| Low transcriptomic of PTPRCv1 and CD3E is an independent predictor of mortality in HIV and tuberculosis co-infected patient. | Low transcriptomic of PTPRCv1 and CD3E is an independent predictor of mortality in HIV and tuberculosis co-infected patient.
Gebremicael G, Gebreegziabxier A, Kassa D., Free PMC Article | 06/25/2022 |
| Biallelic Form of a Known CD3E Mutation in a Patient with Severe Combined Immunodeficiency. | Biallelic Form of a Known CD3E Mutation in a Patient with Severe Combined Immunodeficiency.
Erman B, Fırtına S, Fışgın T, Bozkurt C, Çipe FE. | 08/7/2021 |
| Multiple Signaling Roles of CD3epsilon and Its Application in CAR-T Cell Therapy. | Multiple Signaling Roles of CD3ε and Its Application in CAR-T Cell Therapy.
Wu W, Zhou Q, Masubuchi T, Shi X, Li H, Xu X, Huang M, Meng L, He X, Zhu H, Gao S, Zhang N, Jing R, Sun J, Wang H, Hui E, Wong CC, Xu C. | 04/3/2021 |
| Actin polymerization promotes the recruitment of Nck to the TCR, enhancing downstream signaling, such as phosphorylation of CD3epsilon and lymphocyte activation. | Actin polymerization regulates recruitment of Nck to CD3ε upon T-cell receptor triggering.
Wipa P, Paensuwan P, Ngoenkam J, Woessner NM, Minguet S, Schamel WW, Pongcharoen S., Free PMC Article | 05/2/2020 |
| The ionic CD3-epsilon -Lck interaction controls the phosphorylation level of the T-cell receptor. | Ionic CD3-Lck interaction regulates the initiation of T-cell receptor signaling.
Li L, Guo X, Shi X, Li C, Wu W, Yan C, Wang H, Li H, Xu C., Free PMC Article | 05/26/2018 |
| A novel pathogenic frameshift variant of CD3E gene has been found in two unrelated T-B+ NK+ severe combined immunodeficiency infants from Turkey. | A novel pathogenic frameshift variant of CD3E gene in two T-B+ NK+ SCID patients from Turkey.
Firtina S, Ng YY, Ng OH, Nepesov S, Yesilbas O, Kilercik M, Burtecene N, Cinar S, Camcioglu Y, Ozbek U, Sayitoglu M. | 12/9/2017 |
| the stalk domains of NKp30 and NKp46, another NCR employing CD3zeta for signaling, were not exchangeable without drastic deficiencies in folding, plasma membrane targeting, and/or ligand-induced receptor signaling. | The Stalk Domain of NKp30 Contributes to Ligand Binding and Signaling of a Preassembled NKp30-CD3ζ Complex.
Memmer S, Weil S, Beyer S, Zöller T, Peters E, Hartmann J, Steinle A, Koch J., Free PMC Article | 05/27/2017 |
| The inducible recruitment of WASp to the TCR-CD3 complex is partially dependent of tyrosine phosphorylation of Cd3e. | Evidence for inducible recruitment of Wiskott-Aldrich syndrome protein to T cell receptor-CD3 complex in Jurkat T cells.
Paensuwan P, Ngoenkam J, Khamsri B, Preechanukul K, Sanguansermsri D, Pongcharoen S. | 01/28/2017 |
| increase. Our results indicate that the change in CD3zeta-chain expression from the baseline is an independent predictor of residual and recurrent head and neck squamous cell carcinoma. | Change in CD3ζ-chain expression is an independent predictor of disease status in head and neck cancer patients.
Upreti D, Zhang ML, Bykova E, Kung SK, Pathak KA. | 08/27/2016 |
| Data suggest that HIV-1 gp41 transmembrane domain (TMD) directly interacts with TMDs of the T-cell receptor and it's CD3-antigen co-receptors (delta, gamma, and epsilon); these interactions appear to be involved in immune evasion mechanism of HIV-1. | The Transmembrane Domain of HIV-1 gp41 Inhibits T-Cell Activation by Targeting Multiple T-Cell Receptor Complex Components through Its GxxxG Motif.
Rotem E, Reuven EM, Klug YA, Shai Y. | 07/30/2016 |
| The docking site for CD3 subunits on the T Cell receptor beta chain has been identified by solution NMR. | Identification of the Docking Site for CD3 on the T Cell Receptor β Chain by Solution NMR.
He Y, Rangarajan S, Kerzic M, Luo M, Chen Y, Wang Q, Yin Y, Workman CJ, Vignali KM, Vignali DA, Mariuzza RA, Orban J., Free PMC Article | 11/7/2015 |
| analysis of the molecular organization of the TCR-CD3 complex | Molecular architecture of the αβ T cell receptor-CD3 complex.
Birnbaum ME, Berry R, Hsiao YS, Chen Z, Shingu-Vazquez MA, Yu X, Waghray D, Fischer S, McCluskey J, Rossjohn J, Walz T, Garcia KC., Free PMC Article | 05/2/2015 |
| that Nck recruitment to the TCR is fundamental to mount an efficient T cell response in vivo, and that the Nck-CD3epsilon interaction may represent a target for pharmacological modulation of the immune response. | Relevance of Nck-CD3 epsilon interaction for T cell activation in vivo.
