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    Cx3cl1 C-X3-C motif chemokine ligand 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 89808, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Expression and significance of Fractalkine/CX3CL1 in MPO-AAV-associated glomerulonephritis rats.

    Expression and significance of Fractalkine/CX3CL1 in MPO-AAV-associated glomerulonephritis rats.
    Ma J, Wang J, Kang H, Ma R, Zhu Z., Free PMC Article

    07/19/2024
    Spinal Cord Stimulation Increases Chemoefficacy and Prevents Paclitaxel-Induced Pain via CX3CL1.

    Spinal Cord Stimulation Increases Chemoefficacy and Prevents Paclitaxel-Induced Pain via CX3CL1.
    Sivanesan E, Sanchez KR, Zhang C, He SQ, Linderoth B, Stephens KE, Raja SN, Guan Y., Free PMC Article

    07/23/2023
    Dapagliflozin Protects H9c2 Cells Against Injury Induced by Lipopolysaccharide via Suppression of CX3CL1/CX3CR1 Axis and NF-kappaB Activity.

    Dapagliflozin Protects H9c2 Cells Against Injury Induced by Lipopolysaccharide via Suppression of CX3CL1/CX3CR1 Axis and NF-κB Activity.
    Faridvand Y, Nemati M, Zamani-Gharehchamani E, Nejabati HR, Zamani ARN, Nozari S, Safaie N, Nouri M, Jodati A.

    07/23/2022
    FKN/CX3CR1 axis facilitates migraine-Like behaviour by activating thalamic-cortical network microglia in status epilepticus model rats.

    FKN/CX3CR1 axis facilitates migraine-Like behaviour by activating thalamic-cortical network microglia in status epilepticus model rats.
    Zhou Y, Zhang L, Hao Y, Yang L, Fan S, Xiao Z., Free PMC Article

    04/16/2022
    Bone marrow stromal cells reverse the microglia type from pro-inflammatory tumour necrosis factor a microglia to anti-inflammatory CD206 microglia of middle cerebral artery occlusion rats through triggering secretion of CX3CL1.

    Bone marrow stromal cells reverse the microglia type from pro-inflammatory tumour necrosis factor a microglia to anti-inflammatory CD206 microglia of middle cerebral artery occlusion rats through triggering secretion of CX3CL1.
    Bai XJ, Hao L, Guo YE, Shi XB, Wu WP.

    11/27/2021
    MicroRNA-195 prevents hippocampal microglial/macrophage polarization towards the M1 phenotype induced by chronic brain hypoperfusion through regulating CX3CL1/CX3CR1 signaling.

    MicroRNA-195 prevents hippocampal microglial/macrophage polarization towards the M1 phenotype induced by chronic brain hypoperfusion through regulating CX3CL1/CX3CR1 signaling.
    Mao M, Xu Y, Zhang XY, Yang L, An XB, Qu Y, Chai YN, Wang YR, Li TT, Ai J., Free PMC Article

    07/17/2021
    Leptin and fractalkine: novel subcutaneous cytokines in burn injury.

    Leptin and fractalkine: novel subcutaneous cytokines in burn injury.
    Friston D, Junttila S, Lemes JBP, Laycock H, Torres-Perez JV, Want E, Gyenesei A, Nagy I., Free PMC Article

    06/12/2021
    CX3CL1/CX3CR1 axis attenuates early brain injury via promoting the delivery of exosomal microRNA-124 from neuron to microglia after subarachnoid hemorrhage.

    CX3CL1/CX3CR1 axis attenuates early brain injury via promoting the delivery of exosomal microRNA-124 from neuron to microglia after subarachnoid hemorrhage.
    Chen X, Jiang M, Li H, Wang Y, Shen H, Li X, Zhang Y, Wu J, Yu Z, Chen G., Free PMC Article

    05/29/2021
    Maternal Immune Activation Sensitizes Male Offspring Rats to Lipopolysaccharide-Induced Microglial Deficits Involving the Dysfunction of CD200-CD200R and CX3CL1-CX3CR1 Systems.

