| TIM-4 orchestrates mitochondrial homeostasis to promote lung cancer progression via ANXA2/PI3K/AKT/OPA1 axis. | TIM-4 orchestrates mitochondrial homeostasis to promote lung cancer progression via ANXA2/PI3K/AKT/OPA1 axis.
Wang Y, Wang Y, Liu W, Ding L, Zhang X, Wang B, Tong Z, Yue X, Li C, Xu L, Wu Z, Liang X, Ma C, Gao L., Free PMC Article | 02/23/2023 |
| Overexpression of Nuclear Enriched Autosomal Transcript 1 Facilitates Cell Proliferation, Migration Invasion, and Suppresses Apoptosis in Endometrial Cancer by Targeting MicroRNA-202-3p/T Cell Immunoglobulin and Mucin Domain 4 Axis. | Overexpression of Nuclear Enriched Autosomal Transcript 1 Facilitates Cell Proliferation, Migration Invasion, and Suppresses Apoptosis in Endometrial Cancer by Targeting MicroRNA-202-3p/T Cell Immunoglobulin and Mucin Domain 4 Axis.
Xu C, Zhai J, Fu Y. | 11/26/2022 |
| TIM-4 in macrophages contributes to nasal polyp formation through the TGF-beta1-mediated epithelial to mesenchymal transition in nasal epithelial cells. | TIM-4 in macrophages contributes to nasal polyp formation through the TGF-β1-mediated epithelial to mesenchymal transition in nasal epithelial cells.
Qin D, Liu P, Zhou H, Jin J, Gong W, Liu K, Chen S, Huang J, Fan W, Tao Z, Xu Y., Free PMC Article | 09/17/2022 |
| Tim4 recognizes carbon nanotubes and mediates phagocytosis leading to granuloma formation. | Tim4 recognizes carbon nanotubes and mediates phagocytosis leading to granuloma formation.
Omori S, Tsugita M, Hoshikawa Y, Morita M, Ito F, Yamaguchi SI, Xie Q, Noyori O, Yamaguchi T, Takada A, Saitoh T, Toyokuni S, Akiba H, Nagata S, Kinoshita K, Nakayama M. | 01/22/2022 |
| Platelet-derived extracellular vesicles are increased in sera of Alzheimer's disease patients, as revealed by Tim4-based assays. | Platelet-derived extracellular vesicles are increased in sera of Alzheimer's disease patients, as revealed by Tim4-based assays.
Odaka H, Hiemori K, Shimoda A, Akiyoshi K, Tateno H., Free PMC Article | 01/1/2022 |
| Tim-4(+) cavity-resident macrophages impair anti-tumor CD8(+) T cell immunity. | Tim-4(+) cavity-resident macrophages impair anti-tumor CD8(+) T cell immunity.
Chow A, Schad S, Green MD, Hellmann MD, Allaj V, Ceglia N, Zago G, Shah NS, Sharma SK, Mattar M, Chan J, Rizvi H, Zhong H, Liu C, Bykov Y, Zamarin D, Shi H, Budhu S, Wohlhieter C, Uddin F, Gupta A, Khodos I, Waninger JJ, Qin A, Markowitz GJ, Mittal V, Balachandran V, Durham JN, Le DT, Zou W, Shah SP, McPherson A, Panageas K, Lewis JS, Perry JSA, de Stanchina E, Sen T, Poirier JT, Wolchok JD, Rudin CM, Merghoub T., Free PMC Article | 12/25/2021 |
| EphA2 Interacts with Tim-4 through Association between Its FN3 Domain and the IgV Domain of Tim-4. | EphA2 Interacts with Tim-4 through Association between Its FN3 Domain and the IgV Domain of Tim-4.
Moon B, Yang S, Kim K, Lee J, Jeong D, Park D., Free PMC Article | 11/6/2021 |
| TIMD4 exhibits regulatory capability on the proliferation and apoptosis of diffuse large B-cell lymphoma cells via the Wnt/beta-catenin pathway. | TIMD4 exhibits regulatory capability on the proliferation and apoptosis of diffuse large B-cell lymphoma cells via the Wnt/β-catenin pathway.
Li Y, Zhang PY, Yang ZW, Ma F, Li FX. | 08/7/2021 |
| The expression of Tim-1 and Tim-4 molecules in regulatory T cells in type 1 diabetes. | The expression of Tim-1 and Tim-4 molecules in regulatory T cells in type 1 diabetes.
Guo H, Shen Y, Kong YH, Li S, Jiang R, Liu C, Fang C, Hu J. | 07/10/2021 |
| Tim4 regulates NALP3 inflammasome expression and activity during monocyte/macrophage dysfunction in septic shock patients. | Tim4 regulates NALP3 inflammasome expression and activity during monocyte/macrophage dysfunction in septic shock patients.
Liu Z, Tan K, Bu L, Bo L, Ni W, Fei M, Chen F, Deng X, Li J. | 06/19/2021 |
| Autophagic adaptation to oxidative stress alters peritoneal residential macrophage survival and ovarian cancer metastasis. | Autophagic adaptation to oxidative stress alters peritoneal residential macrophage survival and ovarian cancer metastasis.
Xia H, Li S, Li X, Wang W, Bian Y, Wei S, Grove S, Wang W, Vatan L, Liu JR, McLean K, Rattan R, Munkarah A, Guan JL, Kryczek I, Zou W., Free PMC Article | 06/5/2021 |
| Mertk Interacts with Tim-4 to Enhance Tim-4-Mediated Efferocytosis. | Mertk Interacts with Tim-4 to Enhance Tim-4-Mediated Efferocytosis.
