| Varicella Zoster Virus Downregulates Expression of the Nonclassical Antigen Presentation Molecule CD1d. | Varicella Zoster Virus Downregulates Expression of the Nonclassical Antigen Presentation Molecule CD1d.
Traves R, Opadchy T, Slobedman B, Abendroth A., Free PMC Article | 09/25/2024 |
| Cancer-associated fibroblasts express CD1d and activate invariant natural killer T cells under cellular stress. | Cancer-associated fibroblasts express CD1d and activate invariant natural killer T cells under cellular stress.
Pei S, Sjölund J, Pan Y, Pietras K, Karlsson MCI., | 01/13/2024 |
| Epigenetic control of CD1D expression as a mechanism of resistance to immune checkpoint therapy in poorly immunogenic melanomas. | Epigenetic control of CD1D expression as a mechanism of resistance to immune checkpoint therapy in poorly immunogenic melanomas.
Wang MM, Koskela SA, Mehmood A, Langguth M, Maranou E, Figueiredo CR., Free PMC Article | 08/10/2023 |
| CD1d expression in glioblastoma is a promising target for NKT cell-based cancer immunotherapy. | CD1d expression in glioblastoma is a promising target for NKT cell-based cancer immunotherapy.
Hara A, Koyama-Nasu R, Takami M, Toyoda T, Aoki T, Ihara F, Kobayashi M, Hirono S, Matsutani T, Nakayama T, Iwadate Y, Motohashi S., Free PMC Article | 05/8/2021 |
| Low oxygen saturation during sleep reduces CD1D and RAB20 expressions that are reversed by CPAP therapy. | Low oxygen saturation during sleep reduces CD1D and RAB20 expressions that are reversed by CPAP therapy.
Sofer T, Li R, Joehanes R, Lin H, Gower AC, Wang H, Kurniansyah N, Cade BE, Lee J, Williams S, Mehra R, Patel SR, Quan SF, Liu Y, Rotter JI, Rich SS, Spira A, Levy D, Gharib SA, Redline S, Gottlieb DJ., Free PMC Article | 04/17/2021 |
| Structural Dynamics of the Lipid Antigen-Binding Site of CD1d Protein. | Structural Dynamics of the Lipid Antigen-Binding Site of CD1d Protein.
Cuevas-Zuviría B, Mínguez-Toral M, Díaz-Perales A, Garrido-Arandia M, Pacios LF., Free PMC Article | 04/3/2021 |
| Invariant NKT Cells From Donor Lymphocyte Infusions (DLI-iNKTs) Promote ex vivo Lysis of Leukemic Blasts in a CD1d-Dependent Manner. | Invariant NKT Cells From Donor Lymphocyte Infusions (DLI-iNKTs) Promote ex vivo Lysis of Leukemic Blasts in a CD1d-Dependent Manner.
Jahnke S, Schmid H, Secker KA, Einhaus J, Duerr-Stoerzer S, Keppeler H, Schober-Melms I, Baur R, Schumm M, Handgretinger R, Bethge W, Kanz L, Schneidawind C, Schneidawind D., Free PMC Article | 10/24/2020 |
| Expression of CD1d by astrocytes corresponds with relative activity in multiple sclerosis lesions. | Expression of CD1d by astrocytes corresponds with relative activity in multiple sclerosis lesions.
Muir FGW, Samadi-Bahrami Z, Moore GRW, Quandt JA., Free PMC Article | 10/3/2020 |
| Increased cytoplasmatic expression of cancer immune surveillance receptor CD1d in anaplastic thyroid carcinomas. | Increased cytoplasmatic expression of cancer immune surveillance receptor CD1d in anaplastic thyroid carcinomas.
Weber F, Junger H, Werner JM, Velez Char N, Rejas C, Schlitt HJ, Hornung M., Free PMC Article | 09/26/2020 |
| Role of CD1d- and MR1-Restricted T Cells in Asthma. | Role of CD1d- and MR1-Restricted T Cells in Asthma.
Iwamura C, Nakayama T., Free PMC Article | 09/21/2019 |
| It provides the additional data of adipocyte CD1d-dependent regulation of adipose iNKT cell responses as well as systemic insulin sensitivity. In addition, we discuss how the interaction between adipocytes and iNKT cells would be regulated with the progression of obesity. | Adipocyte CD1d determines adipose inflammation and insulin resistance in obesity.
Huh JY, Park YJ, Kim JB., Free PMC Article | 09/7/2019 |
| In samples from lung cancer patients, the antitumor activities of all the T cells were enhanced with the increase of CD1D+DCs. Analysis of The Cancer Genome Atlas data revealed that high levels of CD1D indicated better outcomes for patients. Collectively, CD1D enhanced DCbased antitumor immunity, not only by targeting NKT, but also by activating CD4+T and CD8+T cells. | CD1d highly expressed on DCs reduces lung tumor burden by enhancing antitumor immunity.
Li Y, Zhao C, Liu J, Lu Z, Lu M, Gu J, Liu R., Free PMC Article | 07/6/2019 |
| The increased CD1d expression in HBV-infected liver. | Elevated Hepatic CD1d Levels Coincide with Invariant NKT Cell Defects in Chronic Hepatitis B Virus Infection.
Tan X, Ding Y, Zhu P, Dou R, Liang Z, Yang D, Huang Z, Wang W, Wu X, Weng X. | 04/13/2019 |
| We have studied the relation of CD1d expression in various breast cancer cell lines to their viability and progression. We observed a novel phenomenon that CD1d expression level increases with the progressive stage of the cancer. | Zerumbone modulates CD1d expression and lipid antigen presentation pathway in breast cancer cells.
