| PLOD3 facilitated T cell activation in the colorectal tumor microenvironment and liver metastasis by the TNF-alpha/ NF-kappaB pathway. | PLOD3 facilitated T cell activation in the colorectal tumor microenvironment and liver metastasis by the TNF-α/ NF-κB pathway.
Ding M, Wang C, Hu J, She J, Shi R, Liu Y, Sun Q, Xu H, Zhou G, Wu W, Xia H., Free PMC Article | 01/10/2024 |
| Lysyl hydroxylase 3-mediated post-translational modifications are required for proper biosynthesis of collagen alpha1alpha1alpha2(IV). | Lysyl hydroxylase 3-mediated post-translational modifications are required for proper biosynthesis of collagen α1α1α2(IV).
Ishikawa Y, Taga Y, Coste T, Tufa SF, Keene DR, Mizuno K, Tournier-Lasserve E, Gould DB., Free PMC Article | 01/14/2023 |
| PLOD3 regulates the expression of YAP1 to affect the progression of non-small cell lung cancer via the PKCdelta/CDK1/LIMD1 signaling pathway. | PLOD3 regulates the expression of YAP1 to affect the progression of non-small cell lung cancer via the PKCδ/CDK1/LIMD1 signaling pathway.
Li WH, Huang K, Wen FB, Cui GH, Guo HZ, Zhao S. | 04/30/2022 |
| Polypeptide N-acetylgalactosaminyltransferase 18 retains in endoplasmic reticulum depending on its luminal regions interacting with ER resident UGGT1, PLOD3 and LPCAT1. | Polypeptide N-acetylgalactosaminyltransferase 18 retains in endoplasmic reticulum depending on its luminal regions interacting with ER resident UGGT1, PLOD3 and LPCAT1.
Jia W, Zou X, Xu Z, Bai L, Shan A, Li Y, Shi J, Yang F, Ding C, Narimatsu H, Zhang Y. | 04/9/2022 |
| COLGALT2 is overexpressed in ovarian cancer and interacts with PLOD3. | COLGALT2 is overexpressed in ovarian cancer and interacts with PLOD3.
Guo T, Li B, Kang Y, Gu C, Fang F, Chen X, Liu X, Lu G, Feng C, Xu C., Free PMC Article | 01/15/2022 |
| Characterization of a cancer-associated Epstein-Barr virus EBNA1 variant reveals a novel interaction with PLOD1 and PLOD3. | Characterization of a cancer-associated Epstein-Barr virus EBNA1 variant reveals a novel interaction with PLOD1 and PLOD3.
Shire K, Marcon E, Greenblatt J, Frappier L. | 01/8/2022 |
| Integrated Profiling Identifies PLOD3 as a Potential Prognostic and Immunotherapy Relevant Biomarker in Colorectal Cancer. | Integrated Profiling Identifies PLOD3 as a Potential Prognostic and Immunotherapy Relevant Biomarker in Colorectal Cancer.
Shi J, Bao M, Wang W, Wu X, Li Y, Zhao C, Liu W., Free PMC Article | 12/25/2021 |
| A Human Pan-Cancer System Analysis of Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase 3 (PLOD3). | A Human Pan-Cancer System Analysis of Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase 3 (PLOD3).
Gong S, Duan Y, Wu C, Osterhoff G, Schopow N, Kallendrusch S., Free PMC Article | 10/23/2021 |
| PLOD3 Is Associated with Immune Cell Infiltration and Genomic Instability in Colon Adenocarcinoma. | PLOD3 Is Associated with Immune Cell Infiltration and Genomic Instability in Colon Adenocarcinoma.
Deng X, Pan Y, Yang M, Liu Y, Li J., Free PMC Article | 10/23/2021 |
| Involvement of LH3 and GLT25D1 for glucosyl-galactosyl-hydroxylation on non-collagen-like domain of FGL1. | Involvement of LH3 and GLT25D1 for glucosyl-galactosyl-hydroxylation on non-collagen-like domain of FGL1.
Mori K, Suzuki T, Miura K, Dohmae N, Simizu S. | 08/28/2021 |
| PLODs are overexpressed in ovarian cancer and are associated with gap junctions via connexin 43. | PLODs are overexpressed in ovarian cancer and are associated with gap junctions via connexin 43.
Guo T, Gu C, Li B, Xu C. | 08/7/2021 |
| Knockdown of PLOD3 suppresses the malignant progression of renal cell carcinoma via reducing TWIST1 expression. | Knockdown of PLOD3 suppresses the malignant progression of renal cell carcinoma via reducing TWIST1 expression.
Xie D, Li J, Wei S, Qi P, Ji H, Su J, Du N, Zhang X. | 07/17/2021 |
| Procollagen-lysine, 2-oxoglutarate 5-dioxygenases 1, 2, and 3 are potential prognostic indicators in patients with clear cell renal cell carcinoma. | Procollagen-lysine, 2-oxoglutarate 5-dioxygenases 1, 2, and 3 are potential prognostic indicators in patients with clear cell renal cell carcinoma.
Xu WH, Xu Y, Wang J, Tian X, Wu J, Wan FN, Wang HK, Qu YY, Zhang HL, Ye DW., Free PMC Article | 09/5/2020 |
| These data are consistent with pathogenic variants in PLOD3 resulting in a clinically distinct Stickler-like syndrome with vascular complications and variable features of EDS and EB. Early identification of PLOD3 variants would improve monitoring for comorbidities and may avoid serious adverse ocular and vascular outcomes. | Pathogenic variants in PLOD3 result in a Stickler syndrome-like connective tissue disorder with vascular complications.
