| Functional heterogeneity of MCT1 and MCT4 in metabolic reprogramming affects osteosarcoma growth and metastasis. | Functional heterogeneity of MCT1 and MCT4 in metabolic reprogramming affects osteosarcoma growth and metastasis.
Sheng G, Gao Y, Wu H, Liu Y, Yang Y., Free PMC Article | 02/24/2023 |
| Whole-brain neuronal MCT2 lactate transporter expression links metabolism to human brain structure and function. | Whole-brain neuronal MCT2 lactate transporter expression links metabolism to human brain structure and function.
Medel V, Crossley N, Gajardo I, Muller E, Barros LF, Shine JM, Sierralta J., Free PMC Article | 08/27/2022 |
| Identification of the essential extracellular aspartic acids conserved in human monocarboxylate transporters 1, 2, and 4. | Identification of the essential extracellular aspartic acids conserved in human monocarboxylate transporters 1, 2, and 4.
Yamaguchi A, Narumi K, Furugen A, Iseki K, Kobayashi M. | 02/13/2021 |
| Cooperative transport mechanism of human monocarboxylate transporter 2. | Cooperative transport mechanism of human monocarboxylate transporter 2.
Zhang B, Jin Q, Xu L, Li N, Meng Y, Chang S, Zheng X, Wang J, Chen Y, Neculai D, Gao N, Zhang X, Yang F, Guo J, Ye S., Free PMC Article | 08/29/2020 |
| the present study reports that the combination of tumour stroma percentage and tumour cell expression of cytoplasmic MCT-2 or nuclear LDH-5 is associated with poor prognosis. | The association between markers of tumour cell metabolism, the tumour microenvironment and outcomes in patients with colorectal cancer.
Roseweir AK, Clark J, McSorley ST, vanWyk HC, Quinn JA, Horgan PG, McMillan DC, Park JH, Edwards J. | 08/10/2019 |
| MCT2 dictates the mode of action of N-oxalylglycine (NOG) by determining its intracellular concentration | MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG.
Fets L, Driscoll PC, Grimm F, Jain A, Nunes PM, Gounis M, Doglioni G, Papageorgiou G, Ragan TJ, Campos S, Silva Dos Santos M, MacRae JI, O'Reilly N, Wright AJ, Benes CH, Courtney KD, House D, Anastasiou D., Free PMC Article | 05/11/2019 |
| Adipocytes promote malignant growth of breast tumors with MCT2 expression via beta-hydroxybutyrate. | Adipocytes promote malignant growth of breast tumours with monocarboxylate transporter 2 expression via β-hydroxybutyrate.
Huang CK, Chang PH, Kuo WH, Chen CL, Jeng YM, Chang KJ, Shew JY, Hu CM, Lee WH., Free PMC Article | 11/17/2018 |
| SLC16A7 (MCT2) epigenetic regulation results in protein over-expression, affecting signalling and cellular phenotypes in prostate cancer | Epigenetic and oncogenic regulation of SLC16A7 (MCT2) results in protein over-expression, impacting on signalling and cellular phenotypes in prostate cancer.
Pertega-Gomes N, Vizcaino JR, Felisbino S, Warren AY, Shaw G, Kay J, Whitaker H, Lynch AG, Fryer L, Neal DE, Massie CE., Free PMC Article | 06/11/2016 |
| Data suggest that monocarboxylate transporter 2 (MCT2) at peroxisomes is related to an increase in beta-oxidation levels which may be crucial for malignant transformation. | Localization of MCT2 at peroxisomes is associated with malignant transformation in prostate cancer.
Valença I, Pértega-Gomes N, Vizcaino JR, Henrique RM, Lopes C, Baltazar F, Ribeiro D., Free PMC Article | 04/2/2016 |
| This study identified that CGPs was found to significantly correlate with the differential expression and methylation of genes encoding solute carrier family 16, member 7. | Correlation between DNA methylation and gene expression in the brains of patients with bipolar disorder and schizophrenia.
Chen C, Zhang C, Cheng L, Reilly JL, Bishop JR, Sweeney JA, Chen HY, Gershon ES, Liu C., Free PMC Article | 08/22/2015 |
| Our findings suggest that SNPs in MCT1 and MCT2 genes may affect clinical outcomes and can be used to predict the response to adjuvant chemotherapy in NSCLC patients who received surgical treatment once validated in future study. | Genetic variations in monocarboxylate transporter genes as predictors of clinical outcomes in non-small cell lung cancer.
Guo X, Chen C, Liu B, Wu Y, Chen Y, Zhou X, Huang X, Li X, Yang H, Chen Z, Xing J. | 08/8/2015 |
| SNPs in MCT1 and MCT2 genes may affect clinical outcomes and can be used to predict the response to adjuvant chemotherapy in CRC patients who received surgical treatment. | Polymorphisms of monocarboxylate transporter genes are associated with clinical outcomes in patients with colorectal cancer.
