| CREG1 deficiency impaired myoblast differentiation and skeletal muscle regeneration. | CREG1 deficiency impaired myoblast differentiation and skeletal muscle regeneration.
Song H, Tian X, He L, Liu D, Li J, Mei Z, Zhou T, Liu C, He J, Jia X, Yang Z, Yan C, Han Y., Free PMC Article | 04/11/2024 |
| The role of CREG1 in megakaryocyte maturation and thrombocytopoiesis. | The role of CREG1 in megakaryocyte maturation and thrombocytopoiesis.
Song H, Li J, Peng C, Liu D, Mei Z, Yang Z, Tian X, Zhang X, Jing Q, Yan C, Han Y., Free PMC Article | 08/3/2023 |
| DNA hypermethylation: A novel mechanism of CREG gene suppression and atherosclerogenic endothelial dysfunction. | DNA hypermethylation: A novel mechanism of CREG gene suppression and atherosclerogenic endothelial dysfunction.
Liu Y, Tian X, Liu S, Liu D, Li Y, Liu M, Zhang X, Yan C, Han Y., Free PMC Article | 08/7/2021 |
| Studies demonstrated that CREG may modulate homeostasis of vascular wall cells and inhibit inflammation of vascular tissue cells and macrophages. Mechanistically, CREG behaves like a typical soluble lysosomal protein that regulates the formation and maturation of lysosomes by modulating the small GTPase protein Rab7, to mediate autophagy in vascular vascular tissue cells. [review] | Cellular Repressor of E1A-stimulated Genes, A New Potential Therapeutic Target for Atherosclerosis.
Tian X, Yan C, Han Y. | 06/16/2018 |
| These results indicate that CREG1 is a down-stream effector of KRAS in a sub-type of non-small cell lung cancer cells and a novel candidate biomarker or therapeutic target for KRAS mutant non-small cell lung cancer. | Glycoproteomic Approach Identifies KRAS as a Positive Regulator of CREG1 in Non-small Cell Lung Cancer Cells.
Clark DJ, Mei Y, Sun S, Zhang H, Yang AJ, Mao L., Free PMC Article | 10/8/2016 |
| Results indicate that cellular repressor of E1A-stimulated gene 1 protein (CREG1) increases endothelial cell (EC) filopodia formation. | CREG1 promotes angiogenesis and neovascularization.
Yan C, Fang P, Zhang H, Tao J, Tian X, Li Y, Zhang J, Sun M, Li S, Wang H, Han Y. | 02/14/2015 |
| The results suggest a novel role of CREG to promote HUVEC proliferation through the ERK/cyclin E signaling pathway. | CREG promotes the proliferation of human umbilical vein endothelial cells through the ERK/cyclin E signaling pathway.
Tao J, Yan C, Tian X, Liu S, Li Y, Zhang J, Sun M, Ma X, Han Y., Free PMC Article | 03/22/2014 |
| CREG can inhibit NF-kappaB activation, TNF-alpha-induced inflammatory responses and the hyperpermeability of endothelial cells. | Cellular repressor of E1A stimulated genes enhances endothelial monolayer integrity.
Duan Y, Liu S, Tao J, You Y, Yang G, Yan C, Han Y. | 12/7/2013 |
| miR-31 not only directly binds to its target gene CREG and modulates the vascular smooth muscle cells(VSMC) phenotype through this interaction, but also can be an important biomarker in diseases involving VSMC phenotypic modulation. | MicroRNA-31 controls phenotypic modulation of human vascular smooth muscle cells by regulating its target gene cellular repressor of E1A-stimulated genes.
Wang J, Yan CH, Li Y, Xu K, Tian XX, Peng CF, Tao J, Sun MY, Han YL. | 06/15/2013 |
| Suggest that CREG is a novel adventitial fibroblast phenotypic modulator in a p38MAPK-dependent manner. | Cellular repressor E1A-stimulated genes controls phenotypic switching of adventitial fibroblasts by blocking p38MAPK activation.
Li Y, Tao J, Zhang J, Tian X, Liu S, Sun M, Zhang X, Yan C, Han Y. | 05/4/2013 |
| CREG plays a critical role in protecting the vascular endothelium from apoptosis, and the protective effort of CREG against ECs apoptosis is through the activation of the VEGF/PI3K/AKT signaling pathway | Overexpression of CREG attenuates atherosclerotic endothelium apoptosis via VEGF/PI3K/AKT pathway.
Wang N, Han Y, Tao J, Huang M, You Y, Zhang H, Liu S, Zhang X, Yan C. | 04/14/2012 |
| Upregulation of CREG expression induced HUVEC migration. | Cellular repressor of E1A-stimulated genes regulates vascular endothelial cell migration by the ILK/AKT/mTOR/VEGF(165) signaling pathway.
