| SphK1 deficiency ameliorates the development of atherosclerosis by inhibiting the S1P/S1PR3/Rhoa/ROCK pathway. | SphK1 deficiency ameliorates the development of atherosclerosis by inhibiting the S1P/S1PR3/Rhoa/ROCK pathway.
Piao J, Su Z, He J, Zhu T, Fan F, Wang X, Yang Z, Zhan H, Luo D. | 08/1/2024 |
| Interference with sphingosine kinase-1 reduces the hydrogen peroxide-induced oxidative stress damage in melanocytes through four and a half LIM domains 2. | Interference with sphingosine kinase-1 reduces the hydrogen peroxide-induced oxidative stress damage in melanocytes through four and a half LIM domains 2.
Liao KH, Liao KL. | 07/11/2024 |
| SPHK1 potentiates colorectal cancer progression and metastasis via regulating autophagy mediated by TRAF6-induced ULK1 ubiquitination. | SPHK1 potentiates colorectal cancer progression and metastasis via regulating autophagy mediated by TRAF6-induced ULK1 ubiquitination.
Chen D, Wu J, Qiu X, Luo S, Huang S, Wei E, Qin M, Huang J, Liu S., Free PMC Article | 03/18/2024 |
| Targeting the SphK1/S1P/PFKFB3 axis suppresses hepatocellular carcinoma progression by disrupting glycolytic energy supply that drives tumor angiogenesis. | Targeting the SphK1/S1P/PFKFB3 axis suppresses hepatocellular carcinoma progression by disrupting glycolytic energy supply that drives tumor angiogenesis.
Liu XT, Huang Y, Liu D, Jiang YC, Zhao M, Chung LH, Han XD, Zhao Y, Chen J, Coleman P, Ting KK, Tran C, Su Y, Dennis CV, Bhatnagar A, Liu K, Don AS, Vadas MA, Gorrell MD, Zhang S, Murray M, Kavurma MM, McCaughan GW, Gamble JR, Qi Y., Free PMC Article | 01/16/2024 |
| The role of SphK/S1P/S1PR signaling pathway in bone metabolism. | The role of SphK/S1P/S1PR signaling pathway in bone metabolism.
Xu X, Han Y, Zhu T, Fan F, Wang X, Liu Y, Luo D. | 12/16/2023 |
| Kruppel-like factor 12 regulates aging ovarian granulosa cell apoptosis by repressing SPHK1 transcription and sphingosine-1-phosphate (S1P) production. | Krüppel-like factor 12 regulates aging ovarian granulosa cell apoptosis by repressing SPHK1 transcription and sphingosine-1-phosphate (S1P) production.
Zhang CX, Lin YL, Lu FF, Yu LN, Liu Y, Zhou JD, Kong N, Li D, Yan GJ, Sun HX, Cao GY., Free PMC Article | 10/8/2023 |
| Sphingosine kinase 1 regulates lipid metabolism to promote progression of kidney renal clear cell carcinoma. | Sphingosine kinase 1 regulates lipid metabolism to promote progression of kidney renal clear cell carcinoma.
Zhao L, Wang Z, Xu Y, Zhang P, Qiu J, Nie D, Wu G, Chen C, Chang Y, Xia Q. | 08/17/2023 |
| DNA methylation status of the SPHK1 and LTB genes underlies the clinicopathological diversity of non-alcoholic steatohepatitis-related hepatocellular carcinomas. | DNA methylation status of the SPHK1 and LTB genes underlies the clinicopathological diversity of non-alcoholic steatohepatitis-related hepatocellular carcinomas.
Tsuda N, Tian Y, Fujimoto M, Kuramoto J, Makiuchi S, Ojima H, Gotoh M, Hiraoka N, Yoshida T, Kanai Y, Arai E., Free PMC Article | 07/20/2023 |
| HOXC11 drives lung adenocarcinoma progression through transcriptional regulation of SPHK1. | HOXC11 drives lung adenocarcinoma progression through transcriptional regulation of SPHK1.
Peng X, Liu X, Hu W, Zhou Y, Ouyang L, Peng X, Long Y, Sun J, Tao T, Chen L, Shi Y, Tao Y, Xiao D, Liu S., Free PMC Article | 02/27/2023 |
| Targeting SPHK1/S1PR3-regulated S-1-P metabolic disorder triggers autophagic cell death in pulmonary lymphangiomyomatosis (LAM). | Targeting SPHK1/S1PR3-regulated S-1-P metabolic disorder triggers autophagic cell death in pulmonary lymphangiomyomatosis (LAM).
Li F, Zhang Y, Lin Z, Yan L, Liu Q, Li Y, Pei X, Feng Y, Han X, Yang J, Zheng F, Li T, Zhang Y, Fu Z, Shao D, Yu J, Li C., Free PMC Article | 01/14/2023 |
| Targeting SPHK1/PBX1 Axis Induced Cell Cycle Arrest in Non-Small Cell Lung Cancer. | Targeting SPHK1/PBX1 Axis Induced Cell Cycle Arrest in Non-Small Cell Lung Cancer.
Lin Z, Li Y, Han X, Fu Z, Tian Z, Li C., Free PMC Article | 11/19/2022 |
| Clinical relevance of CERK and SPHK1 in breast cancer and their association with metastasis and drug resistance. | Clinical relevance of CERK and SPHK1 in breast cancer and their association with metastasis and drug resistance.