Moon B, Lee J, Lee SA, Min C, Moon H, Kim D, Yang S, Moon H, Jeon J, Joo YE, Park D., Free PMC Article | 04/17/2021 |
| Tim-4 expressing monocytes as a novel indicator to assess disease activity and severity of ulcerative colitis. | Tim-4 expressing monocytes as a novel indicator to assess disease activity and severity of ulcerative colitis.
Xue G, Hua L, Liu D, Zhong M, Chen Y, Zhou B, Xie Y, Li J. | 02/27/2021 |
| IL-6 in tumour microenvironment enhances TIM-4 expression in lung cancer cells via NF-kappaB, which in turn promotes metastasis and IL-6 production of lung cancer cells. | IL-6 promotes metastasis of non-small-cell lung cancer by up-regulating TIM-4 via NF-κB.
Liu W, Wang H, Bai F, Ding L, Huang Y, Lu C, Chen S, Li C, Yue X, Liang X, Ma C, Xu L, Gao L., Free PMC Article | 04/18/2020 |
| Study results suggest that the TIMD4 rs6882076 single nucleotide polymorphism is associated with decreased risk of coronary heart disease (CHD) and ischemic stroke (IS) in a Southern Chinese Han population. It is likely to decrease the CHD and IS risk by reducing serum triglycerides levels. | TIMD4 rs6882076 SNP Is Associated with Decreased Levels of Triglycerides and the Risk of Coronary Heart Disease and Ischemic Stroke.
Khounphinith E, Yin RX, Cao XL, Huang F, Wu JZ, Li H., Free PMC Article | 02/15/2020 |
| Up-regulated Tim-4 expression on monocytes or in plasma on day 2 was a risk predictor of outcome | Tim-4 expression increases in ischemic stroke patients and is associated with poor outcome.
Xu L, Ye Z, Wang B, Huang Y, Zhou L, Liu C, Chen D, Sun M, Dai F, Guan S, Tang W. | 09/28/2019 |
| These findings suggest that the TIMD4-HAVCR1 variants may be the genetic risk factors for coronary heart disease and ischemic stroke | Association between the TIMD4-HAVCR1 variants and serum lipid levels, coronary heart disease and ischemic stroke risk and atorvastatin lipid-lowering efficacy.
Zhang QH, Yin RX, Chen WX, Cao XL, Chen YM., Free PMC Article | 08/18/2018 |
| High expression of TIMD4 in clear cell renal cancer cells was closely related to short progression free survival time, and was associated with resistance to sorafenib. | The significance of TIMD4 expression in clear cell renal cell carcinoma.
Yano H, Motoshima T, Ma C, Pan C, Yamada S, Nakayama T, Kitada S, Fujimoto N, Kamba T, Takeya M, Komohara Y. | 06/30/2018 |
| VitD deficiency may contribute to the pathogenesis of allergic rhinitis (AR) by increasing the TIM4 expression. The results suggest that to regulate the serum calcitriol levels and the expression of VDR in DCs may be necessary to be taken into account in the treatment of AR. | Vitamin D regulates immunoglobulin mucin domain molecule-4 expression in dendritic cells.
Liu ZQ, Li MG, Geng XR, Liu J, Yang G, Qiu SQ, Liu ZG, Yang PC. | 02/17/2018 |
| This study aimed to investigate the association of two TIM-4 SNPs) with systemic lupus erythematosus (SLE)susceptibility in a Chinese Han population.The results imply that GG genotype of the TIM-4 gene at -1419 site might be associated with the disease activity of SLE. | Promoter polymorphisms of the TIM-4 gene are correlated with disease activity in patients with systemic lupus erythematosus.
Liu B, Liu W, Wang R, Shu Q, Zhang X, Fan X, Zhang Q, Liang X, Ma C, Gao L. | 12/16/2017 |
| Role of TIM-4 in exosome-dependent entry of HIV-1 into human immune cells | Role of TIM-4 in exosome-dependent entry of HIV-1 into human immune cells.
Sims B, Farrow AL, Williams SD, Bansal A, Krendelchtchikov A, Gu L, Matthews QL., Free PMC Article | 10/21/2017 |
| analysis of the molecular characteristics of both mTIM-4 and hTIM-4 provides a better understanding of the regions of the TIM-4 IgV domain critical for Ebola virus entry | Characterization of Human and Murine T-Cell Immunoglobulin Mucin Domain 4 (TIM-4) IgV Domain Residues Critical for Ebola Virus Entry.
Rhein BA, Brouillette RB, Schaack GA, Chiorini JA, Maury W., Free PMC Article | 05/13/2017 |
| Tim-4 expression is closely associated with glioma and may have a regulatory role | Expression of Tim4 in Glioma and its Regulatory Role in LN-18 Glioma Cells.
Li W, Li X, Xu S, Ma X, Zhang Q., Free PMC Article | 04/1/2017 |
| Data indicate that T cell immunoglobulin and mucin domain containing 4 (TIM-4) contributes, at least in part, to the pathogenesis of type 2 diabetes mellitus (T2D), possibly by regulating interleukin-1beta (IL-1beta). | Increased T cell immunoglobulin and mucin domain containing 4 (TIM-4) is negatively correlated with serum concentrations of interleukin-1β in type 2 diabetes.
Zhao P, Wang H, Li T, Lei C, Xu X, Wang W, Liang X, Ma C, Gao L. | 12/17/2016 |
| TIM4 binds TIM3 on the surface of polarized Th1 cells to induce Th1 cell apoptosis, which may contribute to the development of Th2-dominant immune disorders. | Interaction of TIM4 and TIM3 induces T helper 1 cell apoptosis.
Ge RT, Zeng L, Mo LH, Xu LZ, Zhang HP, Yu HQ, Zhang M, Liu ZG, Liu ZJ, Yang PC. | 12/17/2016 |