| Roles of the adaptor protein tumor necrosis factor receptor type 1-associated death domain protein (TRADD) in human diseases. | Roles of the adaptor protein tumor necrosis factor receptor type 1-associated death domain protein (TRADD) in human diseases.
Chen Y, Gu Y, Xiong X, Zheng Y, Liu X, Wang W, Meng G. | 10/1/2022 |
| RIPK1 and TRADD Regulate TNF-Induced Signaling and Ripoptosome Formation. | RIPK1 and TRADD Regulate TNF-Induced Signaling and Ripoptosome Formation.
Feoktistova M, Makarov R, Yazdi AS, Panayotova-Dimitrova D., Free PMC Article | 12/18/2021 |
| Structural basis of NF-kappaB signaling by the p75 neurotrophin receptor interaction with adaptor protein TRADD through their respective death domains. | Structural basis of NF-κB signaling by the p75 neurotrophin receptor interaction with adaptor protein TRADD through their respective death domains.
Zhang N, Kisiswa L, Ramanujan A, Li Z, Sim EW, Tian X, Yuan W, Ibáñez CF, Lin Z., Free PMC Article | 12/4/2021 |
| Modulating TRADD to restore cellular homeostasis and inhibit apoptosis. | Modulating TRADD to restore cellular homeostasis and inhibit apoptosis.
Xu D, Zhao H, Jin M, Zhu H, Shan B, Geng J, Dziedzic SA, Amin P, Mifflin L, Naito MG, Najafov A, Xing J, Yan L, Liu J, Qin Y, Hu X, Wang H, Zhang M, Manuel VJ, Tan L, He Z, Sun ZJ, Lee VMY, Wagner G, Yuan J. | 02/20/2021 |
| Coronin 1B regulates the TNFalpha-induced apoptosis of HUVECs by mediating the interaction between TRADD and FADD. | Coronin 1B regulates the TNFα-induced apoptosis of HUVECs by mediating the interaction between TRADD and FADD.
Kim GY, Lim HJ, Kim WH, Park HY. | 11/28/2020 |
| SNHG9, delivered by adipocyte-derived exosomes, alleviates inflammation and apoptosis of endothelial cells through suppressing TRADD expression. | SNHG9, delivered by adipocyte-derived exosomes, alleviates inflammation and apoptosis of endothelial cells through suppressing TRADD expression.
Song Y, Li H, Ren X, Li H, Feng C. | 11/28/2020 |
| The TRADD C-terminal death domain comprises two super-secondary structures, an all-helix Greek key motif and a beta-hairpin motif flanked by two alpha helices, which make it unique among all known C-terminal death domain structures. | Structure of the C-terminal domain of TRADD reveals a novel fold in the death domain superfamily.
Zhang N, Yuan W, Fan JS, Lin Z., Free PMC Article | 02/16/2019 |
| Translocation of TRADD to DSBs into the nucleus contributes to cell survival in response to DNA damage through an activation of NHEJ DNA repair. | Nuclear TRADD prevents DNA damage-mediated death by facilitating non-homologous end-joining repair.
Koo GB, Ji JH, Cho H, Morgan MJ, Kim YS., Free PMC Article | 01/5/2019 |
| potential biological significance of TRADD mediated inflammatory response in the development of uterine leiomyoma, is reported. | Identification of TRADD as a potential biomarker in human uterine leiomyoma through iTRAQ based proteomic profiling.
Liu Y, Lu D, Sheng J, Luo L, Zhang W. | 06/23/2018 |
| we found that ORF3 protein downregulates TLR3-mediated NF-kappaB signaling via TRADD and RIP1. Our findings provide a new perspective on the cellular response in HEV infection and expand our understanding of the molecular mechanisms of Hepatitis E virus (HEV) pathogenesis in innate immunity. | The ORF3 Protein of Genotype 1 Hepatitis E Virus Suppresses TLR3-induced NF-κB Signaling via TRADD and RIP1.
He M, Wang M, Huang Y, Peng W, Zheng Z, Xia N, Xu J, Tian D., Free PMC Article | 04/28/2018 |
| In conclusion, for the first time, we report that TRADD, TRAF2, RIP1 and TAK1 play a role in the regulating TNF-alpha signalling in human myometrium. These findings are of significance given the central role of TNF-alpha in the processes of human labour and delivery. | TRADD, TRAF2, RIP1 and TAK1 are required for TNF-α-induced pro-labour mediators in human primary myometrial cells.
Lim R, Barker G, Lappas M. | 03/24/2018 |
| These data for the first time identifies miR-485-5p/TRADD axis in hydrogen sulfide protecting against TNF-alpha-induced neuronal cell apoptosis. | Hydrogen sulfide protects against TNF-α induced neuronal cell apoptosis through miR-485-5p/TRADD signaling.
Chen Z, Zhang Z, Zhang D, Li H, Sun Z. | 06/3/2017 |
| By reducing the levels of TRADD, wild type CFTR suppresses downstream proinflammatory NFkappaB signaling. | CFTR Controls the Activity of NF-κB by Enhancing the Degradation of TRADD.
