| CRIF1 deficiency induces FOXP3[LOW] inflammatory non-suppressive regulatory T cells, thereby promoting antitumor immunity. | CRIF1 deficiency induces FOXP3(LOW) inflammatory non-suppressive regulatory T cells, thereby promoting antitumor immunity.
Lee S, Song SG, Kim G, Kim S, Yoo HJ, Koh J, Kim YJ, Tian J, Cho E, Choi YS, Chang S, Shin HM, Jung KC, Kim JH, Kim TM, Jeon YK, Kim HY, Shong M, Kim JH, Chung DH., Free PMC Article | 04/3/2024 |
| Crif1 deficiency in dopamine neurons triggers early-onset parkinsonism. | Crif1 deficiency in dopamine neurons triggers early-onset parkinsonism.
Heo JY, Park AH, Lee MJ, Ryu MJ, Kim YK, Jang YS, Kim SJ, Shin SY, Son HJ, Stein TD, Huh YH, Chung SK, Choi SY, Kim JM, Hwang O, Shong M, Hyeon SJ, Lee J, Ryu H, Kim D, Kweon GR. | 02/1/2024 |
| CRIF1 promotes the progression of non-small-cell lung cancer by SIRT3- mediated deacetylation of PYCR1. | CRIF1 promotes the progression of non-small-cell lung cancer by SIRT3- mediated deacetylation of PYCR1.
Wang Q, Xie Z, Li C, Xu C, Ding C, Ju S, Chen J, Cui Z, Chen C, Gu B, Wei T, Zhao J. | 09/10/2022 |
| CRIF1 deficiency suppresses endothelial cell migration via upregulation of RhoGDI2. | CRIF1 deficiency suppresses endothelial cell migration via upregulation of RhoGDI2.
Nagar H, Kim S, Lee I, Choi SJ, Piao S, Jeon BH, Shong M, Kim CS., Free PMC Article | 12/11/2021 |
| Downregulation of CR6-interacting factor 1 suppresses keloid fibroblast growth via the TGF-beta/Smad signaling pathway. | Downregulation of CR6-interacting factor 1 suppresses keloid fibroblast growth via the TGF-β/Smad signaling pathway.
Nagar H, Kim S, Lee I, Kim S, Choi SJ, Piao S, Jeon BH, Oh SH, Kim CS., Free PMC Article | 08/7/2021 |
| CRIF1 overexpression facilitates tumor growth and metastasis through inducing ROS/NFkappaB pathway in hepatocellular carcinoma. | CRIF1 overexpression facilitates tumor growth and metastasis through inducing ROS/NFκB pathway in hepatocellular carcinoma.
Chang H, Li J, Qu K, Wan Y, Liu S, Zheng W, Zhang Z, Liu C., Free PMC Article | 03/20/2021 |
| CR6-interacting factor 1 deficiency reduces endothelial nitric oxide synthase activity by inhibiting biosynthesis of tetrahydrobiopterin. | CR6-interacting factor 1 deficiency reduces endothelial nitric oxide synthase activity by inhibiting biosynthesis of tetrahydrobiopterin.
Lee I, Kim S, Nagar H, Choi SJ, Jeon BH, Piao S, Kim CS., Free PMC Article | 12/5/2020 |
| CRIF1 deficiency induced mitophagy via p66shc-regulated ROS in endothelial cells. | CRIF1 deficiency induced mitophagy via p66shc-regulated ROS in endothelial cells.
Piao S, Nagar H, Kim S, Lee I, Choi SJ, Kim T, Jeon BH, Kim CS. | 09/5/2020 |
| High CRIF1 expression is associated with radioresistant osteosarcoma. | CRIF1 as a potential target to improve the radiosensitivity of osteosarcoma.
