| Deciphering the SOX4/MAPK1 regulatory axis: a phosphoproteomic insight into IQGAP1 phosphorylation and pancreatic Cancer progression. | Deciphering the SOX4/MAPK1 regulatory axis: a phosphoproteomic insight into IQGAP1 phosphorylation and pancreatic Cancer progression.
Song C, Wang G, Liu M, Han S, Dong M, Peng M, Wang W, Wang Y, Xu Y, Liu L., Free PMC Article | 07/10/2024 |
| In silico predicted compound targeting the IQGAP1-GRD domain selectively inhibits growth of human acute myeloid leukemia. | In silico predicted compound targeting the IQGAP1-GRD domain selectively inhibits growth of human acute myeloid leukemia.
Sahasrabudhe DM, Liesveld JL, Minhajuddin M, Singh NA, Nath S, Kumar VM, Balys M, Evans AG, Azadniv M, Hansen JN, Becker MW, Sharon A, Thomas VK, Moore RG, Khera MK, Jordan CT, Singh RK., Free PMC Article | 06/12/2024 |
| Coordination of actin plus-end dynamics by IQGAP1, formin, and capping protein. | Coordination of actin plus-end dynamics by IQGAP1, formin, and capping protein.
Pimm ML, Haarer BK, Nobles AD, Haney LM, Marcin AG, Alcaide Eligio M, Henty-Ridilla JL., Free PMC Article | 05/29/2024 |
| IQGAP1 and NWASP promote human cancer cell dissemination and metastasis by regulating beta1-integrin via FAK and MRTF/SRF. | IQGAP1 and NWASP promote human cancer cell dissemination and metastasis by regulating β1-integrin via FAK and MRTF/SRF.
Cerutti C, Lucotti S, Menendez ST, Reymond N, Garg R, Romero IA, Muschel R, Ridley AJ. | 04/30/2024 |
| Tight junction protein cingulin variant is associated with cancer susceptibility by overexpressed IQGAP1 and Rac1-dependent epithelial-mesenchymal transition. | Tight junction protein cingulin variant is associated with cancer susceptibility by overexpressed IQGAP1 and Rac1-dependent epithelial-mesenchymal transition.
Huang YT, Hsu YT, Wu PY, Yeh YM, Lin PC, Hsu KF, Shen MR., Free PMC Article | 03/5/2024 |
| IQGAP1 promotes mitochondrial damage and activation of the mtDNA sensor cGAS-STING pathway to induce endothelial cell pyroptosis leading to atherosclerosis. | IQGAP1 promotes mitochondrial damage and activation of the mtDNA sensor cGAS-STING pathway to induce endothelial cell pyroptosis leading to atherosclerosis.
An C, Sun F, Liu C, Huang S, Xu T, Zhang C, Ge S. | 09/25/2023 |
| 7-Ketocholesterol Promotes Retinal Pigment Epithelium Senescence and Fibrosis of Choroidal Neovascularization via IQGAP1 Phosphorylation-Dependent Signaling. | 7-Ketocholesterol Promotes Retinal Pigment Epithelium Senescence and Fibrosis of Choroidal Neovascularization via IQGAP1 Phosphorylation-Dependent Signaling.
Wang H, Ramshekar A, Cung T, Wallace-Carrete C, Zaugg C, Nguyen J, Stoddard GJ, Hartnett ME., Free PMC Article | 07/7/2023 |
| The IQGAP scaffolds: Critical nodes bridging receptor activation to cellular signaling. | The IQGAP scaffolds: Critical nodes bridging receptor activation to cellular signaling.
Thines L, Roushar FJ, Hedman AC, Sacks DB., Free PMC Article | 04/26/2023 |
| Novel Approach Using shRNA of IQGAP1 for Colon Cancer Therapy: HCT166 as a Surrogate Model Colorectal Carcinoma. | Novel Approach Using shRNA of IQGAP1 for Colon Cancer Therapy: HCT116 as a Surrogate Model Colorectal Carcinoma.
Zoheir KMMA, Mahmoud K, Harisa GI, Ashour A, Abdel-Hamied HE, Amara AA, Mahrous KF, Abd-Rabou AA., Free PMC Article | 08/13/2022 |
| IQGAP1 is positively correlated with PD-L1 and regulates its expression via mediating STAT proteins phosphorylation. | IQGAP1 is positively correlated with PD-L1 and regulates its expression via mediating STAT proteins phosphorylation.
Chen Y, Mei J, Zhang P, Liu J, Chen L, Wu L, Zhang Y. | 07/2/2022 |
| IQGAP1 enhances cell invasion and matrix metalloproteinase-2 expression through upregulating NF-kappaB activity in esophageal squamous cell carcinoma cells. | IQGAP1 enhances cell invasion and matrix metalloproteinase-2 expression through upregulating NF-κB activity in esophageal squamous cell carcinoma cells.
Zhang Z, Wei Y, Li X, Zhao R, Wang X, Yang Z, Li T, Wang X, Li X, Wang X. | 04/23/2022 |
| Single-molecule imaging of IQGAP1 regulating actin filament dynamics. | Single-molecule imaging of IQGAP1 regulating actin filament dynamics.
