| Cyclin F-EXO1 axis controls cell cycle-dependent execution of double-strand break repair. | Cyclin F-EXO1 axis controls cell cycle-dependent execution of double-strand break repair.
Yang H, Fouad S, Smith P, Bae EY, Ji Y, Lan X, Van Ess A, Buffa FM, Fischer R, Vendrell I, Kessler BM, D'Angiolella V., Free PMC Article | 08/15/2024 |
| Overexpression of cyclin F/CCNF as an independent prognostic factor for poor survival in clear cell renal cell carcinoma. | Overexpression of cyclin F/CCNF as an independent prognostic factor for poor survival in clear cell renal cell carcinoma.
Kwiatkowski M, Krajewski A, Durślewicz J, Buchholz K, Grzanka D, Gagat M, Zabrzyński J, Klimaszewska-Wiśniewska A., Free PMC Article | 04/26/2024 |
| ALS/FTD-associated mutation in cyclin F inhibits ER-Golgi trafficking, inducing ER stress, ERAD and Golgi fragmentation. | ALS/FTD-associated mutation in cyclin F inhibits ER-Golgi trafficking, inducing ER stress, ERAD and Golgi fragmentation.
Ragagnin AMG, Sundaramoorthy V, Farzana F, Gautam S, Saravanabavan S, Takalloo Z, Mehta P, Do-Ha D, Parakh S, Shadfar S, Hunter J, Vidal M, Jagaraj CJ, Brocardo M, Konopka A, Yang S, Rayner SL, Williams KL, Blair IP, Chung RS, Lee A, Ooi L, Atkin JD., Free PMC Article | 03/13/2024 |
| Cyclin F, Neurodegeneration, and the Pathogenesis of ALS/FTD. | Cyclin F, Neurodegeneration, and the Pathogenesis of ALS/FTD.
Rayner SL, Hogan A, Davidson JM, Cheng F, Luu L, Morsch M, Blair I, Chung R, Lee A. | 03/12/2024 |
| The E3 Ubiquitin Ligase SCF Cyclin F Promotes Sequestosome-1/p62 Insolubility and Foci Formation and is Dysregulated in ALS and FTD Pathogenesis. | The E3 Ubiquitin Ligase SCF Cyclin F Promotes Sequestosome-1/p62 Insolubility and Foci Formation and is Dysregulated in ALS and FTD Pathogenesis.
Davidson JM, Wu SSL, Rayner SL, Cheng F, Duncan K, Russo C, Newbery M, Ding K, Scherer NM, Balez R, García-Redondo A, Rábano A, Rosa-Fernandes L, Ooi L, Williams KL, Morsch M, Blair IP, Di Ieva A, Yang S, Chung RS, Lee A., Free PMC Article | 08/22/2023 |
| ALS-linked CCNF variant disrupts motor neuron ubiquitin homeostasis. | ALS-linked CCNF variant disrupts motor neuron ubiquitin homeostasis.
Farrawell NE, Bax M, McAlary L, McKenna J, Maksour S, Do-Ha D, Rayner SL, Blair IP, Chung RS, Yerbury JJ, Ooi L, Saunders DN., Free PMC Article | 07/12/2023 |
| Genetic and Phenotypic Spectrum of Amyotrophic Lateral Sclerosis Patients with CCNF Variants from a Large Chinese Cohort. | Genetic and Phenotypic Spectrum of Amyotrophic Lateral Sclerosis Patients with CCNF Variants from a Large Chinese Cohort.
Zhao B, Jiang Q, Lin J, Wei Q, Li C, Hou Y, Cao B, Zhang L, Ou R, Liu K, Yang T, Xiao Y, Huang R, Shang H., Free PMC Article | 05/30/2023 |
| The Skp1-Cullin1-FBXO1 complex is a pleiotropic regulator required for the formation of gametes and motile forms in Plasmodium berghei. | The Skp1-Cullin1-FBXO1 complex is a pleiotropic regulator required for the formation of gametes and motile forms in Plasmodium berghei.
