| ACSL6-activated IL-18R1-NF-kappaB promotes IL-18-mediated tumor immune evasion and tumor progression. | ACSL6-activated IL-18R1-NF-κB promotes IL-18-mediated tumor immune evasion and tumor progression.
Di Y, Wang Z, Xiao J, Zhang X, Ye L, Wen X, Qin J, Lu L, Wang X, He W., Free PMC Article | 09/25/2024 |
| Increased expression of serum IL-18 and IL-18R in newly diagnosed type 2 diabetes mellitus. | Increased expression of serum IL-18 and IL-18R in newly diagnosed type 2 diabetes mellitus.
Abhilasha A, Mitra P, Suri S, Saxena I, Shukla R, Shukla KK, Sharma P. | 03/20/2023 |
| Downregulation of T-cell cytotoxic marker IL18R1 promotes cancer proliferation and migration and is associated with dismal prognosis and immunity in lung squamous cell carcinoma. | Downregulation of T-cell cytotoxic marker IL18R1 promotes cancer proliferation and migration and is associated with dismal prognosis and immunity in lung squamous cell carcinoma.
Guo Q, Wu CY, Jiang N, Tong S, Wan JH, Xiao XY, Mei PY, Liu HS, Wang SH., Free PMC Article | 01/11/2023 |
| IL18-family Genes Polymorphism Is Associated with the Risk of Myocardial Infarction and IL18 Concentration in Patients with Coronary Artery Disease. | IL18-family Genes Polymorphism Is Associated with the Risk of Myocardial Infarction and IL18 Concentration in Patients with Coronary Artery Disease.
Ponasenko AV, Tsepokina AV, Khutornaya MV, Sinitsky MY, Barbarash OL. | 06/11/2022 |
| IL-18/IL-18R1 promotes circulating fibrocyte differentiation in the aging population. | IL-18/IL-18R1 promotes circulating fibrocyte differentiation in the aging population.
Niu XH, Xie YP, Yang S, Chen Y, Xu L, Zhang Y, Liu Y. | 02/20/2021 |
| Our replicated associations with HK1 and IL18R1 suggest that variants in inflammatory pathways, such as the biologically-plausible NLRP3 inflammasome, may contribute to nocturnal hypoxemia. | Associations of variants In the hexokinase 1 and interleukin 18 receptor regions with oxyhemoglobin saturation during sleep.
Cade BE, Chen H, Stilp AM, Louie T, Ancoli-Israel S, Arens R, Barfield R, Below JE, Cai J, Conomos MP, Evans DS, Frazier-Wood AC, Gharib SA, Gleason KJ, Gottlieb DJ, Hillman DR, Johnson WC, Lederer DJ, Lee J, Loredo JS, Mei H, Mukherjee S, Patel SR, Post WS, Purcell SM, Ramos AR, Reid KJ, Rice K, Shah NA, Sofer T, Taylor KD, Thornton TA, Wang H, Yaffe K, Zee PC, Hanis CL, Palmer LJ, Rotter JI, Stone KL, Tranah GJ, Wilson JG, Sunyaev SR, Laurie CC, Zhu X, Saxena R, Lin X, Redline S., Free PMC Article | 05/11/2019 |
| asthma is very likely to be determined by balance of IL-18/IL-18BP/IL-18R expression in inflammatory cells. | Role of IL-18 in atopic asthma is determined by balance of IL-18/IL-18BP/IL-18R.
Zhang H, Wang J, Wang L, Xie H, Chen L, He S., Free PMC Article | 02/9/2019 |
| IL-18, IL-18R and IL-18BP expression in eosinophil are involved in the inflammatory reaction of asthma. | [Elevated IL-18, IL-18 binding protein and IL-18 receptor in eosinophil-enriched blood cells in patients with asthma].
Yuan L, Lu S, Zhang H, Wang J, Hu Y, Wang L, He S. | 09/16/2017 |
| IL18R1 rs1035130 may be associated with schizophrenia. | Potential involvement of the interleukin-18 pathway in schizophrenia.
