2013 |
| GCF2/LRRFIP1 plays an important role in colorectal cancer metastasis by regulating RhoA-induced cell adhesion. | GCF2/LRRFIP1 promotes colorectal cancer metastasis and liver invasion through integrin-dependent RhoA activation.
Ariake K, Ohtsuka H, Motoi F, Douchi D, Oikawa M, Rikiyama T, Fukase K, Katayose Y, Egawa S, Unno M. | 01/26/2013 |
| LRRFIP1 is phosphorylated in response to immunologic stimuli and it is directed to lysosomal structures. | Characterization of LRRFIP1.
Arakawa R, Bagashev A, Song L, Maurer K, Sullivan KE. | 02/26/2011 |
| An association study of 6 of the 63 genes in 4235 cases and 6379 controls showed a putative association with myocardial infarction for COMMD7 (COMM domain-containing protein 7) and a major deviation from the null hypo thesis for LRRFIP1. | Transcription profiling in human platelets reveals LRRFIP1 as a novel protein regulating platelet function.
Goodall AH, Burns P, Salles I, Macaulay IC, Jones CI, Ardissino D, de Bono B, Bray SL, Deckmyn H, Dudbridge F, Fitzgerald DJ, Garner SF, Gusnanto A, Koch K, Langford C, O'Connor MN, Rice CM, Stemple D, Stephens J, Trip MD, Zwaginga JJ, Samani NJ, Watkins NA, Maguire PB, Ouwehand WH, Bloodomics Consortium., Free PMC Article | 01/15/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Immediately following lipopolysaccharide stimulation, both LRRFIP2 and Flap-1/LRRFIP1 compete with Fliih for interacting with MyD88 to activate the signaling. | Modulation of TLR signaling by multiple MyD88-interacting partners including leucine-rich repeat Fli-I-interacting proteins.
Dai P, Jeong SY, Yu Y, Leng T, Wu W, Xie L, Chen X. | 01/21/2010 |
| GCF2/LRRFIP1 appears to act as a repressor and occupies the -308 site in cells that do not make TNF-alpha. | GCF2/LRRFIP1 represses tumor necrosis factor alpha expression.
Suriano AR, Sanford AN, Kim N, Oh M, Kennedy S, Henderson MJ, Dietzmann K, Sullivan KE., Free PMC Article | 01/21/2010 |