Rashpa R, Klages N, Schvartz D, Pasquarello C, Brochet M., Free PMC Article | 03/29/2023 |
| ALS-linked loss of Cyclin-F function affects HSP90. | ALS-linked loss of Cyclin-F function affects HSP90.
Siebert A, Gattringer V, Weishaupt JH, Behrends C., Free PMC Article | 10/22/2022 |
| ALS/FTD-causing mutation in cyclin F causes the dysregulation of SFPQ. | ALS/FTD-causing mutation in cyclin F causes the dysregulation of SFPQ.
Rayner SL, Cheng F, Hogan AL, Grima N, Yang S, Ke YD, Au CG, Morsch M, De Luca A, Davidson JM, Molloy MP, Shi B, Ittner LM, Blair I, Chung RS, Lee A. | 03/5/2022 |
| Increased expression of Cyclin F in liver cancer predicts poor prognosis: A study based on TCGA database. | Increased expression of Cyclin F in liver cancer predicts poor prognosis: A study based on TCGA database.
Zelong Y, Han Y, Ting G, Yifei W, Kun H, Haoran H, Yong C., Free PMC Article | 08/28/2021 |
| Pathogenic mutations in the ALS gene CCNF cause cytoplasmic mislocalization of Cyclin F and elevated VCP ATPase activity | Pathogenic mutations in the ALS gene CCNF cause cytoplasmic mislocalization of Cyclin F and elevated VCP ATPase activity.
Yu Y, Nakagawa T, Morohoshi A, Nakagawa M, Ishida N, Suzuki N, Aoki M, Nakayama K. | 05/23/2020 |
| Cyclin F controls cell-cycle transcriptional outputs by directing the degradation of the E2F1, E2F2, and E2F3a. | Cyclin F Controls Cell-Cycle Transcriptional Outputs by Directing the Degradation of the Three Activator E2Fs.
Clijsters L, Hoencamp C, Calis JJA, Marzio A, Handgraaf SM, Cuitino MC, Rosenberg BR, Leone G, Pagano M., Free PMC Article | 01/18/2020 |
| Cyclin F is regulated by proteolysis through beta-TrCP at the G2/M transition. | β-TrCP- and Casein Kinase II-Mediated Degradation of Cyclin F Controls Timely Mitotic Progression.
Mavrommati I, Faedda R, Galasso G, Li J, Burdova K, Fischer R, Kessler BM, Carrero ZI, Guardavaccaro D, Pagano M, D'Angiolella V., Free PMC Article | 12/14/2019 |
| the cyclin F-RBPJ axis has a key role in response to metabolic stress in cancer cells | Cyclin F-Dependent Degradation of RBPJ Inhibits IDH1(R132H)-Mediated Tumorigenesis.
Deshmukh RS, Sharma S, Das S. | 10/12/2019 |
| Higher mRNA expression levels of FBXO1, FBXO31, SKP2, and FBXO5 were significantly associated with worse prognosis for breast cancer patients. (Review) | Prognostic values of F-box members in breast cancer: an online database analysis and literature review.
Wang X, Zhang T, Zhang S, Shan J., Free PMC Article | 07/27/2019 |
| A single missense mutation in cyclin F causes hyper-ubiquitylation of proteins that can indirectly impair the autophagy degradation pathway, which is implicated in amyotrophic lateral sclerosis pathogenesis. | Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy.
Lee A, Rayner SL, Gwee SSL, De Luca A, Shahheydari H, Sundaramoorthy V, Ragagnin A, Morsch M, Radford R, Galper J, Freckleton S, Shi B, Walker AK, Don EK, Cole NJ, Yang S, Williams KL, Yerbury JJ, Blair IP, Atkin JD, Molloy MP, Chung RS., Free PMC Article | 10/27/2018 |
| Cyclin F and ribonucleotide reductase family member 2 (RRM2) compose a functional axis responsible for nucleotide metabolism. Impairment in this pathway may contribute to increased DNA damage repair and drug resistance. Additionally, we analyzed the expression of RRM2 mRNA and discovered that high expression of RRM2 is associated with worse overall survival. | Potential role of cyclin F mRNA expression in the survival of skin melanoma patients: Comprehensive analysis of the pathways altered due to cyclin F upregulation.
