| Kalirin-RAC controls nucleokinetic migration in ADRN-type neuroblastoma. | Kalirin-RAC controls nucleokinetic migration in ADRN-type neuroblastoma.
Afanasyeva EA, Gartlgruber M, Ryl T, Decaesteker B, Denecker G, Mönke G, Toprak UH, Florez A, Torkov A, Dreidax D, Herrmann C, Okonechnikov K, Ek S, Sharma AK, Sagulenko V, Speleman F, Henrich KO, Westermann F., Free PMC Article | 10/16/2021 |
| KALRN mutations promote antitumor immunity and immunotherapy response in cancer. | KALRN mutations promote antitumor immunity and immunotherapy response in cancer.
Li M, Ma Y, Zhong Y, Liu Q, Chen C, Qiang L, Wang X., Free PMC Article | 10/9/2021 |
| Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-Dependent Neuroligin-1 Mechanism of Action. | Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-Dependent Neuroligin-1 Mechanism of Action.
Paskus JD, Tian C, Fingleton E, Shen C, Chen X, Li Y, Myers SA, Badger JD 2nd, Bemben MA, Herring BE, Roche KW., Free PMC Article | 10/3/2020 |
| The interaction of kalirin with the C-terminal region of Htt influences the function of kalirin and modulates the cytotoxicity induced by C-terminal Htt. | The COOH-terminal domain of huntingtin interacts with RhoGEF kalirin and modulates cell survival.
McClory H, Wang X, Sapp E, Gatune LW, Iuliano M, Wu CY, Nathwani G, Kegel-Gleason KB, DiFiglia M, Li X., Free PMC Article | 10/26/2019 |
| The data of this study reveal a novel mechanism for disease-associated single nucleotide variants of KALARN and provide a platform for modeling morphological changes in mental disorders. | A Schizophrenia-Linked KALRN Coding Variant Alters Neuron Morphology, Protein Function, and Transcript Stability.
Russell TA, Grubisha MJ, Remmers CL, Kang SK, Forrest MP, Smith KR, Kopeikina KJ, Gao R, Sweet RA, Penzes P., Free PMC Article | 06/15/2019 |
| SNPs of the KALRN gene are associated with intracranial atherosclerotic stenosis in the northern Chinese population. | Genetic Variation of the Kalirin Gene is Associated with ICAS in the Chinese Population.
Dang M, Song Y, Li Q, Zhang C, Peng Y, Wei Z, Huang P. | 12/22/2018 |
| Combination of polymorphisms in the NOD2, IL17RA, EPHA2 and KALRN genes could play a significant role in the development of sarcoidosis by maintaining a chronic pro-inflammatory status in macrophages | G908R NOD2 variant in a family with sarcoidosis.
Besnard V, Calender A, Bouvry D, Pacheco Y, Chapelon-Abric C, Jeny F, Nunes H, Planès C, Valeyre D., Free PMC Article | 11/17/2018 |
| The GG genotype and G allele of SNP rs7620580 were associated with a risk for ischemic stroke with an adjusted OR of 3.195 and an OR of 1.446, respectively. Haplotype analysis revealed that A-T-G,G-T-A, and A-T-A haplotypes were associated with ischemic stroke. Our results provide evidence that kalirin gene variations were associated with ischemic stroke in the Chinese Han population. | Genetic Variant of Kalirin Gene Is Associated with Ischemic Stroke in a Chinese Han Population.
Li H, Yu S, Wang R, Sun Z, Zhou X, Zheng L, Yin Z, Zhang X, Sun Y., Free PMC Article | 04/14/2018 |
| DNA sequencing provided evidence linking KALRN to monogenic intellectual disability in two patients. | Exome sequencing discloses KALRN homozygous variant as likely cause of intellectual disability and short stature in a consanguineous pedigree.
Makrythanasis P, Guipponi M, Santoni FA, Zaki M, Issa MY, Ansar M, Hamamy H, Antonarakis SE., Free PMC Article | 12/2/2017 |
| Data suggest protein levels of kalirin and CHD7 in circulating extracellular vesicles (EVs) as endothelial dysfunction markers to monitor vascular condition in hypertensive patients with albuminuria. | Kalirin and CHD7: novel endothelial dysfunction indicators in circulating extracellular vesicles from hypertensive patients with albuminuria.
de la Cuesta F, Baldan-Martin M, Moreno-Luna R, Alvarez-Llamas G, Gonzalez-Calero L, Mourino-Alvarez L, Sastre-Oliva T, López JA, Vázquez J, Ruiz-Hurtado G, Segura J, Vivanco F, Ruilope LM, Barderas MG., Free PMC Article | 09/2/2017 |
| GG genotype and the G allele of the rs9289231 polymorphism of KALRN and the rs224766 polymorphism of ADIPOQ genes may be considered genetic risk factors for Iranian type 2 diabetic patients with coronary artery disease. | Association of KALRN, ADIPOQ, and FTO gene polymorphism in type 2 diabetic patients with coronary artery disease: possible predisposing markers.
Mofarrah M, Ziaee S, Pilehvar-Soltanahmadi Y, Zarghami F, Boroumand M, Zarghami N. | 04/1/2017 |
| 4 KALRN gene SNPs were studied in Han ischemic stroke patients. rs11712619 seemed associated with lacunar stroke until risk factors were considered. re6438833 was significantly associated with ischemic and lacunar stroke. | KALRN Rare and Common Variants and Susceptibility to Ischemic Stroke in Chinese Han Population.