Xu Y, Yue W, Shugart YY, Yuan J, Wang G, Wang HZ, Lehrman B, Zhang F, Zhang D. | 12/17/2016 |
| some SNPs of ST2-IL18R1-IL18RAP gene cluster might increase the risk of susceptibility of Graves' disease (GD) and Hashimoto's thyroiditis (HT) in Chinese Han population. | Polymorphisms of ST2-IL18R1-IL18RAP gene cluster: a new risk for autoimmune thyroid diseases.
Wang X, Zhu YF, Li DM, Qin Q, Wang Q, Muhali FS, Jiang WJ, Zhang JA. | 12/17/2016 |
| IL-18 and IL-18R polymorphisms may contribute to the development and lymph node metastasis of PTC. | Single Nucleotide Polymorphism of Interleukin-18 and Interleukin-18 Receptor and the Risk of Papillary Thyroid Cancer.
Chung JH, Lee YC, Eun YG, Chung JH, Kim SK, Chon S, Oh SJ, Rhee SY, Hong IK. | 09/10/2016 |
| strong evidence that IL-18 and IL18Ralpha have important functions in the pathogenesis of allergic asthma | Allergic airway inflammation: unravelling the relationship between IL-37, IL-18Rα and Tir8/SIGIRR.
Lunding L, Schröder A, Wegmann M. | 07/2/2016 |
| Human memory IL-18Ralpha and DR3 CD4+ T cells may contribute to antigen-independent innate responses at barrier surfaces. | A major population of mucosal memory CD4+ T cells, coexpressing IL-18Rα and DR3, display innate lymphocyte functionality.
Holmkvist P, Roepstorff K, Uronen-Hansson H, Sandén C, Gudjonsson S, Patschan O, Grip O, Marsal J, Schmidtchen A, Hornum L, Erjefält JS, Håkansson K, Agace WW., Free PMC Article | 03/12/2016 |
| PDGFB and IL18R1 represent plausible candidates for studying the pathophysiology of these disorders in the context of TLR4 activation | Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes.
Kim S, Becker J, Bechheim M, Kaiser V, Noursadeghi M, Fricker N, Beier E, Klaschik S, Boor P, Hess T, Hofmann A, Holdenrieder S, Wendland JR, Fröhlich H, Hartmann G, Nöthen MM, Müller-Myhsok B, Pütz B, Hornung V, Schumacher J. | 02/27/2016 |
| The architecture of the IL-18 receptor second domain (D2) is unique among the other IL-1R family members, which presumably distinguishes them from the IL-1 receptors that exhibit a more promiscuous ligand recognition mode. | The structural basis for receptor recognition of human interleukin-18.
Tsutsumi N, Kimura T, Arita K, Ariyoshi M, Ohnishi H, Yamamoto T, Zuo X, Maenaka K, Park EY, Kondo N, Shirakawa M, Tochio H, Kato Z., Free PMC Article | 11/7/2015 |
| polymorphisms in the interleukin 18 receptor 1 gene and tuberculosis susceptibility among Chinese | Polymorphisms in the interleukin 18 receptor 1 gene and tuberculosis susceptibility among Chinese.
Zhang J, Zheng L, Zhu D, An H, Yang Y, Liang Y, Zhao W, Ding W, Wu X., Free PMC Article | 06/27/2015 |
| IL-37 requires the receptors IL-18Ralpha and IL-1R8 to carry out its multifaceted anti-inflammatory program upon innate signal transduction. | IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction.
Nold-Petry CA, Lo CY, Rudloff I, Elgass KD, Li S, Gantier MP, Lotz-Havla AS, Gersting SW, Cho SX, Lao JC, Ellisdon AM, Rotter B, Azam T, Mangan NE, Rossello FJ, Whisstock JC, Bufler P, Garlanda C, Mantovani A, Dinarello CA, Nold MF. | 05/23/2015 |
| There was no association between the rs917997 in IL18R gene and rs187238 in IL18 gene polymorphisms and risk for non-Hodgkin's malignant lymphomas in Novosibirsk population. | Analysis of the association of polymorphic loci rs917997 in IL18RAP gene and rs187238 in IL18 gene with the risk for non-Hodgkin's malignant lymphomas in Novosibirsk population.
