| SRC kinase activator CDCP1 promotes hepatocyte growth factor-induced cell migration/invasion of a subset of breast cancer cells. | SRC kinase activator CDCP1 promotes hepatocyte growth factor-induced cell migration/invasion of a subset of breast cancer cells.
Kawase N, Sugihara A, Kajiwara K, Hiroshima M, Akamatsu K, Nada S, Matsumoto K, Ueda M, Okada M., Free PMC Article | 04/30/2022 |
| Beta-Pix-dynamin 2 complex promotes colorectal cancer progression by facilitating membrane dynamics. | Beta-Pix-dynamin 2 complex promotes colorectal cancer progression by facilitating membrane dynamics.
Keum S, Yang SJ, Park E, Kang T, Choi JH, Jeong J, Hwang YE, Kim JW, Park D, Rhee S., Free PMC Article | 03/12/2022 |
| ARHGEF7 (beta-PIX) Is Required for the Maintenance of Podocyte Architecture and Glomerular Function. | ARHGEF7 (β-PIX) Is Required for the Maintenance of Podocyte Architecture and Glomerular Function.
Matsuda J, Maier M, Aoudjit L, Baldwin C, Takano T., Free PMC Article | 01/2/2021 |
| Indispensable role of STIL in the regulation of cancer cell motility through the lamellipodial accumulation of ARHGEF7-PAK1 complex. | Indispensable role of STIL in the regulation of cancer cell motility through the lamellipodial accumulation of ARHGEF7-PAK1 complex.
Ito H, Tsunoda T, Riku M, Inaguma S, Inoko A, Murakami H, Ikeda H, Matsuda M, Kasai K. | 11/28/2020 |
| our results demonstrate the importance of AMPK-mediated phosphorylation of beta1Pix at Ser(71), which promotes 14-3-3 interactions with beta1Pix and Nedd4-2 to form a tripartite ENaC inhibitory complex, in the mechanism of ENaC regulation by AMPK | AMPK phosphorylation of the β(1)Pix exchange factor regulates the assembly and function of an ENaC inhibitory complex in kidney epithelial cells.
Ho PY, Li H, Cheng L, Bhalla V, Fenton RA, Hallows KR., Free PMC Article | 04/18/2020 |
| Expression of ARHGEF7 is significantly increased and associated with metastasis in colorectal adenocarcinoma. | ARHGEF7 promotes metastasis of colorectal adenocarcinoma by regulating the motility of cancer cells.
Lei X, Deng L, Liu D, Liao S, Dai H, Li J, Rong J, Wang Z, Huang G, Tang C, Xu C, Xiao B, Li T., Free PMC Article | 03/30/2019 |
| Induced association of beta-PIX with GIT1 is essential for the stimulation of intestinal epithelial restitution by activating Rac1, and this signaling pathway is tightly regulated by cellular polyamines. | β-PIX plays an important role in regulation of intestinal epithelial restitution by interacting with GIT1 and Rac1 after wounding.
Rathor N, Chung HK, Wang SR, Qian M, Turner DJ, Wang JY, Rao JN., Free PMC Article | 03/2/2019 |
| Traction forces generated by beta-PIX knockdown cells are increased relative to those in control cells, a result consistent with an unexpected enhancement in the migration of single beta-PIX knockdown cells and monolayers of such cells. Authors propose that targeting beta-PIX might be a means of promoting epithelialization of wounds in vivo. | Loss of β-PIX inhibits focal adhesion disassembly and promotes keratinocyte motility via myosin light chain activation.
Hiroyasu S, Stimac GP, Hopkinson SB, Jones JCR., Free PMC Article | 09/15/2018 |
| S340E mutation enhances Nox1 activation (Kaito et al., 2014), the present study suggests that betaPix can also play an inhibitory role in O2(-) production, depending on the sites of phosphorylation. | Phosphorylation of Ser-525 in βPix impairs Nox1-activating ability in Caco-2 cells.
Kaito Y, Kataoka R, Mihara T, Takechi K, Takahira A, Watanabe S, Han F, Tamura M. | 02/17/2018 |
| Data suggest that Scribble PDZ-domain-1 and PDZ-domain-3 are major domains that interact with beta-PIX and exhibit distinct binding hierarchy in interactions between individual Scribble PDZ domains and beta-PIX. (Scribble = scribbled planar cell polarity protein; beta-PIX = Rho guanine nucleotide exchange factor 7) | Structural basis for the differential interaction of Scribble PDZ domains with the guanine nucleotide exchange factor β-PIX.
Lim KYB, Gödde NJ, Humbert PO, Kvansakul M., Free PMC Article | 01/27/2018 |
| each mutation in LRRK2 and ARHGEF7 demonstrated its unique functional property, which may contribute to the pathogenesis of Parkinson disease | Functional properties of LRRK2 mutations in Taiwanese Parkinson disease.
Chang KH, Chen CM, Lin CH, Chang WT, Jiang PR, Hsiao YC, Wu YR, Lee-Chen GJ. | 08/19/2017 |
| we discuss recent findings in key physiological systems that exemplify current understanding of the function of this important regulatory complex. Further, we draw attention to gaps in crucial information that remain to be filled to allow a better understanding of the many roles of the GIT-PIX complex in health and disease | Expanding functions of GIT Arf GTPase-activating proteins, PIX Rho guanine nucleotide exchange factors and GIT-PIX complexes.
