| Circular RNA circSEMA5A facilitates colorectal cancer development by regulating microRNA-195-5p to target CCNE1 axis. | Circular RNA circSEMA5A facilitates colorectal cancer development by regulating microRNA-195-5p to target CCNE1 axis.
Ye Q, Liu S, Lin S, Xie W. | 05/17/2023 |
| SEMA5A-PLXNB3 Axis Promotes PDAC Liver Metastasis Outgrowth through Enhancing the Warburg Effect. | SEMA5A-PLXNB3 Axis Promotes PDAC Liver Metastasis Outgrowth through Enhancing the Warburg Effect.
Wang K, He M, Fan X, Zhou J, Yang J, Wang L, Zhao Z, Dai C, Zhang Z., Free PMC Article | 02/9/2023 |
| Semaphorin 5A suppresses ferroptosis through activation of PI3K-AKT-mTOR signaling in rheumatoid arthritis. | Semaphorin 5A suppresses ferroptosis through activation of PI3K-AKT-mTOR signaling in rheumatoid arthritis.
Cheng Q, Chen M, Liu M, Chen X, Zhu L, Xu J, Xue J, Wu H, Du Y., Free PMC Article | 07/23/2022 |
| TSP1 is the essential domain of SEMA5A involved in pannus formation in rheumatoid arthritis. | TSP1 is the essential domain of SEMA5A involved in pannus formation in rheumatoid arthritis.
Xiao C, Lv C, Sun S, Zhao H, Ling H, Li M, Qin Y, Zhang J, Wang J, Yang X. | 01/1/2022 |
| Relationship between disease and disease severity and semaphorin 5A and hemogram level in obsessive-compulsive disorder. | Relationship between disease and disease severity and semaphorin 5A and hemogram level in obsessive-compulsive disorder.
Karatas KS, Bahceci I, Telatar TG, Bahceci B, Hocaoglu C. | 10/16/2021 |
| The Expression of IL-17, in Chronic Spontaneous Urticaria Is Linked to Semaphorin5A. | The Expression of IL-17, in Chronic Spontaneous Urticaria Is Linked to Semaphorin5A.
Lobna M, Nasren E, Adi S, Jacob B, Maria GA, Marcus M, Zahava V., Free PMC Article | 09/18/2021 |
| Circular RNA circSEMA5A promotes bladder cancer progression by upregulating ENO1 and SEMA5A expression. | Circular RNA circSEMA5A promotes bladder cancer progression by upregulating ENO1 and SEMA5A expression.
Wang L, Li H, Qiao Q, Ge Y, Ma L, Wang Q., Free PMC Article | 05/15/2021 |
| Semaphorin 5A suppresses the proliferation and migration of lung adenocarcinoma cells. | Semaphorin 5A suppresses the proliferation and migration of lung adenocarcinoma cells.
Ko PH, Lenka G, Chen YA, Chuang EY, Tsai MH, Sher YP, Lai LC., Free PMC Article | 10/24/2020 |
| High Expression Levels of Long Noncoding RNA Small Nucleolar RNA Host Gene 18 and Semaphorin 5A Indicate Poor Prognosis in Multiple Myeloma. | High Expression Levels of Long Noncoding RNA Small Nucleolar RNA Host Gene 18 and Semaphorin 5A Indicate Poor Prognosis in Multiple Myeloma.
Huang LJ, Shen Y, Bai J, Wang FX, Feng YD, Chen HL, Peng Y, Zhang R, Li FM, Zhang PH, Lei XR, Xue F, Ma YP, Hu JS, He AL. | 08/29/2020 |
| Semaphorin-5A downregulation is associated with enhanced migration and invasion of BRAF-positive melanoma cells under vemurafenib treatment in melanomas with heterogeneous BRAF status | Semaphorin-5A downregulation is associated with enhanced migration and invasion of BRAF-positive melanoma cells under vemurafenib treatment in melanomas with heterogeneous BRAF status.
