| PYGO2 increases proliferation and migration capacities through critical signaling pathways in esophageal squamous cell carcinoma. | PYGO2 increases proliferation and migration capacities through critical signaling pathways in esophageal squamous cell carcinoma.
Ardalan Moghadam Al F, Forghanifard MM, Zarrinpour V. | 02/6/2024 |
| Pygo2 activates BRPF1 via Pygo2-H3K4me2/3 interaction to maintain malignant progression in colon cancer. | Pygo2 activates BRPF1 via Pygo2-H3K4me2/3 interaction to maintain malignant progression in colon cancer.
Ling J, Tang Z, Yang W, Li Y, Dong X. | 09/11/2023 |
| Novel biphasic mechanism of the canonical Wnt signalling component PYGO2 promotes cardiomyocyte differentiation from hUC-MSCs. | Novel biphasic mechanism of the canonical Wnt signalling component PYGO2 promotes cardiomyocyte differentiation from hUC-MSCs.
Shi Y, Qin B, Fan X, Li Y, Wang Y, Yuan W, Jiang Z, Zhu P, Chen J, Chen Y, Li F, Wan Y, Wu X, Zhuang J., Free PMC Article | 07/3/2023 |
| Association of Single Nucleotide Polymorphisms in the PYGO2 and PRDM9 Genes with Idiopathic Azoospermia in Iranian Infertile Male Patients. | Association of Single Nucleotide Polymorphisms in the PYGO2 and PRDM9 Genes with Idiopathic Azoospermia in Iranian Infertile Male Patients.
Soleymani Moud S, Kamal Seraji K, Ramezani M, Piravar Z., Free PMC Article | 01/28/2023 |
| Interference of EFNA4 suppresses cell proliferation, invasion and angiogenesis in hepatocellular carcinoma by downregulating PYGO2. | Interference of EFNA4 suppresses cell proliferation, invasion and angiogenesis in hepatocellular carcinoma by downregulating PYGO2.
Yuan W, Zhao H, Zhou A, Wang S., Free PMC Article | 11/26/2022 |
| Pygopus2 ameliorates mesenteric adipocyte poor differentiation to alleviate Crohn's disease -like colitis via the Axin2/GSK3beta pathway. | Pygopus2 ameliorates mesenteric adipocyte poor differentiation to alleviate Crohn's disease -like colitis via the Axin2/GSK3β pathway.
Li J, Zuo L, Geng Z, Li Q, Cheng Y, Yang Z, Shi R, Zhou Y, Nie W, Wang Y, Zhang X, Ge S, Song X, Hu J., Free PMC Article | 10/15/2022 |
| Long non-coding RNA SNHG8 enhances triple-negative breast cancer cell proliferation and migration by regulating the miR-335-5p/PYGO2 axis. | Long non-coding RNA SNHG8 enhances triple-negative breast cancer cell proliferation and migration by regulating the miR-335-5p/PYGO2 axis.
Qian J, Lei X, Sun Y, Zheng L, Li J, Zhang S, Zhang L, Li W, Shi J, Jia W, Tang T., Free PMC Article | 12/11/2021 |
| Overexpression of Pygo2 Increases Differentiation of Human Umbilical Cord Mesenchymal Stem Cells into Cardiomyocyte-like Cells. | Overexpression of Pygo2 Increases Differentiation of Human Umbilical Cord Mesenchymal Stem Cells into Cardiomyocyte-like Cells.
Yang L, Zhu S, Li Y, Zhuang J, Chen J, Huang H, Chen Y, Wen Y, Wen Y, Guo H, Fan X, Yuan W, Jiang Z, Wang Y, Wu X, Zhu P. | 06/12/2021 |
| LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/beta-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes. | LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes.
Zhou C, Yi C, Yi Y, Qin W, Yan Y, Dong X, Zhang X, Huang Y, Zhang R, Wei J, Ali DW, Michalak M, Chen XZ, Tang J., Free PMC Article | 05/29/2021 |
| miR-516a-3p inhibits breast cancer cell growth and EMT by blocking the Pygo2/Wnt signalling pathway. | miR-516a-3p inhibits breast cancer cell growth and EMT by blocking the Pygo2/Wnt signalling pathway.
Chi Y, Wang F, Zhang T, Xu H, Zhang Y, Shan Z, Wu S, Fan Q, Sun Y., Free PMC Article | 08/22/2020 |
| The expression pattern of pygopus 2 (PYGO2) was evaluated by immunohistochemistry in colorectal cancer(CRC) tissues. results showed expression was significantly higher in CRC samples than in normal tissues, and there was a significant association between PYGO2 expression in CRC and tumor cell metastasis to the lymph nodes. | PYGO2 as an independent diagnostic marker expressed in a majority of colorectal cancers.
Soleymani S, Khales SA, Jafarian AH, Kalat HR, Forghanifard MM. | 05/2/2020 |
| evidence supports a role for Pygo2 as an essential component of MYC oncogenic activity required for mitosis. | Augmentation of Myc-Dependent Mitotic Gene Expression by the Pygopus2 Chromatin Effector.
Andrews PGP, Popadiuk C, Belbin TJ, Kao KR. | 10/5/2019 |
| Amplification/overexpression of PYGO2 may serve as a biomarker. | An In Vivo Screen Identifies PYGO2 as a Driver for Metastatic Prostate Cancer.
