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    CCN4 cellular communication network factor 4 [ Homo sapiens (human) ]

    Gene ID: 8840, updated on 12-Sep-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    An overview of CCN4 (WISP1) role in human diseases.

    An overview of CCN4 (WISP1) role in human diseases.
    Singh K, Oladipupo SS., Free PMC Article

    07/19/2024
    Silencing of METTL3 prevents the proliferation, migration, epithelial-mesenchymal transition, and renal fibrosis of high glucose-induced HK2 cells by mediating WISP1 in m6A-dependent manner.

    Silencing of METTL3 prevents the proliferation, migration, epithelial-mesenchymal transition, and renal fibrosis of high glucose-induced HK2 cells by mediating WISP1 in m6A-dependent manner.
    Chen Y, Li P, Lin M, Jiang Y, Tan G, Huang L, Song D., Free PMC Article

    03/6/2024
    WISP1 induces the expression of macrophage migration inhibitory factor in human lung fibroblasts through Src kinases and EGFR-activated signaling pathways.

    WISP1 induces the expression of macrophage migration inhibitory factor in human lung fibroblasts through Src kinases and EGFR-activated signaling pathways.
    Christopoulou ME, Skandalis SS, Papakonstantinou E, Stolz D, Aletras AJ., Free PMC Article

    03/4/2024
    Effect of WISP1 on paraquat-induced EMT.

    Effect of WISP1 on paraquat-induced EMT.
    Liu J, Lv S, Ma W, Yang D, Zhang X.

    11/6/2023
    CCN4/WISP1 Promotes Migration of Human Primary Osteoarthritic Chondrocytes.

    CCN4/WISP1 Promotes Migration of Human Primary Osteoarthritic Chondrocytes.
    Timmermans RGM, Blom AB, Bloks NGC, Nelissen RGHH, van der Linden EHMJ, van der Kraan PM, Meulenbelt I, Ramos YFM, van den Bosch MHJ., Free PMC Article

    03/8/2023
    The ADAM9/WISP-1 axis cooperates with osteoblasts to stimulate primary prostate tumor growth and metastasis.

    The ADAM9/WISP-1 axis cooperates with osteoblasts to stimulate primary prostate tumor growth and metastasis.
    Chang AC, Lin LW, Chen YC, Chen PC, Liu SC, Tai HC, Wu HC, Sung SY, Lin TH, Tang CH., Free PMC Article

    02/14/2023
    WNT1 Inducible Signaling Pathway Protein 1 Is a Stroma-Specific Secreting Protein Inducing a Fibroblast Contraction and Carcinoma Cell Growth in the Human Prostate.

    WNT1 Inducible Signaling Pathway Protein 1 Is a Stroma-Specific Secreting Protein Inducing a Fibroblast Contraction and Carcinoma Cell Growth in the Human Prostate.
    Chang KS, Chen ST, Sung HC, Hsu SY, Lin WY, Hou CP, Lin YH, Feng TH, Tsui KH, Juang HH., Free PMC Article

    10/22/2022
    WISP1 induces ovarian cancer via the IGF1/alphavbeta3/Wnt axis.

    WISP1 induces ovarian cancer via the IGF1/αvβ3/Wnt axis.
    Li Y, Wang F, Liu T, Lv N, Yuan X, Li P., Free PMC Article

    08/27/2022
    Circulating levels of WISP-1 (Wnt1-inducible signaling pathway protein 1) and other selected adipokines in children with inflammatory bowel disease.

    Circulating levels of WISP-1 (Wnt1-inducible signaling pathway protein 1) and other selected adipokines in children with inflammatory bowel disease.
    Karásková E, Kubickova V, Velganova-Veghova M, Geryk M, Foltenova H, Karasek D., Free PMC Article

    05/28/2022
    Increased Serum WISP1 Levels are Associated with Lower Extremity Atherosclerotic Disease in Patients with Type 2 Diabetes Mellitus.

    Increased Serum WISP1 Levels are Associated with Lower Extremity Atherosclerotic Disease in Patients with Type 2 Diabetes Mellitus.
    Cheng Y, Du X, Zhang B, Zhang J.

    05/7/2022
    Matricellular Protein WISP2 Is an Endogenous Inhibitor of Collagen Linearization and Cancer Metastasis.

    Matricellular Protein WISP2 Is an Endogenous Inhibitor of Collagen Linearization and Cancer Metastasis.
    Janjanam J, Pano G, Wang R, Minden-Birkenmaier BA, Breeze-Jones H, Baker E, Garcin C, Clayton G, Shirinifard A, Zaske AM, Finkelstein D, Labelle M., Free PMC Article

    01/15/2022
    WISP1 aggravates cell metastatic potential by abrogating TGF-beta-Smad2/3-dependent epithelial-to-mesenchymal transition in laryngeal squamous cell carcinoma.

    WISP1 aggravates cell metastatic potential by abrogating TGF-β-Smad2/3-dependent epithelial-to-mesenchymal transition in laryngeal squamous cell carcinoma.
    Song D, Wang L, Su K, Wu H, Li J., Free PMC Article

    11/6/2021
    Hepatic Wnt1 Inducible Signaling Pathway Protein 1 (WISP-1/CCN4) Associates with Markers of Liver Fibrosis in Severe Obesity.

