| MPDZ is associated with immune infiltration and regulates migration and invasion by switching YAP1 phosphorylation in colorectal cancer. | MPDZ is associated with immune infiltration and regulates migration and invasion by switching YAP1 phosphorylation in colorectal cancer.
Chen Z, Ba Y, Zhao N, Dang Q, Xu H, Weng S, Zhang Y, Liu S, Zuo A, Han X, Liu Z. | 01/13/2024 |
| Retinal manifestations in autosomal recessive MPDZ maculopathy: report of two cases and literature review. | Retinal manifestations in autosomal recessive MPDZ maculopathy: report of two cases and literature review.
Iyengar R, Deardorff M, Schmidt R, Nagiel A., | 11/22/2023 |
| Evaluating the association between MPDZ-NF1B rs1324183 and keratoconus in an independent northwestern Chinese population. | Evaluating the association between MPDZ-NF1B rs1324183 and keratoconus in an independent northwestern Chinese population.
Yuan S, Li D, Ma M, Zhou L, Ma Z, Shi B, Zhang S, Li H, Sheng X, Liu J., Free PMC Article | 03/26/2022 |
| ADAMTS1, MPDZ, MVD, and SEZ6: candidate genes for autosomal recessive nonsyndromic hearing impairment. | ADAMTS1, MPDZ, MVD, and SEZ6: candidate genes for autosomal recessive nonsyndromic hearing impairment.
Bharadwaj T, Schrauwen I, Rehman S, Liaqat K, Acharya A, Giese APJ, Nouel-Saied LM, Nasir A, Everard JL, Pollock LM, Zhu S, Bamshad MJ, Nickerson DA, Ali RH, Ullah A, Wali A, Ali G, Santos-Cortez RLP, Ahmed ZM, McDermott BM Jr, Ansar M, Riazuddin S, Ahmad W, Leal SM., Free PMC Article | 03/26/2022 |
| MPDZ as a novel epigenetic silenced tumor suppressor inhibits growth and progression of lung cancer through the Hippo-YAP pathway. | MPDZ as a novel epigenetic silenced tumor suppressor inhibits growth and progression of lung cancer through the Hippo-YAP pathway.
Liu W, Huang Y, Wang D, Han F, Chen H, Chen J, Jiang X, Cao J, Liu J. | 12/25/2021 |
| Observation of nine previously reported and 10 non-reported SLC4A11 mutations among 20 Iranian CHED probands and identification of an MPDZ mutation as possible cause of CHED and FECD in one family. | Observation of nine previously reported and 10 non-reported SLC4A11 mutations among 20 Iranian CHED probands and identification of an MPDZ mutation as possible cause of CHED and FECD in one family.
Moazzeni H, Javadi MA, Asgari D, Khani M, Emami M, Moghadam A, Panahi-Bazaz MR, Hosseini Tehrani M, Karimian F, Hosseini B, Nekuie Moghadam T, Hassanpour H, Akbari MT, Elahi E. | 02/27/2021 |
| DAPLE and MPDZ function as cooperative partners at apical junctions. | DAPLE and MPDZ bind to each other and cooperate to promote apical cell constriction.
Marivin A, Garcia-Marcos M., Free PMC Article | 01/11/2020 |
| Tumor angiogenesis was enhanced upon endothelial-specific inactivation of MPDZ leading to an excessively branched and poorly functional vessel network resulting in tumor hypoxia through DLL4-induced Notch signaling. | MPDZ promotes DLL4-induced Notch signaling during angiogenesis.
Tetzlaff F, Adam MG, Feldner A, Moll I, Menuchin A, Rodriguez-Vita J, Sprinzak D, Fischer A., Free PMC Article | 07/27/2019 |
| This study confirmed the association of SNP rs1324183 in MPDZ-NF1B with keratoconus and revealed the association of this SNP with keratoconus severity and corneal parameters. It is thus a putative genetic marker for monitoring the progression of keratoconus to a severe form and facilitating early intervention. | Analysis of multiple genetic loci reveals MPDZ-NF1B rs1324183 as a putative genetic marker for keratoconus.
Wang YM, Ma L, Lu SY, Chan TCY, Yam JCS, Tang SM, Kam KW, Tam POS, Tham CC, Young AL, Jhanji V, Pang CP, Chen LJ. | 06/1/2019 |
| two peptides (SIAPNV(-COOH) and SIVMNV(-COOH)) were identified to have considerably improved affinity with K d increase by ~tenfold relative to wild type peptide. Thus, the two peptides are considered as promising lead entities to develop therapeutic molecular agents with high efficacy and specificity to target CaMKIIalpha-MUPP1 interaction. | Structure-based identification of CaMKIIα-interacting MUPP1 PDZ domains and rational design of peptide ligands to target such interaction in human fertilization.
Zhang YL, Han ZF, Sun YP. | 12/9/2017 |
| Phenotypic spectrum of congenital hydrocephalus is associated with 5 recessive MPDZ alleles. | The genetic landscape of familial congenital hydrocephalus.
Shaheen R, Sebai MA, Patel N, Ewida N, Kurdi W, Altweijri I, Sogaty S, Almardawi E, Seidahmed MZ, Alnemri A, Madirevula S, Ibrahim N, Abdulwahab F, Hashem M, Al-Sheddi T, Alomar R, Alobeid E, Sallout B, AlBaqawi B, AlAali W, Ajaji N, Lesmana H, Hopkin RJ, Dupuis L, Mendoza-Londono R, Al Rukban H, Yoon G, Faqeih E, Alkuraya FS. | 07/22/2017 |
| The replication association of rs1324183 (MPDZ-NF1B) with KC in our population and the results, which are identical to those in different populations, suggest that rs1324183 (MPDZ-NF1B) is a common genetic risk for Keratoconus. | Evaluating the Association between Keratoconus and Reported Genetic Loci in a Han Chinese Population.