    Maternal Immune Activation Sensitizes Male Offspring Rats to Lipopolysaccharide-Induced Microglial Deficits Involving the Dysfunction of CD200-CD200R and CX3CL1-CX3CR1 Systems.
    Chamera K, Szuster-Głuszczak M, Trojan E, Basta-Kaim A., Free PMC Article

    03/6/2021
    MMP-9 regulates CX3CL1/CX3CR1 in the early phase of neuropathic pain in chronic sciatic nerve constriction injury (CCI) rats.

    MMP-9 regulates CX3CL1/CX3CR1 in the early phase of neuropathic pain in chronic sciatic nerve constriction injury (CCI) rats.
    Zhao L, Song C, Huang Y, Lei W, Sun J.

    02/27/2021
    CX3CL1/CX3CR1-signalling in the CD9/S100beta/SOX2-positive adult pituitary stem/progenitor cells modulates differentiation into endothelial cells.

    CX3CL1/CX3CR1-signalling in the CD9/S100β/SOX2-positive adult pituitary stem/progenitor cells modulates differentiation into endothelial cells.
    Horiguchi K, Fujiwara K, Yoshida S, Tsukada T, Hasegawa R, Takigami S, Ohsako S, Yashiro T, Kato T, Kato Y.

    12/19/2020
    Study shows that a persistent model of inflammatory hypernociception induced by arthritis in the temporomandibular joint elicited protein levels of P2X7 receptors, cathepsin S and fractalkine in the trigeminal subnucleus caudalis. Cx3cl1

    The P2X7 Receptor, Cathepsin S and Fractalkine in the Trigeminal Subnucleus Caudalis Signal Persistent Hypernociception in Temporomandibular Rat Joints.
    Bonfante R, Napimoga MH, Macedo CG, Abdalla HB, Pieroni V, Clemente-Napimoga JT.

    03/2/2019
    that activation of STAT3 after /muscle incision and retraction mediates the up-regulation of CX3CL1

    Up-Regulation of CX3CL1 via STAT3 Contributes to SMIR-Induced Chronic Postsurgical Pain.
    Shen Y, Li D, Li B, Xi P, Zhang Y, Jiang Y, Xu Y, Chen H, Xiong Y.

    09/1/2018
    These results suggest that upregulation of CX3CL1 in dorsal root ganglion mediated by NF-kappaB activation contributes to the peripheral sensitization and chronic pain induced by oxaliplatin administration.

    Upregulation of CX3CL1 mediated by NF-κB activation in dorsal root ganglion contributes to peripheral sensitization and chronic pain induced by oxaliplatin administration.
    Wang J, Zhang XS, Tao R, Zhang J, Liu L, Jiang YH, Ma SH, Song LX, Xia LJ., Free PMC Article

    07/28/2018
    basal fractalkine signalling within the trigeminal ganglion plays an important role in mechanical sensitivity of masticatory muscle sensory afferent fibers and that inhibition of CX3CR1 signaling within the trigeminal ganglia may induce analgesia through a peripheral mechanism.

    Elevated Fractalkine (CX3CL1) Levels in the Trigeminal Ganglion Mechanically Sensitize Temporalis Muscle Nociceptors.
    Cairns BE, O'Brien M, Dong XD, Gazerani P.

    03/10/2018
    Study demonstrates that noradrenaline (NA) induces the production of CX3CL1 in neurons and that the activation of beta2-adrenergic receptors is involved in the process. The increased mRNA levels and the accumulation of this protein in the cells indicate that NA treatment stimulates neuronal expression and synthesis of CX3CL1.

    Noradrenaline induces CX3CL1 production and release by neurons.
    Madrigal JL, Caso JR, García-Bueno B, Gutiérrez IL, Leza JC.

