| Breast cancer risk is associated with the HULC rs7763881, MTMR3 rs12537 polymorphisms, and serum levels of HULC and MTMR3 in Egyptian patients. | Breast cancer risk is associated with the HULC rs7763881, MTMR3 rs12537 polymorphisms, and serum levels of HULC and MTMR3 in Egyptian patients.
Elhelaly M, Shaker OG, Ayeldeen G, Elsergany AR, Mostafa N., Free PMC Article | 11/28/2023 |
| MTMR3 risk alleles enhance Toll Like Receptor 9-induced IgA immunity in IgA nephropathy. | MTMR3 risk alleles enhance Toll Like Receptor 9-induced IgA immunity in IgA nephropathy.
Wang YN, Gan T, Qu S, Xu LL, Hu Y, Liu LJ, Shi SF, Lv JC, Tsoi LC, Patrick MT, He K, Berthier CC, Xu HJ, Zhou XJ, Zhang H. | 08/25/2023 |
| miR-100-5p is upregulated in multiple myeloma and involves in the pathogenesis of multiple myeloma through targeting MTMR3. | miR-100-5p is upregulated in multiple myeloma and involves in the pathogenesis of multiple myeloma through targeting MTMR3.
Wei X, Feng Y, Fu Y, Liu F, Chen Q, Zhang W, Zhao Y, Huang X, Chen Y, Li Q, Zhang Q. | 04/7/2023 |
| Circular RNA MCTP2 inhibits cisplatin resistance in gastric cancer by miR-99a-5p-mediated induction of MTMR3 expression. | Circular RNA MCTP2 inhibits cisplatin resistance in gastric cancer by miR-99a-5p-mediated induction of MTMR3 expression.
Sun G, Li Z, He Z, Wang W, Wang S, Zhang X, Cao J, Xu P, Wang H, Huang X, Xia Y, Lv J, Xuan Z, Jiang T, Fang L, Yang J, Zhang D, Xu H, Xu Z., Free PMC Article | 07/31/2021 |
| Exosomal miR-1910-3p promotes proliferation, metastasis, and autophagy of breast cancer cells by targeting MTMR3 and activating the NF-kappaB signaling pathway. | Exosomal miR-1910-3p promotes proliferation, metastasis, and autophagy of breast cancer cells by targeting MTMR3 and activating the NF-κB signaling pathway.
Wang B, Mao JH, Wang BY, Wang LX, Wen HY, Xu LJ, Fu JX, Yang H. | 01/16/2021 |
| Three SNPs of FCRL3 and one SNP of MTMR3 are associated with immunoglobulin A nephropathy risk. | Three SNPs of FCRL3 and one SNP of MTMR3 are associated with immunoglobulin A nephropathy risk.
Zhang H, He Y, He X, Wang L, Jin T, Yuan D. | 01/9/2021 |
| Association of MTMR3 rs12537 at miR-181a binding site with rheumatoid arthritis and systemic lupus erythematosus risk in Egyptian patients. | Association of MTMR3 rs12537 at miR-181a binding site with rheumatoid arthritis and systemic lupus erythematosus risk in Egyptian patients.
Senousy MA, Helmy HS, Fathy N, Shaker OG, Ayeldeen GM., Free PMC Article | 10/24/2020 |
| Study demonstrated that high levels of MTMR3 were associated with relapsefree survival and the triplenegative breast cancer subtype, as well as with a protumorigenic function in human breast cancer cells. Its knockdown suppressed proliferation and colony formation through cell cycle arrest and autophagy in MDAMB231 cells. These results provided novel insights into the pathological mechanism of breast cancer. | MTMR3 is upregulated in patients with breast cancer and regulates proliferation, cell cycle progression and autophagy in breast cancer cells.
Wang Z, Zhang M, Shan R, Wang YJ, Chen J, Huang J, Sun LQ, Zhou WB., Free PMC Article | 02/29/2020 |
| Data suggest MTMR3 has multiple functions in regulation of autophagy; one mechanism appears to be direct interaction between MTMR3 and mTORC1 (MTOR, mLST8, raptor) which inhibits phosphorylation activity of mTORC1; MTMR3 is localized to Golgi apparatus. | The PtdIns3-phosphatase MTMR3 interacts with mTORC1 and suppresses its activity.
Hao F, Itoh T, Morita E, Shirahama-Noda K, Yoshimori T, Noda T., Free PMC Article | 08/13/2016 |
| the rs713875 IBD risk polymorphism increases MTMR3 expression, which modulates pattern recognition receptor (PRR)-induced outcomes, including increased induced caspase-1 activation | MTMR3 risk allele enhances innate receptor-induced signaling and cytokines by decreasing autophagy and increasing caspase-1 activation.