Bhadwal P, Randhawa V, Vaiphei K, Dahiya D, Agnihotri N., Free PMC Article | 11/12/2022 |
| Metabolomic Analysis Reveals that SPHK1 Promotes Oral Squamous Cell Carcinoma Progression through NF-kappaB Activation. | Metabolomic Analysis Reveals that SPHK1 Promotes Oral Squamous Cell Carcinoma Progression through NF-κB Activation.
Hou CX, Mao GY, Sun QW, Meng Y, Zhu QH, Tang YT, Han W, Sun NN, Song XM, Wang CX, Ye JH. | 10/22/2022 |
| Sphingosine kinase 1 mediates sexual dimorphism in fibrosis in a mouse model of NASH. | Sphingosine kinase 1 mediates sexual dimorphism in fibrosis in a mouse model of NASH.
Montefusco D, Jamil M, Maczis MA, Schroeder W, Levi M, Ranjit S, Allegood J, Bandyopadhyay D, Retnam R, Spiegel S, Cowart LA., Free PMC Article | 07/16/2022 |
| Stimulating the expression of sphingosine kinase 1 (SphK1) is beneficial to reduce acrylamide-induced nerve cell damage. | Stimulating the expression of sphingosine kinase 1 (SphK1) is beneficial to reduce acrylamide-induced nerve cell damage.
Yu CP, Pan YL, Wang XL, Xin R, Li HQ, Lei YT, Zhao FF, Zhang D, Zhou XR, Ma WW, Wang SY, Wu YH. | 05/14/2022 |
| Hemorrhage-Induced Sphingosine Kinase 1 Contributes to Ferroptosis-Mediated Secondary Brain Injury in Intracerebral Hemorrhage. | Hemorrhage-Induced Sphingosine Kinase 1 Contributes to Ferroptosis-Mediated Secondary Brain Injury in Intracerebral Hemorrhage.
Diao X, Cui Q, Tian N, Zhou Z, Xiang W, Jiang Y, Deng J, Liao H, Lin X, Li Q, Liao R. | 04/16/2022 |
| Sphk1 promotes salivary adenoid cystic carcinoma progression via PI3K/Akt signaling. | Sphk1 promotes salivary adenoid cystic carcinoma progression via PI3K/Akt signaling.
Hou CX, Wang L, Cai M, Meng Y, Tang YT, Zhu QH, Han W, Sun NN, Ma B, Hu Y, Ye JH. | 03/5/2022 |
| LncRNA PSMG3AS1 promotes proliferation of non-small cell lung cancer cells by sponging miR-613 to upregulate SphK1. | LncRNA PSMG3AS1 promotes proliferation of non-small cell lung cancer cells by sponging miR-613 to upregulate SphK1.
Shen W, Hong X, Jin C, Xi Y., Free PMC Article | 02/19/2022 |
| Sphingosine kinase 1 regulates lysyl oxidase through STAT3 in hyperoxia-mediated neonatal lung injury. | Sphingosine kinase 1 regulates lysyl oxidase through STAT3 in hyperoxia-mediated neonatal lung injury.
Ha AW, Bai T, Ebenezer DL, Sethi T, Sudhadevi T, Mangio LA, Garzon S, Pryhuber GS, Natarajan V, Harijith A., Free PMC Article | 02/5/2022 |
| SPHK1 contributes to cisplatin resistance in bladder cancer cells via the NONO/STAT3 axis. | SPHK1 contributes to cisplatin resistance in bladder cancer cells via the NONO/STAT3 axis.
Qin Z, Tong H, Li T, Cao H, Zhu J, Yin S, He W., Free PMC Article | 01/29/2022 |
| LINC00514 promotes lipogenesis and tumor progression in esophageal squamous cell carcinoma by sponging miR378a5p to enhance SPHK1 expression. | LINC00514 promotes lipogenesis and tumor progression in esophageal squamous cell carcinoma by sponging miR‑378a‑5p to enhance SPHK1 expression.
Wang X, Liu H, Zhang Q, Zhang X, Qin Y, Zhu G, Dang J, Wang F, Yang X, Fan R., Free PMC Article | 01/29/2022 |
| [The effect and mechanism of sphingosine kinase-1 knockdown on non-small cell lung cancer cell proliferation and mitochondrial apoptotic pathway]. | [The effect and mechanism of sphingosine kinase-1 knockdown on non-small cell lung cancer cell proliferation and mitochondrial apoptotic pathway].
Cao YH, Yin W, Lyu YR. | 01/1/2022 |
| Cell fate determined by the activation balance between PKR and SPHK1. | Cell fate determined by the activation balance between PKR and SPHK1.
Qiao H, Jiang T, Mu P, Chen X, Wen X, Hu Z, Tang S, Wen J, Deng Y., Free PMC Article | 12/25/2021 |
| Activation of SphK1 by adipocytes mediates epithelial ovarian cancer cell proliferation. | Activation of SphK1 by adipocytes mediates epithelial ovarian cancer cell proliferation.
Dai L, Wang C, Song K, Wang W, Di W., Free PMC Article | 11/22/2021 |
| Erythrocyte sphingosine kinase regulates intraerythrocytic development of Plasmodium falciparum. | Erythrocyte sphingosine kinase regulates intraerythrocytic development of Plasmodium falciparum.
Sah RK, Pati S, Saini M, Singh S., Free PMC Article | 08/14/2021 |