| A dual-activity topoisomerase complex regulates mRNA translation and turnover. | A dual-activity topoisomerase complex regulates mRNA translation and turnover.
Su S, Xue Y, Sharov A, Zhang Y, Lee SK, Martindale JL, Li W, Ku WL, Zhao K, De S, Shen W, Sen P, Gorospe M, Xu D, Wang W., Free PMC Article | 12/17/2022 |
| Structural and biochemical basis for DNA and RNA catalysis by human Topoisomerase 3beta. | Structural and biochemical basis for DNA and RNA catalysis by human Topoisomerase 3β.
Yang X, Saha S, Yang W, Neuman KC, Pommier Y., Free PMC Article | 08/20/2022 |
| DNA and RNA Cleavage Complexes and Repair Pathway for TOP3B RNA- and DNA-Protein Crosslinks. | DNA and RNA Cleavage Complexes and Repair Pathway for TOP3B RNA- and DNA-Protein Crosslinks.
Saha S, Sun Y, Huang SN, Baechler SA, Pongor LS, Agama K, Jo U, Zhang H, Tse-Dinh YC, Pommier Y., Free PMC Article | 10/16/2021 |
| Further evidence of GABRA4 and TOP3B as autism susceptibility genes. | Further evidence of GABRA4 and TOP3B as autism susceptibility genes.
Riley JD, Delahunty C, Alsadah A, Mazzola S, Astbury C. | 01/2/2021 |
| Topoisomerase III-beta is required for efficient replication of positive-sense RNA viruses. | Topoisomerase III-β is required for efficient replication of positive-sense RNA viruses.
Prasanth KR, Hirano M, Fagg WS, McAnarney ET, Shan C, Xie X, Hage A, Pietzsch CA, Bukreyev A, Rajsbaum R, Shi PY, Bedford MT, Bradrick SS, Menachery V, Garcia-Blanco MA., Free PMC Article | 10/31/2020 |
| Our data show that TOP3B is necessary to prevent the accumulation of excessive R-loops and identify TOP3B as a putative cancer gene, and support recent data showing that R-loops are involved in cancer aetiology. | Loss of TOP3B leads to increased R-loop formation and genome instability.
Zhang T, Wallis M, Petrovic V, Challis J, Kalitsis P, Hudson DF., Free PMC Article | 06/6/2020 |
| Findings indicate the regulation of DNA topoisomerase III beta (TOP3B) activity by post-translational modification (PTM). | Arginine methylation of the C-terminus RGG motif promotes TOP3B topoisomerase activity and stress granule localization.
Huang L, Wang Z, Narayanan N, Yang Y., Free PMC Article | 07/27/2019 |
| Structural basis of the interaction between TOP3B and the TDRD3 auxiliary factor has been reported. | Structural basis of the interaction between Topoisomerase IIIβ and the TDRD3 auxiliary factor.
Goto-Ito S, Yamagata A, Takahashi TS, Sato Y, Fukai S., Free PMC Article | 11/3/2018 |
| Results identified TOP3B gene deletion as candidate gene in the etiology of neurodevelopmental disorders including juvenile myoclonic epilepsy. | TOP3B: A Novel Candidate Gene in Juvenile Myoclonic Epilepsy?
Daghsni M, Lahbib S, Fradj M, Sayeb M, Kelmemi W, Kraoua L, Kchaou M, Maazoul F, Echebbi S, Ben Ali N, Abdelhak S, M'rad R. | 04/21/2018 |
| Top3beta mutants lacking either its RNA-binding domain or catalytic residue fail to promote synapse formation, suggesting that Top3beta requires both its mRNA-binding and catalytic activity to facilitate neurodevelopment. | Topoisomerase 3β is the major topoisomerase for mRNAs and linked to neurodevelopment and mental dysfunction.
Ahmad M, Shen W, Li W, Xue Y, Zou S, Xu D, Wang W., Free PMC Article | 08/12/2017 |
| Top3b proteins from several animals associate with polyribosomes, which are units of mRNA translation, whereas the Top3 homologs from E. coli and yeast lack the association. The Top3b-polyribosome association requires TDRD3, which directly interacts with Top3beta and is present in animals but not bacteria or yeast. | RNA topoisomerase is prevalent in all domains of life and associates with polyribosomes in animals.
Ahmad M, Xue Y, Lee SK, Martindale JL, Shen W, Li W, Zou S, Ciaramella M, Debat H, Nadal M, Leng F, Zhang H, Wang Q, Siaw GE, Niu H, Pommier Y, Gorospe M, Hsieh TS, Tse-Dinh YC, Xu D, Wang W., Free PMC Article | 06/24/2017 |
| TOP3B promotes transcription, protects against DNA damage, and reduces the frequency of chromosomal translocations. | Arginine methylation facilitates the recruitment of TOP3B to chromatin to prevent R loop accumulation.
Yang Y, McBride KM, Hensley S, Lu Y, Chedin F, Bedford MT., Free PMC Article | 05/10/2014 |
| Topoisomerase IIIbeta expression can be a useful marker in assessing the prognosis of patients with breast cancer and is an independent predictor of survival. | Significance of topoisomerase IIIβ expression in breast ductal carcinomas: strong associations with disease-specific survival and metastasis.
Oliveira-Costa JP, Zanetti J, Oliveira LR, Soares FA, Ramalho LZ, Silva Ramalho F, Garcia SB, Ribeiro-Silva A. | 11/13/2010 |
| the positive regulatory region including the 5'GGAACC3' core element is essential for efficient expression of the DNA topoisomerase III beta gene | Identification of the functional elements in the promoter region of human DNA topoisomerase IIIbeta gene.
Cho YH, Park JY, Han SY, Chung IK. | 01/21/2010 |
| Two isoforms of human DNA topoisomerase IIIbeta were expressed in HeLa cells. Isoform 1 was localized to the nucleus and associated with chromosomes during metaphase and anaphase. Isoform 2 was found in the cytoplasm. | M phase-specific association of human topoisomerase IIIbeta with chromosomes.
Kobayashi M, Hanai R. | 10/2/2001 |