| Targeting diacylglycerol kinase alpha impairs lung tumorigenesis by inhibiting cyclin D3. | Targeting diacylglycerol kinase α impairs lung tumorigenesis by inhibiting cyclin D3.
Zhou D, Liu T, Rao X, Jie X, Chen Y, Wu Z, Deng H, Zhang D, Wang J, Wu G., Free PMC Article | 05/12/2023 |
| Cyclin D3 restricts SARS-CoV-2 envelope incorporation into virions and interferes with viral spread. | Cyclin D3 restricts SARS-CoV-2 envelope incorporation into virions and interferes with viral spread.
Gupta RK, Mlcochova P., Free PMC Article | 11/26/2022 |
| Recurrent Mutations in Cyclin D3 Confer Clinical Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia. | Recurrent Mutations in Cyclin D3 Confer Clinical Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia.
Smith CC, Viny AD, Massi E, Kandoth C, Socci ND, Rapaport F, Najm M, Medina-Martinez JS, Papaemmanuil E, Tarver TC, Hsu HH, Le MH, West B, Bollag G, Taylor BS, Levine RL, Shah NP., Free PMC Article | 04/2/2022 |
| CircMYLK promotes the growth, migration, invasion, and survival of bladder cancer cells by upregulating CCND3 level via competitively binding to miR-34a. | CircMYLK promotes the growth, migration, invasion, and survival of bladder cancer cells by upregulating CCND3 level via competitively binding to miR-34a.
Ye W, Chen L, Feng C, Liang T. | 04/2/2022 |
| Keratin 19 interacts with GSK3beta to regulate its nuclear accumulation and degradation of cyclin D3. | Keratin 19 interacts with GSK3β to regulate its nuclear accumulation and degradation of cyclin D3.
Sharma P, Tiufekchiev S, Lising V, Chung SW, Suk JS, Chung BM., Free PMC Article | 03/26/2022 |
| CCND2 played an oncogenic role in gastric cancer, whereas it could also be a tumor suppressor in NSCLC. | Prognostic role of cyclin D2/D3 in multiple human malignant neoplasms: A systematic review and meta-analysis.
Ding ZY, Li R, Zhang QJ, Wang Y, Jiang Y, Meng QY, Xi QL, Wu GH., Free PMC Article | 07/11/2020 |
| miR-195 targets cyclin D3 to cause cell cycle arrest at the G1 phase and that miR-195 targets survivin to induce apoptosis and senescence in NSCLC cells. Overexpression of cyclin D3 or survivin reverses the effects of miR-195 in NSCLC cells. | miR-195 targets cyclin D3 and survivin to modulate the tumorigenesis of non-small cell lung cancer.
Yu X, Zhang Y, Cavazos D, Ma X, Zhao Z, Du L, Pertsemlidis A., Free PMC Article | 11/30/2019 |
| virtually all cyclin D1(-) mantle cell lymphoma carry CCND2/CCND3 rearrangements with immunoglobulin genes, including a novel IGK/L enhancer hijacking mechanism | CCND2 and CCND3 hijack immunoglobulin light-chain enhancers in cyclin D1(-) mantle cell lymphoma.
Martín-Garcia D, Navarro A, Valdés-Mas R, Clot G, Gutiérrez-Abril J, Prieto M, Ribera-Cortada I, Woroniecka R, Rymkiewicz G, Bens S, de Leval L, Rosenwald A, Ferry JA, Hsi ED, Fu K, Delabie J, Weisenburger D, de Jong D, Climent F, O'Connor SJ, Swerdlow SH, Torrents D, Beltran S, Espinet B, González-Farré B, Veloza L, Costa D, Matutes E, Siebert R, Ott G, Quintanilla-Martinez L, Jaffe ES, López-Otín C, Salaverria I, Puente XS, Campo E, Beà S., Free PMC Article | 11/16/2019 |
| Cyclin D3 expression is regulated by Hes3 in lung cancer cells. | Hes3 Enhances the Malignant Phenotype of Lung Cancer through Upregulating Cyclin D1, Cyclin D3 and MMP7 Expression.
