| Studies with neutralizing antibodies suggest CXCL8-mediated neutrophil activation is independent of C-C motif chemokine receptor-like 2 (CCRL2) ligand binding function. | Studies with neutralizing antibodies suggest CXCL8-mediated neutrophil activation is independent of C-C motif chemokine receptor-like 2 (CCRL2) ligand binding function.
Su Z, Brooks J, Pelker J, Andreyeva T, Sobon H, Gifford R, Powers M, Wang J, Dower C, Hegen M, Messing D, Sheehan AD, Brennan JJ., Free PMC Article | 02/4/2023 |
| Genomics Links Inflammation With Neurocognitive Impairment in Children Living With Human Immunodeficiency Virus Type-1. | Genomics Links Inflammation With Neurocognitive Impairment in Children Living With Human Immunodeficiency Virus Type-1.
Rawat P, Brummel SS, Singh KK, Kim J, Frazer KA, Nichols S, Seage GR, Williams PL, Van Dyke RB, Harismendy O, Trout RN, Spector SA., Free PMC Article | 02/26/2022 |
| C-C Chemokine receptor-like 2 (CCRL2) acts as coreceptor for human immunodeficiency virus-2. | C-C Chemokine receptor-like 2 (CCRL2) acts as coreceptor for human immunodeficiency virus-2.
Islam S, Moni MA, Urmi UL, Tanaka A, Hoshino H. | 11/22/2021 |
| The Atypical Receptor CCRL2 Is Essential for Lung Cancer Immune Surveillance. | The Atypical Receptor CCRL2 Is Essential for Lung Cancer Immune Surveillance.
Del Prete A, Sozio F, Schioppa T, Ponzetta A, Vermi W, Calza S, Bugatti M, Salvi V, Bernardini G, Benvenuti F, Vecchi A, Bottazzi B, Mantovani A, Sozzani S., Free PMC Article | 08/29/2020 |
| CCRL2 mRNA was not significantly changed in murine and human non-alcoholic steatohepatitis liver. CCRL2 mRNA levels were positively correlated with inflammation, fibrosis and NASH scores in the patients. | Chemokine (CC-motif) receptor-like 2 mRNA is expressed in hepatic stellate cells and is positively associated with characteristics of non-alcoholic steatohepatitis in mice and men.
Zimny S, Pohl R, Rein-Fischboeck L, Haberl EM, Krautbauer S, Weiss TS, Buechler C. | 08/26/2017 |
| CCRL2 inhibited the growth of breast cancer cells in vitro and in vivo. | The human chemokine receptor CCRL2 suppresses chemotaxis and invasion by blocking CCL2-induced phosphorylation of p38 MAPK in human breast cancer cells.
Wang LP, Cao J, Zhang J, Wang BY, Hu XC, Shao ZM, Wang ZH, Ou ZL. | 07/30/2016 |
| in breast cancer, CRAM-A becomes specifically upregulated under inflammatory stimuli and may serve as a potential marker of immune response. | CRAM-A indicates IFN-γ-associated inflammatory response in breast cancer.
Sarmadi P, Tunali G, Esendagli-Yilmaz G, Yilmaz KB, Esendagli G. | 04/23/2016 |
| these results suggest for the first time that elevated CCRL2 in glioma promotes cell migration and invasion. | Elevated chemokine CC-motif receptor-like 2 (CCRL2) promotes cell migration and invasion in glioblastoma.
Yin F, Xu Z, Wang Z, Yao H, Shen Z, Yu F, Tang Y, Fu D, Lin S, Lu G, Kung HF, Poon WS, Huang Y, Lin MC. | 04/6/2013 |
| Considering the newly defined role of CCRL2 in lung dendritic cell trafficking, this atypical chemokine receptor may affect pneumocystis pneumonia through immune regulation and inducing inflammation. | Role of exonic variation in chemokine receptor genes on AIDS: CCRL2 F167Y association with pneumocystis pneumonia.
An P, Li R, Wang JM, Yoshimura T, Takahashi M, Samudralal R, O'Brien SJ, Phair J, Goedert JJ, Kirk GD, Troyer JL, Sezgin E, Buchbinder SP, Donfield S, Nelson GW, Winkler CA., Free PMC Article | 02/18/2012 |
| Observational study of gene-disease association. (HuGE Navigator) | An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
Shimada M, Miyagawa T, Kawashima M, Tanaka S, Honda Y, Honda M, Tokunaga K. | 09/15/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.
Segat L, Brandão LAC, Guimarães RL, Pontillo A, Athanasakis E, de Oliveira RM, Arraes LC, de Lima Filho JL, Crovella S. | 06/30/2010 |
| demonstration that the homeostatic chemokine CCL19 is a specific ligand for CRAM | CCL19 is a specific ligand of the constitutively recycling atypical human chemokine receptor CRAM-B.
Leick M, Catusse J, Follo M, Nibbs RJ, Hartmann TN, Veelken H, Burger M., Free PMC Article | 05/31/2010 |
| Results identify chemerin as a natural nonsignaling protein ligand for both human and mouse CCRL2. | Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis.
Zabel BA, Nakae S, Zúñiga L, Kim JY, Ohyama T, Alt C, Pan J, Suto H, Soler D, Allen SJ, Handel TM, Song CH, Galli SJ, Butcher EC., Free PMC Article | 01/21/2010 |
| CCRL2 expression is up-regulated on synovial neutrophils of rheumatoid arthritis patients | Up-regulated expression and activation of the orphan chemokine receptor, CCRL2, in rheumatoid arthritis.
Galligan CL, Matsuyama W, Matsukawa A, Mizuta H, Hodge DR, Howard OM, Yoshimura T. | 01/21/2010 |