| Structural resemblance of the DNAJA-family protein, Tid1, to the DNAJB-family Hsp40. | Structural resemblance of the DNAJA-family protein, Tid1, to the DNAJB-family Hsp40.
Jang J, Lee SH, Kang DH, Sim DW, Ryu KS, Jo KS, Lee J, Ryu H, Kim EH, Won HS, Kim JH., Free PMC Article | 11/5/2022 |
| Mitochondrial ""dysmorphology"" in variant classification. | Mitochondrial "dysmorphology" in variant classification.
Shamseldin HE, Alhashem A, Tabarki B, Abdulwahab F, Hashem M, Sougrat R, Alkuraya FS. | 01/22/2022 |
| Tid1-S attenuates LPS-induced cardiac hypertrophy and apoptosis through ER-a mediated modulation of p-PI3K/p-Akt signaling cascade. | Tid1-S attenuates LPS-induced cardiac hypertrophy and apoptosis through ER-a mediated modulation of p-PI3K/p-Akt signaling cascade.
Chao CN, Lo JF, Khan FB, Day CH, Lai CH, Chen CH, Chen RJ, Viswanadha VP, Kuo CH, Huang CY. | 09/5/2020 |
| identified HSPA1A and HSPA8 as the HSP70 family proteins that physically interact with DNAJA3, and established their requirement for the phosphorylation of NF-kappaB p65 | HSP70/DNAJA3 chaperone/cochaperone regulates NF-κB activity in immune responses.
Kumada K, Fuse N, Tamura T, Okamori C, Kurata S. | 07/11/2020 |
| A novel variant of the human mitochondrial DnaJ protein, Tid1, associates with a human disease exhibiting developmental delay and polyneuropathy. | A novel variant of the human mitochondrial DnaJ protein, Tid1, associates with a human disease exhibiting developmental delay and polyneuropathy.
Patra M, Weiss C, Abu-Libdeh B, Ashhab M, Abuzer S, Elpeleg O, Mahajnah M, Kessel A, Azem A., Free PMC Article | 06/13/2020 |
| Herein, the authors first revealed that Galectin-7 was one of the Tid1-interacting client proteins. An inverse association of protein expression profile between Tid1 and Galectin-7 was determined in head and neck squamous cell carcinoma patients. Low Tid1 and high Galectin-7 expression predicted poor overall survival in head and neck squamous cell carcinoma. | HSP40 co-chaperone protein Tid1 suppresses metastasis of head and neck cancer by inhibiting Galectin-7-TCF3-MMP9 axis signaling.
Chen YS, Chang CW, Tsay YG, Huang LY, Wu YC, Cheng LH, Yang CC, Wu CH, Teo WH, Hung KF, Huang CY, Lee TC, Lo JF., Free PMC Article | 08/31/2019 |
| Impaired stoichiometry between mtHsp40 and mtHsp70 promotes Opa1L cleavage, leading to cristae opening, decreased OXPHOS, and triggering of mitochondrial fragmentation after reduction in their chaperone function. | Stoichiometric expression of mtHsp40 and mtHsp70 modulates mitochondrial morphology and cristae structure via Opa1L cleavage.
Lee B, Ahn Y, Kang SM, Park Y, Jeon YJ, Rho JM, Kim SW., Free PMC Article | 05/21/2016 |
| The Role of the Phylogenetically Conserved Cochaperone Protein Droj2/DNAJA3 in NF-kappaB Signaling. | The Role of the Phylogenetically Conserved Cochaperone Protein Droj2/DNAJA3 in NF-κB Signaling.
Momiuchi Y, Kumada K, Kuraishi T, Takagaki T, Aigaki T, Oshima Y, Kurata S., Free PMC Article | 12/19/2015 |
| Tid1 increases autophagic flux by interacting with the Beclin 1-containing autophagy protein complex. | Tid1, the Mammalian Homologue of Drosophila Tumor Suppressor Tid56, Mediates Macroautophagy by Interacting with Beclin1-containing Autophagy Protein Complex.
Niu G, Zhang H, Liu D, Chen L, Belani C, Wang HG, Cheng H., Free PMC Article | 10/17/2015 |
| TID1 prevents complex I aggregation and support the existence of a TID1-mediated stress response to ATP synthase inhibition | Essential role of TID1 in maintaining mitochondrial membrane potential homogeneity and mitochondrial DNA integrity.
Ng AC, Baird SD, Screaton RA., Free PMC Article | 05/24/2014 |
| Tid1 acts as a tumor suppressor by inhibiting EGFR signaling through interaction with EGFR/HSP70/HSP90 and enhancing EGFR ubiquitinylation and degradation. | Tid1-L inhibits EGFR signaling in lung adenocarcinoma by enhancing EGFR Ubiquitinylation and degradation.
Chen CY, Jan CI, Lo JF, Yang SC, Chang YL, Pan SH, Wang WL, Hong TM, Yang PC. | 09/7/2013 |
| Data show that elevated DnaJA3 induces dynamin-related protein 1 (Drp1)-depedendent mitochondrial fragmentation and decreased cell viability. | Mitochondrial chaperone DnaJA3 induces Drp1-dependent mitochondrial fragmentation.