Fang C, Jiang B, Shi X, Fan C., Free PMC Article | 07/27/2019 |
| The novel tumor suppressor miR-4779 inhibits cancer cell growth via cell cycle arrest and apoptosis by directly targeting PAK2 and CCND3. | MicroRNA miR-4779 suppresses tumor growth by inducing apoptosis and cell cycle arrest through direct targeting of PAK2 and CCND3.
Koo KH, Kwon H., Free PMC Article | 06/22/2019 |
| The Novel Short Isoform of Securin Stimulates the Expression of Cyclin D3 and Angiogenesis Factors VEGFA and FGF2, but Does Not Affect the Expression of MYC Transcription Factor | [The Novel Short Isoform of Securin Stimulates the Expression of Cyclin D3 and Angiogenesis Factors VEGFA and FGF2, but Does Not Affect the Expression of MYC Transcription Factor].
Demin DE, Bogolyubova AV, Zlenko DV, Uvarova AN, Deikin AV, Putlyaeva LV, Belousov PV, Mitkin NA, Korneev KV, Sviryaeva EN, Kulakovskiy IV, Tatosyan KA, Kuprash DV, Schwartz AM. | 12/22/2018 |
| miR-212 exerts growth-suppressive effects in Adult T-cell leukemia/lymphoma (ATL) cells largely by targeting CCND3 and may have therapeutic potential in ATL. | Restoration of microRNA-212 causes a G0/G1 cell cycle arrest and apoptosis in adult T-cell leukemia/lymphoma cells by repressing CCND3 expression.
Wang H, Guo Q, Yang P, Long G. | 02/10/2018 |
| Cyclin D3 is expressed in the majority of splenic diffuse red pulp small B-cell lymphomas. Increased expression is sometimes the result of somatic mutations in the PEST domain of the CCND3 gene. | Splenic diffuse red pulp small B-cell lymphoma displays increased expression of cyclin D3 and recurrent CCND3 mutations.
Curiel-Olmo S, Mondéjar R, Almaraz C, Mollejo M, Cereceda L, Marès R, Derdak S, Campos-Martín Y, Batlle A, González de Villambrosía S, Gut M, Blanc J, Traverse-Glehen A, Verney A, Baseggio L, Camacho FI, Wotherspoon A, Stamatopoulos K, Xochelli A, Papadaki T, Kanellis G, Ponzoni M, García-Cosío M, Vaqué JP, Beltrán S, Gut I, Piris MA, Martínez N. | 01/27/2018 |
| in ovarian cancer cells, DOT1L regulates the transcription of G1 phase genes CDK6 and CCND3 through H3K79 dimethylation | Prognostic and therapeutic value of disruptor of telomeric silencing-1-like (DOT1L) expression in patients with ovarian cancer.
Zhang X, Liu D, Li M, Cao C, Wan D, Xi B, Li W, Tan J, Wang J, Wu Z, Ma D, Gao Q., Free PMC Article | 12/2/2017 |
| metabolic function of cyclin D3-CDK6 kinase in cancer cell survival | The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival.
Wang H, Nicolay BN, Chick JM, Gao X, Geng Y, Ren H, Gao H, Yang G, Williams JA, Suski JM, Keibler MA, Sicinska E, Gerdemann U, Haining WN, Roberts TM, Polyak K, Gygi SP, Dyson NJ, Sicinski P., Free PMC Article | 10/14/2017 |
| we showed that ZNF224 positively modulates cyclin D3 gene expression. Consistently, we observed that alteration of ZNF224 expression leads to defects in cell cycle control. All together, our results strongly suggest that in Chronic lymphocytic leukaemia (CLL)cells high expression level of ZNF224 can lead to inappropriate cell growth and apoptosis resistance, thus contributing to CLL progression | Role of ZNF224 in cell growth and chemoresistance of chronic lymphocitic leukemia.