Zhang H, Han Y, Tao J, Liu S, Yan C, Li S. | 03/10/2012 |
| Cooperation of CREG1 and p16 (INK4a) inhibits the expression of cyclin A and cyclin B by inhibiting promoter activity thereby decreasing mRNA and protein levels; these proteins are required for S-phase entry and G2/M transition. | CREG1 enhances p16(INK4a) -induced cellular senescence.
Moolmuang B, Tainsky MA., Free PMC Article | 07/9/2011 |
| Data suggest that soluble CREG protein can exert its biological function via glycosylation-independent binding to the extracellular domains 11-13 of cell surface M6P/IGF2R, modulating SMC phenotypic switching from contractile to proliferative. | Glycosylation-independent binding to extracellular domains 11-13 of mannose-6-phosphate/insulin-like growth factor-2 receptor mediates the effects of soluble CREG on the phenotypic modulation of vascular smooth muscle cells.
Han Y, Luan B, Sun M, Guo L, Guo P, Tao J, Deng J, Wu G, Liu S, Yan C, Li S. | 06/25/2011 |
| no ssociation between common variants of CREG and coronary artery disease in the northern Chinese Han population | Lack of association between cellular repressor of E1A-stimulated genes (CREG) [corrected] polymorphisms and coronary artery disease in the Han population of North China.
Wang T, Zhang M, Han Y, Zhang X, Yan C, Liang Z, Sun Y, Kang J, Wang T, Zhang M, Han Y, Zhang X, Yan C, Liang Z, Sun Y, Kang J. | 03/26/2011 |
| CREG plays a key role in modulating VSMC apoptosis through the p38 and JNK signal transduction pathways, both in vitro and in s | Cellular repressor of E1A-stimulated genes inhibits human vascular smooth muscle cell apoptosis via blocking P38/JNK MAP kinase activation.
Han Y, Wu G, Deng J, Tao J, Guo L, Tian X, Kang J, Zhang X, Yan C. | 11/27/2010 |
| CREG plays a critical role in the inhibition of SMC migration, as well as maintaining SMCs in a mature phenotype | CREG inhibits migration of human vascular smooth muscle cells by mediating IGF-II endocytosis.
Han Y, Cui J, Tao J, Guo L, Guo P, Sun M, Kang J, Zhang X, Yan C, Li S. | 01/25/2010 |
| The expression of CREG improves cardiac functions and inhibits cardiac hypertrophy, inflammation and fibrosis through blocking MEK-ERK1/2-dependent signalling. | Cellular repressor of E1A-stimulated genes attenuates cardiac hypertrophy and fibrosis.
Bian Z, Cai J, Shen DF, Chen L, Yan L, Tang Q, Li H., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesLack of association between cellular repressor of E1A-stimulated genes (CREG) [corrected] polymorphisms and coronary artery disease in the Han population of North China.
Wang T, Zhang M, Han Y, Zhang X, Yan C, Liang Z, Sun Y, Kang J, Wang T, Zhang M, Han Y, Zhang X, Yan C, Liang Z, Sun Y, Kang J. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.
Ehret GB, O'Connor AA, Weder A, Cooper RS, Chakravarti A. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation.
Cheung CL, Chan BY, Chan V, Ikegawa S, Kou I, Ngai H, Smith D, Luk KD, Huang QY, Mori S, Sham PC, Kung AW. | 01/11/2009 |
| CREG promotes a mature smooth muscle cell phenotype and reduces neointimal formation in balloon-injured rat carotid artery. | CREG promotes a mature smooth muscle cell phenotype and reduces neointimal formation in balloon-injured rat carotid artery.
Han Y, Deng J, Guo L, Yan C, Liang M, Kang J, Liu H, Graham AM, Li S. | 01/21/2010 |
| We demonstrate that CREG is expressed in the vascular endothelium; data suggests that CREG differentially regulates the growth of the denuded artery wall and smooth vascular muscle cell. | Adenovirus-mediated intra-arterial delivery of cellular repressor of E1A-stimulated genes inhibits neointima formation in rabbits after balloon injury.
Han Y, Guo L, Yan C, Guo P, Deng J, Mai X, Kang J, Li S. | 01/21/2010 |
| putative flavin mononucleotide-binding pocket in CREG is sterically blocked by a loop and several key bulky residues | The crystal structure of CREG, a secreted glycoprotein involved in cellular growth and differentiation.
Sacher M, Di Bacco A, Lunin VV, Ye Z, Wagner J, Gill G, Cygler M., Free PMC Article | 01/21/2010 |