| A functional variant of ALDH1A2 is associated with hand osteoarthritis in the Chinese population. | A functional variant of ALDH1A2 is associated with hand osteoarthritis in the Chinese population.
Dai J, Jiang H, Yang Z, Chen C, Tang X. | 07/9/2024 |
| ALDH1A2-related disorder: A new genetic syndrome due to alteration of the retinoic acid pathway. | ALDH1A2-related disorder: A new genetic syndrome due to alteration of the retinoic acid pathway.
Leon E, Nde C, Ray RS, Preciado D, Zohn IE., Free PMC Article | 12/31/2022 |
| An eQTL variant of ALDH1A2 is associated with Kashin-Beck disease in Chinese population. | An eQTL variant of ALDH1A2 is associated with Kashin-Beck disease in Chinese population.
Zhang D, Li Q, Zhang D, Yang X, Wang C, Zhang R, Yang X, Li Z, Xiong Y. | 03/19/2022 |
| The Presence and Potential Role of ALDH1A2 in the Glioblastoma Microenvironment. | The Presence and Potential Role of ALDH1A2 in the Glioblastoma Microenvironment.
Sanders S, Herpai DM, Rodriguez A, Huang Y, Chou J, Hsu FC, Seals D, Mott R, Miller LD, Debinski W., Free PMC Article | 11/27/2021 |
| Peanut protein acts as a TH2 adjuvant by inducing RALDH2 in human antigen-presenting cells. | Peanut protein acts as a T(H)2 adjuvant by inducing RALDH2 in human antigen-presenting cells.
Ruiter B, Smith NP, Fleming E, Patil SU, Hurlburt BK, Maleki SJ, Shreffler WG., Free PMC Article | 10/16/2021 |
| ALDH1A2 and ALDH1A3 showed higher catalytic efficiency for all-trans-retinaldehyde. Magnesium inhibited ALDH1A1 and ALDH1A2, while it activated ALDH1A3. | Structural and kinetic features of aldehyde dehydrogenase 1A (ALDH1A) subfamily members, cancer stem cell markers active in retinoic acid biosynthesis.
Pequerul R, Vera J, Giménez-Dejoz J, Crespo I, Coines J, Porté S, Rovira C, Parés X, Farrés J. | 05/16/2020 |
| The ALDH1A2 locus seems to increase the risk of hand osteoarthritis through decreased expression of ALDH1A2 in joint tissues, with the effect dependent on single-nucleotide polymorphism rs12915901. | Functional Characterization of the Osteoarthritis Genetic Risk Residing at ALDH1A2 Identifies rs12915901 as a Key Target Variant.
Shepherd C, Zhu D, Skelton AJ, Combe J, Threadgold H, Zhu L, Vincent TL, Stuart P, Reynard LN, Loughlin J., Free PMC Article | 07/27/2019 |
| The authors findings indicate that the SNP rs4238326 in ALDH1A2 gene may potentially modify individual susceptibility to knee OA in the Chinese population. | The rs4238326 polymorphism in ALDH1A2 gene potentially associated with non-post traumatic knee osteoarthritis susceptibility: a two-stage population-based study.
Chu M, Zhu X, Wang C, Rong J, Wang Y, Wang S, Xing B, Tao Y, Zhuang X, Jiang L. | 04/7/2018 |
| high transcription activities of ALDH1A2, ALDH1A3 and ALDH1L1 predicted worsen overall survival in gastric cancer patients | Mining distinct aldehyde dehydrogenase 1 (ALDH1) isoenzymes in gastric cancer.
Shen JX, Liu J, Li GW, Huang YT, Wu HT., Free PMC Article | 01/6/2018 |
| Data show that hRALDH2 is not inhibited by its oxidation product, all-trans-RA, suggesting the absence of a negative feedback regulatory loop. Expression of the Raldh2 gene is known to be regulated by RA itself, suggesting that the main regulation of the hRALDH2 activity level is transcriptional. | Kinetic characterization and regulation of the human retinaldehyde dehydrogenase 2 enzyme during production of retinoic acid.
