| Syntaxin-4 and SNAP23 are involved in neutrophil degranulation, but not in the release of mitochondrial DNA during NET formation. | Syntaxin-4 and SNAP23 are involved in neutrophil degranulation, but not in the release of mitochondrial DNA during NET formation.
Gigon L, Fettrelet T, Miholic M, McLeish KR, Yousefi S, Stojkov D, Simon HU., Free PMC Article | 11/16/2023 |
| Tumor-derived extracellular vesicles delivering TNF-alpha promotes colorectal cancer metastasis via the NF-kB/LAMB3/AKT axis by targeting SNAP23. | Tumor-derived extracellular vesicles delivering TNF-α promotes colorectal cancer metastasis via the NF-kB/LAMB3/AKT axis by targeting SNAP23.
Xie BW, Guan B, Chen W, Zhou M, Gu Q, Liu Y, Yan D. | 05/20/2023 |
| SNAP23 is essential for germination of EV-D68 replication organelles. | SNAP23 is essential for germination of EV-D68 replication organelles.
Miller K, Wagner MA, Jassey A, Jackson WT., Free PMC Article | 01/14/2023 |
| SNAP23-Mediated Perturbation of Cholesterol-Enriched Membrane Microdomain Promotes Extracellular Vesicle Production in Src-Activated Cancer Cells. | SNAP23-Mediated Perturbation of Cholesterol-Enriched Membrane Microdomain Promotes Extracellular Vesicle Production in Src-Activated Cancer Cells.
Mitani F, Hayasaka R, Hirayama A, Oneyama C. | 10/8/2022 |
| Pancreas-specific SNAP23 depletion prevents pancreatitis by attenuating pathological basolateral exocytosis and formation of trypsin-activating autolysosomes. | Pancreas-specific SNAP23 depletion prevents pancreatitis by attenuating pathological basolateral exocytosis and formation of trypsin-activating autolysosomes.
Dolai S, Takahashi T, Qin T, Liang T, Xie L, Kang F, Miao YF, Xie H, Kang Y, Manuel J, Winter E, Roche PA, Cattral MS, Gaisano HY., Free PMC Article | 04/16/2022 |
| LINC00511 drives invasive behavior in hepatocellular carcinoma by regulating exosome secretion and invadopodia formation. | LINC00511 drives invasive behavior in hepatocellular carcinoma by regulating exosome secretion and invadopodia formation.
Peng X, Li X, Yang S, Huang M, Wei S, Ma Y, Li Y, Wu B, Jin H, Li B, Tang S, Fan Q, Liu J, Yang L, Li H., Free PMC Article | 12/11/2021 |
| Let-7a regulates EV secretion and mitochondrial oxidative phosphorylation by targeting SNAP23 in colorectal cancer. | Let-7a regulates EV secretion and mitochondrial oxidative phosphorylation by targeting SNAP23 in colorectal cancer.
Liu YD, Zhuang XP, Cai DL, Cao C, Gu QS, Liu XN, Zheng BB, Guan BJ, Yu L, Li JK, Ding HB, Yan DW., Free PMC Article | 09/4/2021 |
| SNAP23 depletion enables more SNAP25/calcium channel excitosome formation to increase insulin exocytosis in type 2 diabetes. | SNAP23 depletion enables more SNAP25/calcium channel excitosome formation to increase insulin exocytosis in type 2 diabetes.
Liang T, Qin T, Kang F, Kang Y, Xie L, Zhu D, Dolai S, Greitzer-Antes D, Baker RK, Feng D, Tuduri E, Ostenson CG, Kieffer TJ, Banks K, Pessin JE, Gaisano HY., Free PMC Article | 06/26/2021 |
| IKKbeta activation promotes amphisome formation and extracellular vesicle secretion in tumor cells. | IKKβ activation promotes amphisome formation and extracellular vesicle secretion in tumor cells.
Peng X, Yang L, Ma Y, Li X, Yang S, Li Y, Wu B, Tang S, Zhang F, Zhang B, Liu J, Li H. | 04/17/2021 |
| Reduction in SNAP-23 Alters Microfilament Organization in Myofibrobastic Hepatic Stellate Cells. | Reduction in SNAP-23 Alters Microfilament Organization in Myofibrobastic Hepatic Stellate Cells.
Eubanks HB, Lavoie EG, Goree J, Kamykowski JA, Gokden N, Fausther M, Dranoff JA., Free PMC Article | 04/17/2021 |
| issue and biofluid enrichment analyses show broad representation of EVs from across the body without bias towards kidney or urine proteins. Among the proteins linked to neurological diseases, SNAP23 and calbindin were the most elevated in Parkinson's disease with 86% prediction success for disease diagnosis in the discovery cohort and 76% prediction success in the replication cohort. | Proteomic analysis of urinary extracellular vesicles reveal biomarkers for neurologic disease.
Wang S, Kojima K, Mobley JA, West AB., Free PMC Article | 12/21/2019 |
| Results show that SNAP23 is phosphorylated by HOTAIR promoting the release of exosome from hepatocellular carcinoma cells. | Long non-coding RNA HOTAIR promotes exosome secretion by regulating RAB35 and SNAP23 in hepatocellular carcinoma.
Yang L, Peng X, Li Y, Zhang X, Ma Y, Wu C, Fan Q, Wei S, Li H, Liu J., Free PMC Article | 08/24/2019 |
| Rab5 is essential for FcepsilonRI-triggered association of the SNARE protein SNAP23 with the secretory granules. | Rab5 is critical for SNAP23 regulated granule-granule fusion during compound exocytosis.