Komina AV, Palkina NV, Aksenenko MB, Lavrentev SN, Moshev AV, Savchenko AA, Averchuk AS, Rybnikov YA, Ruksha TG. | 07/11/2020 |
| In our study of SEMA5A expression in endometrial cancer, we observed an increased level of this protein compared to the control. The homogeneity of expression changes at the transcriptome and proteome levels suggests that SEMA5A could be a new potential supplementary molecular marker in endometrial cancer. | Assessment of the Usefulness of the SEMA5A Concentration Profile Changes as a Molecular Marker in Endometrial Cancer.
Dziobek K, Opławski M, Grabarek BO, Zmarzły N, Kieszkowski P, Januszyk P, Kiełbasiński K, Kiełbasiński R, Boroń D. | 03/28/2020 |
| Study provide the first evidence that SEMA3C, SEMA5A and SEMA6D can be considered as markers of liver injury in chronic hepatitis C. While serum concentrations of SEMA3C and SEMA6D significantly increased with fibrosis stage in both HCV-g1 and HCV-g3 infections, the concentration of SEMA5A inversely correlated with fibrosis stage in both HCV genotypes. | The association of semaphorins 3C, 5A and 6D with liver fibrosis stage in chronic hepatitis C.
Papic N, Zidovec Lepej S, Gorenec L, Grgic I, Gasparov S, Filipec Kanizaj T, Vince A., Free PMC Article | 06/1/2019 |
| Collectively, our data suggest that SEMA5A expression maintains epithelial phenotype in the metastatic microenvironment | Semaphorin-5A maintains epithelial phenotype of malignant pancreatic cancer cells.
Saxena S, Purohit A, Varney ML, Hayashi Y, Singh RK., Free PMC Article | 03/30/2019 |
| Data provide evidences supporting the role of Sema5A in melanoma progression and the involvement of Bcl-2, miR-204 and c-Myb in regulating its expression. | Semaphorin 5A drives melanoma progression: role of Bcl-2, miR-204 and c-Myb.
D'Aguanno S, Valentini E, Tupone MG, Desideri M, Di Martile M, Spagnuolo M, Buglioni S, Ercolani C, Falcone I, De Dominici M, Milella M, Rizzo MG, Calabretta B, Cota C, Anichini A, Trisciuoglio D, Del Bufalo D., Free PMC Article | 02/2/2019 |
| SEMA5A gene is associated with hippocampal volume, and their interaction is associated with reasoning ability. | The SEMA5A gene is associated with hippocampal volume, and their interaction is associated with performance on Raven's Progressive Matrices.
Zhu B, Chen C, Xue G, Moyzis RK, Dong Q, Chen C, Li J, He Q, Lei X, Wang Y, Lin C. | 01/20/2018 |
| De novo translocation t(5;22)(p15.3;q11.21) associated with a partial deletion of SEMA5A identified in a patient with ASD. | A de novo microdeletion of SEMA5A in a boy with autism spectrum disorder and intellectual disability.
Mosca-Boidron AL, Gueneau L, Huguet G, Goldenberg A, Henry C, Gigot N, Pallesi-Pocachard E, Falace A, Duplomb L, Thevenon J, Duffourd Y, St-Onge J, Chambon P, Rivière JB, Thauvin-Robinet C, Callier P, Marle N, Payet M, Ragon C, Goubran Botros H, Buratti J, Calderari S, Dumas G, Delorme R, Lagarde N, Pinoit JM, Rosier A, Masurel-Paulet A, Cardoso C, Mugneret F, Saugier-Veber P, Campion D, Faivre L, Bourgeron T., Free PMC Article | 07/29/2017 |
| Our data demonstrated that elevated serum Semaphorin5A (Sema5A) in SLE patients correlated with disease activity and are involved in kidney and blood system damage; ADAM17 might be involved in the release of secreted Sema5A. | Elevated semaphorin5A in systemic lupus erythematosus is in association with disease activity and lupus nephritis.