Gagat M, Krajewski A, Grzanka D, Grzanka A., Free PMC Article | 10/13/2018 |
| Mutational spectrum of CCNF emphasizes the pathogenic role of CCNF mutations in ALS. | Investigating CCNF mutations in a Taiwanese cohort with amyotrophic lateral sclerosis.
Tsai PC, Liao YC, Chen PL, Guo YC, Chen YH, Jih KY, Lin KP, Soong BW, Tsai CP, Lee YC. | 09/29/2018 |
| Our result indicates that the mutation of CCNF is rare in patients with amyotrophic lateral sclerosis and frontotemporal dementia from Mainland China | Mutations of CCNF gene is rare in patients with amyotrophic lateral sclerosis and frontotemporal dementia from Mainland China.
Pan C, Jiao B, Xiao T, Hou L, Zhang W, Liu X, Xu J, Tang B, Shen L. | 03/3/2018 |
| These data indicate that the coordinated, temporal ordering of cyclin F and Cdh1 degradation, organized in a double-negative feedback loop, represents a fundamental aspect of cell-cycle control | APC/C and SCF(cyclin F) Constitute a Reciprocal Feedback Circuit Controlling S-Phase Entry.
Choudhury R, Bonacci T, Arceci A, Lahiri D, Mills CA, Kernan JL, Branigan TB, DeCaprio JA, Burke DJ, Emanuele MJ., Free PMC Article | 02/10/2018 |
| Authors demonstrated a significant correlation between the severity of the CCNF-induced axonopathy and a reduced motor response to a light stimulus (photomotor response). | Expression of ALS/FTD-linked mutant CCNF in zebrafish leads to increased cell death in the spinal cord and an aberrant motor phenotype.
Hogan AL, Don EK, Rayner SL, Lee A, Laird AS, Watchon M, Winnick C, Tarr IS, Morsch M, Fifita JA, Gwee SSL, Formella I, Hortle E, Yuan KC, Molloy MP, Williams KL, Nicholson GA, Chung RS, Blair IP, Cole NJ. | 01/13/2018 |
| Cyclin F-mediated degradation of SLBP limits H2A.X accumulation and apoptosis upon genotoxic stress in G2 cell cycle checkpoint. | Cyclin F-Mediated Degradation of SLBP Limits H2A.X Accumulation and Apoptosis upon Genotoxic Stress in G2.
Dankert JF, Rona G, Clijsters L, Geter P, Skaar JR, Bermudez-Hernandez K, Sassani E, Fenyö D, Ueberheide B, Schneider R, Pagano M., Free PMC Article | 09/2/2017 |
| cyclin F is a novel F-box protein that functions as an intrinsic cellular regulator of HIV-1 Vif and has a negative regulatory effect on the maintenance of viral infectivity by restoring APOBEC3G expression | Cyclin F/FBXO1 Interacts with HIV-1 Viral Infectivity Factor (Vif) and Restricts Progeny Virion Infectivity by Ubiquitination and Proteasomal Degradation of Vif Protein through SCF(cyclin F) E3 Ligase Machinery.
Augustine T, Chaudhary P, Gupta K, Islam S, Ghosh P, Santra MK, Mitra D., Free PMC Article | 06/24/2017 |
| The SCYL1- BP1 affects the cell cycle through increasing steady state levels of Cyclin F and RRM2 proteins, thus constituting a dual regulatory circuit. | SCYL1-BP1 affects cell cycle arrest in human hepatocellular carcinoma cells via Cyclin F and RRM2.
Wang Y, Zhi Q, Ye Q, Zhou C, Zhang L, Yan W, Wu Q, Zhang D, Li P, Huo K. | 11/5/2016 |