| FBW7 suppresses ovarian cancer development by targeting the N(6)-methyladenosine binding protein YTHDF2. | FBW7 suppresses ovarian cancer development by targeting the N(6)-methyladenosine binding protein YTHDF2.
Xu F, Li J, Ni M, Cheng J, Zhao H, Wang S, Zhou X, Wu X., Free PMC Article | 10/2/2021 |
| The transcription factor IRF4 represses proapoptotic BMF and BIM to licence multiple myeloma survival. | The transcription factor IRF4 represses proapoptotic BMF and BIM to licence multiple myeloma survival.
Fedele PL, Liao Y, Gong JN, Yao Y, van Delft MF, Low MSY, Tai L, Herold MJ, Jackson JT, Teh CE, Tan T, O'Reilly LA, Tellier J, Grigoriadis G, Huang DCS, Shi W, Nutt SL, Willis SN. | 08/21/2021 |
| Characterization of an alternative BAK-binding site for BH3 peptides. | Characterization of an alternative BAK-binding site for BH3 peptides.
Ye K, Meng WX, Sun H, Wu B, Chen M, Pang YP, Gao J, Wang H, Wang J, Kaufmann SH, Dai H., Free PMC Article | 09/5/2020 |
| The findings are consistent with rs539846 influencing chronic lymphocytic leukemia (CLL) susceptibility through differential RELA binding, with direct modulation of BMF expression impacting on anti-apoptotic BCL2, a hallmark of oncogenic dependency in CLL. | Genetic Predisposition to Chronic Lymphocytic Leukemia Is Mediated by a BMF Super-Enhancer Polymorphism.
Kandaswamy R, Sava GP, Speedy HE, Beà S, Martín-Subero JI, Studd JB, Migliorini G, Law PJ, Puente XS, Martín-García D, Salaverria I, Gutiérrez-Abril J, López-Otín C, Catovsky D, Allan JM, Campo E, Houlston RS., Free PMC Article | 11/18/2017 |
| Reciprocal regulation of BMF and BIRC5 is linked to Eomes overexpression in colorectal cancer. | Reciprocal regulation of BMF and BIRC5 (Survivin) linked to Eomes overexpression in colorectal cancer.
Wang R, Kang Y, Löhr CV, Fischer KA, Bradford CS, Johnson G, Dashwood WM, Williams DE, Ho E, Dashwood RH., Free PMC Article | 07/29/2017 |
| Early generated B1 B cells with restricted BCRs become chronic lymphocytic leukemia with continued c-Myc and low Bmf expression | Early generated B1 B cells with restricted BCRs become chronic lymphocytic leukemia with continued c-Myc and low Bmf expression.
Hayakawa K, Formica AM, Brill-Dashoff J, Shinton SA, Ichikawa D, Zhou Y, Morse HC 3rd, Hardy RR., Free PMC Article | 07/22/2017 |
| these findings suggest that p53-R273H can specifically drive AKT signaling and suppress BMF expression, resulting in enhanced cell survivability and anoikis resistance. | Mutant p53-R273H mediates cancer cell survival and anoikis resistance through AKT-dependent suppression of BCL2-modifying factor (BMF).
Tan BS, Tiong KH, Choo HL, Chung FF, Hii LW, Tan SH, Yap IK, Pani S, Khor NT, Wong SF, Rosli R, Cheong SK, Leong CO., Free PMC Article | 05/14/2016 |
| On the corresponding BMF gene promoter, loss of HDAC8 was associated with signal transducer and activator of transcription 3 (STAT3)/specificity protein 3 (Sp3) transcription factor exchange and recruitment of p300. | HDAC8 and STAT3 repress BMF gene activity in colon cancer cells.
Kang Y, Nian H, Rajendran P, Kim E, Dashwood WM, Pinto JT, Boardman LA, Thibodeau SN, Limburg PJ, Löhr CV, Bisson WH, Williams DE, Ho E, Dashwood RH., Free PMC Article | 06/20/2015 |
| Overexpression of ApoL2 did not induce cell death on its own. ApoL2 did not sensitize or protect cells from overexpression of the BH3-only proteins Bmf or Noxa. | Apolipoprotein L2 contains a BH3-like domain but it does not behave as a BH3-only protein.
Galindo-Moreno J, Iurlaro R, El Mjiyad N, Díez-Pérez J, Gabaldón T, Muñoz-Pinedo C., Free PMC Article | 02/14/2015 |
| Diva binds peptides derived from the BH3 domain of several other proapoptotic Bcl-2 proteins, including mouse Harakiri, Bid, Bak and Bmf. | Nuclear magnetic resonance study of protein-protein interactions involving apoptosis regulator Diva (Boo) and the BH3 domain of proapoptotic Bcl-2 members.
Santiveri CM, Sborgi L, de Alba E. | 04/27/2013 |
| BMF is induced in human IEC by the loss of cell attachment and is likely to play an important role in the regulation of IEC survival | BCL-2 modifying factor (BMF) is a central regulator of anoikis in human intestinal epithelial cells.