Lahiri A, Hedl M, Abraham C., Free PMC Article | 04/30/2016 |
| myotubularin-related protein 3 and myotubularin-related protein 4 may act as a bridge between CEP55 and polo-like kinase 1, ensuring proper CEP55 phosphorylation and regulating CEP55 recruitment to the midbody. | Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission.
St-Denis N, Gupta GD, Lin ZY, Gonzalez-Badillo B, Pelletier L, Gingras AC., Free PMC Article | 12/26/2015 |
| cloning, expression, purification and crystallization of human myotubularin-related protein 3 encompassing the PH-GRAM and the phosphatase catalytic domain are reported | Expression, purification, crystallization and preliminary crystallographic analysis of human myotubularin-related protein 3.
Son JY, Lee JU, Yoo KY, Shin W, Im DW, Kim SJ, Ryu SE, Heo YS., Free PMC Article | 05/23/2015 |
| These results indicate that MTMR3 may play an important role in the progression of CRC and suggest that siRNA mediated silencing of MTMR3 could be an effective tool in CRC treatment. | Myotubularin-related phosphatase 3 promotes growth of colorectal cancer cells.
Zheng B, Yu X, Chai R., Free PMC Article | 05/23/2015 |
| Our results suggest that the MTMR3 gene is shared between IgA nephropathy and lupus nephritis in the northern Chinese population, further highlighting the role of autophagy in systemic lupus erythematosus. | Brief Report: identification of MTMR3 as a novel susceptibility gene for lupus nephritis in northern Han Chinese by shared-gene analysis with IgA nephropathy.
Zhou XJ, Nath SK, Qi YY, Cheng FJ, Yang HZ, Zhang Y, Yang W, Ma JY, Zhao MH, Shen N, Zhang H., Free PMC Article | 11/29/2014 |
| Data suggest MTMR3, PIKFYVE (phosphoinositide kinase FYVE), and their product phosphatidylinositol 5-phosphate are involved in activation of RAC1 (rho family small GTP binding protein); this process regulates migration/invasion of carcinoma/sarcoma. | PIKfyve, MTMR3 and their product PtdIns5P regulate cancer cell migration and invasion through activation of Rac1.
Oppelt A, Haugsten EM, Zech T, Danielsen HE, Sveen A, Lobert VH, Skotheim RI, Wesche J. | 09/27/2014 |
| Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration. | Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration.
Oppelt A, Lobert VH, Haglund K, Mackey AM, Rameh LE, Liestøl K, Schink KO, Pedersen NM, Wenzel EM, Haugsten EM, Brech A, Rusten TE, Stenmark H, Wesche J., Free PMC Article | 06/8/2013 |
| A phylogenetic study revealing co-evolution of myotubularins with PI 3-kinase class III complex | PtdIns5P regulation through evolution: roles in membrane trafficking?
Lecompte O, Poch O, Laporte J. | 07/28/2010 |
| MTMR3 shares similar phosphatase activity and substrate specificity with its homologous proteins MTM1 and MTMR3 | Functional redundancy in the myotubularin family.
Laporte J, Liaubet L, Blondeau F, Tronchère H, Mandel JL, Payrastre B. | 07/28/2010 |
| MTMR3 belongs to the myotubularin family of phosphoinositides phosphatases | Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human.
Laporte J, Blondeau F, Buj-Bello A, Tentler D, Kretz C, Dahl N, Mandel JL. | 07/28/2010 |
| Autophagosome formation was triggered by the overexpression of a dominant-negative inactive mutant of Myotubularin-related phosphatase 3 (MTMR3). | Modulation of local PtdIns3P levels by the PI phosphatase MTMR3 regulates constitutive autophagy.
Taguchi-Atarashi N, Hamasaki M, Matsunaga K, Omori H, Ktistakis NT, Yoshimori T, Noda T. | 07/12/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Mutational analysis of mononucleotide repeats in dual specificity tyrosine phosphatase genes in gastric and colon carcinomas with microsatellite instability.
Song SY, Kang MR, Yoo NJ, Lee SH. | 06/30/2010 |
| analysis of MTMR3 phosphoinositide binding domain properties | Analysis of phosphoinositide binding domain properties within the myotubularin-related protein MTMR3.
Lorenzo O, Urbé S, Clague MJ. | 01/21/2010 |