| [Altered expression of 15-hydroxyprostaglandin dehydrogenase in chronic rhinosinusitis with nasal polyps]. | [Altered expression of 15-hydroxyprostaglandin dehydrogenase in chronic rhinosinusitis with nasal polyps].
Chen S, Chen J, Chen J, Wang Y., Free PMC Article | 11/1/2023 |
| CBR1 is an efficient catalyst for the reduction of glutathionylated aldehydes derived from lipid peroxidation. | Human carbonyl reductase 1 as efficient catalyst for the reduction of glutathionylated aldehydes derived from lipid peroxidation.
Rotondo R, Moschini R, Renzone G, Tuccinardi T, Balestri F, Cappiello M, Scaloni A, Mura U, Del-Corso A. | 09/19/2023 |
| LncRNA MYMLR promotes pituitary adenoma development by upregulating carbonyl reductase 1 via sponging miR-197-3p. | LncRNA MYMLR promotes pituitary adenoma development by upregulating carbonyl reductase 1 via sponging miR-197-3p.
Wang T, Mao P, Zhang Y, Cui B, Wang MD, Li Y, Gao K. | 10/22/2022 |
| Carbonyl Reductase 1 Attenuates Ischemic Brain Injury by Reducing Oxidative Stress and Neuroinflammation. | Carbonyl Reductase 1 Attenuates Ischemic Brain Injury by Reducing Oxidative Stress and Neuroinflammation.
Mao L, Wang K, Zhang P, Ren S, Sun J, Yang M, Zhang F, Sun B. | 01/22/2022 |
| Transcription of carbonyl reductase 1 is regulated by DNA topoisomerase II beta. | Transcription of carbonyl reductase 1 is regulated by DNA topoisomerase II beta.
Khazeem MM, Cowell IG, Harkin LF, Casement JW, Austin CA. | 05/15/2021 |
| Dehydrogenase/reductase activity of human carbonyl reductase 1 with NADP(H) acting as a prosthetic group. | Dehydrogenase/reductase activity of human carbonyl reductase 1 with NADP(H) acting as a prosthetic group.
Barracco V, Moschini R, Renzone G, Cappiello M, Balestri F, Scaloni A, Mura U, Del-Corso A. | 08/22/2020 |
| These findings suggest that CBR1 generating 20beta-dihydrocortisol is a novel pathway modulating GR activation and providing enzymatic protection against excessive GR activation in obesity. | Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity.
Morgan RA, Beck KR, Nixon M, Homer NZM, Crawford AA, Melchers D, Houtman R, Meijer OC, Stomby A, Anderson AJ, Upreti R, Stimson RH, Olsson T, Michoel T, Cohain A, Ruusalepp A, Schadt EE, Björkegren JLM, Andrew R, Kenyon CJ, Hadoke PWF, Odermatt A, Keen JA, Walker BR., Free PMC Article | 05/25/2019 |
| Findings suggest that CBR1 has an important role in DNA damage response through regulation of irradiation-mediated ROS generation causing to regulation of radiosensitivity, and CBR1 inhibition with IR might be a potent therapeutic strategy for head and neck squamous cell carcinoma treatment. | Carbonyl reductase 1 is a new target to improve the effect of radiotherapy on head and neck squamous cell carcinoma.
Yun M, Choi AJ, Lee YC, Kong M, Sung JY, Kim SS, Eun YG., Free PMC Article | 01/12/2019 |
| This study examined the impact of the functional single nucleotide polymorphism CBR1 rs9024 on the bioactivation of loxoprofen in a collection of human liver samples and tumor cell lines. | CBR1 rs9024 genotype status impacts the bioactivation of loxoprofen in human liver.
Quiñones-Lombraña A, Li N, Del Solar V, Atilla-Gokcumen GE, Blanco JG., Free PMC Article | 11/3/2018 |
| The ability of human carbonyl reductase 1 to efficiently catalyze the reduction of glutathionylated aldehydes derived from lipid peroxidation, that in the case of glutathionylated-4-hydroxyalkanals is associated to the ability to oxidize the hemiacetal hydroxyl group | Kinetic features of carbonyl reductase 1 acting on glutathionylated aldehydes.
Moschini R, Rotondo R, Renzone G, Balestri F, Cappiello M, Scaloni A, Mura U, Del-Corso A. | 12/2/2017 |
| Data suggest that fatty acids and acyl-CoAs bind competitively with respect to substrate binding to carbonyl reductase 1 (CBR1), an enzyme involved in first-pass drug metabolism in intestinal mucosa; inhibition of CBR1 by these products of digestion may lead to food-drug interactions. | Human carbonyl reductase 1 participating in intestinal first-pass drug metabolism is inhibited by fatty acids and acyl-CoAs.
Hara A, Endo S, Matsunaga T, El-Kabbani O, Miura T, Nishinaka T, Terada T. | 07/29/2017 |
| AKR1C3 is the primary enzyme and CBR1 is a minor enzyme responsible for warfarin reduction in human liver cytosol. | Carbonyl reduction of warfarin: Identification and characterization of human warfarin reductases.