Shabtai Y, Jubran H, Nassar T, Hirschberg J, Fainsod A. | 05/20/2017 |
| Study shows no evidence that genetic variants alter prostate cancer incidence, but show that SNPs in the ALDH1A2 gene affect prostate cancer mortality. | Alcohol consumption and prostate cancer incidence and progression: A Mendelian randomisation study.
Brunner C, Davies NM, Martin RM, Eeles R, Easton D, Kote-Jarai Z, Al Olama AA, Benlloch S, Muir K, Giles G, Wiklund F, Gronberg H, Haiman CA, Schleutker J, Nordestgaard BG, Travis RC, Neal D, Donovan J, Hamdy FC, Pashayan N, Khaw KT, Stanford JL, Blot WJ, Thibodeau S, Maier C, Kibel AS, Cybulski C, Cannon-Albright L, Brenner H, Park J, Kaneva R, Batra J, Teixeira MR, Pandha H, PRACTICAL Consortium,, Zuccolo L., Free PMC Article | 05/13/2017 |
| a critical role of ALDH1A2-RAR signaling in the pathogenesis of head and neck cancer. | Impaired aldehyde dehydrogenase 1 subfamily member 2A-dependent retinoic acid signaling is related with a mesenchymal-like phenotype and an unfavorable prognosis of head and neck squamous cell carcinoma.
Seidensaal K, Nollert A, Feige AH, Muller M, Fleming T, Gunkel N, Zaoui K, Grabe N, Weichert W, Weber KJ, Plinkert P, Simon C, Hess J., Free PMC Article | 09/10/2016 |
| High expression of ALDH1A2 and ALDH1B1 mRNA was found to be significantly correlated to worser survival in all NSCLC patients. | Distinct prognostic values and potential drug targets of ALDH1 isoenzymes in non-small-cell lung cancer.
You Q, Guo H, Xu D., Free PMC Article | 07/16/2016 |
| the distribution of RALDH1, RALDH2, and RALDH3 in the postnatal eye was determined. | Identification of active retinaldehyde dehydrogenase isoforms in the postnatal human eye.
Harper AR, Wiechmann AF, Moiseyev G, Ma JX, Summers JA., Free PMC Article | 02/13/2016 |
| ALDH1A2 is involved in the regulation of cancer stem cell properties in neuroblastoma. | Involvement of aldehyde dehydrogenase 1A2 in the regulation of cancer stem cell properties in neuroblastoma.
Hartomo TB, Van Huyen Pham T, Yamamoto N, Hirase S, Hasegawa D, Kosaka Y, Matsuo M, Hayakawa A, Takeshima Y, Iijima K, Nishio H, Nishimura N. | 10/10/2015 |
| Genetic association replicative and exploratory studies identify SNPs in ADA and MTR highly associated with isolated Neural tube defects (NTD)and SNP in ARID1A and ALDH1A2 associated with NTDs in whites and African Americans respectively. | Replication and exploratory analysis of 24 candidate risk polymorphisms for neural tube defects.
Pangilinan F, Molloy AM, Mills JL, Troendle JF, Parle-McDermott A, Kay DM, Browne ML, McGrath EC, Abaan HO, Sutton M, Kirke PN, Caggana M, Shane B, Scott JM, Brody LC., Free PMC Article | 07/4/2015 |
| At the transcript level, the cisplatin + DEAB-resistant cells showed upregulated mRNA expression levels for ALDH1A2, ALDH1A3 isozymes and CD44 indicating the involvement of these markers in conferring chemoresistance | Cisplatin-resistant cells in malignant pleural mesothelioma cell lines show ALDH(high)CD44(+) phenotype and sphere-forming capacity.
