| Cyclin G2 reverses immunosuppressive tumor microenvironment and potentiates PD-1 blockade in glioma. | Cyclin G2 reverses immunosuppressive tumor microenvironment and potentiates PD-1 blockade in glioma.
Li S, Zhao C, Gao J, Zhuang X, Liu S, Xing X, Liu Q, Chen C, Wang S, Luo Y., Free PMC Article | 01/8/2022 |
| miR-17-5p drives G2/M-phase accumulation by directly targeting CCNG2 and is related to recurrence of head and neck squamous cell carcinoma. | miR-17-5p drives G2/M-phase accumulation by directly targeting CCNG2 and is related to recurrence of head and neck squamous cell carcinoma.
Huang Q, Shen YJ, Hsueh CY, Guo Y, Zhang YF, Li JY, Zhou L., Free PMC Article | 10/23/2021 |
| Cyclin G2 upregulation impairs migration, invasion, and network formation through RNF123/Dvl2/JNK signaling in the trophoblast cell line HTR8/SVneo, a possible role in preeclampsia. | Cyclin G2 upregulation impairs migration, invasion, and network formation through RNF123/Dvl2/JNK signaling in the trophoblast cell line HTR8/SVneo, a possible role in preeclampsia.
Sun M, Gao J, Meng T, Liu S, Chen H, Liu Q, Xing X, Zhao C, Luo Y. | 06/26/2021 |
| Cyclin G2 Is Involved in the Proliferation of Placental Trophoblast Cells and Their Interactions with Endothelial Cells. | Cyclin G2 Is Involved in the Proliferation of Placental Trophoblast Cells and Their Interactions with Endothelial Cells.
Sun M, Liu S, Gao J, Meng T, Xing X, Chen C, Chen H, Luo Y., Free PMC Article | 05/22/2021 |
| Cyclin G2 regulates canonical Wnt signalling via interaction with Dapper1 to attenuate tubulointerstitial fibrosis in diabetic nephropathy. | Cyclin G2 regulates canonical Wnt signalling via interaction with Dapper1 to attenuate tubulointerstitial fibrosis in diabetic nephropathy.
Zhao C, Gao J, Li S, Liu Q, Hou X, Xing X, Wang D, Sun M, Wang S, Luo Y., Free PMC Article | 04/24/2021 |
| MiR-1290 targets CCNG2 to promote the metastasis of oral squamous cell carcinoma. | MiR-1290 targets CCNG2 to promote the metastasis of oral squamous cell carcinoma.
Qin WJ, Wang WP, Wang XB, Zhang XT, Du JD. | 11/21/2020 |
| these results suggest that miR-590-3p promotes ovarian cancer development, in part by directly targeting CCNG2 and FOXO3. | miR-590-3p Targets Cyclin G2 and FOXO3 to Promote Ovarian Cancer Cell Proliferation, Invasion, and Spheroid Formation.
Salem M, Shan Y, Bernaudo S, Peng C., Free PMC Article | 08/17/2019 |
| This study demonstrates that cyclin G2 suppresses Wnt/beta-catenin signaling and inhibits gastric cancer cell growth and migration through Dapper1. | Cyclin G2 suppresses Wnt/β-catenin signaling and inhibits gastric cancer cell growth and migration through Dapper1.
Gao J, Zhao C, Liu Q, Hou X, Li S, Xing X, Yang C, Luo Y., Free PMC Article | 02/16/2019 |
| Low CCNG2 expression is associated with colorectal cancer. | Farnesoid X receptor inhibits proliferation of human colorectal cancer cells via the miR‑135A1/CCNG2 signaling pathway.
Qiao P, Li S, Zhang H, Yao L, Wang F. | 11/17/2018 |
| EGF-induced, calpain-mediated proteolysis contributes to the rapid destruction of cyclin G2 and that the PEST domain is critical for EGF/calpain actions | Epidermal growth factor promotes cyclin G2 degradation via calpain-mediated proteolysis in gynaecological cancer cells.
Bernaudo S, Khazai S, Honarparvar E, Kopteva A, Peng C., Free PMC Article | 09/23/2017 |
| Taken together, our novel findings demonstrate that cyclin G2 has potent tumor-suppressive effects in Epithelial ovarian cancer (EOC) by inhibiting EMT through attenuating Wnt/beta-catenin signaling. | Cyclin G2 inhibits epithelial-to-mesenchymal transition by disrupting Wnt/β-catenin signaling.
Bernaudo S, Salem M, Qi X, Zhou W, Zhang C, Yang W, Rosman D, Deng Z, Ye G, Yang BB, Vanderhyden B, Wu Z, Peng C., Free PMC Article | 09/2/2017 |
| CycG2 contributes to signaling networks that limit breast cancer. | Cyclin G2 promotes cell cycle arrest in breast cancer cells responding to fulvestrant and metformin and correlates with patient survival.