Ran Q, Jin F, Xiang Y, Xiang L, Wang Q, Li F, Chen L, Zhang Y, Wu C, Zhou L, Xiao Y, Chen L, Wu J, Zhong JF, Li SC, Li Z., Free PMC Article | 04/4/2020 |
| NRF2 Ser40 phosphorylation was inhibited in Crif1-deficient bone marrow multipotent mesenchymal stromal cells even in the presence of three kinds of PKC agonists, suggesting that CRIF1 might co-activate PKC-delta to phosphorylate NRF2 Ser40. | Co-Activation of PKC-δ by CRIF1 Modulates Oxidative Stress in Bone Marrow Multipotent Mesenchymal Stromal Cells after Irradiation by Phosphorylating NRF2 Ser40.
Chen L, Ran Q, Xiang Y, Xiang L, Chen L, Li F, Wu J, Wu C, Li Z., Free PMC Article | 05/5/2018 |
| strongly suggest that CRIF1 deficiency promotes endothelial cell inflammation by increasing VCAM-1 expression, elevating inflammatory cytokines levels, and activating the transcription factor NF-kappaB, all of which were inhibited by SIRT1 overexpression | CR6 interacting factor 1 deficiency promotes endothelial inflammation by SIRT1 downregulation.
Piao S, Lee JW, Nagar H, Jung SB, Choi S, Kim S, Lee I, Kim SM, Shin N, Lee YR, Lee SD, Park JB, Irani K, Won M, Hur GM, Jeon BH, Kim DW, Kim CS., Free PMC Article | 04/7/2018 |
| Results demonstrate that knockdown of CRIF1 in HUVECs induces mitochondrial dysfunction and reduces SIRT1 expression along with decreased eNOS phosphorylation and increased eNOS acetylation, thereby promoting endothelial dysfunction. These findings indicate that CRIF1 plays an important role in maintaining mitochondrial and endothelial function through its effects on the SIRT1-eNOS pathway. | CR6-Interacting Factor 1 Deficiency Impairs Vascular Function by Inhibiting the Sirt1-Endothelial Nitric Oxide Synthase Pathway.
Nagar H, Jung SB, Ryu MJ, Choi SJ, Piao S, Song HJ, Kang SK, Shin N, Kim DW, Jin SA, Jeong JO, Irani K, Jeon BH, Shong M, Kweon GR, Kim CS. | 03/3/2018 |
| SNF5 is indispensable for CRIF1-enhanced p53 activity and its function in the suppression of cell cycle arrest in human cancer cells. | CRIF1 enhances p53 activity via the chromatin remodeler SNF5 in the HCT116 colon cancer cell lines.
Yan HX, Zhang YJ, Zhang Y, Ren X, Shen YF, Cheng MB, Zhang Y. | 06/24/2017 |
| Study shows that Lck interacts with CRIF1 in the mitochondria and negatively regulates CRIF1-mediated translation of mitochondrion-encoded proteins. | Lymphocyte-specific protein tyrosine kinase (Lck) interacts with CR6-interacting factor 1 (CRIF1) in mitochondria to repress oxidative phosphorylation.
Vahedi S, Chueh FY, Chandran B, Yu CL., Free PMC Article | 05/14/2016 |
| our results support a novel function of nuclear Lck in promoting human leukemic T cell survival through interaction with a tumor suppressor, CRIF1 | Nuclear lymphocyte-specific protein tyrosine kinase and its interaction with CR6-interacting factor 1 promote the survival of human leukemic T cells.
Vahedi S, Chueh FY, Dutta S, Chandran B, Yu CL., Free PMC Article | 03/19/2016 |
| Crif1 is an indispensable regulator of PKAalpha cat that modulates the PKA/CREB signaling pathway to promote adipogenic differentiation of bone marrow mesenchymal stem cells after irradiation | Crif1 Promotes Adipogenic Differentiation of Bone Marrow Mesenchymal Stem Cells After Irradiation by Modulating the PKA/CREB Signaling Pathway.