Cortes-Dericks L, Froment L, Boesch R, Schmid RA, Karoubi G., Free PMC Article | 02/21/2015 |
| DNA methylation at multiple CpG sites is associated with loss of control over alcohol drinking. | Methylation of a CpG site near the ALDH1A2 gene is associated with loss of control over drinking and related phenotypes.
Harlaar N, Bryan AD, Thayer RE, Karoly HC, Oien N, Hutchison KE., Free PMC Article | 11/22/2014 |
| Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31. | Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31.
Styrkarsdottir U, Thorleifsson G, Helgadottir HT, Bomer N, Metrustry S, Bierma-Zeinstra S, Strijbosch AM, Evangelou E, Hart D, Beekman M, Jonasdottir A, Sigurdsson A, Eiriksson FF, Thorsteinsdottir M, Frigge ML, Kong A, Gudjonsson SA, Magnusson OT, Masson G, TREAT-OA Consortium, arcOGEN Consortium, Hofman A, Arden NK, Ingvarsson T, Lohmander S, Kloppenburg M, Rivadeneira F, Nelissen RG, Spector T, Uitterlinden A, Slagboom PE, Thorsteinsdottir U, Jonsdottir I, Valdes AM, Meulenbelt I, van Meurs J, Jonsson H, Stefansson K. | 06/21/2014 |
| These findings suggest that ALDH1A2 is the enzyme involved in retinoic acid biosynthesis in human germ cells. | Levels of the retinoic acid synthesizing enzyme aldehyde dehydrogenase-1A2 are lower in testicular tissue from men with infertility.
Amory JK, Arnold S, Lardone MC, Piottante A, Ebensperger M, Isoherranen N, Muller CH, Walsh T, Castro A., Free PMC Article | 06/7/2014 |
| all three proteins (RDH10, RALDH2, and CRABP2) appeared to be required for ATRA production induced by activation of PPARgamma | RDH10, RALDH2, and CRABP2 are required components of PPARγ-directed ATRA synthesis and signaling in human dendritic cells.
Gyöngyösi A, Szatmari I, Pap A, Dezso B, Pos Z, Széles L, Varga T, Nagy L., Free PMC Article | 04/26/2014 |
| ALDH1A2 protein was effective in AraC resistance. ALDH1A2 knock-down induced sensitivity to AraC treatment in K562AC cells. ALDH1A2 overexpressed K562S cells acquired the AraC resistance. Ara-C-resistant patients had increased ALDH1A2. | Acquired resistance of leukemic cells to AraC is associated with the upregulation of aldehyde dehydrogenase 1 family member A2.
Kawasoe M, Yamamoto Y, Okawa K, Funato T, Takeda M, Hara T, Tsurumi H, Moriwaki H, Arioka Y, Takemura M, Matsunami H, Markey SP, Saito K., Free PMC Article | 09/14/2013 |
| In vivo reduction of vitamin A levels results in an increase in astrocyte RALDH2 expression in the hippocampus. | Astrocytes as a regulated source of retinoic acid for the brain.
Shearer KD, Fragoso YD, Clagett-Dame M, McCaffery PJ. | 08/10/2013 |
| Aberrant methylation of ALDH1a2 gene is the main cause for gene transcriptional inactivation in human bladder cancer cell lines. 5-Aza-2'-deoxycitydine or trichostatin A treatment induces ALDH1a2 expression. | [Effects of 5-Aza-2'-deoxycitydine and trichostatin A on expression and apoptosis of ALDH1a2 gene in human bladder cancer cell lines].
Ju ZH, Ying MG, Ai X, Shi TP, Wang BJ, Wang C, Zhang GX, Zhang X. | 02/5/2011 |
| A human ALDH1A2 gene variant is associated with increased newborn kidney size and serum retinoic acid. | A human ALDH1A2 gene variant is associated with increased newborn kidney size and serum retinoic acid.
El Kares R, Manolescu DC, Lakhal-Chaieb L, Montpetit A, Zhang Z, Bhat PV, Goodyer P. | 09/27/2010 |