Malátková P, Sokolová S, Chocholoušová Havlíková L, Wsól V. | 04/29/2017 |
| These results suggest that CR1 induces apoptosis by activating the caspase pathway via binding to TNFR1. | Inhibitory effect of carbonyl reductase 1 on ovarian cancer growth via tumor necrosis factor receptor signaling.
Miura R, Yokoyama Y, Shigeto T, Futagami M, Mizunuma H. | 09/10/2016 |
| Results demonstrate a trend toward decreased functional expression of selective hepatic reductases in ESRD livers. | Downregulation of Hepatic Carbonyl Reductase Type 1 in End-Stage Renal Disease.
Alshogran OY, Urquhart BL, Nolin TD. | 08/27/2016 |
| Critical insights into the substrate selectivity of hCBR1 and the interaction between hCBR1 and glutathione. | Structural insights on the catalytic site protection of human carbonyl reductase 1 by glutathione.
Liang Q, Liu R, Du S, Ding Y. | 07/30/2016 |
| Up-Regulation of Carbonyl Reductase 1 Renders Development of Doxorubicin Resistance in Human Gastrointestinal Cancers | Up-Regulation of Carbonyl Reductase 1 Renders Development of Doxorubicin Resistance in Human Gastrointestinal Cancers.
Matsunaga T, Kezuka C, Morikawa Y, Suzuki A, Endo S, Iguchi K, Miura T, Nishinaka T, Terada T, El-Kabbani O, Hara A, Ikari A. | 06/28/2016 |
| CBR1 decreases promoted tumor proliferation and growth as well as invasion and metastasis; CBR1 has potential to become a new candidate for molecular targeting therapy. | Decreased expression of carbonyl reductase 1 promotes ovarian cancer growth and proliferation.
Osawa Y, Yokoyama Y, Shigeto T, Futagami M, Mizunuma H. | 10/10/2015 |
| Inhibition of CBR1 may increase the efficacy of daunorubicin in cancer tissue. | Curcumin is a tight-binding inhibitor of the most efficient human daunorubicin reductase--Carbonyl reductase 1.
Hintzpeter J, Hornung J, Ebert B, Martin HJ, Maser E. | 07/4/2015 |
| Protein products of AKR1C1, AKR1C2, AKR7A3, CYP3A4, and carbonyl reductase (CBR1) were found in tumors and those of AKR1C1, AKR7A3, and CBR1 correlated with their transcript levels. | The role of cytochromes p450 and aldo-keto reductases in prognosis of breast carcinoma patients.
Hlaváč V, Brynychová V, Václavíková R, Ehrlichová M, Vrána D, Pecha V, Trnková M, Kodet R, Mrhalová M, Kubáčková K, Gatěk J, Vážan P, Souček P., Free PMC Article | 03/21/2015 |
| we suggest that PEP-1-CBR1 protein may be a therapeutic agent for the treatment of ischemic injuries as well as oxidative-stress-induced cell damage and death. | Neuroprotective effects of PEP-1-carbonyl reductase 1 against oxidative-stress-induced ischemic neuronal cell damage.
Kim YN, Jung HY, Eum WS, Kim DW, Shin MJ, Ahn EH, Kim SJ, Lee CH, Yong JI, Ryu EJ, Park J, Choi JH, Hwang IK, Choi SY. | 11/22/2014 |
| The stimulatory effect of cortisol on CBR1 expression may partly explain the concurrent increases of cortisol and prostaglandin PGF2alpha in human amnion tissue prior to the onset of labor | Induction of PGF2α synthesis by cortisol through GR dependent induction of CBR1 in human amnion fibroblasts.
Guo C, Wang W, Liu C, Myatt L, Sun K., Free PMC Article | 09/20/2014 |
| Nrf2 is a novel transcriptional regulator of CBR1 genes in humans. | Regulation of human carbonyl reductase 1 (CBR1, SDR21C1) gene by transcription factor Nrf2.
Miura T, Taketomi A, Nishinaka T, Terada T. | 08/10/2013 |
| GSNO-induced covalent modification of cysteine residues affects the kinetic mechanism of CBR1. | S-nitrosoglutathione covalently modifies cysteine residues of human carbonyl reductase 1 and affects its activity.
Hartmanová T, Tambor V, Lenčo J, Staab-Weijnitz CA, Maser E, Wsól V. | 08/10/2013 |
| regulation of human CBR1 expression by hsa-miR-574-5p and hsa-miR-921 depends upon rs9024 genotype status | MicroRNAs differentially regulate carbonyl reductase 1 (CBR1) gene expression dependent on the allele status of the common polymorphic variant rs9024.
Kalabus JL, Cheng Q, Blanco JG., Free PMC Article | 05/11/2013 |
| This pilot study suggests that CBR1 RNA expression may be helpful in identifying AML patients at risk of developing resistance or toxicity to daunorubicin due to increased formation of daunorubicinol. | Carbonyl reductase 1 expression influences daunorubicin metabolism in acute myeloid leukemia.
Varatharajan S, Abraham A, Zhang W, Shaji RV, Ahmed R, Abraham A, George B, Srivastava A, Chandy M, Mathews V, Balasubramanian P. | 05/4/2013 |