    07/15/2017
    CX3CL1(+) apo-MPs released by apoptotic cells mediate the chemotactic transmigration of alveolar macrophages.

    CX3CL1(+) microparticles mediate the chemoattraction of alveolar macrophages toward apoptotic acute promyelocytic leukemic cells.
    Tsai WH, Shih CH, Feng SY, Li IT, Chang SC, Lin YC, Hsu HC.

    08/6/2016
    CX3CL1/CX3CR1 signaling is involved in LTP of C-fiber-evoked field potentials in the rodent spinal dorsal horn

    Involvement of CX3CL1/CX3CR1 signaling in spinal long term potentiation.
    Bian C, Zhao ZQ, Zhang YQ, Lü N., Free PMC Article

    01/30/2016
    Cx3cl1 overexpression suppresses alpha-synuclein-mediated neurodegeneration.

    Fractalkine over expression suppresses α-synuclein-mediated neurodegeneration.
    Nash KR, Moran P, Finneran DJ, Hudson C, Robinson J, Morgan D, Bickford PC., Free PMC Article

    10/3/2015
    up-regulation of CX3CL1 via NF-kappaB-dependent H4 acetylation might be critical for paclitaxel-induced mechanical allodynia

    Up-regulation of CX3CL1 via Nuclear Factor-κB-dependent Histone Acetylation Is Involved in Paclitaxel-induced Peripheral Neuropathy.
    Li D, Huang ZZ, Ling YZ, Wei JY, Cui Y, Zhang XZ, Zhu HQ, Xin WJ.

    08/1/2015
    CX3CL1 activates Jak2-Stat5alpha-ERK1/2 signaling through CX3CR1, thereby triggering integrin-dependent machinery reorganization to allow chemotactic migration of bone marrow-derived mesenchymal stem cells towards an ischemic cerebral lesion.

    Fractalkine promotes chemotaxis of bone marrow-derived mesenchymal stem cells towards ischemic brain lesions through Jak2 signaling and cytoskeletal reorganization.
    Zhang Y, Zheng J, Zhou Z, Zhou H, Wang Y, Gong Z, Zhu J.

    05/9/2015
    These findings identify a novel mechanistic interaction between the ET-1/ETB receptor axis and CX3CL1/CX3CR1 in mediating pulmonary angiogenesis and vascular monocyte accumulation in experimental HPS.

    Endothelin-1 activation of the endothelin B receptor modulates pulmonary endothelial CX3CL1 and contributes to pulmonary angiogenesis in experimental hepatopulmonary syndrome.
    Zhang J, Yang W, Hu B, Wu W, Fallon MB., Free PMC Article

    01/3/2015
    CX3CR1 modulate cardiovascular function.

    The cardiovascular actions of fractalkine/CX3CL1 in the hypothalamic paraventricular nucleus are attenuated in rats with heart failure.
    Ruchaya PJ, Antunes VR, Paton JF, Murphy D, Yao ST.

    09/27/2014
    This is the first study to identify CX3CL1 signaling through CX3CR1 via the DRG/SC anatomical connection that represents a critical pathway involved in NPP induction in an EAE model of MS.

    Elevated expression of fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) in the dorsal root ganglia and spinal cord in experimental autoimmune encephalomyelitis: implications in multiple sclerosis-induced neuropathic pain.
    Zhu W, Acosta C, MacNeil B, Cortes C, Intrater H, Gong Y, Namaka M., Free PMC Article

    06/14/2014
    Anti-T-lymphocyte globulin depleted fractalkine, inhibiting migration of dendritic cells and macrophages into the kidney, reducing ischemia-reperfusion injury.

    A novel mechanism of anti-T-lymphocyte globulin mediated by fractalkine in renal ischemia-reperfusion injury in rats.
    Gunay Y, Inal A, Yener N, Sinanoglu O, Selvi O, Bircan HY.

    05/3/2014
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