Zimmermann M, Arachchige-Don AP, Donaldson MS, Patriarchi T, Horne MC., Free PMC Article | 06/24/2017 |
| CCNG2 knockdown eradicated the effects of miR-340 silencing. | MicroRNA-340 promotes the tumor growth of human gastric cancer by inhibiting cyclin G2.
Yin G, Zhou H, Xue Y, Yao B, Zhao W. | 03/11/2017 |
| Neisseria meningitidis caused changes in the abundance of several cell cycle regulatory mRNAs, including the cell cycle inhibitors p21(WAF1/CIP1) and cyclin G2 in human brain microvascular endothelial cells. | Neisseria meningitidis causes cell cycle arrest of human brain microvascular endothelial cells at S phase via p21 and cyclin G2.
Oosthuysen WF, Mueller T, Dittrich MT, Schubert-Unkmeir A. | 10/22/2016 |
| Upregulation of miR1246 mediated the malignant progression of colorectal cancer and is partly attributed to the downregulation of the expression of CycG2. | MicroRNA-1246 promotes growth and metastasis of colorectal cancer cells involving CCNG2 reduction.
Wang S, Zeng Y, Zhou JM, Nie SL, Peng Q, Gong J, Huo JR. | 10/1/2016 |
| miR-93-CCNG2 axis may be involved in Laryngeal squamous cell carcinoma proliferation and progression. | MicroRNA-93 regulates cyclin G2 expression and plays an oncogenic role in laryngeal squamous cell carcinoma.
Xiao X, Zhou L, Cao P, Gong H, Zhang Y. | 08/15/2015 |
| Data shows the human CCNG2 and CDK4 expression of visceral adipose tissue are inversely associated with glucose and insulin resistance. | CCNG2 and CDK4 is associated with insulin resistance in adipose tissue.
Garrido-Sánchez L, Roca-Rodríguez Mdel M, Fernández-Veledo S, Vendrell J, Yubero-Serrano EM, Ocaña-Wilhelmi L, García-Fuentes E, Tinahones FJ. | 05/30/2015 |
| Data (from studies using BeWo cells, a choriocarcinoma cell line, as model of placentation) suggest that miR-378a-5p (microRNA 378a) inhibits cell differentiation in syncytiotrophoblasts, in part, by down-regulating CCNG2 (cyclin G2) expression. | MicroRNA-378a-5p targets cyclin G2 to inhibit fusion and differentiation in BeWo cells.
Nadeem U, Ye G, Salem M, Peng C. | 05/23/2015 |
| miR-1246 expression was associated with chemoresistance and CSC-like properties via CCNG2, and could predict worse prognosis in pancreatic cancer patients | MicroRNA-1246 expression associated with CCNG2-mediated chemoresistance and stemness in pancreatic cancer.
Hasegawa S, Eguchi H, Nagano H, Konno M, Tomimaru Y, Wada H, Hama N, Kawamoto K, Kobayashi S, Nishida N, Koseki J, Nishimura T, Gotoh N, Ohno S, Yabuta N, Nojima H, Mori M, Doki Y, Ishii H., Free PMC Article | 12/20/2014 |
| Cyclin G2-involved invasion in vitro and in vivo. | Cyclin G2 promotes hypoxia-driven local invasion of glioblastoma by orchestrating cytoskeletal dynamics.
Fujimura A, Michiue H, Cheng Y, Uneda A, Tani Y, Nishiki T, Ichikawa T, Wei FY, Tomizawa K, Matsui H., Free PMC Article | 08/30/2014 |
| Low CCNG2 expression is associated with thyroid cancer. | CCNG2 suppressor biological effects on thyroid cancer cell through promotion of CDK2 degradation.
Li WJ, Liu GL, Yu F, Xiang XX, Lu YF, Xiao HZ, Shi YP. | 08/16/2014 |
| CCNG2 may play important roles as a negative regulator to kidney cancer ACHN cell by promoting degradation of CDK2. | Change in expression of cyclin G2 in kidney cancer cell and its significance.
Cui DW, Sun GG, Cheng YJ. | 06/14/2014 |
| The level of CCNG2 was correlated with T stages, lymph node metastasis, clinic stage, and histological grade (P < 0.05) in colorectal carcinoma. | CCNG2 expression is downregulated in colorectal carcinoma and its clinical significance.
Sun GG, Zhang J, Hu WN. | 06/14/2014 |
| CCNG2 may play important roles as a negative regulator to esophageal cancer cell by promoting degradation of CDK2. | Changes in the expression of cyclin G2 in esophageal cancer cell and its significance.
Chen JQ, Liu CJ, Wen HX, Shi CL, Zhang HS, Li M, Sun GG. | 06/14/2014 |
| CCNG2 expression decreased in prostate cancer and correlated significantly with lymph node metastasis, clinic stage, and Gleason score. | Effect of cyclin G2 on proliferative ability of prostate cancer PC-3 cell.
Cui DW, Cheng YJ, Jing SW, Sun GG. | 06/14/2014 |