    Hepatic Wnt1 Inducible Signaling Pathway Protein 1 (WISP-1/CCN4) Associates with Markers of Liver Fibrosis in Severe Obesity.
    Pivovarova-Ramich O, Loske J, Hornemann S, Markova M, Seebeck N, Rosenthal A, Klauschen F, Castro JP, Buschow R, Grune T, Lange V, Rudovich N, Ouwens DM., Free PMC Article

    10/23/2021
    Diagnostic Value of the Hypomethylation of the WISP1 Promoter in Patients with Hepatocellular Carcinoma Associated with Hepatitis B Virus.

    Diagnostic Value of the Hypomethylation of the WISP1 Promoter in Patients with Hepatocellular Carcinoma Associated with Hepatitis B Virus.
    Chen LM, Xiang L, Sun WJ, Zhai YJ, Gao S, Fan YC, Wang K.

    10/2/2021
    High expression of WISP1 promotes metastasis and predicts poor prognosis in hepatocellular carcinoma.

    High expression of WISP1 promotes metastasis and predicts poor prognosis in hepatocellular carcinoma.
    Wang QY, Feng YJ, Ji R.

    07/3/2021
    Endogenous CCN family member WISP1 inhibits trauma-induced heterotopic ossification.

    Endogenous CCN family member WISP1 inhibits trauma-induced heterotopic ossification.
    Hsu GC, Marini S, Negri S, Wang Y, Xu J, Pagani C, Hwang C, Stepien D, Meyers CA, Miller S, McCarthy E, Lyons KM, Levi B, James AW., Free PMC Article

    06/12/2021
    miRNA repertoires of cystic fibrosis ex vivo models highlight miR-181a and miR-101 that regulate WISP1 expression.

    miRNA repertoires of cystic fibrosis ex vivo models highlight miR-181a and miR-101 that regulate WISP1 expression.
    Pommier A, Varilh J, Bleuse S, Delétang K, Bonini J, Bergougnoux A, Brochiero E, Koenig M, Claustres M, Taulan-Cadars M.

    06/12/2021
    TGF-beta1/WISP1/Integrin-alpha interaction mediates human chondrocytes dedifferentiation.

    TGF-β1/WISP1/Integrin-α interaction mediates human chondrocytes dedifferentiation.
    Zhang M, Meng QC, Yang XF, Mu WD.

    05/15/2021
    An Update to the WISP-1/CCN4 Role in Obesity, Insulin Resistance and Diabetes.

    An Update to the WISP-1/CCN4 Role in Obesity, Insulin Resistance and Diabetes.
    Mirr M, Owecki M., Free PMC Article

    05/8/2021
    WISP1 Protects Against Chondrocyte Senescence and Apoptosis by Regulating alphavbeta3 and PI3K/Akt Pathway in Osteoarthritis.

    WISP1 Protects Against Chondrocyte Senescence and Apoptosis by Regulating αvβ3 and PI3K/Akt Pathway in Osteoarthritis.
    Cheng C, Tian J, Zhang F, Deng Z, Tu M, Li L, Yang H, Xiao K, Guo W, Yang R, Gao S, Zhou Z.

    04/17/2021
    Mechanical stimulations can inhibit local and remote tumor progression by downregulating WISP1.

    Mechanical stimulations can inhibit local and remote tumor progression by downregulating WISP1.
    Liu S, Wu D, Sun X, Fan Y, Zha R, Jalali A, Teli M, Sano T, Siegel A, Sudo A, Agarwal M, Robling A, Li BY, Yokota H., Free PMC Article

    03/13/2021
    Circ_KATNAL1 regulates prostate cancer cell growth and invasiveness through the miR-145-3p/WISP1 pathway.

    Circ_KATNAL1 regulates prostate cancer cell growth and invasiveness through the miR-145-3p/WISP1 pathway.
    Zheng Y, Chen CJ, Lin ZY, Li JX, Liu J, Lin FJ, Zhou X.

    02/27/2021
    Association of WISP1/CCN4 with Risk of Overweight and Gestational Diabetes Mellitus in Chinese Pregnant Women.

    Association of WISP1/CCN4 with Risk of Overweight and Gestational Diabetes Mellitus in Chinese Pregnant Women.
    Liu L, Hu J, Yang L, Wang N, Liu Y, Wei X, Gao M, Wang Y, Ma Y, Wen D., Free PMC Article

    02/6/2021
    The Effects of microRNA-515-5p on the Toll-Like Receptor 4 (TLR4)/JNK Signaling Pathway and WNT1-Inducible-Signaling Pathway Protein 1 (WISP-1) Expression in Rheumatoid Arthritis Fibroblast-Like Synovial (RAFLS) Cells Following Treatment with Receptor Activator of Nuclear Factor-kappa-B Ligand (RANKL).

    The Effects of microRNA-515-5p on the Toll-Like Receptor 4 (TLR4)/JNK Signaling Pathway and WNT1-Inducible-Signaling Pathway Protein 1 (WISP-1) Expression in Rheumatoid Arthritis Fibroblast-Like Synovial (RAFLS) Cells Following Treatment with Receptor Activator of Nuclear Factor-kappa-B Ligand (RANKL).
    Cai D, Hong S, Yang J, San P., Free PMC Article

    01/9/2021
    Wisp1 is a circulating factor that stimulates proliferation of adult mouse and human beta cells.

    Wisp1 is a circulating factor that stimulates proliferation of adult mouse and human beta cells.
    Fernandez-Ruiz R, García-Alamán A, Esteban Y, Mir-Coll J, Serra-Navarro B, Fontcuberta-PiSunyer M, Broca C, Armanet M, Wojtusciszyn A, Kram V, Young MF, Vidal J, Gomis R, Gasa R., Free PMC Article

    12/12/2020
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