| Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality. | Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality.
Navare AT, Mast FD, Olivier JP, Bertomeu T, Neal ML, Carpp LN, Kaushansky A, Coulombe-Huntington J, Tyers M, Aitchison JD., Free PMC Article | 11/5/2022 |
| Src activates retrograde membrane traffic through phosphorylation of GBF1. | Src activates retrograde membrane traffic through phosphorylation of GBF1.
Chia J, Wang SC, Wee S, Gill DJ, Tay F, Kannan S, Verma CS, Gunaratne J, Bard FA., Free PMC Article | 01/29/2022 |
| Modeling the dynamic behaviors of the COPI vesicle formation regulators, the small GTPase Arf1 and its activating Sec7 guanine nucleotide exchange factor GBF1 on Golgi membranes. | Modeling the dynamic behaviors of the COPI vesicle formation regulators, the small GTPase Arf1 and its activating Sec7 guanine nucleotide exchange factor GBF1 on Golgi membranes.
Sager G, Szul T, Lee E, Kawai R, Presley JF, Sztul E., Free PMC Article | 08/21/2021 |
| SON DNA-binding protein mediates macrophage autophagy and responses to intracellular infection. | SON DNA-binding protein mediates macrophage autophagy and responses to intracellular infection.
Gregory DJ, DeLoid GM, Salmon SL, Metzger DW, Kramnik I, Kobzik L., Free PMC Article | 05/15/2021 |
| SNPs in SNCA, MCCC1, DLG2, GBF1 and MBNL2 are associated with Parkinson's disease in southern Chinese population. | SNPs in SNCA, MCCC1, DLG2, GBF1 and MBNL2 are associated with Parkinson's disease in southern Chinese population.
Zhao A, Li Y, Niu M, Li G, Luo N, Zhou L, Kang W, Liu J., Free PMC Article | 05/15/2021 |
| Class II Arfs require a brefeldin-A-sensitive factor for Golgi association. | Class II Arfs require a brefeldin-A-sensitive factor for Golgi association.
Dejgaard SY, Presley JF. | 02/27/2021 |
| Role of the Guanine Nucleotide Exchange Factor GBF1 in the Replication of RNA Viruses. | Role of the Guanine Nucleotide Exchange Factor GBF1 in the Replication of RNA Viruses.
Martínez JL, Arias CF., Free PMC Article | 02/20/2021 |
| De Novo and Inherited Variants in GBF1 are Associated with Axonal Neuropathy Caused by Golgi Fragmentation. | De Novo and Inherited Variants in GBF1 are Associated with Axonal Neuropathy Caused by Golgi Fragmentation.
Mendoza-Ferreira N, Karakaya M, Cengiz N, Beijer D, Brigatti KW, Gonzaga-Jauregui C, Fuhrmann N, Hölker I, Thelen MP, Zetzsche S, Rombo R, Puffenberger EG, De Jonghe P, Deconinck T, Zuchner S, Strauss KA, Carson V, Schrank B, Wunderlich G, Baets J, Wirth B., Free PMC Article | 12/5/2020 |
| Rab18 plays a role upstream of the cytosolic lipolytic enzyme adipose triglyceride lipase (ATGL) and that recruitment of ATGL by Rab18 is mediated by elements of the Arf/GBF1 machinery. We find that Arf4-GFP is accumulated on the subset of lipid droplets associated with Rab18. | Rab18 regulates lipolysis via Arf/GBF1 and adipose triglyceride lipase.
Dejgaard SY, Presley JF. | 07/18/2020 |
| GBF1 is required for the life cycle of positive strand RNA viruses | Quantitative Proteomics of Uukuniemi Virus-host Cell Interactions Reveals GBF1 as Proviral Host Factor for Phleboviruses.
Uckeley ZM, Moeller R, Kühn LI, Nilsson E, Robens C, Lasswitz L, Lindqvist R, Lenman A, Passos V, Voss Y, Sommerauer C, Kampmann M, Goffinet C, Meissner F, Överby AK, Lozach PY, Gerold G., Free PMC Article | 07/4/2020 |
| The Arf-activating property, but not the primary structure of the Sec7 domain of golgi brefeldin A resistant guanine nucleotide exchange factor 1 (GBF1), is indispensable for viral replication. However the C terminal HDS2 and HDS3 domains of GBF1 become important for replication of a poliovirus mutant with impaired 3A GBF1 interaction. | A Redundant Mechanism of Recruitment Underlies the Remarkable Plasticity of the Requirement of Poliovirus Replication for the Cellular ArfGEF GBF1.
Viktorova EG, Gabaglio S, Meissner JM, Lee E, Moghimi S, Sztul E, Belov GA., Free PMC Article | 06/20/2020 |
| The authors report that the catalytic activity of GBF1, but not the activation of Arf1, is essential for the assembly of the outer capsid of rotavirus. | The Guanine Nucleotide Exchange Factor GBF1 Participates in Rotavirus Replication.
Martínez JL, Arnoldi F, Schraner EM, Eichwald C, Silva-Ayala D, Lee E, Sztul E, Burrone ÓR, López S, Arias CF., Free PMC Article | 06/6/2020 |
| GBF1 alone maintains Golgi architecture; facilitates secretion; activates ADP-ribosylation factor (ARF)1, 3, 4, and 5; and recruits ARF effectors to Golgi membranes. | Promiscuity of the catalytic Sec7 domain within the guanine nucleotide exchange factor GBF1 in ARF activation, Golgi homeostasis, and effector recruitment.