Hoeprich GJ, Sinclair AN, Shekhar S, Goode BL., Free PMC Article | 03/26/2022 |
| IQGAP1-mediated mechanical signaling promotes the foreign body response to biomedical implants. | IQGAP1-mediated mechanical signaling promotes the foreign body response to biomedical implants.
Sivaraj D, Padmanabhan J, Chen K, Henn D, Noishiki C, Trotsyuk AA, Kussie HC, Leeolou MC, Magbual NJ, Andrikopoulos S, Perrault DP, Barrera JA, Januszyk M, Gurtner GC. | 02/19/2022 |
| AmotL2, IQGAP1, and FKBP51 Scaffold Proteins in Glioblastoma Stem Cell Niches. | AmotL2, IQGAP1, and FKBP51 Scaffold Proteins in Glioblastoma Stem Cell Niches.
Rotoli D, Díaz-Flores L, Gutiérrez R, Morales M, Ávila J, Martín-Vasallo P., Free PMC Article | 02/19/2022 |
| CRMP2 as a Candidate Target to Interfere with Lung Cancer Cell Migration. | CRMP2 as a Candidate Target to Interfere with Lung Cancer Cell Migration.
Morales X, Peláez R, Garasa S, Ortiz de Solórzano C, Rouzaut A., Free PMC Article | 01/22/2022 |
| Generation of Rat Monoclonal Antibody for Human IQGAP1 by Immunization of Three-Dimensional-Cultured Cancer Cells. | Generation of Rat Monoclonal Antibody for Human IQGAP1 by Immunization of Three-Dimensional-Cultured Cancer Cells.
Soeta K, Yamaguchi R, Iuchi K, Hisatomi H, Yokoyama C. | 01/8/2022 |
| Selectivity Determinants of RHO GTPase Binding to IQGAPs. | Selectivity Determinants of RHO GTPase Binding to IQGAPs.
Mosaddeghzadeh N, Nouri K, Krumbach OHF, Amin E, Dvorsky R, Ahmadian MR., Free PMC Article | 12/18/2021 |
| Identification of the interactome of the DP1 receptor for Prostaglandin D2: Regulation of DP1 receptor signaling and trafficking by IQGAP1. | Identification of the interactome of the DP1 receptor for Prostaglandin D(2): Regulation of DP1 receptor signaling and trafficking by IQGAP1.
Fréchette L, Degrandmaison J, Binda C, Boisvert M, Côté L, Michaud T, Lalumière MP, Gendron L, Parent JL. | 11/22/2021 |
| IQGAP1 binds AMPK and is required for maximum AMPK activation. | IQGAP1 binds AMPK and is required for maximum AMPK activation.
Hedman AC, Li Z, Gorisse L, Parvathaneni S, Morgan CJ, Sacks DB., Free PMC Article | 09/18/2021 |
| Role of the small GTPase activating protein IQGAP1 in collagen phagocytosis. | Role of the small GTPase activating protein IQGAP1 in collagen phagocytosis.
Nakajima K, Arora PD, Plaha A, McCulloch CA. | 09/11/2021 |
| IQGAP1 Is a Scaffold of the Core Proteins of the Hippo Pathway and Negatively Regulates the Pro-Apoptotic Signal Mediated by This Pathway. | IQGAP1 Is a Scaffold of the Core Proteins of the Hippo Pathway and Negatively Regulates the Pro-Apoptotic Signal Mediated by This Pathway.
Quinn NP, García-Gutiérrez L, Doherty C, von Kriegsheim A, Fallahi E, Sacks DB, Matallanas D., Free PMC Article | 08/28/2021 |
| MAL2 interacts with IQGAP1 to promote pancreatic cancer progression by increasing ERK1/2 phosphorylation. | MAL2 interacts with IQGAP1 to promote pancreatic cancer progression by increasing ERK1/2 phosphorylation.
Zhang B, Xiao J, Cheng X, Liu T. | 07/17/2021 |
| The Correct Localization of Borealin in Midbody during Cytokinesis Depends on IQGAP1. | The Correct Localization of Borealin in Midbody during Cytokinesis Depends on IQGAP1.
Wumaier R, Aili A, Saiyin H, Zhang P, Cao L, Muheremu A., Free PMC Article | 04/17/2021 |
| IQGAP1 Negatively Regulates HIV-1 Gag Trafficking and Virion Production. | IQGAP1 Negatively Regulates HIV-1 Gag Trafficking and Virion Production.
Sabo Y, de Los Santos K, Goff SP., Free PMC Article | 04/13/2021 |
| IQGAP1 promotes anoikis resistance and metastasis through Rac1-dependent ROS accumulation and activation of Src/FAK signalling in hepatocellular carcinoma. | IQGAP1 promotes anoikis resistance and metastasis through Rac1-dependent ROS accumulation and activation of Src/FAK signalling in hepatocellular carcinoma.
Mo CF, Li J, Yang SX, Guo HJ, Liu Y, Luo XY, Wang YT, Li MH, Li JY, Zou Q., Free PMC Article | 03/27/2021 |