Klein O, Roded A, Zur N, Azouz NP, Pasternak O, Hirschberg K, Hammel I, Roche PA, Yatsu A, Fukuda M, Galli SJ, Sagi-Eisenberg R., Free PMC Article | 07/6/2019 |
| Data suggest that acylation of SNAP23 (synaptosome associated protein 23) and STX11 (syntaxin-11) regulates exocytosis in platelets; maintaining acylation states of SNAP23 and STX11 is important for platelet function. | Dynamic cycling of t-SNARE acylation regulates platelet exocytosis.
Zhang J, Huang Y, Chen J, Zhu H, Whiteheart SW., Free PMC Article | 01/12/2019 |
| PKM2 promotes tumor cell exosome release via phosphorylating protein SNAP23. | Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23.
Wei Y, Wang D, Jin F, Bian Z, Li L, Liang H, Li M, Shi L, Pan C, Zhu D, Chen X, Hu G, Liu Y, Zhang CY, Zen K., Free PMC Article | 11/17/2018 |
| SNAP23 suppressed progression of cervical cancer and induced cell cycle G2/M arrest via upregulating p21(cip1) and downregulating CyclinB1 | SNAP23 suppresses cervical cancer progression via modulating the cell cycle.
Zhu B, Zhang Q, Wu Y, Luo J, Zheng X, Xu L, Lu E, Qu J, Ren B. | 08/25/2018 |
| Knockdown of VAMP3 and SNAP23 reduces endothelial secretion of miR-126-3p and miR-200a-3p, as well as the proliferation, migration, and suppression of contractile markers in smooth muscle cells caused by vascular endothelial cell-coculture. | VAMP3 and SNAP23 mediate the disturbed flow-induced endothelial microRNA secretion and smooth muscle hyperplasia.
Zhu JJ, Liu YF, Zhang YP, Zhao CR, Yao WJ, Li YS, Wang KC, Huang TS, Pang W, Wang XF, Wang X, Chien S, Zhou J., Free PMC Article | 05/26/2018 |
| Study showed that SNAP23 was recruited to the close sites of lipid droplet (LD) in HCV-infected cells, implying that SNAP23 was required for HCV-induced LD enlargement and, HCV production. | ADP-ribosylation Factor-related Protein 1 Interacts with NS5A and Regulates Hepatitis C Virus Propagation.
Lim YS, Ngo HT, Lee J, Son K, Park EM, Hwang SB., Free PMC Article | 05/5/2018 |
| A novel regulatory mechanism for SNAP23-dependent mast cell activation of T. vaginalis-secreted LTB4 involving surface trafficking of BLT1. | SNAP23-Dependent Surface Translocation of Leukotriene B4 (LTB4) Receptor 1 Is Essential for NOX2-Mediated Exocytotic Degranulation in Human Mast Cells Induced by Trichomonas vaginalis-Secreted LTB4.
Min A, Lee YA, Kim KA, El-Benna J, Shin MH., Free PMC Article | 05/20/2017 |
| Study identified SNAP23 as a novel oncogene in Ovarian Cancer (OC). It is over-expressed in OC and could promote the proliferation, migration and invasion of OC in vitro. | SNAP23 promotes the malignant process of ovarian cancer.
Sun Q, Huang X, Zhang Q, Qu J, Shen Y, Wang X, Sun H, Wang J, Xu L, Chen X, Ren B., Free PMC Article | 03/18/2017 |
| Localization of SNAP23 was found in plasma membrane, lipid droplets and mitochondria of skeletal muscle. | Immunofluorescence microscopy of SNAP23 in human skeletal muscle reveals colocalization with plasma membrane, lipid droplets, and mitochondria.
Strauss JA, Shaw CS, Bradley H, Wilson OJ, Dorval T, Pilling J, Wagenmakers AJ., Free PMC Article | 09/17/2016 |
| these data suggest that SNAP23 is a key component of the endothelial SNARE machinery that mediates endothelial exocytosis. | SNAP23 Regulates Endothelial Exocytosis of von Willebrand Factor.
Zhu Q, Yamakuchi M, Lowenstein CJ., Free PMC Article | 05/14/2016 |
| Increased level of SNAP23-Syntaxin4-VAMP7 interaction correlates with decreased Syntaxin4 phosphorylation and trafficking of MT1-MMP to invadopodia during cellular invasion. | SNAP23, Syntaxin4, and vesicle-associated membrane protein 7 (VAMP7) mediate trafficking of membrane type 1-matrix metalloproteinase (MT1-MMP) during invadopodium formation and tumor cell invasion.
Williams KC, McNeilly RE, Coppolino MG., Free PMC Article | 02/28/2015 |
| The association of Src, EGFR and beta1 integrin is dependent upon membrane traffic that is mediated by syntaxin13 (officially known as STX12) and SNAP23. | SNARE-dependent interaction of Src, EGFR and β1 integrin regulates invadopodia formation and tumor cell invasion.
Williams KC, Coppolino MG. | 12/6/2014 |
| Data suggest SNAP23 and VAMP3 (vesicle-associated membrane protein 3) participate in interleukin-1beta-, interleukin-1 receptor-, calcium signaling-dependent secretion/exocytosis of interleukin-6 and tumor necrosis factor alpha from synoviocytes. | SNAP-23 and VAMP-3 contribute to the release of IL-6 and TNFα from a human synovial sarcoma cell line.
Boddul SV, Meng J, Dolly JO, Wang J. | 04/12/2014 |