Bhatt JM, Hancock W, Meissner JM, Kaczmarczyk A, Lee E, Viktorova E, Ramanadham S, Belov GA, Sztul E., Free PMC Article | 01/11/2020 |
| GBF1 regulates the spatial organization of mitochondria in a microtubule-dependent manner.GBF1 and Arf1 interact with Miro2. | GBF1 and Arf1 interact with Miro and regulate mitochondrial positioning within cells.
Walch L, Pellier E, Leng W, Lakisic G, Gautreau A, Contremoulins V, Verbavatz JM, Jackson CL., Free PMC Article | 12/21/2019 |
| that the recruitment to Golgi membranes via a putative receptor requires only the HDS1 and HDS2 domains in the C-terminal half of GBF1 | The Arf-GDP-regulated recruitment of GBF1 to Golgi membranes requires domains HDS1 and HDS2 and a Golgi-localized protein receptor.
Quilty D, Chan CJ, Yurkiw K, Bain A, Babolmorad G, Melançon P., Free PMC Article | 12/7/2019 |
| GBF1 interacts with NS3. | Functional and Physical Interaction between the Arf Activator GBF1 and Hepatitis C Virus NS3 Protein.
Lebsir N, Goueslain L, Farhat R, Callens N, Dubuisson J, Jackson CL, Rouillé Y., Free PMC Article | 11/23/2019 |
| GBF1 binds phosphoinositides, preferentially PI3P, PI4P and PI(4,5)P2, and that lipid binding requires the HDS1 domain. | The ARF guanine nucleotide exchange factor GBF1 is targeted to Golgi membranes through a PIP-binding domain.
Meissner JM, Bhatt JM, Lee E, Styers ML, Ivanova AA, Kahn RA, Sztul E., Free PMC Article | 08/10/2019 |
| GBF1 is a key protein in the cellular secretory pathway and is essential in the life cycle of many viruses. When GBF1 is targeted by viperin, a release of noninfectious capsid particles is produced. | Viperin Targets Flavivirus Virulence by Inducing Assembly of Noninfectious Capsid Particles.
Vonderstein K, Nilsson E, Hubel P, Nygård Skalman L, Upadhyay A, Pasto J, Pichlmair A, Lundmark R, Överby AK., Free PMC Article | 06/8/2019 |
| Experiments confirmed that GBF1 is required for hepatitis E virus replication. | Identification of GBF1 as a cellular factor required for hepatitis E virus RNA replication.
Farhat R, Ankavay M, Lebsir N, Gouttenoire J, Jackson CL, Wychowski C, Moradpour D, Dubuisson J, Rouillé Y, Cocquerel L., Free PMC Article | 08/4/2018 |
| Study provides evidence that GBF-1 is required in endoplasmic reticulum structure and endosomal traffic. | The ArfGEF GBF-1 Is Required for ER Structure, Secretion and Endocytic Transport in C. elegans.
Ackema KB, Sauder U, Solinger JA, Spang A., Free PMC Article | 10/14/2017 |
| GBF1 could regulate different metabolic pathways through the activation of different pairs of Arf proteins. | Identification of class II ADP-ribosylation factors as cellular factors required for hepatitis C virus replication.
Farhat R, Séron K, Ferlin J, Fénéant L, Belouzard S, Goueslain L, Jackson CL, Dubuisson J, Rouillé Y. | 07/15/2017 |
| Oligomerization appears to stabilize GBF1 in cells. | Oligomerization of the Sec7 domain Arf guanine nucleotide exchange factor GBF1 is dispensable for Golgi localization and function but regulates degradation.
Bhatt JM, Viktorova EG, Busby T, Wyrozumska P, Newman LE, Lin H, Lee E, Wright J, Belov GA, Kahn RA, Sztul E., Free PMC Article | 07/30/2016 |
| GBF1 plays a critical role early in dengue infection that is independent of its role in the maintenance of Golgi structure. | Quantitative proteomic analysis of host-virus interactions reveals a role for Golgi brefeldin A resistance factor 1 (GBF1) in dengue infection.
Carpp LN, Rogers RS, Moritz RL, Aitchison JD., Free PMC Article | 10/24/2015 |
| The role of GBF1 in poliovirus replication is independent of its Arf activating function. | Cell-specific establishment of poliovirus resistance to an inhibitor targeting a cellular protein.
Viktorova EG, Nchoutmboube J, Ford-Siltz LA, Belov GA., Free PMC Article | 05/30/2015 |
| Although human rhinovirus 3A protein was previously shown to interact with ACBD3, these data suggest that PI4KIIIbeta recruitment occurred independently of both GBF1 and ACBD3. | GBF1- and ACBD3-independent recruitment of PI4KIIIβ to replication sites by rhinovirus 3A proteins.
Dorobantu CM, Ford-Siltz LA, Sittig SP, Lanke KH, Belov GA, van Kuppeveld FJ, van der Schaar HM., Free PMC Article | 04/11/2015 |