Fei F, Guo X, Chen Y, Liu X, Tu J, Xing J, Chen Z, Ji J, He X. | 08/1/2015 |
| MCT2-3' UTR SNP (+2626 G > A) had a strong association with oligoasthenoteratozoospermia. | The genetic variation in monocarboxylic acid transporter 2 (MCT2) has functional and clinical relevance with male infertility.
Lee J, Lee DR, Lee S., Free PMC Article | 07/4/2015 |
| this study provided evidence for the presence of MCT2 in prostate cancer, selectively labeling malignant glands. | Monocarboxylate transporter 2 (MCT2) as putative biomarker in prostate cancer.
Pértega-Gomes N, Vizcaíno JR, Gouveia C, Jerónimo C, Henrique RM, Lopes C, Baltazar F. | 06/29/2013 |
| The monocarboxylate transporter 2 (MCT2) protein was tumor-selectively expressed in human colorectal malignancies and knockdown of MCT2 induces mitochondrial dysfunction, cell-cycle arrest, and senescence. | Inhibition of monocarboxylate transporter 2 induces senescence-associated mitochondrial dysfunction and suppresses progression of colorectal malignancies in vivo.
Lee I, Lee SJ, Kang WK, Park C. | 04/27/2013 |
| Light microscopic immunohistochemistry revealed significantly less perivascular MCT2 immunoreactivity in the hippocampal formation in medial temporal lobe epilepsy than in non-MTLE patients | Redistribution of monocarboxylate transporter 2 on the surface of astrocytes in the human epileptogenic hippocampus.
Lauritzen F, Heuser K, de Lanerolle NC, Lee TS, Spencer DD, Kim JH, Gjedde A, Eid T, Bergersen LH., Free PMC Article | 09/22/2012 |
| Data show that a significant increase of MCT2 and MCT4 expression in the cytoplasm of tumour cells and a significant decrease in both MCT1 and CD147 expression in prostate tumour cells was observed when compared to normal tissue. | Monocarboxylate transporter 4 (MCT4) and CD147 overexpression is associated with poor prognosis in prostate cancer.
Pértega-Gomes N, Vizcaíno JR, Miranda-Gonçalves V, Pinheiro C, Silva J, Pereira H, Monteiro P, Henrique RM, Reis RM, Lopes C, Baltazar F., Free PMC Article | 02/11/2012 |
| data suggest that extracellular membrane-bound CAIV, but not cytosolic CAII, augments transport activity of MCT2 in a non-catalytic manner, possibly by facilitating a proton pathway other than His-88 | Transport activity of the high-affinity monocarboxylate transporter MCT2 is enhanced by extracellular carbonic anhydrase IV but not by intracellular carbonic anhydrase II.
Klier M, Schüler C, Halestrap AP, Sly WS, Deitmer JW, Becker HM., Free PMC Article | 10/15/2011 |
| MCT1, MCT2, and MCT4 protein expression in breast, colon, lung, and ovary neoplasms, as well as CD147 and CD44, were analysed. | Expression of monocarboxylate transporters 1, 2, and 4 in human tumours and their association with CD147 and CD44.
Pinheiro C, Reis RM, Ricardo S, Longatto-Filho A, Schmitt F, Baltazar F., Free PMC Article | 09/20/2010 |
| Ocular absorption of monocarboxylic acid drugs may be enhanced by MCT transporter SLC16A7, and the absorption route provided by this transporter may be utilized to improve the bioavailability of topically applied ophthalmic drugs. | Monocarboxylate transport in human corneal epithelium and cell lines.
Vellonen KS, Häkli M, Merezhinskaya N, Tervo T, Honkakoski P, Urtti A. | 09/6/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Data suggest that hypoxia increases lactate release from adipocytes and modulates MCT expression in a type-specific manner, with MCT1 and MCT4, but not MCT2 expression, being hypoxia-inducible transcription factor-1 (HIF-1) dependent. | Hypoxia stimulates lactate release and modulates monocarboxylate transporter (MCT1, MCT2, and MCT4) expression in human adipocytes.
Pérez de Heredia F, Wood IS, Trayhurn P. | 03/29/2010 |
| These data demonstrate neuronal MCT2 expression in human, but since a portion of it exhibits a distinct synaptic localization, it further supports a putative role for MCT2 in adjustment of energy supply to levels of activity. | Distribution of the monocarboxylate transporter MCT2 in human cerebral cortex: an immunohistochemical study.
Chiry O, Fishbein WN, Merezhinskaya N, Clarke S, Galuske R, Magistretti PJ, Pellerin L. | 01/21/2010 |
| Colorectal neoplasms showed a loss of expression of MCT2 in plasma membranes. | Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas.
Pinheiro C, Longatto-Filho A, Scapulatempo C, Ferreira L, Martins S, Pellerin L, Rodrigues M, Alves VA, Schmitt F, Baltazar F. | 01/21/2010 |
| Gamma-hydroxybutyric acid (GHB) is a substrate for both MCT2 and MCT4. | The role of monocarboxylate transporter 2 and 4 in the transport of gamma-hydroxybutyric acid in mammalian cells.
Wang Q, Morris ME. | 01/21/2010 |