Hao XD, Chen P, Chen ZL, Li SX, Wang Y. | 02/27/2016 |
| MUPP-1 controls the PALS-1/PATJ complex levels at the post-translational level. | The multi-PDZ domain protein-1 (MUPP-1) expression regulates cellular levels of the PALS-1/PATJ polarity complex.
Assémat E, Crost E, Ponserre M, Wijnholds J, Le Bivic A, Massey-Harroche D. | 12/7/2013 |
| Our data strongly support the candidacy of MPDZ as a novel congenital hydrocephalus disease gene. | Mutation in MPDZ causes severe congenital hydrocephalus.
Al-Dosari MS, Al-Owain M, Tulbah M, Kurdi W, Adly N, Al-Hemidan A, Masoodi TA, Albash B, Alkuraya FS. | 05/18/2013 |
| The data indicates potential association between variation in mpdz NMDA dependent AMPA trafficking and alcohol dependence. | Genetic variability in the NMDA-dependent AMPA trafficking cascade is associated with alcohol dependence.
Karpyak VM, Geske JR, Colby CL, Mrazek DA, Biernacka JM., Free PMC Article | 10/6/2012 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| These data suggest that NMDA receptor complex formation, localization, and downstream signaling may be abnormal in schizophrenia as PSD95, SynGAP and MUPP1 expression is altered. | Decreased expression of NMDA receptor-associated proteins in frontal cortex of elderly patients with schizophrenia.
Funk AJ, Rumbaugh G, Harotunian V, McCullumsmith RE, Meador-Woodruff JH., Free PMC Article | 01/21/2010 |
| MUPP1 and Kir4.2 may participate in a protein complex in the nephron that could regulate transport of K(+) as well as other ions. | MUPP1 complexes renal K+ channels to alter cell surface expression and whole cell currents.
Sindic A, Huang C, Chen AP, Ding Y, Miller-Little WA, Che D, Romero MF, Miller RT., Free PMC Article | 01/21/2010 |
| Exploratory haplotype and single nucleotide polymorphisms association analyses suggest a possible association between the MPDZ gene and alcohol dependence but not alcohol withdrawal seizures. | Sequence variations of the human MPDZ gene and association with alcoholism in subjects with European ancestry.
Karpyak VM, Kim JH, Biernacka JM, Wieben ED, Mrazek DA, Black JL, Choi DS, Karpyak VM, Kim JH, Biernacka JM, Wieben ED, Mrazek DA, Black JL, Choi DS., Free PMC Articles: PMC2819379, PMC2819379 | 01/21/2010 |
| Results suggest that signaling mediated by Pals1, which has a higher affinity for Patj than for MUPP1 and is involved in the activation of the Par6-aPKC complex, is of principal importance for the function of Patj in epithelial cells. | Similar and distinct properties of MUPP1 and Patj, two homologous PDZ domain-containing tight-junction proteins.
Adachi M, Hamazaki Y, Kobayashi Y, Itoh M, Tsukita S, Furuse M, Tsukita S., Free PMC Article | 01/21/2010 |
| An interaction between the human somatostatin receptor 3 and the multiple PDZ protein MUPP1 was identified. | Interaction of the human somatostatin receptor 3 with the multiple PDZ domain protein MUPP1 enables somatostatin to control permeability of epithelial tight junctions.
Liew CW, Vockel M, Glassmeier G, Brandner JM, Fernandez-Ballester GJ, Schwarz JR, Schulz S, Buck F, Serrano L, Richter D, Kreienkamp HJ. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesGene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. Genetical genomic determinants of alcohol consumption in rats and humans.
Tabakoff B, Saba L, Printz M, Flodman P, Hodgkinson C, Goldman D, Koob G, Richardson HN, Kechris K, Bell RL, Hübner N, Heinig M, Pravenec M, Mangion J, Legault L, Dongier M, Conigrave KM, Whitfield JB, Saunders J, Grant B, Hoffman PL, WHO/ISBRA Study on State and Trait Markers of Alcoholism. Sequence variations of the human MPDZ gene and association with alcoholism in subjects with European ancestry.
Karpyak VM, Kim JH, Biernacka JM, Wieben ED, Mrazek DA, Black JL, Choi DS, Karpyak VM, Kim JH, Biernacka JM, Wieben ED, Mrazek DA, Black JL, Choi DS. | 02/11/2009 |
| MUPP1 binds to the G protein-coupled MT(1) melatonin receptor and directly regulates its G(i)-dependent signal transduction | The PDZ protein mupp1 promotes Gi coupling and signaling of the Mt1 melatonin receptor.
Guillaume JL, Daulat AM, Maurice P, Levoye A, Migaud M, Brydon L, Malpaux B, Borg-Capra C, Jockers R. | 01/21/2010 |
| the apparent occurrence of an unusual TG 3' splice site in intron 39 is discussed | Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.
Szafranski K, Schindler S, Taudien S, Hiller M, Huse K, Jahn N, Schreiber S, Backofen R, Platzer M., Free PMC Article | 10/9/2007 |
| Results indicate that the coxsackievirus and adenovirus receptor interacts with multi-PDZ domain protein 1 (MUPP1) and is involved in MUPP1 recruitment to the tight junction. | The coxsackievirus and adenovirus receptor interacts with the multi-PDZ domain protein-1 (MUPP-1) within the tight junction.
Coyne CB, Voelker T, Pichla SL, Bergelson JM. | 01/21/2010 |