Shyanti RK, Sehrawat A, Singh SV, Mishra JPN, Singh RP. | 05/12/2018 |
| CD1D has a role in disease progression and survival of chronic lymphocytic leukemia and may interact with CD161 | CD1d expression on chronic lymphocytic leukemia B cells affects disease progression and induces T cell skewing in CD8 positive and CD4CD8 double negative T cells.
Zaborsky N, Gassner FJ, Asslaber D, Reinthaler P, Denk U, Flenady S, Hofbauer JP, Danner B, Rebhandl S, Harrer A, Geisberger R, Greil R, Egle A., Free PMC Article | 02/24/2018 |
| CD1d-expressing cells isolated from peripheral blood of allogeneic hematopoietic stem cell transplantation patients showed the suppressive activity of T cell proliferation and higher expression of MyD88 and IDO compared with CD1d(-) cells. | CD1d is a novel cell-surface marker for human monocytic myeloid-derived suppressor cells with T cell suppression activity in peripheral blood after allogeneic hematopoietic stem cell transplantation.
An B, Lim JY, Jeong S, Shin DM, Choi EY, Min CK, Hong SH. | 01/6/2018 |
| These findings suggest that VP22 is required (but not sufficient) for the inhibition of CD1d-mediated antigen presentation in herpes simplex virus type 1 infection. | A VP22-Null HSV-1 Is Impaired in Inhibiting CD1d-Mediated Antigen Presentation.
Liu J, Gallo RM, Duffy C, Brutkiewicz RR., Free PMC Article | 01/6/2018 |
| FasL expression in splenic CD5(+)CD1d(hi) B cells was decreased compared to the control group after TLR4 ligation. | TLR4 supports the expansion of FasL(+)CD5(+)CD1d(hi) regulatory B cells, which decreases in contact hypersensitivity.
Wang K, Tao L, Su J, Zhang Y, Zou B, Wang Y, Zou M, Chen N, Lei L, Li X. | 09/16/2017 |
| The expression of CD1d showed a significantly negative correlation with CD86 level in B cells from imiquimod (IMQ)-treated mice, B6.MRLlpr mice, and lupus erythematosus (SLE) patients. | Decreased CD1d level is associated with CD86 over-expression in B cells from systemic lupus erythematosus.
Liu F, Ji J, Li X, Li X, Xu J, Yue H, Zhao S, Fan H, Hou Y. | 09/2/2017 |
| CD1d-restricted peripheral T cell lymphoma in mice and humans | CD1d-restricted peripheral T cell lymphoma in mice and humans.
Bachy E, Urb M, Chandra S, Robinot R, Bricard G, de Bernard S, Traverse-Glehen A, Gazzo S, Blond O, Khurana A, Baseggio L, Heavican T, Ffrench M, Crispatzu G, Mondière P, Schrader A, Taillardet M, Thaunat O, Martin N, Dalle S, Le Garff-Tavernier M, Salles G, Lachuer J, Hermine O, Asnafi V, Roussel M, Lamy T, Herling M, Iqbal J, Buffat L, Marche PN, Gaulard P, Kronenberg M, Defrance T, Genestier L., Free PMC Article | 07/22/2017 |
| BCR-ABL-dependent ROCK, but not TK, is involved in CD1d downregulation. We propose that ROCK, which is most likely activated by the DH/PH domain of BCR-ABL, mediates iNKT-cell immune subversion in chronic myeloid leukaemia (CML) patients by downregulating CD1d expression on CML mDCs. | The Rho-ROCK pathway as a new pathological mechanism of innate immune subversion in chronic myeloid leukaemia.
Basbous S, Levescot A, Piccirilli N, Brizard F, Guilhot F, Roy L, Bourmeyster N, Gombert JM, Herbelin A. | 07/1/2017 |
| Importantly, among the analyzed molecules, only CD1d expression showed an association with the activation of double-negative T cells, as well as with worse ventricular function in patients with Chagas disease. | Blocking of CD1d Decreases Trypanosoma cruzi-Induced Activation of CD4-CD8- T Cells and Modulates the Inflammatory Response in Patients With Chagas Heart Disease.
Passos LS, Villani FN, Magalhães LM, Gollob KJ, Antonelli LR, Nunes MC, Dutra WO. | 05/27/2017 |
| Data suggest that CD1d antigen-restricted B lymphocytes (Bc) presentation of NGcGM3 drives effective invariant natural killer T cells (iNKT) activation. | The tumor antigen N-glycolyl-GM3 is a human CD1d ligand capable of mediating B cell and natural killer T cell interaction.
Gentilini MV, Pérez ME, Fernández PM, Fainboim L, Arana E., Free PMC Article | 09/10/2016 |
| the spatiotemporal distribution of CD1d molecules on the surface of antigen-presenting cells (APCs) modulates activation of Invariant natural killer T cells. | The actin cytoskeleton modulates the activation of iNKT cells by segregating CD1d nanoclusters on antigen-presenting cells.
Torreno-Pina JA, Manzo C, Salio M, Aichinger MC, Oddone A, Lakadamyali M, Shepherd D, Besra GS, Cerundolo V, Garcia-Parajo MF., Free PMC Article | 07/16/2016 |
| both membrane-bound (V4) and soluble (V5) isoforms of CD1d were over-expressed in gastric tumor tissues, suggesting that they are involved in anti-tumor immune responses. | Increased Expression of Two Alternative Spliced Variants of CD1d Molecule in Human Gastric Cancer.
Hafezi N, Ajami A, Farazmandfar T, Hosseini V, Alizadeh-Navaei R, Tehrani M. | 04/30/2016 |