Zhang X, Xiang L, Ran Q, Liu Y, Xiang Y, Xiao Y, Chen L, Li F, Zhong JF, Li Z. | 03/19/2016 |
| The results identify the ROS-Sp1-Crif1 pathway to be a new mechanism underlying Abeta-induced mitochondrial dysfunction and suggest that ROS-mediated downregulation of Crif1 is a crucial event in AD pathology. | CR6-interacting factor 1 is a key regulator in Aβ-induced mitochondrial disruption and pathogenesis of Alzheimer's disease.
Byun J, Son SM, Cha MY, Shong M, Hwang YJ, Kim Y, Ryu H, Moon M, Kim KS, Mook-Jung I., Free PMC Article | 10/31/2015 |
| CRIF1 knockdown partially induces endothelial activation via increased ROS production and phosphorylation of p66shc | CRIF1 deficiency induces p66shc-mediated oxidative stress and endothelial activation.
Nagar H, Jung SB, Kwon SK, Park JB, Shong M, Song HJ, Jeon BH, Irani K, Kim CS., Free PMC Article | 01/31/2015 |
| CRIF1 may play a regulatory role in the BM microenvironment-induced leukemia cell cycle arrest possibly through interacting with CDK2 and acting as a cyclin-dependent kinase inhibitor. | CRIF1 interacting with CDK2 regulates bone marrow microenvironment-induced G0/G1 arrest of leukemia cells.
Ran Q, Hao P, Xiao Y, Xiang L, Ye X, Deng X, Zhao J, Li Z., Free PMC Article | 10/18/2014 |
| CKbetaBP2/CRIF1 is expressed with STAT3 in prostate cancer where STAT3 may help to offset the AR repressor effect of CKbetaBP2/CRIF1. | Mechanism of androgen receptor corepression by CKβBP2/CRIF1, a multifunctional transcription factor coregulator expressed in prostate cancer.
Tan JA, Bai S, Grossman G, Titus MA, Harris Ford O, Pop EA, Smith GJ, Mohler JL, Wilson EM, French FS., Free PMC Article | 08/30/2014 |
| results indicated cell cycle arrest of Jurkat cells in the G0/G1 phase to be induced by primary cultured leukemic BMSCs associated with increased expression of CRIF1 by leukemic cells | Cell cycle arrest of Jurkat cells by leukemic bone marrow stromal cells: possible mechanisms and involvement of CRIF1.
Zhang X, Ran Q, Li Z, Liu Y, Liang X, Chen X. | 01/14/2012 |
| CRIF1, unlike KEAP1 (which only interacts with N-terminal region of NRF2), physically interacts with both N- and C-terminal regions of NRF2 and promotes NRF2 ubiquitination and subsequent proteasome-mediated NRF2 protein degradation | CR6-interacting factor 1 (CRIF1) regulates NF-E2-related factor 2 (NRF2) protein stability by proteasome-mediated degradation.
Kang HJ, Hong YB, Kim HJ, Bae I., Free PMC Article | 08/16/2010 |
| Results suggest that CRIF1 acts as an AR corepressor and may play an important role in the regulation of AR-positive growth of prostate cancer. | CR6-interacting factor 1 represses the transactivation of androgen receptor by direct interaction.
Suh JH, Shong M, Choi HS, Lee K., Free PMC Article | 01/21/2010 |
| NAC-1 contributes to tumor growth and survival by at least inhibiting Gadd45GIP1 expression, which has a tumor suppressor effect in cancer cells. | NAC-1 controls cell growth and survival by repressing transcription of Gadd45GIP1, a candidate tumor suppressor.
Nakayama K, Nakayama N, Wang TL, Shih IeM. | 01/21/2010 |
| Phosphorylation of serine-221 in CKBBP2/CRIF1 promotes proliferation of green monkey COS7 cells. | Phosphorylation of CKBBP2/CRIF1 by protein kinase CKII promotes cell proliferation.
Oh NS, Yoon SH, Lee WK, Choi JY, Min do S, Bae YS. | 01/21/2010 |