Dang M, Wang Z, Zhang R, Li X, Peng Y, Han X, Sun L, Tian J. | 05/21/2016 |
| consider the GG genotype and the G allele of rs9289231 polymorphism of KALRN to be genetic risk factors for CAD in an Iranian population, especially in early-stage atherosclerotic vascular disease | The Kalirin Gene rs9289231 Polymorphism as a Novel Predisposing Marker for Coronary Artery Disease.
Boroumand M, Ziaee S, Zarghami N, Anvari MS, Cheraghi S, Abbasi SH, Jalali A, Pourgholi L. | 05/7/2016 |
| A sequence variant in human KALRN impairs protein ability to activate Rac1 and coincides with reduced cortical thickness. | A sequence variant in human KALRN impairs protein function and coincides with reduced cortical thickness.
Russell TA, Blizinsky KD, Cobia DJ, Cahill ME, Xie Z, Sweet RA, Duan J, Gejman PV, Wang L, Csernansky JG, Penzes P., Free PMC Article | 10/31/2015 |
| The kalirin expression were reduced in Alzheimer disease with psychosis. | β-Amyloid 42/40 ratio and kalirin expression in Alzheimer disease with psychosis.
Murray PS, Kirkwood CM, Gray MC, Ikonomovic MD, Paljug WR, Abrahamson EE, Henteleff RA, Hamilton RL, Kofler JK, Klunk WE, Lopez OL, Penzes P, Sweet RA., Free PMC Article | 03/16/2013 |
| The age-at-onset of Huntington disease (HD) is not associated with eleven SNPs, including SNP rs10934657 in the kalirin gene in 680 European HD patients. | Genetic analysis of polymorphisms in the kalirin gene for association with age-at-onset in European Huntington disease patients.
Tsai YC, Metzger S, Riess O, Soehn AS, Nguyen HP., Free PMC Article | 11/17/2012 |
| Neuronal guanine nucleotide exchange factor (GEF) kalirin is emerging as a key regulator of structural and functional plasticity at dendritic spines. | Kalirin signaling: implications for synaptic pathology.
Penzes P, Remmers C., Free PMC Article | 09/29/2012 |
| In both anterior cingulate cortex (ACC) and dorsolateral prefrontal cortex (DLPFC), study found a reduction of Duo expression and PAK1 phosphorylation in schizophrenia. Cdc42 protein expression was decreased in ACC but not in DLPFC | Abnormalities of the Duo/Ras-related C3 botulinum toxin substrate 1/p21-activated kinase 1 pathway drive myosin light chain phosphorylation in frontal cortex in schizophrenia.
Rubio MD, Haroutunian V, Meador-Woodruff JH., Free PMC Article | 09/1/2012 |
| Missense mutations in KALRN may be genetic risk factors for schizophrenia. | Resequencing and association analysis of the KALRN and EPHB1 genes and their contribution to schizophrenia susceptibility.
Kushima I, Nakamura Y, Aleksic B, Ikeda M, Ito Y, Shiino T, Okochi T, Fukuo Y, Ujike H, Suzuki M, Inada T, Hashimoto R, Takeda M, Kaibuchi K, Iwata N, Ozaki N., Free PMC Article | 09/1/2012 |
| We found Kalirin-9 expression to be paradoxically increased in schizophrenia | Increased expression of Kalirin-9 in the auditory cortex of schizophrenia subjects: its role in dendritic pathology.
Deo AJ, Cahill ME, Li S, Goldszer I, Henteleff R, Vanleeuwen JE, Rafalovich I, Gao R, Stachowski EK, Sampson AR, Lewis DA, Penzes P, Sweet RA., Free PMC Article | 05/19/2012 |
| KALRN gene variation is not associated with overall ischemic stroke | Lack of association between genetic variations in the KALRN region and ischemic stroke.
Olsson S, Jood K, Melander O, Sjögren M, Norrving B, Nilsson M, Lindgren A, Jern C. | 03/3/2012 |
| SNX1 and SNX2 interact with Kalirin-7. Overexpression of SNX1 or SNX2 and Kalirin-7 partially redistributes both SNXs to the plasma membrane, and results in RhoG-dependent lamellipodia formation. | A novel, retromer-independent role for sorting nexins 1 and 2 in RhoG-dependent membrane remodeling.
Prosser DC, Tran D, Schooley A, Wendland B, Ngsee JK. | 03/5/2011 |
| Studies indicate that Kalirin-7 plays a key role in excitatory synapse formation and function. | Kalirin-7 is a key player in the formation of excitatory synapses in hippocampal neurons.
Ma XM., Free PMC Article | 11/27/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Two SNPs in the KALRN gene region (rs17286604 and rs11712619)constitute risk factors for ischemic stroke. | Kalirin: a novel genetic risk factor for ischemic stroke.
Krug T, Manso H, Gouveia L, Sobral J, Xavier JM, Albergaria I, Gaspar G, Correia M, Viana-Baptista M, Simões RM, Pinto AN, Taipa R, Ferreira C, Fontes JR, Silva MR, Gabriel JP, Matos I, Lopes G, Ferro JM, Vicente AM, Oliveira SA. | 05/3/2010 |