Elwi AN, Lee B, Meijndert HC, Braun JE, Kim SW. | 10/27/2012 |
| loss of hTid-1(S) expression in the basal layer of skin epidermis correlates with the enhanced HSP27 phosphorylation, keratinocyte hyperproliferation, and excess actin cytoskeleton organization in lesional psoriatic skin | Absence of a human DnaJ protein hTid-1S correlates with aberrant actin cytoskeleton organization in lesional psoriatic skin.
Choi JH, Choi DK, Sohn KC, Kwak SS, Suk J, Lim JS, Shin I, Kim SW, Lee JH, Joe CO., Free PMC Article | 10/13/2012 |
| Tid1 and CHIP play pivotal roles in affecting the levels of ErbB2 protein, and that both are significant prognostic indicators of breast cancer patient survival. | Tid1, CHIP and ErbB2 interactions and their prognostic implications for breast cancer patients.
Jan CI, Yu CC, Hung MC, Harn HJ, Nieh S, Lee HS, Lou MA, Wu YC, Chen CY, Huang CY, Chen FN, Lo JF. | 12/3/2011 |
| findings denote hTid-1(S) as an essential regulatory component of MetR signaling | hTID-1 defines a novel regulator of c-Met Receptor signaling in renal cell carcinomas.
Copeland E, Balgobin S, Lee CM, Rozakis-Adcock M., Free PMC Article | 07/16/2011 |
| hTid1 negatively regulates the expression and transcriptional activity of STAT5b and suppresses the growth of hematopoietic cells transformed by an oncogenic form of STAT5b. | The tumor suppressor hTid1 inhibits STAT5b activity via functional interaction.
Dhennin-Duthille I, Nyga R, Yahiaoui S, Gouilleux-Gruart V, Régnier A, Lassoued K, Gouilleux F., Free PMC Article | 04/16/2011 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesGenetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanché H, Schreiber S, Nebel A. | 12/5/2010 |
| htid is a tissue independent and evolutionarily conserved suppressor of ErbB-2. | In vivo evidence of htid suppressive activity on ErbB-2 in breast cancers over expressing the receptor.
Kurzik-Dumke U, Hörner M, Nicotra MR, Koslowski M, Natali PG., Free PMC Article | 10/23/2010 |
| amino-terminal segment of APC promotes cell sensitivity to apoptosis modulated through its binding to 40- and 43-kilodalton hTID-1 isoforms. | The mitochondrial protein hTID-1 partners with the caspase-cleaved adenomatous polyposis cell tumor suppressor to facilitate apoptosis.
Qian J, Perchiniak EM, Sun K, Groden J., Free PMC Article | 05/3/2010 |
| The expression of the genes htid-1 and APC was altered in colorectal tumors. | Progression of colorectal cancers correlates with overexpression and loss of polarization of expression of the htid-1 tumor suppressor.
Kurzik-Dumke U, Hörner M, Czaja J, Nicotra MR, Simiantonaki N, Koslowski M, Natali PG. | 01/21/2010 |
| The association of the endogenous Tid50/Tid48 proteins with the adenomatous polyposis coli (APC) tumor suppressor is shown. | Htid-1, the human homolog of the Drosophila melanogaster l(2)tid tumor suppressor, defines a novel physiological role of APC.
Kurzik-Dumke U, Czaja J. | 01/21/2010 |
| hTid1 may act as a chaperone to facilitate the folding, processing and maturation of Epstein-Barr virus-encoded BARF1 protein. | Biochemical and functional characterization of Epstein-Barr virus-encoded BARF1 protein: interaction with human hTid1 protein facilitates its maturation and secretion.
Wang L, Tam JP, Liu DX. | 01/21/2010 |
| Tid1 negatively regulates the motility and metastasis of breast cancer cells, most likely through attenuation of nuclear factor kappaB activity on the promoter of the IL8 gene. | Tid1 negatively regulates the migratory potential of cancer cells by inhibiting the production of interleukin-8.
Kim SW, Hayashi M, Lo JF, Fearns C, Xiang R, Lazennec G, Yang Y, Lee JD. | 01/21/2010 |
| role as a repressor of Ikappa B kinase beta subunit | HTLV-1 Tax-associated hTid-1, a human DnaJ protein, is a repressor of Ikappa B kinase beta subunit.
Cheng H, Cenciarelli C, Tao M, Parks WP, Cheng-Mayer C. | 01/21/2010 |
| hTid-1 represses the activity of NF-kappaB through physical and functional interactions with the IKK complex and IkappaB | Molecular mechanism of hTid-1, the human homolog of Drosophila tumor suppressor l(2)Tid, in the regulation of NF-kappaB activity and suppression of tumor growth.
Cheng H, Cenciarelli C, Nelkin G, Tsan R, Fan D, Cheng-Mayer C, Fidler IJ., Free PMC Article | 01/21/2010 |