Borroto A, Arellano I, Blanco R, Fuentes M, Orfao A, Dopfer EP, Prouza M, Suchànek M, Schamel WW, Alarcón B. | 04/19/2014 |
| ABCB1 homozygous 3435 TT carrier subjects showed the lowest Pgp activity compared with 3435 CT and CC carriers of renal transplant patients. | Do drug transporter (ABCB1) SNPs and P-glycoprotein function influence cyclosporine and macrolides exposure in renal transplant patients? Results of the pharmacogenomic substudy within the symphony study.
Llaudó I, Colom H, Giménez-Bonafé P, Torras J, Caldés A, Sarrias M, Cruzado JM, Oppenheimer F, Sánchez-Plumed J, Gentil MÁ, Ekberg H, Grinyó JM, Lloberas N. | 06/29/2013 |
| Local changes in the lipid composition of TCR microclusters render the CD3epsilon cytoplasmic domain accessible during early stages of T cell activation. | Local changes in lipid environment of TCR microclusters regulate membrane binding by the CD3ε cytoplasmic domain.
Gagnon E, Schubert DA, Gordo S, Chu HH, Wucherpfennig KW., Free PMC Article | 03/2/2013 |
| Altered expression of the TCR signaling related genes CD3 and FcepsilonRIgamma in patients with aplastic anemia. | Altered expression of the TCR signaling related genes CD3 and FcεRIγ in patients with aplastic anemia.
Li B, Liu S, Niu Y, Fang S, Wu X, Yu Z, Chen S, Yang L, Li Y., Free PMC Article | 09/8/2012 |
| Results show that levels of CD3epsilon, CD25, CD68, and ICAM-1 mRNA in BCC biopsies may predict risk for new basal cell carcinomas. | Tumor site immune markers associated with risk for subsequent basal cell carcinomas.
Glaser R, Andridge R, Yang EV, Shana'ah AY, Di Gregorio M, Chen M, Johnson SL, De Renne LA, Lambert DR, Jewell SD, Bechtel MA, Hearne DW, Herron JB, Kiecolt-Glaser JK., Free PMC Article | 03/10/2012 |
| Study characterized the expression pattern of CD3-gamma, -delta, -epsilon and -zeta chain genes from placenta, which contributes to further understanding of the features of T-cell immune status in placenta. | The expression pattern of CD3 chain genes in fetal/maternal interface.
Lu X, Chen S, Yang L, Zha X, Yang X, Li Y. | 10/8/2011 |
| Data show that the expression pattern of the four CD3 chains was epsilon>zeta>delta>gamma in peripheral blood mononuclear cells from MM, while a gamma>epsilon>zeta>delta expression pattern was found in healthy controls. | Change in expression pattern of TCR-CD3 complex in patients with multiple myeloma.
Li Y, Chen S, Yang L, Chen S, Lin C, Wang L, Lu Y, Geng S, Du X, Schmidt CA. | 10/8/2011 |
| analysis of the transgenic integration site in immunodeficient tgepsilon26 human CD3epsilon transgenic mice | Identification of the transgenic integration site in immunodeficient tgε26 human CD3ε transgenic mice.
Ohigashi I, Yamasaki Y, Hirashima T, Takahama Y., Free PMC Article | 07/9/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Results suggest that generation of CD3varepsilon chain isoforms with different N-terminal sequence and pI is a general phenomenon. | N-terminal negatively charged residues in CD3varepsilon chains as a phylogenetically conserved trait potentially yielding isoforms with different isoelectric points: analysis of human CD3varepsilon chains.
Bello R, Feito MJ, Ojeda G, Portolés P, Rojo JM. | 02/8/2010 |
| Results revealed that the human CD3 epsilon subunit forms a homodimer structure, which provide insight into our understanding of the molecular assembly of the CD3 molecular complex. | In vitro preparation and characterization of the human CD3 epsilon epsilon homodimer and CD3 epsilon gamma and CD3 epsilon delta heterodimers.
Su Z, Wang H, Wan Y, Bi Z. | 01/21/2010 |
| Data show that anti-CD3 monoclonal antibody (MAb)-mediated chimpanzee T-cell activation is a function of the anti-CD3 MAb isotype and is not governed by Siglec expression. | The quality of chimpanzee T-cell activation and simian immunodeficiency virus/human immunodeficiency virus susceptibility achieved via antibody-mediated T-cell receptor/CD3 stimulation is a function of the anti-CD3 antibody isotype.
Bibollet-Ruche F, McKinney BA, Duverger A, Wagner FH, Ansari AA, Kutsch O., Free PMC Article | 01/21/2010 |
| In lung adenocarcinoma patients, significant decreases of MFI values for CD3epsilon, but not CD3zeta, were found in CD4+T and CD8+T cells from pleural effusion compared to peripheral blood and in peripheral blood of patients compared to healthy donors. | Lung carcinomas do not induce T-cell apoptosis via the Fas/Fas ligand pathway but down-regulate CD3 epsilon expression.
Prado-Garcia H, Aguilar-Cazares D, Meneses-Flores M, Morales-Fuentes J, Lopez-Gonzalez JS., Free PMC Article | 01/21/2010 |