Hausmann M, Leucht K, Ploner C, Kiessling S, Villunger A, Becker H, Hofmann C, Falk W, Krebs M, Kellermeier S, Fried M, Schölmerich J, Obermeier F, Rogler G., Free PMC Article | 10/1/2011 |
| characterization of the bmf gene locus; molecular basis of the generation of the 2 major isoforms of Bmf; provide evidence that Bmf can act as a sensor for stress that associates with the repression of the conventional CAP-dependent translation machinery | BH3-only protein Bmf mediates apoptosis upon inhibition of CAP-dependent protein synthesis.
Grespi F, Soratroi C, Krumschnabel G, Sohm B, Ploner C, Geley S, Hengst L, Häcker G, Villunger A., Free PMC Article | 03/26/2011 |
| Data show that hypoxic conditions inhibit anoikis and block expression of proapoptotic BH3-only family members Bim and Bmf in epithelial cells. | Hypoxia suppression of Bim and Bmf blocks anoikis and luminal clearing during mammary morphogenesis.
Whelan KA, Caldwell SA, Shahriari KS, Jackson SR, Franchetti LD, Johannes GJ, Reginato MJ., Free PMC Article | 03/19/2011 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.
Zhang X, Yang H, Lee JJ, Kim E, Lippman SM, Khuri FR, Spitz MR, Lotan R, Hong WK, Wu X., Free PMC Article | 12/5/2010 |
| Bmf is upregulated by PS-341 and has a crucial role in PS-341-mediated glioma cell death through JNK phosphorylation. | Bmf is upregulated by PS-341-mediated cell death of glioma cells through JNK phosphorylation.
Tianhu Z, Shiguang Z, Xinghan L. | 05/10/2010 |
| MicroRNA-221 targets Bmf in hepatocellular carcinoma and correlates with tumor multifocality. | MicroRNA-221 targets Bmf in hepatocellular carcinoma and correlates with tumor multifocality.
Gramantieri L, Fornari F, Ferracin M, Veronese A, Sabbioni S, Calin GA, Grazi GL, Croce CM, Bolondi L, Negrini M., Free PMC Article | 01/21/2010 |
| Bmf supports Bim in regulating cell death processes in response to many stimuli. Review. | Bim and Bmf in tissue homeostasis and malignant disease.
Piñon JD, Labi V, Egle A, Villunger A., Free PMC Article | 01/21/2010 |
| Our data indicate a synergistic role for both bim and Bmf in an apoptotic pathway leading to the clearance of Neisseria gonorrhoeae -infected cells. | Bim and Bmf synergize to induce apoptosis in Neisseria gonorrhoeae infection.
Kepp O, Gottschalk K, Churin Y, Rajalingam K, Brinkmann V, Machuy N, Kroemer G, Rudel T., Free PMC Article | 01/21/2010 |
| arsenic trioxide upregulated expression of Bmf, Noxa, and Bim. Silencing of Bmf, Noxa, and Bim significantly protected MM cells from ATO-induced apoptosis | BH3-only proteins Noxa, Bmf, and Bim are necessary for arsenic trioxide-induced cell death in myeloma.
Morales AA, Gutman D, Lee KP, Boise LH., Free PMC Article | 01/21/2010 |
| Up or downregulation of Bmf isoforms may have a role in regulating growth and survival in B cells and leukemic B-CLL cells | Expression and transcriptional regulation of functionally distinct Bmf isoforms in B-chronic lymphocytic leukemia cells.
Morales AA, Olsson A, Celsing F, Osterborg A, Jondal M, Osorio LM. | 01/21/2010 |
| There was no somatic mutation of BH3 domains of Bad, Bmf and Bcl-G genes in transitional cell carcinoma samples. The data presented here indicate that BH3 domain mutation of these genes is rare in TCCs and may not contribute to the pathogenesis of TCCs. | BH3 domain mutation of proapoptotic genes Bad, Bmf and Bcl-G is rare in transitional cell carcinomas of the urinary bladder.
Soung YH, Lee JW, Park WS, Nam SW, Lee JY, Yoo NJ, Lee SH. | 01/21/2010 |
| Bmf is a central mediator of anoikis in mammary cells and a target of oncogenes that contribute to the progression of glandular epithelial tumors | Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis.
Schmelzle T, Mailleux AA, Overholtzer M, Carroll JS, Solimini NL, Lightcap ES, Veiby OP, Brugge JS., Free PMC Article | 01/21/2010 |
| data presented here indicate that BH3 domain mutation of the proapoptotic genes Bad, Bmf and Bcl-G is rare in laryngeal squamous cell carcinoma and may not contribute to the apoptosis-resistance mechanisms of laryngeal squamous cell carcinoma | Mutational analysis of the BH3 domains of proapoptotic Bcl-2 family genes Bad, Bmf and Bcl-G in laryngeal squamous cell carcinomas.
Yoo NJ, Soung YH, Lee SH, Jeong EG, Lee SH. | 01/21/2010 |
| histone hyperacetylation may enhance ionizing radiation-induced death via activation of Bmf transcription, thereby implying Bmf as a key molecule for HDAC inhibitors (FK228 and CBHA)-mediated enhancing effect on IR-induced cell death | Bmf contributes to histone deacetylase inhibitor-mediated enhancing effects on apoptosis after ionizing radiation.
Zhang Y, Adachi M, Kawamura R, Zou HC, Imai K, Hareyama M, Shinomura Y. | 01/21/2010 |