Wang H, Cebotaru L, Lee HW, Yang Q, Pollard BS, Pollard HB, Guggino WB., Free PMC Article | 02/18/2017 |
| NPM-RAR binding to TRADD selectively inhibits caspase activation, while allowing activation of NFkappaB and JNK | NPM-RAR binding to TRADD selectively inhibits caspase activation, while allowing activation of NFκB and JNK.
Chattopadhyay A, Abecassis I, Redner RL., Free PMC Article | 09/24/2016 |
| The release of extracellular vesicles was triggered by TNFA from BEAS-2b cells.TNFA-triggered extracellular vesicles contained TNFR1 and TRADD. | TNFα triggers release of extracellular vesicles containing TNFR1 and TRADD, which can modulate TNFα responses of the parental cells.
Sohda M, Misumi Y, Oda K. | 02/20/2016 |
| MicroRNA-30c-2-3p negatively regulates NF-kappaB signaling and cell cycle progression through downregulation of TRADD and CCNE1 in breast cancer. | MicroRNA-30c-2-3p negatively regulates NF-κB signaling and cell cycle progression through downregulation of TRADD and CCNE1 in breast cancer.
Shukla K, Sharma AK, Ward A, Will R, Hielscher T, Balwierz A, Breunig C, Münstermann E, König R, Keklikoglou I, Wiemann S., Free PMC Article | 02/13/2016 |
| domains of calmodulin mediate FADD and TRADD interaction | N-terminal and C-terminal domains of calmodulin mediate FADD and TRADD interaction.
Papoff G, Trivieri N, Marsilio S, Crielesi R, Lalli C, Castellani L, Balog EM, Ruberti G., Free PMC Article | 10/17/2015 |
| PA induced the apoptosis of HUVECs by initiating the death pathway (TNF-R1/TRADD/caspases 8 pathway), whereas AA enhanced cell survival to protect vascular endothelial cells by activating the survival pathway (TNF-R1/RIP/NF-kappaB 50/NF-kappaB 65). | Life and death of human vascular endothelial cells by stimulation with free fatty acids through death receptors.
Zhan XR, Mu YM, Pan CY, Xiao YJ, Lu ZQ, Liu FH, Li XY, Yu JJ. | 09/26/2015 |
| Biologic assessment found that NPM-RAR expression impaired TNF-induced signaling through TRADD, blunting TNF-mediated activation of caspase-3 (CASP3) and caspase-8 (CASP8), to ultimately block apoptosis. | Extrinsic apoptosis is impeded by direct binding of the APL fusion protein NPM-RAR to TRADD.
Chattopadhyay A, Hood BL, Conrads TP, Redner RL., Free PMC Article | 06/6/2015 |
| TRADD gene expression was knocked down by an antisense oligonucleotide. | Anticancer activity of an antisense oligonucleotide targeting TRADD combined with proteasome inhibitors in chemoresistant hepatocellular carcinoma cells.
Witort E, Lulli M, Carloni V, Capaccioli S. | 05/24/2014 |
| structure-based mutations of TNFR-1 (P367A and P368A), TRADD (F266A), and RIP1 (M637A and R638A) disrupted formation of the death domain (DD) complex and prevented stable interactions among those DDs | Death domain complex of the TNFR-1, TRADD, and RIP1 proteins for death-inducing signaling.
Park YH, Jeong MS, Jang SB. | 04/19/2014 |
| Data indicate that the ASK1-FoxO3a-TRADD-caspase 8 pathway is present in neural tube defects (NTDs)-affected tissues. | Maternal hyperglycemia activates an ASK1-FoxO3a-caspase 8 pathway that leads to embryonic neural tube defects.
Yang P, Li X, Xu C, Eckert RL, Reece EA, Zielke HR, Wang F., Free PMC Article | 04/5/2014 |
| we demonstrated that the association between DR6 and TRADD was enhanced upon DQM3 stimulation and TRADD was involved in DR6-induced signaling activation | Agonist antibody activates death receptor 6 downstream signaling involving TRADD recruitment.
Hu R, Du Q, Yin X, Li J, Wang T, Zhang L. | 03/29/2014 |
| Data indicate that silencing tumor necrosis factor receptor 1 (TNFR1)-associated death domain protein (TRADD) in glioma cells results in decreased NF-kappaB activity, decreased proliferation of cells, and increased sensitivity to temozolomide. | Cytoplasmic TRADD confers a worse prognosis in glioblastoma.
Chakraborty S, Li L, Tang H, Xie Y, Puliyappadamba VT, Raisanen J, Burma S, Boothman DA, Cochran B, Wu J, Habib AA., Free PMC Article | 03/8/2014 |
| death domains in several proteins, including TRADD, FADD, RIPK1 and TNFR1, were directly inactivated by NleB, an enteropathogenic Escherichia coli (EPEC) type III secretion system effector known to inhibit host nuclear factor-kappaB (NF-kappaB) signalling | Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains.
Li S, Zhang L, Yao Q, Li L, Dong N, Rong J, Gao W, Ding X, Sun L, Chen X, Chen S, Shao F. | 12/14/2013 |