Busiello T, Ciano M, Romano S, Sodaro G, Garofalo O, Bruzzese D, Simeone L, Chiurazzi F, Fiammetta Romano M, Costanzo P, Cesaro E. | 09/23/2017 |
| the activation of TLR7 increased CCND3 expression via the downregulation of miR-15b in B cells. | Activation of TLR7 increases CCND3 expression via the downregulation of miR-15b in B cells of systemic lupus erythematosus.
Ren D, Liu F, Dong G, You M, Ji J, Huang Y, Hou Y, Fan H., Free PMC Article | 07/15/2017 |
| This study describes the identification and characterization of cyclin D3 as a novel interactor of influenza A virus M2 protein. | Cell Cycle-independent Role of Cyclin D3 in Host Restriction of Influenza Virus Infection.
Fan Y, Mok CK, Chan MC, Zhang Y, Nal B, Kien F, Bruzzone R, Sanyal S., Free PMC Article | 06/24/2017 |
| MicroRNA-138 interacts with cyclin D3 and negatively regulates non-small cell lung cancer cells | MicroRNA-138 negatively regulates non-small cell lung cancer cells through the interaction with cyclin D3.
Han LP, Fu T, Lin Y, Miao JL, Jiang QF. | 02/18/2017 |
| Combined urinary FGFR3/Cyclin D3 expression shows improved detection rates for bladder cancer recurrence with high specificity and sensitivity. | FGFR3 and Cyclin D3 as urine biomarkers of bladder cancer recurrence.
Blanca A, Requena MJ, Alvarez J, Cheng L, Montironi R, Raspollini MR, Reymundo C, Lopez-Beltran A. | 12/17/2016 |
| cyclin-D1 and cyclin-D3 within human islet cells varies according to the status of the pancreas donor | The subcellular distribution of cyclin-D1 and cyclin-D3 within human islet cells varies according to the status of the pancreas donor.
Taniguchi K, Russell MA, Richardson SJ, Morgan NG. | 06/11/2016 |
| The CDK6-cyclin D3 pair play a fundamental role in controlling CDK2-dependent SAMHD1 phosphorylation and the dNTP pool in primary macrophages. | Cyclin D3-dependent control of the dNTP pool and HIV-1 replication in human macrophages.
Ruiz A, Pauls E, Badia R, Torres-Torronteras J, Riveira-Muñoz E, Clotet B, Martí R, Ballana E, Esté JA., Free PMC Article | 03/5/2016 |
| Two recurrent fusion genes associated with the 12q locus, LRP1-SNRNP25 and KCNMB4-CCND3, were by RT-PCR, Sanger sequencing and FISH, and were found to be osteosarcoma specific in a validation cohort of 240 other sarcomas. | Recurrent LRP1-SNRNP25 and KCNMB4-CCND3 fusion genes promote tumor cell motility in human osteosarcoma.
Yang J, Annala M, Ji P, Wang G, Zheng H, Codgell D, Du X, Fang Z, Sun B, Nykter M, Chen K, Zhang W., Free PMC Article | 11/7/2015 |
| G1 arrest induced by SB265610 occurred at concentrations lacking CXCR2 selectivity and revealed cyclin-dependent kinase 2 (CDK2) (Thr160) hypophosphorylation, cyclin D3 gene down-regulation, and p21 post-translational induction | Induction of G1 Arrest by SB265610 Involves Cyclin D3 Down-regulation and Suppression of CDK2 (Thr160) Phosphorylation.
Goda AE, Erikson RL, Ahn JS, Kim BY. | 08/8/2015 |
| sLZIP regulates the transcription of cyclin D3 by binding directly to the AP-1 region in the cyclin D3 promoter. | The role of sLZIP in cyclin D3-mediated negative regulation of androgen receptor transactivation and its involvement in prostate cancer.
Kim Y, Kim J, Jang SW, Ko J. | 05/2/2015 |