Lu X, Pan X, Wu CJ, Zhao D, Feng S, Zang Y, Lee R, Khadka S, Amin SB, Jin EJ, Shang X, Deng P, Luo Y, Morgenlander WR, Weinrich J, Lu X, Jiang S, Chang Q, Navone NM, Troncoso P, DePinho RA, Wang YA., Free PMC Article | 08/31/2019 |
| Elevated PYGO2 expression in primary prostate adenocarcinoma is a potential risk factor for biochemical recurrence. | PYGOPUS2 expression in prostatic adenocarcinoma is a potential risk stratification marker for PSA progression following radical prostatectomy.
Kao KR, Popadiuk P, Thoms J, Aoki S, Anwar S, Fitzgerald E, Andrews P, Voisey K, Gai L, Challa S, He Z, Gonzales-Aguirre P, Simmonds A, Popadiuk C. | 05/5/2018 |
| Overexpression of Pygo2 facilitated the expression of P-glycoprotein, which acts as a drug efflux pump, by promoting the transcription of MDR1 at the MDR1 promoter loci, resulting in acceleration of the efflux of paclitaxel in human glioma cells. | Pygopus2 inhibits the efficacy of paclitaxel-induced apoptosis and induces multidrug resistance in human glioma cells.
Zhou C, Cheng H, Qin W, Zhang Y, Xiong H, Yang J, Huang H, Wang Y, Chen XZ, Tang J., Free PMC Article | 04/7/2018 |
| We also determined the effect of Pygo2 on the sensitivity of breast tumors resistant to doxorubicin in a mouse model. Finally, RNA samples from 64 paired patient tumors (before and after chemotherapy) highly and significantly overexpressed Pygo2 and/or MDR1 after treatment, thus underlining a pivotal role for the Pygo2-mediated Wnt/b-catenin pathway in the clinical chemoresistance of breast cancer. | Pygo2 activates MDR1 expression and mediates chemoresistance in breast cancer via the Wnt/β-catenin pathway.
Zhang ZM, Wu JF, Luo QC, Liu QF, Wu QW, Ye GD, She HQ, Li BA. | 09/2/2017 |
| Findings are consistent with a model in which acetylation of Pygo2 by CBP/p300 family members in the active TCF/beta-catenin complex occurs coincident with histone acetylation and may be required for the recycling of Pygo2 away from the complex subsequent to target gene activation. | Wnt/β-catenin-dependent acetylation of Pygo2 by CBP/p300 histone acetyltransferase family members.
Andrews PG, Kao KR. | 06/24/2017 |
| The activation of its expression by ERalpha and/or specificity protein-1 (SP1) suggests hPYGO2 as a theranostic target for hormone therapy responsive and refractory breast cancer. | Selective estrogen receptor modulators and betulinic acid act synergistically to target ERα and SP1 transcription factor dependent Pygopus expression in breast cancer.
Tzenov YR, Andrews P, Voisey K, Gai L, Carter B, Whelan K, Popadiuk C, Kao KR. | 04/1/2017 |
| Pygo2 functions as a prognostic factor for glioma due to its up-regulation of H3K4me3 and promotion of MLL1/MLL2 complex recruitment. | Pygo2 functions as a prognostic factor for glioma due to its up-regulation of H3K4me3 and promotion of MLL1/MLL2 complex recruitment.
Zhou C, Zhang Y, Dai J, Zhou M, Liu M, Wang Y, Chen XZ, Tang J., Free PMC Article | 02/4/2017 |
| this study demonstrated that SNPs in the coding region of Pygo2 might be one of the causative factors in idiopathic oligospermia and azoospermia, resulting in male infertility. | Associations of single nucleotide polymorphisms in the Pygo2 coding sequence with idiopathic oligospermia and azoospermia.
Ge SQ, Grifin J, Liu LH, Aston KI, Simon L, Jenkins TG, Emery BR, Carrell DT. | 06/11/2016 |
| Our findings suggest that Pygopus-2 may be an important predictor of poor outcome in HCC patients, and could serve as a novel biomarker for HCC. | Abnormal nuclear expression of Pygopus-2 in human primary hepatocellular carcinoma correlates with a poor prognosis.
Zhang S, Li J, He F, Wang XM. | 04/30/2016 |
| Pygopus-2 over-expression is associated with hepatic carcinoma. | Pygopus-2 promotes invasion and metastasis of hepatic carcinoma cell by decreasing E-cadherin expression.
Zhang S, Li J, Liu P, Xu J, Zhao W, Xie C, Yin Z, Wang X., Free PMC Article | 03/19/2016 |
| Pygo2 is a common node downstream of oncogenic Wnt and Akt signaling pathways. | Akt Phosphorylates Wnt Coactivator and Chromatin Effector Pygo2 at Serine 48 to Antagonize Its Ubiquitin/Proteasome-mediated Degradation.
Li Q, Li Y, Gu B, Fang L, Zhou P, Bao S, Huang L, Dai X., Free PMC Article | 11/21/2015 |
| The results of the present study suggest a novel involvement of Pygo in the promotion of rRNA transcription in cancer cells | Evidence of a novel role for Pygopus in rRNA transcription.
Andrews PG, He Z, Tzenov YR, Popadiuk C, Kao KR. | 10/16/2015 |
| We conclude that abnormal Pygo2 protein expression may be a marker for advanced non-small cell lung cancer | Abnormal expression of Pygopus 2 correlates with a malignant phenotype in human lung cancer.
Liu Y, Dong QZ, Wang S, Fang CQ, Miao Y, Wang L, Li MZ, Wang EH., Free PMC Article | 11/30/2013 |