Surovtseva MN, Vainer AS, Berezina OV, Ovchinnikov VS, Voropaeva EN, Pospelova TI, Filipenko ML. | 02/21/2015 |
| IL-18, IL-18BP, and IL-18R may have roles in the pathogenesis of epithelial ovarian carcinoma | Expression of IL-18, IL-18 binding protein, and IL-18 receptor by normal and cancerous human ovarian tissues: possible implication of IL-18 in the pathogenesis of ovarian carcinoma.
Medina L, Rabinovich A, Piura B, Dyomin V, Levy RS, Huleihel M., Free PMC Article | 02/14/2015 |
| IL-18R downregulates IFN-alpha production by activation-induced splicing of IL-18Ralpha into 2 isoforms: the full-length receptor (IL-18Ralpha1) and a novel, truncated variant (IL-18Ralpha2), a competitive molecular decoy inhibiting canonical IL-18Ralpha1/IL-18Rbeta signaling. | Human plasmacytoid dendritic cells regulate IFN-α production through activation-induced splicing of IL-18Rα.
Chao Y, Kaliaperumal N, Chretien AS, Tang S, Lee B, Poidinger M, Fairhurst AM, Connolly JE. | 01/31/2015 |
| structural basis for the specific recognition of IL-18 by its alpha receptor | Structural basis for the specific recognition of IL-18 by its alpha receptor.
Wei H, Wang D, Qian Y, Liu X, Fan S, Yin HS, Wang X. | 01/24/2015 |
| results demonstrate clear functional consequences of the rs917997 risk polymorphism; this polymorphism leads to a loss-of-function through decreased IL-18RAP, IL-18R1, and IL-1R1 protein expression, which impairs autocrine IL-18 and IL-1 signaling | The IL18RAP region disease polymorphism decreases IL-18RAP/IL-18R1/IL-1R1 expression and signaling through innate receptor-initiated pathways.
Hedl M, Zheng S, Abraham C., Free PMC Article | 08/23/2014 |
| increased levels of soluble IL-18Ralpha complex in serum may also exert an antagonistic effect in vivo and play an important role in the inflammatory process in allergic asthma. | Increased serum levels of soluble IL-18 receptor complex in patients with allergic asthma.
Imaoka H, Takenaka S, Kawayama T, Oda H, Kaku Y, Matsuoka M, Sakazaki Y, O'Byrne PM, Hoshino T. | 07/26/2014 |
| Association between single nucleotide polymorphisms in the IL18R1, IL18 and interferon-gamma genes and smallpox vaccine induced adaptive immunity. | Genetic variation in IL18R1 and IL18 genes and Inteferon γ ELISPOT response to smallpox vaccination: an unexpected relationship.
Ovsyannikova IG, Haralambieva IH, Kennedy RB, O'Byrne MM, Pankratz VS, Poland GA., Free PMC Article | 11/23/2013 |
| Our study reveals the important role of IL12/IL18-mediated transcriptional regulation of IFN-gamma production in leprosy. | Identification of IL18RAP/IL18R1 and IL12B as leprosy risk genes demonstrates shared pathogenesis between inflammation and infectious diseases.
Liu H, Irwanto A, Tian H, Fu X, Yu Y, Yu G, Low H, Chu T, Li Y, Shi B, Chen M, Sun Y, Yuan C, Lu N, You J, Bao F, Li J, Liu J, Liu H, Liu D, Yu X, Zhang L, Yang Q, Wang N, Niu G, Ma S, Zhou Y, Wang C, Chen S, Zhang X, Liu J, Zhang F., Free PMC Article | 01/26/2013 |