Zhou W, Li X, Premont RT., Free PMC Article | 08/5/2017 |
| Data show association of G protein-coupled receptor kinase-interacting protein 1 (GIT1), p21-activated kinase interacting exchange factor (betaPIX), and p21 protein (Cdc42/Rac)-activated kinase 1 (PAK1) with centrosomes. | GIT1/βPIX signaling proteins and PAK1 kinase regulate microtubule nucleation.
Černohorská M, Sulimenko V, Hájková Z, Sulimenko T, Sládková V, Vinopal S, Dráberová E, Dráber P. | 07/30/2016 |
| Data show the role of Rho guanine nucleotide exchange factor 7 (beta-PIX) to the regulation of high mobility of lung adenocarcinoma cell line H1299 via regulation of focal adhesions dynamics, changes in actin cytoskeleton organization and cell polarity. | β-PIX controls intracellular viscoelasticity to regulate lung cancer cell migration.
Yu HW, Chen YQ, Huang CM, Liu CY, Chiou A, Wang YK, Tang MJ, Kuo JC., Free PMC Article | 04/2/2016 |
| Phosphorylation of LRRK2 by casein kinase 1alpha regulates trans-Golgi clustering via differential interaction with ARHGEF7. | Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7.
Chia R, Haddock S, Beilina A, Rudenko IN, Mamais A, Kaganovich A, Li Y, Kumaran R, Nalls MA, Cookson MR., Free PMC Article | 11/7/2015 |
| GIT1/betaPIX/Rac1/PAK pathway plays a crucial role in regulating GABA(A)R synaptic stability and hence inhibitory synaptic transmission with important implications for inhibitory plasticity and information processing in the brain. | GIT1 and βPIX are essential for GABA(A) receptor synaptic stability and inhibitory neurotransmission.
Smith KR, Davenport EC, Wei J, Li X, Pathania M, Vaccaro V, Yan Z, Kittler JT., Free PMC Article | 07/25/2015 |
| Conversely, increased expression of betaPIX in breast cancer cell lines re-couples the Hippo kinase cassette to Yap/Taz, promoting localization of Yap/Taz to the cytoplasm and inhibiting cell migration and proliferation. | Arhgef7 promotes activation of the Hippo pathway core kinase Lats.
Heidary Arash E, Song KM, Song S, Shiban A, Attisano L., Free PMC Article | 07/25/2015 |
| Data indicate that suppression of c-Cbl protein by rho guanine nucleotide exchange factor 7 (Cool-1) may be critical for generation of at least a subset of glioblastoma (GBM). | Cool-1-mediated inhibition of c-Cbl modulates multiple critical properties of glioblastomas, including the ability to generate tumors in vivo.
Stevens BM, Folts CJ, Cui W, Bardin AL, Walter K, Carson-Walter E, Vescovi A, Noble M. | 12/20/2014 |
| The interaction of betaPix with srGAP1 is critical for maintaining suppressive crosstalk between Cdc42 and RhoA during 3D collagen migration. | An extracellular-matrix-specific GEF-GAP interaction regulates Rho GTPase crosstalk for 3D collagen migration.
Kutys ML, Yamada KM., Free PMC Article | 11/8/2014 |
| BetaPix phosphorylation at Ser-340 upregulates Nox1 through Rac activation. | Nox1 activation by βPix and the role of Ser-340 phosphorylation.
Kaito Y, Kataoka R, Takechi K, Mihara T, Tamura M. | 07/12/2014 |
| It has identified and characterized a novel interaction between CaM and beta-p21-activated kinase interacting exchange factor (beta-PIX), a putative guanine exchange factor implicated in cell signaling. | A novel calmodulin-β-PIX interaction and its implication in receptor tyrosine kinase regulation.
Singh VK, Munro K, Jia Z. | 03/1/2014 |
| Inhibition of glycogen synthase kinase (GSK)-3beta increases the migration capacity of mesenchymal stromal cells during ex vivo expansion. | Direct GSK-3β inhibition enhances mesenchymal stromal cell migration by increasing expression of β-PIX and CXCR4.
Kim YS, Noh MY, Kim JY, Yu HJ, Kim KS, Kim SH, Koh SH. | 02/15/2014 |
| beta1Pix functions as a transcriptional regulator of beta-catenin signaling through direct interaction with beta-catenin, an action that may be functionally relevant to colon cancer biology. | The Cdc42/Rac nucleotide exchange factor protein β1Pix (Pak-interacting exchange factor) modulates β-catenin transcriptional activity in colon cancer cells: evidence for direct interaction of β1PIX with β-catenin.
Chahdi A, Raufman JP., Free PMC Article | 02/8/2014 |
| Data suggest a coordination between paxillin kinase linker (PKL)/Vav2 signaling and PKL/beta-PIX signaling during cell migration. | Paxillin kinase linker (PKL) regulates Vav2 signaling during cell spreading and migration.
Jones MC, Machida K, Mayer BJ, Turner CE., Free PMC Article | 01/18/2014 |
| BETA-PIX is a novel downstream signalling mediator during invadopodia formation. | Hypoxia-induced invadopodia formation: a role for β-PIX.
Md Hashim NF, Nicholas NS, Dart AE, Kiriakidis S, Paleolog E, Wells CM., Free PMC Article | 01/4/2014 |