Ewans LJ, Colley A, Gaston-Massuet C, Gualtieri A, Cowley MJ, McCabe MJ, Anand D, Lachke SA, Scietti L, Forneris F, Zhu Y, Ying K, Walsh C, Kirk EP, Miller D, Giunta C, Sillence D, Dinger M, Buckley M, Roscioli T. | 06/13/2020 |
| PLOD3 siRNA suppresses radioresistance and chemoresistance by inducing apoptosis and renders PLOD3 as a candidate lung cancer biomarker. | PLOD3 suppression exerts an anti-tumor effect on human lung cancer cells by modulating the PKC-delta signaling pathway.
Baek JH, Yun HS, Kwon GT, Lee J, Kim JY, Jo Y, Cho JM, Lee CW, Song JY, Ahn J, Kim JS, Kim EH, Hwang SG., Free PMC Article | 04/11/2020 |
| our results demonstrate the novel function of the collagen-like glycosylation of CCN1 and suggest that lysyl hydroxylase3-mediated glycosylation is important for CCN1 secretion. | Identification and characterization of collagen-like glycosylation and hydroxylation of CCN1.
Ishizawa Y, Niwa Y, Suzuki T, Kawahara R, Dohmae N, Simizu S. | 04/11/2020 |
| These results indicate that PLOD3 promotes lung cancer metastasis in a RAS-MAP kinase pathway-independent manner. Therefore, secreted PLOD3 serves as a potent inducer of lung cancer metastasis and a potential therapeutic target to enhance survival in lung cancer. | PLOD3 promotes lung metastasis via regulation of STAT3.
Baek JH, Yun HS, Kwon GT, Kim JY, Lee CW, Song JY, Um HD, Kang CM, Park JK, Kim JS, Kim EH, Hwang SG., Free PMC Article | 12/14/2019 |
| Results indicate that procollagen-lysine, 2-oxoglutarate 5-dioxygenase (PLOD3) may promote the progression of gastric cancer (GC). | PLOD3 is Upregulated in Gastric Cancer and Correlated with Clinicopathologic Characteristics.
Wang B, Xu L, Ge Y, Cai X, Li Q, Yu Z, Wang J, Wang Y, Lu C, Wang D, Wang Y, Chen X, Gu Y. | 11/30/2019 |
| VIPAR, with its partner proteins, regulate sorting of lysyl hydroxylase 3 (LH3, also known as PLOD3) into newly identified post-Golgi collagen IV carriers | Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis.
Banushi B, Forneris F, Straatman-Iwanowska A, Strange A, Lyne AM, Rogerson C, Burden JJ, Heywood WE, Hanley J, Doykov I, Straatman KR, Smith H, Bem D, Kriston-Vizi J, Ariceta G, Risteli M, Wang C, Ardill RE, Zaniew M, Latka-Grot J, Waddington SN, Howe SJ, Ferraro F, Gjinovci A, Lawrence S, Marsh M, Girolami M, Bozec L, Mills K, Gissen P., Free PMC Article | 09/1/2018 |
| Proteomic analysis revealed that PLOD3, which is the gene encoding for collagen-modifying lysyl hydroxylase 3 (LH3), is regulated by miR-663a. | Identification of a microRNA (miR-663a) induced by ER stress and its target gene PLOD3 by a combined microRNome and proteome approach.
Amodio G, Sasso E, D'Ambrosio C, Scaloni A, Moltedo O, Franceschelli S, Zambrano N, Remondelli P. | 09/23/2017 |
| The study shows that lysyl hydroxylase 3 localizes to epidermal basement membrane and is reduced in patients with recessive dystrophic epidermolysis bullosa. | Lysyl Hydroxylase 3 Localizes to Epidermal Basement Membrane and Is Reduced in Patients with Recessive Dystrophic Epidermolysis Bullosa.
Watt SA, Dayal JH, Wright S, Riddle M, Pourreyron C, McMillan JR, Kimble RM, Prisco M, Gartner U, Warbrick E, McLean WH, Leigh IM, McGrath JA, Salas-Alanis JC, Tolar J, South AP., Free PMC Article | 06/4/2016 |
| MMP-9 recruitment to the fibroblast cell surface by Lysyl Hydroxylase 3 (LH3) triggers TGF-beta activation and fibroblast differentiation | Recruitment of Matrix Metalloproteinase-9 (MMP-9) to the Fibroblast Cell Surface by Lysyl Hydroxylase 3 (LH3) Triggers Transforming Growth Factor-β (TGF-β) Activation and Fibroblast Differentiation.
Dayer C, Stamenkovic I., Free PMC Article | 08/22/2015 |
| LH3 molecules found in the cell medium are secreted through the Golgi complex, and the secretion is dependent on LH3 glycosyltransferase activity; LH3 found on the cell surface bypasses the Golgi complex | Lysyl hydroxylase 3 is secreted from cells by two pathways.
Wang C, Ristiluoma MM, Salo AM, Eskelinen S, Myllylä R. | 02/4/2012 |
| Dimerization of human lysyl hydroxylase 3 is mediated by the amino acids 541-547 | Dimerization of human lysyl hydroxylase 3 (LH3) is mediated by the amino acids 541-547.
Heikkinen J, Risteli M, Lampela O, Alavesa P, Karppinen M, Juffer AH, Myllylä R. | 07/2/2011 |
| The deficiency of LH3 glycosyltransferase activities, especially in the extracellular space, causes growth arrest. | The glycosyltransferase activities of lysyl hydroxylase 3 (LH3) in the extracellular space are important for cell growth and viability.
Wang C, Kovanen V, Raudasoja P, Eskelinen S, Pospiech H, Myllylä R., Free PMC Article | 01/21/2010 |