Du Y, Wu X, Chen M, Wang W, Xv W, Ye L, Wu D, Xue J, Sun W, Luo J, Wu H, Du Y, Wu X, Chen M, Wang W, Xv W, Ye L, Wu D, Xue J, Sun W, Luo J, Wu H., Free PMC Articles: PMC5383448, PMC5383448 | 05/8/2017 |
| data demonstrated that elevated serum Semaphorin5A in systemic lupus erythematosus patients correlated with disease activity and are involved in kidney and blood system damage; ADAM17 might be involved in the release of secreted Sema5A | Elevated semaphorin5A in systemic lupus erythematosus is in association with disease activity and lupus nephritis.
Du Y, Wu X, Chen M, Wang W, Xv W, Ye L, Wu D, Xue J, Sun W, Luo J, Wu H, Du Y, Wu X, Chen M, Wang W, Xv W, Ye L, Wu D, Xue J, Sun W, Luo J, Wu H., Free PMC Articles: PMC5383448, PMC5383448 | 05/6/2017 |
| Multigenerational autosomal dominant inheritance of 5p chromosomal deletions resulting in Cri-du-Chat Syndrome with SEMA5A, CTNND2, and ICE1 deficiencies has been described. | Multigenerational autosomal dominant inheritance of 5p chromosomal deletions.
Zhang B, Willing M, Grange DK, Shinawi M, Manwaring L, Vineyard M, Kulkarni S, Cottrell CE. | 12/17/2016 |
| The Single-Nucleotide Polymorphism (SNP) of rs7702187 within the SEMA5A gene would be a high-penetrant risk factor for PD development. | Meta analysis of the association of rs7702187 SNP in SEMA5A gene with risk of Parkinson's disease.
Yu X, Wang F, Zhang JP. | 04/4/2015 |
| Using human gastric cancer cell lines, found semaphorin 5A significantly promoted invasive & metastatic abilities of gastric cancer cell in vitro. Semaphorin 5A increased expression of MMP9 by activating phosphorylated ErK1/2 in gastric cancer cell. | Semaphorin 5A, an axon guidance molecule, enhances the invasion and metastasis of human gastric cancer through activation of MMP9.
Pan G, Zhang X, Ren J, Lu J, Li W, Fu H, Zhang S, Li J. | 11/16/2013 |
| Results suggest that a bioactive, secreted form of Sema5A-ECD has an intriguing and potentially important role in its ability to enhance pancreatic tumour invasiveness, angiogenesis and micrometastases. | Secreted semaphorin 5A suppressed pancreatic tumour burden but increased metastasis and endothelial cell proliferation.
Sadanandam A, Sidhu SS, Wullschleger S, Singh S, Varney ML, Yang CS, Ashour AE, Batra SK, Singh RK., Free PMC Article | 01/12/2013 |
| Data show that Semaphorin 5A (Sema5A) and plexin-B3 inhibit glioma cell invasion through Rac1 inactivation. | Semaphorin 5A and plexin-B3 regulate human glioma cell motility and morphology through Rac1 and the actin cytoskeleton.
Li X, Law JW, Lee AY. | 03/31/2012 |
| The downregulation of SEMA5A in tumor tissue, both at the transcriptional and translational levels, was associated with poor survival among nonsmoking women with NSCLC. | Identification of a novel biomarker, SEMA5A, for non-small cell lung carcinoma in nonsmoking women.
Lu TP, Tsai MH, Lee JM, Hsu CP, Chen PC, Lin CW, Shih JY, Yang PC, Hsiao CK, Lai LC, Chuang EY. | 02/26/2011 |
| Data represent a novel signaling of semaphorin 5A and plexin B3 in the control of cell motility by indirect inactivation of Rac1 through RhoGDIalpha. | Semaphorin 5A and plexin-B3 inhibit human glioma cell motility through RhoGDIalpha-mediated inactivation of Rac1 GTPase.
Li X, Lee AY., Free PMC Article | 12/11/2010 |